Jurnal Penelitian Pendidikan IPA,
Journal Year:
2024,
Volume and Issue:
10(7), P. 3597 - 3604
Published: July 25, 2024
Neuroinflammation,
an
inflammatory
response
within
the
central
nervous
system
(CNS),
plays
a
critical
role
in
various
neurological
disorders,
including
neurodegenerative
diseases.
Alpha
linolenic
acid
(ALA),
essential
omega-3
polyunsaturated
fatty
acid,
has
shown
promising
health
benefits
due
to
its
antioxidant
and
anti-inflammatory
properties.
This
article
aims
thoroughly
examine
potential
effects
of
ALA
reducing
neuroinflammation,
emphasizing
roles
as
agent.
The
review
focuses
on
studies
published
between
2018
2023,
sourced
from
reputable
academic
databases
such
PubMed,
Semantic
Scholar,
Google
ScienceDirect,
with
nine
key
papers
selected.
findings
indicate
that
significantly
mitigates
neuroinflammation
by
decreasing
reactive
oxygen
species
(ROS)
via
Nrf-2/HO-1/JNK
signaling
pathway.
Additionally,
reduces
cytokines
inhibiting
p-JNK
activation,
disrupting
lipid
rafts,
blocking
pro-inflammatory
transcription
factor
NF-κB,
altering
cell
membrane
phospholipid
composition.
concludes
may
have
therapeutic
through
actions,
offering
possible
for
conditions,
Alzheimer's
Parkinson's
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(6), P. 3169 - 3189
Published: April 14, 2024
Abstract
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
the
accumulation
of
amyloid‐beta
plaques
and
neurofibrillary
tangles,
leading
to
neuronal
loss.
Curcumin,
polyphenolic
compound
derived
from
Curcuma
longa
,
has
shown
potential
neuroprotective
effects
due
its
anti‐inflammatory
antioxidant
properties.
This
review
aims
synthesize
current
preclinical
data
on
anti‐neuroinflammatory
mechanisms
curcumin
in
context
AD,
addressing
pharmacokinetics,
bioavailability,
as
therapeutic
adjunct.
An
exhaustive
literature
search
was
conducted,
focusing
recent
studies
within
last
10
years
related
curcumin's
impact
neuroinflammation
role
AD.
The
methodology
included
sourcing
articles
specialized
databases
using
specific
medical
subject
headings
terms
ensure
precision
relevance.
Curcumin
demonstrates
significant
properties
modulating
neuroinflammatory
pathways,
scavenging
reactive
oxygen
species,
inhibiting
production
pro‐inflammatory
cytokines.
Despite
potential,
challenges
remain
regarding
limited
bioavailability
scarcity
comprehensive
human
clinical
trials.
emerges
promising
adjunct
AD
multimodal
benefits.
However,
further
research
required
overcome
establish
effective
dosing
regimens
subjects.
Developing
novel
delivery
systems
formulations
may
enhance
treatment.
Journal of Neuroimmune Pharmacology,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Feb. 29, 2024
Abstract
Inflammasomes
are
important
modulators
of
inflammation.
Dysregulation
inflammasomes
can
enhance
vulnerability
to
conditions
such
as
neurodegenerative
diseases,
autoinflammatory
and
metabolic
disorders.
Among
various
inflammasomes,
Nucleotide-binding
oligomerization
domain
leucine-rich
repeat
pyrin
domain-containing
protein
3
(NLRP3)
is
the
best-characterized
inflammasome
related
inflammatory
diseases.
NLRP3
an
intracellular
sensor
that
recognizes
pathogen-associated
molecular
patterns
damage-associated
resulting
in
assembly
activation
inflammasome.
The
includes
NLRP3,
adaptor
apoptosis-associated
speck-like
(ASC),
effector
cysteine
protease
procaspase-1
plays
imperative
role
caspase-1
stimulation
which
further
initiates
a
secondary
response.
Regulation
ameliorates
NLRP3-mediated
Much
effort
has
been
invested
studying
activation,
exploration
specific
inhibitors
epigenetic
mechanisms
controlling
This
review
gives
overview
established
assembly,
its
brief
mechanistic
activations
well
current
update
on
non-specific
could
be
used
We
also
focused
recently
discovered
mediated
by
DNA
methylation,
histone
alterations,
microRNAs
regulating
expression
inflammasome,
resulted
novel
method
gaining
insight
into
modulate
activity
introducing
potential
therapeutic
strategies
for
CNS
Graphical
"Image
missing"
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(1), P. 104 - 104
Published: Jan. 15, 2025
Cytokine-mediated
inflammation
is
increasingly
recognized
for
playing
a
vital
role
in
the
pathophysiology
of
wide
range
brain
disorders,
including
neurodegenerative,
psychiatric,
and
neurodevelopmental
problems.
Pro-inflammatory
cytokines
such
as
interleukin-1
(IL-1),
tumor
necrosis
factor-alpha
(TNF-α),
interleukin-6
(IL-6)
cause
neuroinflammation,
alter
function,
accelerate
disease
development.
Despite
progress
understanding
these
pathways,
effective
medicines
targeting
are
still
limited.
Traditional
anti-inflammatory
immunomodulatory
drugs
peripheral
inflammatory
illnesses.
Still,
they
face
substantial
hurdles
when
applied
to
central
nervous
system
(CNS),
blood-brain
barrier
(BBB)
unwanted
systemic
effects.
This
review
highlights
developing
treatment
techniques
modifying
cytokine-driven
focusing
on
advances
that
selectively
target
critical
involved
pathology.
Novel
approaches,
cytokine-specific
inhibitors,
antibody-based
therapeutics,
gene-
RNA-based
interventions,
sophisticated
drug
delivery
systems
like
nanoparticles,
show
promise
with
respect
lowering
neuroinflammation
greater
specificity
safety.
Furthermore,
developments
biomarker
discoveries
neuroimaging
improving
our
ability
monitor
responses,
allowing
more
accurate
personalized
regimens.
Preclinical
clinical
trial
data
demonstrate
therapeutic
potential
tailored
techniques.
However,
significant
challenges
remain,
across
BBB
reducing
off-target
As
research
advances,
creation
personalized,
cytokine-centered
therapeutics
has
therapy
landscape
illnesses,
giving
patients
hope
better
results
higher
quality
life.
Frontiers in Cellular Neuroscience,
Journal Year:
2025,
Volume and Issue:
19
Published: March 19, 2025
The
nervous
system
relies
on
a
balance
of
excitatory
and
inhibitory
signals.
Aberrant
neuronal
hyperactivity
is
pathological
phenotype
associated
with
several
neurological
disorders,
its
most
severe
effects
observed
in
epilepsy
patients.
This
review
explores
the
literature
spontaneous
synchronized
activity,
physiological
role,
aberrant
forms
disease.
Emphasizing
importance
targeting
underlying
disease
mechanisms
beyond
traditional
neuron-focused
therapies,
delves
into
role
astroglia
progression.
We
detail
how
transitions
from
normal
to
state,
leading
epileptogenic
seizures
cognitive
decline.
Astroglia
activity
correlated
epileptiform
both
animal
models
human
tissue,
indicating
their
potential
seizure
induction
modulation.
Understanding
astroglia's
dual
beneficial
detrimental
roles
could
lead
novel
treatments
for
other
disorders
as
substrate.
Neurorehabilitation and neural repair,
Journal Year:
2023,
Volume and Issue:
38(1), P. 7 - 18
Published: Oct. 14, 2023
Rationale:
Fatigue
affects
almost
half
of
all
people
living
with
stroke.
Stroke
survivors
rank
understanding
fatigue
and
how
to
reduce
it
as
one
the
highest
research
priorities.
Methods:
We
convened
an
interdisciplinary,
international
group
clinical
pre-clinical
researchers
lived
experience
experts.
identified
four
priority
areas:
(1)
best
measurement
tools
for
research,
(2)
identification
potentially
modifiable
causes,
(3)
promising
interventions
recommendations
future
trials,
(4)
possible
biological
mechanisms
fatigue.
Cross-cutting
themes
were
aphasia
voice
experience.
Working
parties
formed
structured
consensus
building
processes
followed.
Results:
present
20
covering
outcome
measures
development,
testing
new
areas
on
biology
post-stroke
developed
recommend
use
Clinical
Assessment
Tool.
Conclusions:
By
synthesizing
current
knowledge
in
across
fields,
our
work
provides
a
roadmap
into
International Journal of Stroke,
Journal Year:
2023,
Volume and Issue:
19(2), P. 133 - 144
Published: July 10, 2023
Fatigue
affects
almost
half
of
all
people
living
with
stroke.
Stroke
survivors
rank
understanding
fatigue
and
how
to
reduce
it
as
one
the
highest
research
priorities.
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: June 7, 2024
There
is
a
well-established
link
between
physical
activity
and
brain
health.
As
such,
the
effectiveness
of
exercise
as
therapeutic
strategy
has
been
explored
in
variety
neurological
contexts.
To
determine
extent
to
which
could
be
most
beneficial
under
different
circumstances,
studies
are
needed
uncover
underlying
mechanisms
behind
benefits
activity.
Interest
grown
understanding
how
can
regulate
microglia,
resident
immune
cells
central
nervous
system.
Microglia
key
mediators
neuroinflammatory
processes
play
role
maintaining
homeostasis
healthy
pathological
settings.
Here,
we
explore
evidence
suggesting
that
potential
microglia
various
animal
models.
We
emphasize
areas
where
future
research
contribute
uncovering
engaging
exercise.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(19), P. 3421 - 3421
Published: Oct. 9, 2024
Due
to
the
continuous
aging
of
population
and
consequent
increase
in
dementia,
focus
on
its
prevention
is
growing
importance
for
public
health.
Since
effective
pharmacological
treatments
are
not
yet
available,
other
determinants
cognitive
decline
have
become
fundamental.
Several
studies
indicated
that
Mediterranean
diet
(MedDiet)
associated
with
reduced
incident
but
few
been
conducted
persons
already
diagnosed
Alzheimer’s
disease
(AD).
We
age-matched
73
patients
mild–moderate
AD
controls
(mean
age
whole
group
=
76.5
±
6.5;
67.5%
women).
The
cases
had
a
significantly
lower
adherence
MedDiet
physical
activity
vs.
controls,
where
only
one
participant
(1.4%)
high
among
compared
5.5%
while
52.5%
moderate
82.2%
controls.
In
multivariate
analysis,
presence
was
Other
factors
examined
(gender,
age,
level,
multimorbidity,
polypharmacy)
were
MedDiet.
Thus,
low
very
activity.
Public
health
strategies
aimed
at
promoting
older
people
should
be
priority.
