Exploring the Relationship Between Lymphatic System Damage and Insulin Resistance in T2DM Based on Vascular Periadventitial Tensor Analysis and Triglyceride-Glucose Index DOI Creative Commons

Shan Xu,

Xuyang Wang, Dong Yang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 15, 2023

Abstract Type 2 diabetes mellitus (T2DM) can lead to dysfunction in the brain's glymphatic system, but relationship between system function and insulin resistance remains unclear. The aim of this study was investigate connection changes T2DM surrogate marker for resistance, Triglyceride-Glucose Index (TyG). A total 28 patients (T2DM group) 24 healthy volunteers (HC were included study. We outlined circular regions with a diameter 5.0 mm on diffusion tensor imaging (DTI) projection association fibers body lateral ventricle. compared differences DTI-ALPS index related fiber diffusivity two groups. Additionally, TyG calculated based fasting blood glucose triglyceride levels. Age as covariate analyze correlation ALPS patients. results showed that Dxproj group lower than those HC group, while Dyproj higher group. In index, Dxassoc, all negatively correlated. decreased may be associated suggesting lymphatic damage, white matter microstructure.

Language: Английский

Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associations DOI Creative Commons
Lusen Ran,

Yuanyuan Fang,

Chang Cheng

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(3)

Published: Jan. 17, 2025

We applied an MRI technique diffusion tensor imaging along the perivascular space (DTI-ALPS) for assessing glymphatic system (GS) in a genome-wide association study (GWAS) and phenome-wide (PheWAS) of 40,486 European individuals. Exploratory analysis revealed 17 genetic loci significantly associating with regional DTI-ALPS index. found 58 genes, including SPPL2C EFCAB5 , which prioritized index subtypes associated neurodegenerative diseases. PheWAS 241 traits suggested that body mass blood pressure phenotypes closely related to GS function. Moreover, we detected disrupted function 44 625 predefined disease conditions. Notably, Mendelian randomization mediation indicated lower was risk factor ischemic stroke (odds ratio = 1.56, P 0.028) by partly mediating obesity. Results provide insights into architecture mechanism DIT-ALPS highlight its great clinical value, especially cerebral stroke.

Language: Английский

Citations

0
Microstructure changes of the brain preceded glymphatic function changes in young obesity with and without food addiction DOI Creative Commons

Meizhi Yi,

Zeng Yule,

Song Wu

et al.

Meta-Radiology, Journal Year: 2025, Volume and Issue: unknown, P. 100137 - 100137

Published: March 1, 2025

Language: Английский

Citations

0
Early detection of dopaminergic dysfunction and glymphatic system impairment in Parkinson's disease DOI
Jun Yao, Ting Huang,

You‐Yong Tian

et al.

Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 127, P. 107089 - 107089

Published: Aug. 3, 2024

Language: Английский

Citations

3
Glymphatic Dysfunction as a Biomarker for Post-stroke Cognitive Impairment DOI
Sheng Zhang,

Weitao Yu,

Xiaofan Zhang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Ischemic stroke impacts glymphatic function, but its role in prognosis remains unclear. This study evaluated function 146 participants, including non-stroke (healthy controls, n = 48; nonvascular cognitive impairment patients, 47) and ischemic cohorts (n 51). The bilateral diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index, choroid plexus (CP), (PVS) volume ratio, which represent system, were compared across two between pre-rehabilitation (Time 1) 30 days post-rehabilitation 2). Post-stroke (PSCI) was characterized as enduring deficits persisting six months after a stroke. Stroke patients exhibited significantly lower DTI-ALPS index to population (P < 0.05), with improvement observed on infarct side following rehabilitation 0.05). of at Time 1 did not predict poor outcome correlated 6-month PSCI These results indicate that diminishes partially recovering post-rehabilitation, suggest could serve predictor for

Language: Английский

Citations

0
Neurologic symptoms as a hallmark of glymphatic alteration in recovered patients with COVID-19 DOI Creative Commons
Minhoe Kim, Kyung Hoon Lee, Ji Su Ko

et al.

BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 28, 2025

Language: Английский

Citations

0
Diffusion tensor imaging assessments to investigate motor impairment recovery after minor basal ganglia hemorrhage post-stereotactic surgery DOI Creative Commons

Changpin Liao,

Zhen Lu,

Guozheng PAN

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: May 9, 2025

Objective To investigate the efficacy of diffusion tensor imaging (DTI) in assessing motor impairment resulting from minor basal ganglia hemorrhage post-stereotactic surgery. Methods A total 104 patients with hemorrhages (hematoma volume ≤15 ml) underwent DTI within 48 h and 1 month post-treatment. Patients were divided into two groups: 42 experimental group, receiving stereotactic surgery medication, 62 control medication alone. The corticospinal tract (CST) posterior limb internal capsule was region interest (ROI) for mean FA values on both sides. Fugl-Meyer function (FMF) scores recorded post-treatment, Modified Rankin Scale (MRS) at 6 months. Results After treatment, FMF affected side group 0.34 ± 0.17 67.84 4.72, respectively, significantly surpassing those which 0.21 0.06 45.38 2.25 ( P &lt; 0.05). months exhibited MRS 10 cases (23.81%) grade 0, 12 (28.57%) 1, 16 (38.10%) 2, 2 (4.76%) 3, 4, 0 5. In contrast, demonstrated 8 (12.90%) (19.35%) 18 (29.03%) 15 (24.19%) (9.68%) 3 (4.84%) There are 5 group. showed a better score compared to Conclusion can accurately evaluate structural integrity CST following surgery, particularly regarding pathways involved control, providing valuable guidance clinical treatment.

Language: Английский

Citations

0
Motor progression phenotypes in early-stage Parkinson’s Disease: A clinical prediction model and the role of glymphatic system imaging biomarkers DOI

Peikun He,

Yuyuan Gao, Lin Shi

et al.

Neuroscience Letters, Journal Year: 2023, Volume and Issue: 814, P. 137435 - 137435

Published: Aug. 9, 2023

Language: Английский

Citations

5
Glymphatic-System Function Is Associated with Addiction and Relapse in Heroin Dependents Undergoing Methadone Maintenance Treatment DOI Creative Commons
Lei Wang, Yue Qin, Xiaoshi Li

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(9), P. 1292 - 1292

Published: Sept. 7, 2023

This study investigates the impact of methadone maintenance treatment (MMT) on brain glymphatic system (GS) in opioid addiction China. A total 51 male MMT patients, 48 demographically matched healthy controls (HCs), and 20 heroin dependents (HDs) were recruited for this study. The GS functioning was assessed using diffusion-tensor-imaging analysis along perivascular spaces (DTI-ALPS index) bilateral ALPS divergency (DivALPS). Group differences analyzed utilizing ANOVA two-sample

Language: Английский

Citations

5
Early Improvement in Interstitial Fluid Flow in Patients With Severe Carotid Stenosis After Angioplasty and Stenting DOI Creative Commons
Chia‐Hung Wu, Shih‐Pin Chen, Chih‐Ping Chung

et al.

Journal of Stroke, Journal Year: 2024, Volume and Issue: 26(3), P. 415 - 424

Published: Aug. 29, 2024

Background and Purpose This study aimed to investigate early changes in interstitial fluid (ISF) flow patients with severe carotid stenosis after angioplasty stenting (CAS).Methods We prospectively recruited participants ≥80% undergoing CAS at our institute between October 2019 March 2023. Magnetic resonance imaging (MRI), including diffusion tensor (DTI), the Mini-Mental State Examination (MMSE) were performed 3 days before CAS. MRI DTI MMSE conducted within 24 hours 2 months CAS, respectively. The image analysis along perivascular space (DTI-ALPS) index was calculated from data determine ISF status. Increments defined as ratio of difference post- preprocedural values values.Results In total, 102 (age: 67.1±8.9 years; stenosis: 89.5%±5.7%) longitudinal evaluated. DTI-ALPS increased (0.85±0.15; 0.85 [0.22] vs. 0.86±0.14; 0.86 [0.21]; <i>P</i>=0.022), did score (25.9±3.7; 24.0 [4.0] 26.9±3.4; 26.0 [3.0]; <i>P</i><0.001). Positive correlations increments found all (r<sub>s</sub>=0.468; <i>P</i><0.001).Conclusion An 24-hour post-CAS suggests improvement efficiency. positive correlation 2-month that may contribute long-term cognitive

Language: Английский

Citations

1
Glymphatic System, Sleep, and Parkinson’s Disease – Interconnections, Research Opportunities, and Potential for Disease Modification DOI Creative Commons
Jiří Nepožitek, Petr Dušek, Karel Šonka

et al.

SLEEP, Journal Year: 2024, Volume and Issue: 48(1)

Published: Oct. 25, 2024

Language: Английский

Citations

1