Potential role of modulating autophagy levels in sensorineural hearing loss

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 222, P. 116115 - 116115

Published: March 7, 2024

Language: Английский

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Functional and Structural Changes in the Inner Ear and Cochlear Hair Cell Loss Induced by Hypergravity

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 758 - 758

Published: Jan. 17, 2025

Gravitational changes have been shown to cause significant abnormalities in various body systems, including the cardiovascular, immune, vestibular, and musculoskeletal systems. While numerous studies examined response of vestibular system gravitational stimulation, research on functional peripheral inner ear remains limited. The comprises two closely related structures: vestibule cochlea. These components share similar structures neural functions, highlighting importance investigating auditory nerve cells alterations. To address this gap, we studied structural following exposure hypergravity stimuli. Our findings demonstrate brainstem responses (ABRs) ABR recordings were used analyze click thresholds, as well amplitude latency tone bursts. thresholds at all frequencies increased group exposed long term. Additionally, burst results revealed significantly reduced amplitudes high delayed latencies models. Notably, greater hair cell loss was observed middle basal turns cochlea, indicating that mid high-frequency regions are more vulnerable stimulation. Furthermore, damage cochlear surface evident subjects 4G stimulation for 4 weeks. suggest its activity can be functionally structurally affected by prolonged hypergravity.

Language: Английский

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Global Trends and Burden of Age-related Hearing Loss: 32-Year Study

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: unknown, P. 105847 - 105847

Published: March 1, 2025

Language: Английский

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Contributions of Auditory Nerve Density and Synchrony to Speech Understanding in Older Cochlear Implant Users

Journal of the Association for Research in Otolaryngology, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

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Conditional Overexpression of Neuritin in Supporting Cell Protects Cochlear Hair Cell and Delays Age-Related Hearing Loss by Enhancing Autophagy

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3709 - 3709

Published: April 14, 2025

Age-related hearing loss (ARHL) is a highly prevalent, burdensome sensorineural closely associated with impaired autophagic influx. Our previous studies revealed that neuritin, neurotrophic factor primarily expressed in the central nervous system, could alleviate drug-induced damages hair cells (HCs) and spiral ganglion neurons. However, its effects on ARHL whether these are related to autophagy remain unclear. Using Nrn1 knock-in mice cultured cochlear basilar membrane (CBM) of neonatal mouse, we show neuritin restore aging-associated senescence-associated damage cochlea. Overexpression support (SCs) alleviates HCs nerve fibers, reducing neurons shifts ABR’s high-frequency threshold. Furthermore, conditional overexpression SCs improves influx by upregulating expression microtubule-associated protein 1 light chain 3 type B (LCB3) downregulating p21 protein. In mouse CBM, administration significantly inhibits D-galactose-induced HC loss, cellular apoptosis, ROS production promotes These were weakened when inhibitor 3-MA was added. summary, our results confirm therapeutic potential treatment for ARHL.

Language: Английский

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Identifying educational interventions aimed at improving communication with older adults with age-related hearing loss: a scoping review and thematic analysis

International Journal of Audiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: April 17, 2025

This scoping review summarises existing interventions aimed at educating individuals without hearing loss to enhance their communication with older adults experiencing age-related (ARHL). Data collection employed a systematic search approach as per the guidelines of Arksey & O'Malley, and followed PRISMA-ScR guidelines. A structured was conducted involving four research databases from 2000 2023, additional grey literature searching. Original papers written in English, reporting design implementation educational targeting ARHL, were included. Reflexive thematic analysis used identify themes related intervention type methodology, key findings. 13 eligible studies identified summarised. Four main described: (1) education skills training; (2) mode delivery; (3) appropriateness satisfaction among participants; (4) transforming attitudes on for better relationships emotional well-being. The link between diminished quality life ARHL highlights importance ongoing development innovative programmes effective diverse settings, including clinical environments.

Language: Английский

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Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis

Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

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Single-unit data for sensory neuroscience: Responses from the auditory nerve of young-adult and aging gerbils

Scientific Data, Journal Year: 2024, Volume and Issue: 11(1)

Published: April 22, 2024

This dataset was collected to study the functional consequences of age-related hearing loss for auditory nerve, which carries acoustic information from periphery central system. Using high-impedance glass electrodes, raw voltage traces and spike times were recorded more than one thousand single fibres nerve young-adult, middle-aged, old Mongolian gerbils raised in a quiet environment. The contains not only responses simple stimuli characterize fibres, but also complex stimuli, such as speech logatomes background noise Schroeder-phase stimuli. A software toolbox is provided search through dataset, plot various analysed outcomes, give insight into analyses. may serve valuable resource test further hypotheses about loss. Additionally, it can aid optimizing available computational models system, contribute to, or eventually even fully replace, animal experiments.

Language: Английский

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The emerging roles and therapeutic implications of immunosenescence-mediated inflammaging in age-related hearing loss

American Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 101 - 109

Published: Jan. 1, 2024

Age-related hearing loss (ARHL) represents one of the most prevalent chronic sensory deficits experienced by elderly, significantly diminishing their quality life and correlating with various medical psychological morbidities. This condition arises from cumulative effects aging on auditory system, implicating intricate interactions between genetic predispositions environmental factors. Aging entails a progressive decline in immune system functionality, termed immunosenescence, leading to low-grade inflammation known as inflammaging. phenomenon potentially serves common mechanism underlying ARHL other age-related pathologies. Recent research suggests that rejuvenating immunosenescence could mitigate inflammaging ameliorate functional declines, offering promising insights into anti-aging therapies. Consequently, this review endeavors elucidate role immunosenescence-mediated progression discuss its therapeutic implications.

Language: Английский

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Serum Prealbumin as a Potential Predictive Factor for Age-Related Hearing Loss: A Retrospective Study

Ear Nose & Throat Journal, Journal Year: 2024, Volume and Issue: unknown

Published: June 22, 2024

Age-related hearing loss (ARHL) is a complex disease associated with the interaction of multiple factors. Furthermore, indicators liver function represent body's metabolic, immune, and repair abilities. This study investigated correlations between ARHL.

Language: Английский

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