Cerebellar microglia: On the edge between neuroinflammation and neuroregulation DOI Creative Commons
Marina Dukhinova,

Jingwen Guo,

En-Wei Shen

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 21(1), P. 156 - 172

Published: Oct. 22, 2024

The cerebellum is receiving increasing attention for its cognitive, emotional, and social functions, as well unique metabolic profiles. Cerebellar microglia exhibit specialized highly immunogenic phenotypes under both physiological pathological conditions. These immune cells communicate with intrinsic systemic factors contribute to the structural functional compartmentalization of cerebellum. In this review, we discuss roles in cerebellar microenvironment, neuroinflammation, adaptation, neuronal activity, associated molecular cellular mechanisms, potential therapeutic strategies targeting context neuroinflammation. Future directions unresolved questions field are further highlighted, particularly regarding interventions microglia, mechanisms activities circuitry, connectivity, neurofunctional outcomes their activity. morphology performance influenced by that actively monitored healthy diseased states. Under conditions, local subsets diverse responses altered microenvironment Microglia undergo early maturation during embryonic stage display specialized, phenotypes. summary, have capacity serve regulatory tools influence across a wide range neurological including neurodevelopmental, neurodegenerative, metabolic, stress-related disorders.

Language: Английский

Cerebral Blood Flow Changes and Their Spatial Correlations With GABAa and Dopamine‐D1 Receptor Explaining Individual Differences in Chronic Insomnia and the Therapeutic Effects of Acupuncture DOI Creative Commons
Liyong Yu, Lili Yang, Xiaoqin Chen

et al.

Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(4)

Published: March 1, 2025

ABSTRACT This study integrated neuroimaging and neurochemistry data to explore brain mechanisms in chronic insomnia disorder (CID) the neuromodulatory effects of acupuncture. We analyzed a cross‐sectional arterial spin labeling (ASL) dataset ( N = 197) CID patients healthy controls identify cerebral blood flow (CBF) changes. Additionally, longitudinal ASL 44) examined CBF changes after 4‐week acupuncture treatment or on waitlist. then assessed impact 19 neurotransmitter receptors/transporters these alterations. In comparisons, exhibited increased cortical areas decreased subcortical regions, correlating with severity. enhanced alleviated symptoms, not observed waitlist group. The left putamen was identified as an overlapping region involved both CID‐related post‐treatment Moreover, patterns induced by negatively correlated abnormal patients, were significantly associated GABAa dopamine‐D1 receptor densities. decrease could potentially serve neural biomarker for CID, while may alleviate symptoms increasing this region, through modulation D1 expressions.

Language: Английский

Citations

2
Neural correlates of insomnia with depression and anxiety from a neuroimaging perspective: A systematic review DOI
Peng Chen, Kai Wang, Jinyu Wang

et al.

Sleep Medicine Reviews, Journal Year: 2025, Volume and Issue: 81, P. 102093 - 102093

Published: May 2, 2025

Language: Английский

Citations

1
Pain-Insomnia-Depression Syndrome: Triangular Relationships, Pathobiological Correlations, Current Treatment Modalities, and Future Direction DOI Creative Commons
Murtaza Haidary, Shamim Arif,

Dawood Hossaini

et al.

Pain and Therapy, Journal Year: 2024, Volume and Issue: 13(4), P. 733 - 744

Published: May 30, 2024

Pain-insomnia-depression syndrome (PIDS) is a complex triad of chronic pain, insomnia, and depression that has profound effects on an individual's quality life mental health. The pathobiological context PIDS involves neurobiological physiological mechanisms, including alterations in neurotransmitter systems impaired pain processing pathways. first-line therapeutic approaches for the treatment depression, insomnia are combination pharmacological non-pharmacological therapies. In cases where patients do not respond adequately to these treatments, additional interventions such as deep brain stimulation (DBS) may be required. Despite advances understanding treatment, there still gaps knowledge need addressed. To improve our understanding, future research should focus conducting longitudinal studies uncover temporal associations, identify biomarkers genetic markers associated with PIDS, examine influence psychosocial factors responses, develop innovative address nature PIDS. aim this study provide comprehensive overview components discuss their underlying relationships.

Language: Английский

Citations

5
Esketamine and Dexmedetomidine Co-Administration: A Novel Approach to Alleviating Depression and Sleep Disturbances in Chronic Restraint Stress Mouse Models DOI
Muyan Zuo,

Ruoguo Wang,

Cheng-hao Yang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Altered Brain Functional Connectivity and Peripheral Transcriptomic Profiles in Major Depressive Disorder With Childhood Maltreatment DOI Creative Commons
Min Wang, Jinxue Wei,

Yushun Yan

et al.

Depression and Anxiety, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Childhood maltreatment (CM) is a significant risk factor for major depressive disorder (MDD), yet the underlying biological mechanisms remain unclear. This study aimed to investigate brain functional networks and peripheral transcriptomics in patients with MDD who have history of CM. Methods: Functional imaging data were collected network-based statistics used identify differences among CM (MDD_CM, n = 78), without (MDD_nCM, 61), healthy controls (HC, 126). Additionally, blood transcriptional clustered into co-expression modules, module differential connectivity analysis was utilized assess variations gene network modules groups. Results: The results revealed difference an inferior occipital gyrus-centered three Furthermore, eight differed groups enriched multiple branches related immune responses or metabolic processes. Notably, type I interferon-related signaling pathways demonstrated correlation disrupted MDD_nCM group. Moreover, immune-related found be significantly correlated sleep disturbances MDD_CM patients. Conclusions: Dysregulation transcriptomic alterations associate pathophysiology MDD_CM.

Language: Английский

Citations

0
Abnormal intrinsic functional network connectivity in adolescent major depressive disorder related to severity of insomnia DOI

Weijie Bao,

Yingxue Gao, Ruohan Feng

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111357 - 111357

Published: April 1, 2025

Language: Английский

Citations

0
Relationship of Sleep Disorder with Neurodegenerative and Psychiatric Diseases: An Updated Review DOI
Xiao Xiao,

Yimin Rui,

Yu Jin

et al.

Neurochemical Research, Journal Year: 2023, Volume and Issue: 49(3), P. 568 - 582

Published: Dec. 18, 2023

Language: Английский

Citations

9
The efficacy and mechanism of action of the Umei decoction in insomnia: A randomized active-controlled clinical trial DOI Creative Commons

Dongli Guo,

Ji Liu,

Sun Hong-yun

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 121, P. 106405 - 106405

Published: Aug. 31, 2024

Language: Английский

Citations

1
Longitudinal neurofunctional alterations following nonpharmacological treatments and the mediating role of regional homogeneity in subclinical depression comorbid with sleep disorders among college students DOI Creative Commons
Xinyu Liang, Hanyue Zhang, Xiaotong Wang

et al.

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 181, P. 663 - 672

Published: Dec. 22, 2024

Language: Английский

Citations

1
Cerebral blood flow in the paracentral lobule is associated with poor subjective sleep quality among patients with a history of methadone maintenance treatment DOI Creative Commons

Jiaxue Sun,

Yi Lü,

Deshenyue Kong

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 8, 2024

Introduction Sleep disorders are prevalent and significant among individuals receiving methadone maintenance treatment (MMT), adversely affecting their quality of life adherence. While cerebral blood flow (CBF) plays a crucial role in the development various diseases, its relationship with sleep remains uncertain. This observational study focuses on possible correlations between CBF poor subjective MMT patients. Methods A total 75 participants history were recruited assessed using pseudo-continuous arterial spin labeling magnetic resonance imaging to determine CBF. LAASO regression model was employed identify region interest (ROI) most associated disturbance. The association ROI Pittsburgh Quality Index (PSQI) examined analyses. Age, gender, BMI, hypertension, diabetes, hyperlipidemia, withdrawal included as covariates. Results Among patients quality, significantly higher observed right paracentral lobule (56.1057 ± 11.1624 ml/100 g/min, p = 0.044), cerebelum_3 (56.6723 15.3139 0.026), caudate nucleus (48.9168 6.9910 0.009), left (47.6207 6.1374 0.006). Furthermore, positive correlation found PSQI score (β 0.1135, 0.0323), remaining even after adjustment for covariates 0.1276, 0.0405). Conclusion exhibited altered multiple brain regions. increased could be understanding undergoing MMT. Clinical trial registration https://www.chictr.org.cn/ , identifier: ChiCTR2100051931.

Language: Английский

Citations

0