Efficacy of Internet-Based Cognitive Behavioral Therapy for Depression and Anxiety among Global Population during the COVID-19 Pandemic: A Systematic Review and Meta-Analysis of a Randomized Controlled Trial Study

Healthcare, Journal Year: 2022, Volume and Issue: 10(7), P. 1224 - 1224

Published: June 30, 2022

Background: Depression and anxiety have become the most common mental health disorders worldwide during COVID-19 pandemic, increasing interest in telemedicine has led to innovation of using internet-based cognitive behavioral therapy (iCBT). Objective: This systematic review meta-analysis aimed evaluate efficacy iCBT for depression among global population pandemic. Methods: A literature search was conducted on PubMed, Scopus, Cochrane, ProQuest, Wiley, Web Science PRISMA framework, only randomized controlled trials (RCTs) were included study. critical appraisal also performed Cochrane’s Risk Bias (RoB) 2. The used random-effects models analyze pooled mean difference (MD) its p-value. Results: Twelve RCTs qualitative analysis nine RCTs, which yielded 6778 patients with 6556 quantitative analysis. Despite high heterogeneity, all studies had a low risk bias. Pre- post-iCBT intervention forest plot depicts significant effect (p < 0.00001) MD 4.73 (95% CI: 4.55–4.90), while pre- 4.50 4.34–4.67). demonstrates that found significantly decrease scores However, substantial heterogeneity (I2 = 93%; p 0.00001 I2 90%) pre-/post-depression plots, respectively. Conclusions: comprises an evidence-based result treat population, as indicated by lower assessment scores. Delivering this situation needs be considered more extensively, it promising results yields benefits technological advancement psychotherapy.

Language: Английский

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Sleep Patterns and the Risk of Acute Stroke

Neurology, Journal Year: 2023, Volume and Issue: 100(21)

Published: April 5, 2023

Symptoms of sleep disturbance are common and may represent important modifiable risk factors stroke. We evaluated the association between a spectrum symptoms acute stroke in an international setting.The INTERSTROKE study is case-control patients presenting with first controls matched by age (±5 years) sex. Sleep previous month were assessed through questionnaire. Conditional logistic regression estimated stroke, expressed as odds ratios (ORs) 95% CIs. The primary model adjusted for age, occupation, marital status, modified Rankin scale at baseline, subsequent models adjusting potential mediators (behavioral/disease factors).Overall, 4,496 participants included, 1,799 them having experienced ischemic 439 intracerebral hemorrhage. Short (<5 hours: OR 3.15, CI 2.09-4.76), long (>9 2.67, 1.89-3.78), impaired quality (OR 1.52, 1.32-1.75), difficulty getting to 1.32, 1.13-1.55) or maintaining 1.33, 1.15-1.53), unplanned napping 1.48, 1.20-1.84), prolonged (>1 hour: 1.88, 1.49-2.38), snoring 1.91, 1.62-2.24), snorting 2.64, 2.17-3.20), breathing cessation 2.87, 2.28-3.60) all significantly associated increased model. A derived obstructive apnea score 2-3 (2.67, 2.25-3.15) cumulative (>5: 5.38, 4.03-7.18) also latter showing graded association. After extensive adjustment, significance was maintained most (not to/maintaining napping), similar findings subtypes.We found that These be marker individual independent factors. Future clinical trials warranted determine efficacy interventions prevention.

Language: Английский

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Sleep disturbance and activation of cellular and transcriptional mechanisms of inflammation in older adults

Brain Behavior and Immunity, Journal Year: 2022, Volume and Issue: 106, P. 67 - 75

Published: Aug. 8, 2022

Sleep disturbance, including poor subjective sleep quality and insomnia disorder, is common in older adults associated with increases age-related morbidity risk. Accumulating evidence implicates inflammation as an underlying mechanism. In two complementary studies, we examined whether disturbance activation of cellular transcriptional mechanisms adults.Study 1 healthy (n = 62), compared to those good 101), differed monocytic production interleukin (IL)-6 and/or tumor necrosis factor (TNF)-α following stimulation lipopolysaccharide. Study 2 disorder 17), without 25), the regulation transcription factors (TFs) related immune (i.e., nuclear factor-κB/Rel family), sympathetic nervous system (SNS) activity cAMP-response element-binding protein), hypothalamic-pituitary-adrenal (HPA) axis glucocorticoid receptor) anti-viral responses interferon-regulatory factor/interferon-stimulated response element) assessed peripheral blood mononuclear cells.In 1, quality, showed higher percentages stimulated monocytes producing IL-6 only (25.4 ± 16.8 % vs 20.4 13.9 %; p < 0.05, ηp2 0.03), TNF-α (37.6 13.1 31.2 14.3 0.01, 0.05), co-producing IL-6/TNF-α simultaneously (17.8 11.7 9.6 0.03). 2, TF (p's 0.05) SNS function 0.001), along lower HPA 0.05).In adults, diagnosis are cytokine changes activation, function, function. Activation markers might contribute link between

Language: Английский

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Malnutrition Risk in Older Adults: Evaluating the Diagnostic Relevance of Serum Biomarkers: SIRT-1, CCK-8, Melatonin, and Total Antioxidant Capacity (TAC)

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 726 - 726

Published: Feb. 18, 2025

Background/Objectives: Addressing the risk of malnutrition at an early stage is crucial to preventing its development, which can have a detrimental impact on physical and mental health status. This study investigates potential role biochemical biomarkers such as sirtuin 1 (SIRT-1), melatonin, cholecystokinin-8 (CCK-8), total antioxidant capacity (TAC) in identifying malnutrition. Methods: cross-sectional assessed 153 community-dwelling older adults using Mini Nutritional Assessment (MNA). Serum levels SIRT-1, CCK-8 were analyzed with enzyme-linked immunosorbent assay (ELISA), was measured ferric reducing ability plasma (FRAP) method. Results: TAC significantly positively correlated grip strength visceral adipose tissue, also showing associations appendicular skeletal muscle mass index (ASMI), body water, energy expenditure, fat-free index, fat (p < 0.001). emerged strong predictor (AUC = 0.58 females, AUC 0.64 males), whereas SIRT-1 0.57 for both sexes), melatonin 0.46 0.51 0.42 0.54 males) exhibited weaker predictive abilities. A multivariate model incorporating demonstrated excellent accuracy 0.84, 95% CI: 0.77-0.90) indicated association between elevated higher Conclusions: In conclusion, this highlights effectiveness multi-parameter reliable approach assessing adults, offering comprehensive evaluation condition. However, further research needed confirm applicability diverse elderly populations clinical settings.

Language: Английский

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Dietary patterns and insomnia symptoms: A systematic review and meta-analysis

Sleep Medicine Reviews, Journal Year: 2024, Volume and Issue: 75, P. 101936 - 101936

Published: April 15, 2024

Language: Английский

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Efficacy of Lemborexant in Adults ≥ 65 Years of Age with Insomnia Disorder

Neurology and Therapy, Journal Year: 2024, Volume and Issue: 13(4), P. 1081 - 1098

Published: May 15, 2024

Pharmacologic treatments are available to treat insomnia, a common and burdensome sleep disorder, but may be contraindicated in older adults who prone side effects from sleep-promoting drugs. These analyses of diary data Study E2006-G000-303 (Study 303) investigated the benefits lemborexant 5 mg (LEM5) 10 (LEM10) subgroup age ≥ 65 years with insomnia. 303, 12-month, double-blind study LEM5 LEM10 (age 18 years) insomnia disorder (sleep onset and/or maintenance difficulties) assessed subject-reported (subjective) sleep-onset latency (sSOL), efficiency (sSE), wake after (sWASO), total time (sTST). Morning sleepiness/alertness, severity (Insomnia Severity Index [ISI]), fatigue (Fatigue Scale [FSS]), perceptions sleep-related medication (Patient Global Impression–Insomnia [PGI-I] questionnaire), safety were also evaluated. In this (≥ years; n = 262), there significantly larger changes baseline for sSOL, sSE, sTST, sWASO versus placebo through month 6 (except 1), indicating improvement; these improvements sustained 12. Subject-reported increases morning alertness greater one or both LEM doses There ISI daytime functioning score decreases (improvement) at months 1, 3, (total score: doses; functioning: 1 3 6) FSS (both doses), Compared placebo, more subjects reported that doses) positively impacted ability sleep, fall asleep, TST 6, 12, no rebound drug withdrawal. was well tolerated 12; mild somnolence most treatment-emergent adverse event. Improvements efficacy LEM-treated observed as early first week treatment end tolerated. ClinicalTrials.gov identifier NCT02952820: E2006-G000-303; 303; SUNRISE-2 (First posted: October 2016); EudraCT 2015-001463-39 November 2016). Insomnia is associated significant difficulties, particularly adults. Although many available, some important risk not adequately (ability stay asleep), which frequent complaint people. Lemborexant has been approved multiple countries based on studies show improved adults' asleep To examine long-term benefit lemborexant, we participated 1-year study. The results showed within few days taking lasting 12 treatment, nightly nighttime (that is, it reduced took awake during night, increased time) than placebo. compared addition, those their symptoms less severe they had suggest good option disorder.

Language: Английский

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Common Sleep Disorders Affecting Older Adults

The Permanente Journal, Journal Year: 2022, Volume and Issue: 27(1), P. 122 - 132

Published: Dec. 12, 2022

Sleep disorders in older adults increase with aging, likely due to increased sleep latency, decreased efficiency, and total time. Common issues include chronic insomnia, circadian rhythm sleep-wake disorders, sleep-related movement sleep-disordered breathing. Diagnostic tools, such as a comprehensive history questionnaires, or log for more specific complaints, are commonly used. Polysomnography is not recommended routine test; however, it can be used abnormal behaviors during if treatment fails. disorder management based on the etiology may nonpharmacological pharmacological alternative treatments. For example, insomnia some consist of cognitive behavioral therapy, hygiene education, relaxation restriction, light stimulus control therapy. Because quality evidence poor, medication choice should shared decision-making between practitioner patient, limited prescription.

Language: Английский

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In-Home, Smart Sleep Monitoring System for Cardiorespiratory Estimation and Sleep Apnea Detection: Proof of Concept

IEEE Sensors Journal, Journal Year: 2024, Volume and Issue: 24(8), P. 13364 - 13377

Published: March 4, 2024

Apnea is a sleep disorder characterized by breathing interruptions during sleep, impacting cardiorespiratory function and overall health. Traditional diagnostic methods, like polysomnography (PSG), are unobtrusive, leading to noninvasive monitoring. This study aims develop validate novel monitoring system using sensor technology estimate parameters detect apnea. We designed seamless integrating noncontact force-sensitive resistor sensors collect ballistocardiogram signals associated with activity. enhanced the sensor's sensitivity reduced noise designing new concept of edge-measuring hemisphere dome mechanical hanger distribute force mechanically amplify micromovement caused cardiac respiration activities. In total, we deployed three sensors, two under thoracic one abdominal regions. The supported onboard signal preprocessing in multiple physical layers mattress. collected data four sleeping positions from 16 subjects analyzed them ensemble empirical mode decomposition (EMD) avoid frequency mixing. also developed an adaptive thresholding method identify error was 3.98 1.43 beats/min (BPM) heart rate (HR) estimation, respectively. apnea detected accuracy 87%. optimized such that only can measure parameters. Such reduction complexity simplification instruction use shows excellent potential for in-home continuous

Language: Английский

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Poor sleep quality and associated factors among community-dwelling older adult at Gondar town

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 8, 2025

Sleep disturbance poses a significant health concern for older adults, as it is associated with overall decline. Poor sleep quality increases the risk of chronic diseases, depression, anxiety, and diminished life. Therefore, this study aimed to assess prevalence poor its factors among adults living in community Gondar town, Northwest Ethiopia, 2023. A community-based cross-sectional was conducted town from February 20 April 30, assessed using Pittsburgh Quality Index (PSQI), validated tool. Data were coded Epi data version 3.0 analyzed STATA 14. Associated examined univariable multivariable logistic regression models. In total 845 participants involved 99.5% response rate. The elderly 54.6% 95% CI (51- 58%). Age ≥ 75 years [AOR = 3.88, CI: 2.11–7.10], social support 3.7, 2.35–5.81], physically inactive 4.42, 3.11–6.26], disease 2.45–5.55] depression 2.01, (CI: 1.42–2.83)] quality. 55% community-dwelling experience quality, particularly those advanced age, support. To address this, enhancing networking activities recommended. Engaging physical has shown significantly improve Healthcare providers should conduct regular screenings issues provide education about hygiene enhance adults. Future researchers are encouraged use Longitudinal studies explore impact communities.

Language: Английский

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Restful Nights: Strategies for Managing Sleep Disorders in Older Adults

The Journal for Nurse Practitioners, Journal Year: 2025, Volume and Issue: 21(4), P. 105305 - 105305

Published: April 1, 2025

Language: Английский

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