Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 15, 2023
Abstract
Type
2
diabetes
mellitus
(T2DM)
can
lead
to
dysfunction
in
the
brain's
glymphatic
system,
but
relationship
between
system
function
and
insulin
resistance
remains
unclear.
The
aim
of
this
study
was
investigate
connection
changes
T2DM
surrogate
marker
for
resistance,
Triglyceride-Glucose
Index
(TyG).
A
total
28
patients
(T2DM
group)
24
healthy
volunteers
(HC
were
included
study.
We
outlined
circular
regions
with
a
diameter
5.0
mm
on
diffusion
tensor
imaging
(DTI)
projection
association
fibers
body
lateral
ventricle.
compared
differences
DTI-ALPS
index
related
fiber
diffusivity
two
groups.
Additionally,
TyG
calculated
based
fasting
blood
glucose
triglyceride
levels.
Age
as
covariate
analyze
correlation
ALPS
patients.
results
showed
that
Dxproj
group
lower
than
those
HC
group,
while
Dyproj
higher
group.
In
index,
Dxassoc,
all
negatively
correlated.
decreased
may
be
associated
suggesting
lymphatic
damage,
white
matter
microstructure.
Magnetic Resonance in Medical Sciences,
Journal Year:
2024,
Volume and Issue:
23(3), P. 268 - 290
Published: Jan. 1, 2024
More
than
5
years
have
passed
since
the
Diffusion
Tensor
Image
Analysis
ALong
Perivascular
Space
(DTI-ALPS)
method
was
proposed
with
intention
of
evaluating
glymphatic
system.
This
is
handy
due
to
its
noninvasiveness,
provision
a
simple
index
in
straightforward
formula,
and
possibility
retrospective
analysis.
Therefore,
ALPS
adopted
evaluate
system
for
many
disorders
studies.
The
purpose
this
review
look
back
discuss
at
moment.
NMR in Biomedicine,
Journal Year:
2024,
Volume and Issue:
37(9)
Published: May 7, 2024
Abstract
Cerebrospinal
fluid
(CSF)
plays
a
critical
role
in
metabolic
waste
clearance
from
the
brain,
requiring
its
circulation
throughout
various
brain
pathways,
including
ventricular
system,
subarachnoid
spaces,
para‐arterial
interstitial
and
para‐venous
spaces.
The
complexity
of
CSF
has
posed
challenge
obtaining
noninvasive
measurements
dynamics.
assessment
dynamics
circulatory
pathways
is
possible
using
diffusion
magnetic
resonance
imaging
(MRI)
with
optimized
sensitivity
to
incoherent
water
movement
across
brain.
This
review
presents
an
overview
both
established
emerging
MRI
techniques
designed
measure
their
potential
clinical
applications.
discussion
offers
insights
into
optimization
acquisition
parameters
enhance
specificity
metrics
on
underlying
Lastly,
we
emphasize
importance
cautious
interpretations
diffusion‐based
imaging,
especially
when
differentiating
between
tissue‐
fluid‐related
changes
or
elucidating
structural
versus
functional
alterations.
Neurosurgical Review,
Journal Year:
2024,
Volume and Issue:
47(1)
Published: Jan. 23, 2024
Abstract
The
discovery
of
the
glymphatic
system
has
revolutionized
our
understanding
cerebrospinal
fluid
(CSF)
circulation
and
interstitial
waste
clearance
in
brain.
This
scoping
review
aims
to
synthesize
current
literature
on
system’s
role
neurosurgical
conditions
its
potential
as
a
therapeutic
target.
We
conducted
comprehensive
search
PubMed
Scopus
databases
for
studies
published
between
January
1,
2012,
October
31,
2023.
Studies
were
selected
based
their
relevance
function,
with
both
animal
human
included.
Data
extraction
focused
methods
quantifying
function
main
results.
A
total
67
articles
included,
covering
such
idiopathic
normal
pressure
hydrocephalus
(iNPH),
intracranial
hypertension
(IIH),
subarachnoid
hemorrhage
(SAH),
stroke,
tumors,
traumatic
brain
injury
(TBI).
Significant
dysregulation
was
noted
iNPH
IIH,
evidence
impaired
CSF
dynamics
delayed
clearance.
SAH
indicated
dysfunction
effects
nimodipine
tissue
plasminogen
activator.
In
alterations
activity
correlated
extent
edema
neurological
recovery.
TBI
highlighted
post-injury
cognitive
outcomes.
Results
indicate
that
regulation
aquaporin-4
(AQP4)
channels
is
critical
target
intervention.
plays
pathophysiology
various
conditions,
influencing
dynamics.
Targeting
AQP4
presents
significant
strategy.
Although
promising,
translation
these
findings
into
clinical
practice
requires
further
studies.
Future
research
should
focus
establishing
non-invasive
biomarkers
exploring
long-term
dysfunction.
NMR in Biomedicine,
Journal Year:
2024,
Volume and Issue:
37(8)
Published: March 11, 2024
The
glymphatic
system
is
a
of
specialized
perivascular
spaces
in
the
brain
that
facilitates
removal
toxic
waste
solutes
from
brain.
Evaluation
function
by
means
magnetic
resonance
imaging
(MRI)
has
thus
far
been
largely
focused
on
rodents
because
limitations
intrathecal
delivery
gadolinium-based
contrast
agents
to
humans.
This
review
discusses
MRI
methods
can
be
employed
clinically
for
glymphatic-related
measurements
intended
early
diagnosis,
prevention,
and
treatment
various
neurological
conditions.
Although
system-based
research
its
stages,
recent
studies
have
identified
promising
noninvasive
markers
associated
with
alterations
diseases.
However,
further
optimization
data
acquisition,
validation,
modeling
are
needed
investigate
within
clinical
setting.
Japanese Journal of Radiology,
Journal Year:
2024,
Volume and Issue:
42(10), P. 1146 - 1156
Published: May 31, 2024
Abstract
Purpose
To
investigate
glymphatic
system
function
in
patients
with
brain
tumors,
including
both
primary
and
secondary
using
diffusion
tensor
imaging
along
perivascular
spaces
(DTI-ALPS).
Methods
We
retrospectively
analyzed
the
MR
DTI
of
24
unilateral
tumors
compared
them
age
sex-matched
controls.
DTI-ALPS
index
ipsi-
contralateral
hemispheres.
The
region
interest
was
placed
periventricular
vessels
adjacent
to
lateral
ventricles.
Differences
between
sex,
age,
kind
tumor
(primary
or
metastasis)
were
evaluated.
Correlations
tumor's
apparent
coefficient
(ADC)
also
investigated.
Results
significantly
lower
(
p
<
0.05)
tumor-affected
hemisphere
(mean
=
1.26
±
0.24)
than
1.43
0.28).
A
comparison
healthy
controls
revealed
no
significant
difference
on
matched
ipsilateral
side.
However,
side
larger
HC.
Additionally,
statistically
differences
found
when
analyzing
vs.
entity.
we
did
not
find
a
correlation
patient
ADC.
Conclusion
decreased
may
be
related
impaired
function.
cancer
is
often
systemic
disease;
thus,
from
generally
considered
as
normal
control.
Nonetheless,
does
only
reflect
but
it
can
influenced
by
factors
such
axonal
degeneration.
Therefore,
directly
waste
clearance
changes
should
interpreted
carefully.
