The impact of relaxing the requirements for dyspeptic Symptom Onset frequency or duration in Rome IV Criteria on the Symptom Pattern and diagnosis of functional dyspepsia DOI Creative Commons
Jinsheng Wang, Junhao Wu, Xiaohua Hou

et al.

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 5, 2024

The Rome IV criteria for functional dyspepsia (FD) has strict requirements symptom frequency and onset duration, making it difficult patients to meet these in clinical practice. This study aimed investigate the impact of relaxing on diagnosis pattern FD. A cross-sectional, multi-center was conducted involving 2935 consecutive broadly defined FD without positive findings upper gastrointestinal endoscopy or routine examinations. Questionnaires were used collect demographic data. Symptom compared between those by relaxed criteria. Only 22.2% rigorously fulfilled No significant difference found proportion with dyspeptic symptoms, dysmotility-like reflux-like as well severity symptoms (all P > 0.05), who didn't fulfill solely due a duration 3–6 months patients. Patients postprandial distress syndrome (PDS) 1–2 days per week had significantly lower (P < 0.001), but similar characteristics criterion 3 may be sufficient diagnosing Reducing no less than 1 day PDS does not affect its characteristics.

Language: Английский

Exploring Therapeutic Potential of Phytoconstituents as a Gut Microbiota Modulator in the Management of Neurological and Psychological Disorders DOI

Prarit Chandel,

Komal Thapa, Neha Kanojia

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 551, P. 69 - 78

Published: May 14, 2024

Language: Английский

Citations

4
BNSTGABA Neurons Regulate Autophagy to Alleviate Depression with Gastric Dysfunction Symptoms DOI Creative Commons
Yi Yuan, Jiangang Xu, Shujia Zhu

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111360 - 111360

Published: April 1, 2025

Language: Английский

Citations

0
Simultaneous Analysis of Thirteen Compounds in Yeokwisan Using High-Performance Liquid Chromatography–Photodiode Array Detection and Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry and Their Antioxidant Effects DOI Creative Commons
Chang‐Seob Seo,

So-Yeon Kim,

Dong-Seon Kim

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 727 - 727

Published: June 4, 2024

Yeokwisan (YWS) is an herbal medicine prescription consisting of six oriental medicines, developed to treat reflux esophagitis. We focused on developing analytical method capable simultaneously quantifying 13 compounds in YWS samples using high-performance liquid chromatography–photodiode array detection (HPLC–PDA) and ultra-performance chromatography–tandem mass spectrometry (UPLC–MS/MS) exploring their antioxidant effects. All examined both systems were chromatographically separated a SunFireTM C18 (4.6 × 250 mm, 5 μm) column Acquity UPLC BEH (2.1 100 1.7 gradient elution water–acetonitrile mobile phase. Antioxidant effects evaluated based radical scavenging activity (DPPH ABTS tests) ferrous ion chelating activity. In two methods, the coefficient determination regression equation was ≥0.9965, recovery range 81.11–108.21% (relative standard deviation (RSD) ≤ 9.33%), precision RSD 11.10%. Application optimized analysis conditions gave quantitative results for 0.02–100.36 mg/g. Evaluation revealed that baicalein baicalin exhibit significant activity, suggesting they play important role YWS.

Language: Английский

Citations

2
The Impact of Relaxing the Requirements for Dyspeptic Symptom Onset Frequency and Duration in Rome IV Criteria on the Diagnosis and Symptom Pattern of Functional Dyspepsia DOI Creative Commons
Jinsheng Wang, Junhao Wu, Xiaohua Hou

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 8, 2024

Abstract Background The Rome IV criteria for functional dyspepsia (FD) has strict requirements symptom frequency and onset duration, making it challenging to identify patients with broadly defined FD in clinical practice. Aims This study aimed investigate the impact of relaxing on diagnosis pattern FD. Methods A cross-sectional, multi-center was conducted involving 2935 consecutive no positive findings upper GI endoscopy routine examinations. Questionnaires were used collect demographic gastrointestinal data. Symptom compared between those by relaxed criteria. Results Only 22.2% rigorously fulfilled No significant difference found all symptoms mentioned this study, as well dyspeptic severity frequency, who but had a duration 3–6 months Broadly Postprandial Distress Syndrome (PDS) 1–2 days per week significantly lower severity, similar postprandial characteristics Conclusion criterion 3 may be sufficient diagnosing China. Reducing less than 1 day PDS does not affect its characteristics.

Language: Английский

Citations

0
The Impact of Relaxing the Requirements for Dyspeptic Symptom Onset Frequency or Duration in Rome IV Criteria on the Symptom Pattern and Diagnosis of Functional Dyspepsia DOI Creative Commons
Jinsheng Wang, Junhao Wu, Xiaohua Hou

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 4, 2024

Abstract Background The Rome IV criteriafor functional dyspepsia (FD) has strict requirements for symptom frequency and onset duration, making it challenging to identify patients with broadly defined FD in clinical practice. This study aimed investigate the impact of relaxing criteria on diagnosis pattern FD. Methods A cross-sectional, multi-center was conducted involving 2935 consecutive no positive findings upper gastrointestinal endoscopy routine examinations. Questionnaires were used collect demographic data. Symptom compared between those by relaxed criteria. Results Only 22.2% rigorously fulfilled No significant difference found proportion dyspeptic symptoms, dysmotility-like reflux-like as well severity symptoms (all P >0.05), who but had a duration 3-6 months Broadly Postprandial Distress Syndrome (PDS) 1-2 days per week significantly lower ( <0.001), similar postprandial characteristics Conclusions criterion 3 may be sufficient diagnosing Reducing less than 1 day PDS does not affect its characteristics.

Language: Английский

Citations

0
Deciphering the brain-gut axis: elucidating the link between cerebral cortex structures and functional gastrointestinal disorders via integrated Mendelian randomization DOI Creative Commons

Zhiwei Xu,

Fenglan Ning,

Xuecheng Zhang

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 22, 2024

Background Observational studies have suggested associations between functional gastrointestinal disorders (FGIDs) and variations in the cerebral cortex. However, causality of these relationships remains unclear, confounded by anxiety depression. To clarify causal explore mediating roles depression, we applied univariate, multivariable, mediation Mendelian randomization (MR) analyses. Method We utilized genome-wide association study (GWAS) summary data from FinnGen database ENIGMA consortium, identifying genetic variants associated with irritable bowel syndrome (IBS), dyspepsia (FD), cortex structures. Data on depression came a large meta-analysis. Utilizing bidirectional univariate MR approach, explored correlations FD, IBS, variations. Then, independent effects were assessed through multivariable MR. A meta-analysis results, incorporating two cohorts, aimed to increase precision. also potential Results Our findings indicate negative correlation FD thickness rostral anterior cingulate (rACC) across both global regional adjustments (β = −0.142, 95% confidence interval (CI): −0.209 to-0.074, P.FDR 0.004; β −0.112, 95%CI: −0.163 to-0.006, 0.003) positive globally adjusted superior frontal gyrus (SFG) 0.107, 0.062 0.153, 0.001). The rACC persisted after multiple variable −0.137, CI: −0.187 to-0.087, 1.81 × 10 −5 ; −0.109, −0.158 to-0.06, 0.002). significant was found surface area caudal (cACC) IBS (odds ratio 1.267, 1.128 1.424, 0.02). analysis showed that neither nor mediated relationship FGIDs Conclusion research provides evidence This not only confirms two-way communication along brain-gut axis but illuminates underlying pathophysiology, paving way for therapeutic approaches.

Language: Английский

Citations

0
Network pharmacology combined with experimental validation reveals the mechanism of action of erpixing granules on functional dyspepsia DOI Creative Commons

Yuanmei Bai,

Feifan Liu,

Yan Wan

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118553 - 118553

Published: July 10, 2024

Functional dyspepsia (FD) is a prevalent gastrointestinal disorder characterised by high incidence and recurrence rates, posing significant health risks. Erpixing Granules (EPX), approved the National Food Drug Administration in 2002, are known for their spleen stomach invigorating properties, effectively treating FD. However, its mechanism of action remains unclear.

Language: Английский

Citations

0
Integrated metabolomics and network pharmacology to reveal the mechanisms of Processed Aurantii Fructus in the treatment of CUMS-induced functional dyspepsia DOI

Yangbing Fang,

Ying‐Ying Huang,

Qinru Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118765 - 118765

Published: Aug. 29, 2024

Language: Английский

Citations

0
Dyspepsia in medical university students: prevalence of symptoms and risk factors DOI Open Access

I. G. Paliy,

С. В. Заика,

I. V. Chernova

et al.

Reports of Vinnytsia National Medical University, Journal Year: 2024, Volume and Issue: 28(3), P. 490 - 501

Published: Sept. 25, 2024

Annotation. Dyspepsia is one of the most common symptom complex encountered in internal medicine and includes a group symptoms related to gastroduodenal region gastrointestinal tract. The purpose research was study prevalence dyspepsia among 1-6 years students National Pirogov Memorial Medical University, Vinnytsya, who did not seek medical help for also establish risk factors its development comparison with general practitioners. Using Microsoft Forms platform we conducted survey 300 respondents aged 17-65, them 168 (56%) were domestic 1st-6th year study, 64 (21,3%) foreign 5th-6th 68 (22.7%) referred doctors practice. To assess presence or absence complaints from used modified FSSG (Frequency Scale Symptoms GERD) questionnaire supplemented questions about age, gender, body weight height respondents, course academic success (applied students), chronic diseases gastro-intestinal track, taking pharmaceutical drugs, smoking alcohol consumption, indicating number doses per week. There an additional question native country students. arithmetic mean standard error calculated. statistical probability difference between two samples calculated using Student's t-test. We χ2 method influence various on occurrence GERD symptoms, correlation analysis performed non-parametric Spearman method. It found that students, compared ones, there significantly more (p<0.05) those noted (21.4% versus 10.9%), fewer (p<0.01) almost healthy (60.7% vs. 79.7%). Meanwhile, no significant differences groups practice, (p>0.05). In all three established relationship anamnesis respondents. Thus, coefficient Spearman’s ranks 0.36, -0.43, – 0.6 (p<0.01). ones medication appearance GERD. particular, rank 0.2 0.42. At same time, such absent surveyed family 0.43. obtained results indicate dyspepsia, their combination examined groups. pathology factor regardless

Language: Английский

Citations

0
The impact of relaxing the requirements for dyspeptic Symptom Onset frequency or duration in Rome IV Criteria on the Symptom Pattern and diagnosis of functional dyspepsia DOI Creative Commons
Jinsheng Wang, Junhao Wu, Xiaohua Hou

et al.

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 5, 2024

The Rome IV criteria for functional dyspepsia (FD) has strict requirements symptom frequency and onset duration, making it difficult patients to meet these in clinical practice. This study aimed investigate the impact of relaxing on diagnosis pattern FD. A cross-sectional, multi-center was conducted involving 2935 consecutive broadly defined FD without positive findings upper gastrointestinal endoscopy or routine examinations. Questionnaires were used collect demographic data. Symptom compared between those by relaxed criteria. Only 22.2% rigorously fulfilled No significant difference found proportion with dyspeptic symptoms, dysmotility-like reflux-like as well severity symptoms (all P > 0.05), who didn't fulfill solely due a duration 3–6 months patients. Patients postprandial distress syndrome (PDS) 1–2 days per week had significantly lower (P < 0.001), but similar characteristics criterion 3 may be sufficient diagnosing Reducing no less than 1 day PDS does not affect its characteristics.

Language: Английский

Citations

0