Sleep Deprivation and Neurological Disorders

BioMed Research International, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 19

Published: Nov. 23, 2020

Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health wellbeing. deprivation (SD) disturbs the circadian physiology exerts a negative impact on brain behavioural functions. SD impairs cellular clearance of misfolded neurotoxin proteins like α-synuclein, amyloid-β, tau which are involved major neurodegenerative diseases Alzheimer's disease Parkinson's disease. In addition, is also shown to affect glymphatic system, glial-dependent metabolic waste pathway, causing accumulation faulty synaptic compartments resulting cognitive decline. Also, affects immunological redox system neuroinflammation oxidative stress. Hence, it understand molecular biochemical alterations that causative factors leading these pathophysiological effects system. This review attempt this direction. It provides up-to-date information key processes, pathways, negatively affected by become reasons for neurological disorders over prolonged period time, if left unattended.

Language: Английский

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The Promise of Sleep: A Multi-Sensor Approach for Accurate Sleep Stage Detection Using the Oura Ring

Sensors, Journal Year: 2021, Volume and Issue: 21(13), P. 4302 - 4302

Published: June 23, 2021

Consumer-grade sleep trackers represent a promising tool for large scale studies and health management. However, the potential limitations of these devices remain less well quantified. Addressing this issue, we aim at providing comprehensive analysis impact accelerometer, autonomic nervous system (ANS)-mediated peripheral signals, circadian features stage detection on dataset. Four hundred forty nights from 106 individuals, total 3444 h combined polysomnography (PSG) physiological data wearable ring, were acquired. Features extracted to investigate relative different streams 2-stage (sleep wake) 4-stage classification accuracy (light NREM sleep, deep REM wake). Machine learning models evaluated using 5-fold cross-validation standardized framework assessment. Accuracy (sleep, was 94% simple accelerometer-based model 96% full that included ANS-derived features. 57% 79% when including Combining compact form factor finger multidimensional biometric sensory streams, machine learning, high wake-sleep staging can be accomplished.

Language: Английский

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Rising temperatures erode human sleep globally

One Earth, Journal Year: 2022, Volume and Issue: 5(5), P. 534 - 549

Published: May 1, 2022

Language: Английский

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A systematic review of ambient heat and sleep in a warming climate

Sleep Medicine Reviews, Journal Year: 2024, Volume and Issue: 75, P. 101915 - 101915

Published: March 6, 2024

Climate change is elevating nighttime and daytime temperatures worldwide, affecting a broad continuum of behavioral health outcomes. Disturbed sleep plausible pathway linking rising ambient with several observed adverse human responses shown to increase during hot weather. This systematic review aims provide comprehensive overview the literature investigating relationship between temperature valid outcomes measured in real-world settings, globally. We show that higher outdoor or indoor are generally associated degraded quality quantity worldwide. The negative effect heat persists across measures, stronger hottest months days, vulnerable populations, warmest regions. Although we identify opportunities strengthen state science, limited evidence fast adaptation suggests induced by climate urbanization pose planetary threat sleep, therefore health, performance, wellbeing.

Language: Английский

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Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation

Current Biology, Journal Year: 2019, Volume and Issue: 29(19), P. 3315 - 3322.e3

Published: Sept. 19, 2019

Our urge to sleep increases with time spent awake, until becomes inescapable. The following deprivation is longer and deeper, an increased power of delta (0.5–4 Hz) oscillations, a phenomenon termed homeostasis [1Greene R.W. Bjorness T.E. Suzuki A. adenosine-mediated, neuronal-glial, homeostatic response.Curr. Opin. Neurobiol. 2017; 44: 236-242Crossref PubMed Scopus (44) Google Scholar, 2Borbély A.A. Daan S. Wirz-Justice Deboer T. two-process model regulation: reappraisal.J. Sleep Res. 2016; 25: 131-143Crossref (673) 3Porkka-Heiskanen homeostasis.Curr. 2013; 23: 799-805Crossref (58) 4Franken P. Chollet D. Tafti M. regulation need under genetic control.J. Neurosci. 2001; 21: 2610-2621Crossref Scholar]. Although widely expressed genes regulate 5Funato H. Miyoshi C. Fujiyama Kanda Sato Wang Z. Ma J. Nakane Tomita Ikkyu et al.Forward-genetics analysis in randomly mutagenized mice.Nature. 539: 378-383Crossref (162) 6Holst S.C. Sousek Hefti K. Saberi-Moghadam Buck Ametamey S.M. Scheidegger Franken Henning Seifritz E. al.Cerebral mGluR5 availability contributes elevated behavioral adjustment after deprivation.eLife. 6 (e28751)Crossref 7Bjorness Kelly C.L. Gao Poffenberger V. Greene Control function the response by adenosine A1 receptors.J. 2009; 29: 1267-1276Crossref (146) 8Franken A role for clock 864-872Crossref (79) 9Mang G.M. La Spada F. Emmenegger Y. Chappuis Ripperger J.A. Albrecht U. Altered Rev-erbα knockout mice.Sleep (Basel). 39: 589-601Crossref (34) 10Hasan van der Veen D.R. Winsky-Sommerer R. Hogben Laing E.E. Koentgen Dijk D.J. Archer S.N. human phenotype mice expressing primate-specific PER3 variable-number tandem-repeat coding-region polymorphism.FASEB 2014; 28: 2441-2454Crossref (26) Scholar] process tracked somnogens phosphorylation 11Halassa M.M. Florian Fellin Munoz J.R. Lee S.Y. Abel Haydon P.G. Frank M.G. Astrocytic modulation cognitive consequences loss.Neuron. 61: 213-219Abstract Full Text PDF (617) 12Leenaars C.H.C. Savelyev S.A. Van Mierden Joosten R.N.J.M.A. Dematteis Porkka-Heiskanen Feenstra M.G.P. Intracerebral during deprivation: meta-analysis new experimental data.J. Circadian Rhythms. 2018; 16: 11Crossref 13Porkka-Heiskanen Strecker R.E. Thakkar Bjorkum McCarley Adenosine: mediator sleep-inducing effects prolonged wakefulness.Science. 1997; 276: 1265-1268Crossref (921) 14Wang Li Ogawa Lou X. al.Quantitative phosphoproteomic molecular substrates need.Nature. 558: 435-439Crossref (112) Scholar], at circuit level has remained mysterious. Previously, we found that sedation induced α2-adrenergic agonists (e.g., dexmedetomidine) both depend on preoptic (PO) hypothalamus [15Zhang Ferretti Güntan İ. Moro Steinberg E.A. Ye Zecharia A.Y. Yu Vyssotski A.L. Brickley S.G. al.Neuronal ensembles sufficient recovery sedative actions α2 adrenergic agonists.Nat. 2015; 18: 553-561Crossref (144) 16Nelson L.E. Lu Guo Saper C.B. Franks N.P. Maze alpha2-adrenoceptor agonist dexmedetomidine converges endogenous sleep-promoting pathway exert its effects.Anesthesiology. 2003; 98: 428-436Crossref Dexmedetomidine, increasingly used long-term intensive care units [17Adams Brown G.T. Davidson Fisher Mathisen Thomson G. Webster N.R. Efficacy compared midazolam adult patients: systematic review.Br. Anaesth. 111: 703-710Abstract (42) induces non-rapid-eye-movement (NREM)-like but undesirable hypothermia [18Yu Wisden W. states targeting histamine noradrenergic systems.Front. Neural Circuits. 12: 4Crossref (30) 19Seidel W.F. Dement W.C. Edgar D.M. Alpha-2 sleep: time-of-day-dependent pharmacodynamic profiles clonidine rat.J. Pharmacol. Exp. Ther. 1995; 275: 263-273PubMed Within PO, various neuronal subtypes GABA/galanin glutamate/NOS1) induce NREM [20Sherin J.E. Shiromani P.J. Activation ventrolateral neurons sleep.Science. 1996; 271: 216-219Crossref (859) 21Kroeger Absi Gagliardi Bandaru S.S. Madara J.C. Ferrari L.L. Arrigoni Münzberg Scammell Vetrivelan Galanin area promote heat loss mice.Nat. Commun. 9: 4129Crossref (109) 22Harding E.C. Miao Andrews N. Lignos L. Miracca Ba Yustos al.A hub binding initiation body cooling warm external stimulus.Curr. Biol. 2263-2273.e4Abstract (64) concomitant [21Kroeger This could be because sleep's restorative lower temperature [23McGinty Szymusiak Keeping cool: hypothesis about mechanisms functions slow-wave sleep.Trends 1990; 13: 480-487Abstract (309) 24Hoekstra Hubbard Cold-inducible RNA-binding protein (CIRBP) adjusts clock-gene expression REM-sleep 2019; 8 (e43400)Crossref (31) Here, show lesioned PO galanin have reduced homeostasis: there diminished increase power, catch up little lost sleep. Furthermore, cannot high-power oscillations or sustained hypothermia. Some hours administration wild-type rebound when they enter normal sleep, reminiscent emergence from torpor. lacking neurons. Thus, dexmedetomidine-induced require likely share common mechanisms.

Language: Английский

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Automating sleep stage classification using wireless, wearable sensors

npj Digital Medicine, Journal Year: 2019, Volume and Issue: 2(1)

Published: Dec. 20, 2019

Polysomnography (PSG) is the current gold standard in high-resolution sleep monitoring; however, this method obtrusive, expensive, and time-consuming. Conversely, commercially available wrist monitors such as ActiWatch can monitor for multiple days at low cost, but often overestimate cannot differentiate between stages, rapid eye movement (REM) non-REM. Wireless wearable sensors are a promising alternative their portability access to data customizable analytics. We present multimodal sensor system measuring hand acceleration, electrocardiography, distal skin temperature that outperforms ActiWatch, detecting wake with recall of 74.4% 90.0%, respectively, well wake, non-REM, REM 73.3%, 59.0%, 56.0%, respectively. This approach will enable clinicians researchers more easily, accurately, inexpensively assess long-term patterns, diagnose disorders, risk factors disease both laboratory home settings.

Language: Английский

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The effects of seasons and weather on sleep patterns measured through longitudinal multimodal sensing

npj Digital Medicine, Journal Year: 2021, Volume and Issue: 4(1)

Published: April 28, 2021

Abstract Previous studies of seasonal effects on sleep have yielded unclear results, likely due to methodological differences and limitations in data size and/or quality. We measured the habits 216 individuals across U.S. over four seasons for slightly a year using objective, continuous, unobtrusive measures local weather. In addition, we controlled demographics trait-like constructs previously identified correlate with behavior. investigated weather duration, bedtime, wake time. found several small but statistically significant patterns. observe strongest time especially during spring season: times are earlier, duration decreases (compared reference season winter). Sleep also modestly when day lengths get longer (between winter summer solstice). Bedtimes tend be later as outdoor temperature increases.

Language: Английский

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Sleep and thermoregulation

Current Opinion in Physiology, Journal Year: 2019, Volume and Issue: 15, P. 7 - 13

Published: Nov. 26, 2019

In homeothermic animals sleep preparatory behaviours often promote thermal efficiency, including warmth-seeking, adopting particular postures (curling up, head tucking) and nest building, all promoting warmer skin microclimates. Skin warmth induces NREM body cooling via circuitry that connects sensation to the preoptic hypothalamus. Coupling induction lower temperature could serve minimise energy expenditure or allow reallocation. Cooling during may also induce transcriptional changes in genes whose products facilitate housekeeping functions measure time spent sleeping.

Language: Английский

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Fundamental Concepts of Human Thermoregulation and Adaptation to Heat: A Review in the Context of Global Warming

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(21), P. 7795 - 7795

Published: Oct. 24, 2020

The international community has recognized global warming as an impending catastrophe that poses significant threat to life on earth. In response, the signatories of Paris Agreement (2015) have committed limit increase in mean temperature < 1.5 °C from pre-industry period, which is defined 1950-1890. Considering protection human a central focus Agreement, naturally endowed properties body protect itself environmental extremes should form core integrated and multifaceted solution against warming. Scholars believe heat thermoregulation played important roles evolution continue be mechanism allows humans explore, labor live extreme conditions. However, effort focused primarily protecting environment reduction greenhouse gases by changing behavior, industrial practices government policies, with limited consideration given nature design thermoregulatory system. Global projected challenge limits thermoregulation, can enhanced complementing innate thermo-plasticity appropriate behavioral changes technological innovations. Therefore, primary aim this review discuss fundamental concepts physiology underlying bases for adaptation Potential strategies extend tolerance through adaptations innovations will also discussed. An postulated sleep/wake cycles would gravitate towards sub-nocturnal pattern, especially outdoor activities, avoid day. Technologically, current concept air conditioning space room likely steer targeted surface cooling. was conducted using materials were derived PubMed search engine personal library author. combinations keywords are related theme topics respective sections review. final set articles selected considered "state art," based their contributions strength scientific evidence novelty domain knowledge

Language: Английский

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Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(10), P. 1805 - 1819

Published: Sept. 21, 2023

The prefrontal cortex (PFC) enables mammals to respond situations, including internal states, with appropriate actions. One such state could be 'tiredness'. Here, using activity tagging in the mouse PFC, we identified particularly excitable, fast-spiking, somatostatin-expressing, γ-aminobutyric acid (GABA) (PFC

Language: Английский

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