Sleep, major depressive disorder, and Alzheimer disease

Neurology, Journal Year: 2020, Volume and Issue: 95(14)

Published: Aug. 20, 2020

Objective

To explore the causal relationships between sleep, major depressive disorder (MDD), and Alzheimer disease (AD).

Methods

We conducted bidirectional 2-sample Mendelian randomization analyses. Genetic associations were obtained from largest genome-wide association studies currently available in UK Biobank (n = 446,118), Psychiatric Genomics Consortium 18,759), International of Alzheimer9s Project 63,926). used inverse variance–weighted method to estimate effects weighted median randomization–Egger for sensitivity analyses test pleiotropic effects.

Results

found that higher risk AD was significantly associated with being a "morning person" (odds ratio [OR] 1.01, p 0.001), shorter sleep duration (self-reported: β −0.006, 1.9 × 10⁻⁴; accelerometer based: −0.015, 6.9 10⁻⁵), less likely report long (β −0.003, 7.3 10⁻⁷), earlier timing least active 5 hours −0.024, 1.7 10⁻¹³), smaller number episodes −0.025, 5.7 10⁻¹⁴) after adjustment multiple comparisons. also lower insomnia (OR 0.99, 7 10⁻¹³). However, we did not find evidence these abnormal patterns causally related or significant relationship MDD AD.

Conclusion

may influence patterns. supporting role disturbed

Language: Английский

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Is Sleep Disruption a Cause or Consequence of Alzheimer’s Disease? Reviewing Its Possible Role as a Biomarker

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(3), P. 1168 - 1168

Published: Feb. 10, 2020

In recent years, the idea that sleep is critical for cognitive processing has gained strength. Alzheimer’s disease (AD) most common form of dementia worldwide and presents a high prevalence disturbances. However, it difficult to establish causal relations, since vicious circle emerges between different aspects disease. Nowadays, we know crucial consolidate memory remove excess beta-amyloid hyperphosphorilated tau accumulated in AD patients’ brains. this review, discuss how disturbances often precede years some pathological traits, as well decline, AD. We describe relevance consolidation, focusing on changes patterns contrast normal aging. also analyze whether alterations could be useful biomarkers predict risk developing compile sleep-related proposed biomarkers. The analysis microstructure highlighted detect specific oscillatory

Language: Английский

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Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice

Journal of Neuroscience, Journal Year: 2020, Volume and Issue: 40(7), P. 1581 - 1593

Published: Jan. 8, 2020

Alzheimer's disease (AD) is the most common neurodegenerative disorder, resulting in progressive decline of cognitive function patients. Familial forms AD are tied to mutations amyloid precursor protein, but cellular mechanisms that cause remain unclear. Inflammation and amyloidosis from β (Aβ) aggregates implicated neuron loss decline. activates protein-tyrosine phosphatase 1B (PTP1B), this could suppress many signaling pathways activate glycogen synthase kinase 3β (GSK3β) neurodegeneration. However, significance PTP1B pathology remains Here, we show pharmacological inhibition with trodusquemine or selective ablation neurons prevents hippocampal spatial memory deficits a transgenic mouse model Aβ (hAPP-J20 mice both sexes). Intriguingly, while systemic reduced inflammation hippocampus, neuronal did not. These results dissociate demonstrate hastens neurodegeneration AD. The protective effect coincides restoration GSK3β inhibition. Neuronal not affect cerebral levels plaque numbers, size hippocampus. In summary, our preclinical study suggests targeting may be new strategy intervene progression SIGNIFICANCE STATEMENT used expressing human protein bearing two familial asked whether activation participates process. Systemic using inhibitor prevented decline, attenuated inflammation. Importantly, neuron-targeted also reduce Therefore, rather than was critical for model, ameliorated by PTP1B.

Language: Английский

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Sleep Disturbance, Sleep Disorders and Co-Morbidities in the Care of the Older Person

Medical Sciences, Journal Year: 2021, Volume and Issue: 9(2), P. 31 - 31

Published: May 21, 2021

Sleep complaints can be both common and complex in the older patient. Their consideration is an important aspect of holistic care, may have impact on quality life, mortality, falls disease risk. assessment should form part comprehensive geriatric assessment. If sleep disturbance brought to light, disorders, co-morbidity medication management a multifaceted approach. Appreciation bi-directional relationship interplay between patients element patient care. This article provides brief overview disorders patients, addition their association with specific co-morbidities including depression, heart failure, respiratory gastro-oesophageal reflux disease, nocturia, pain, Parkinson’s dementia, polypharmacy falls. A potential systematic multidomain approach outlined, emphasis non-pharmacological treatment where possible.

Language: Английский

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Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: Oct. 25, 2021

Sleep deprivation (SD) is a common condition and an important health concern. In addition to metabolic cardiovascular risks, SD associates with decreases in cognitive performance. Neurovascular coupling (NVC, "functional hyperemia") critical homeostatic mechanism, which maintains adequate blood supply the brain during periods of intensive neuronal activity. To determine whether alters NVC responses performance, hemodynamic assessments were conducted prior 24 h post-SD healthy young male individuals (n = 10, 27 ± 3 years old). Cognition was evaluated battery tests from Cambridge Neuropsychological Test Automated Battery (CANTAB). Hemodynamic components measured by transcranial Doppler sonography (TCD) stimulation, dynamic retinal vessel analysis (DVA) flicker light functional near infrared spectroscopy (fNIRS) finger tapping motor task. Cognitive revealed impairments reaction time sustained attention after SD. Functional NIRS that significantly altered prefrontal cortex somatosensory NVC-related vascular DVA TCD did not change significantly. Interestingly, detected decreased task-associated cerebral flow (CBF) right middle artery sleep deprived participants. Our results demonstrate lead performance together CBF cortical responses.

Language: Английский

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