Pharmacological target sites for restoration of age‐associated deficits in NMDA receptor‐mediated norepinephrine release in brain DOI Creative Commons

Yousef Aljohani,

William D. Payne,

Robert P. Yasuda

et al.

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: 169(1)

Published: Dec. 10, 2024

Aging affects virtually all organs of the body, but perhaps it has most profound effects on brain and its neurotransmitter systems, which influence a wide range crucial functions, such as attention, focus, mood, neuroendocrine autonomic sleep cycles. All these essential well fundamental cognitive processes memory, recall, processing speed, utilize neuronal circuits that depend signaling between neurons. Glutamate (Glu), main excitatory in CNS, is involved including release norepinephrine (NE). Previous studies from our lab demonstrated age-associated decline Glu-stimulated NE rat cerebral cortex hippocampus mediated by NMDA glutamate receptors, deficits dendritic spines, functions are fully rescued CNS stimulant amphetamine. Here we further investigated to identify additional novel target sites for restoration release. We found blockade alpha-2 adrenergic receptors restores levels young controls. In addition, density responsiveness potential underlying mechanism could account observed basal state receptor (no added glycine) aged rats was similar. However, contrast, presence 10 μM glutamate, opens channel increases number available [3H]-MK-801 binding within channel, significantly less rats.

Language: Английский

The Bidirectional Relationship between Sleep and Neurodegeneration: Actionability to Improve Brain Health DOI Creative Commons
Abubaker Ibrahim, Birgit Högl, Ambra Stefani

et al.

Clinical and Translational Neuroscience, Journal Year: 2024, Volume and Issue: 8(1), P. 11 - 11

Published: Feb. 2, 2024

Recently, it has become increasingly clear that there is a bidirectional relationship between sleep/circadian rhythms and neurodegeneration. Knowledge about this topic further improved after the description of glymphatic system, which mainly active during sleep. Changes in sleep circadian are present not only overt neurodegenerative diseases but also their early, prodromal, preclinical phases, supporting they precede (and contribute to) development This narrative review provides brief overview rhythm disruption neurodegeneration, highlights changes addresses future perspectives, particular, whether able to predict neurodegeneration potential actionability prevent or modulate diseases.

Language: Английский

Citations

6
Nonlinear age-related differences in probabilistic learning in mice: A 5-armed bandit task study DOI
Hiroyuki Ohta, Takashi Nozawa, T. Nakano

et al.

Neurobiology of Aging, Journal Year: 2024, Volume and Issue: 142, P. 8 - 16

Published: June 26, 2024

Language: Английский

Citations

2
Regional- and cell type-specific changes of the human brain during aging DOI Creative Commons
Yanxi Chen,

Gaoyu Zu,

Bill Ling Feng Zhang

et al.

Human Brain, Journal Year: 2024, Volume and Issue: 2(3)

Published: Jan. 10, 2024

As individuals age, cognitive decline becomes more prominent, concomitant with an elevated susceptibility to neurodegenerative diseases and dementia. Additionally, symptoms of chronic neuropsychiatric tend worsen age. It is crucial highlight that the aging process does not affect uniformly, its effects can vary, even within same person. This review aims summary impact healthy on human brain, focusing variations from different brain regions cell types. Depending specific regions, exhibits thinning, volume reduction, regional shrinkage, disrupted tissue integrity, decreased complexity, or iron accumulation during aging. Moreover, cells exhibit morphology function changes Neurons undergo characterized by reduced dendrites, dendritic spines, axons less compact myelin sheaths, leading a significant loss synapses. Comparatively, glia often transform into reactive phenotype.

Language: Английский

Citations

1
Locus coeruleus contrast and diffusivity metrics differentially relate to age and memory performance DOI Creative Commons
Ilana J. Bennett, Jason Langley,

Andrew Sun

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 4, 2024

Abstract Neurocognitive aging researchers are increasingly focused on the locus coeruleus, a neuromodulatory brainstem structure that degrades with age. With this rapid growth, field will benefit from consensus regarding which magnetic resonance imaging (MRI) metrics of coeruleus most sensitive to age and cognition. To address need, current study acquired magnetization transfer- diffusion-weighted MRI images in younger older adults who also completed free recall memory task. Results revealed significantly larger differences between for maximum than average transfer-weighted contrast (MTC), axial mean or radial single-tensor diffusivity (DTI), restricted multi-compartment diffusion (NODDI) coeruleus; MTC being best predictor group. Age effects all modalities interacted sex, group males females NODDI metrics. varied across subdivision DTI metrics, hemispheres MTC. Within adults, however, there were no significant only an interaction sex diffusion. Finally, independent higher was related better (lower) variability, but not recall. Whereas has been widely used literature, our comparison inclusion breakdowns by hemisphere make important novel contributions understanding structure.

Language: Английский

Citations

1
A combined MRI, histological and immunohistochemical rendering of the rhesus macaque locus coeruleus (LC) enables the differentiation of three distinct LC subcompartments DOI Creative Commons
Irina Sinakevitch,

Kelsey McDermott,

Daniel T. Gray

et al.

Journal of Chemical Neuroanatomy, Journal Year: 2024, Volume and Issue: 140, P. 102449 - 102449

Published: July 29, 2024

Locus coeruleus (LC) neurons send their noradrenergic axons across multiple brain regions, including neocortex, subcortical and spinal cord. Many aspects of cognition are known to be dependent on the system, it has been suggested that dysfunction in this system may play central roles cognitive decline associated with both normative aging neurodegenerative disease. While basic anatomical biochemical features LC have examined many species, detailed characterizations structure function lifespan not currently available. This includes rhesus macaque, which is an important model human because striking similarities architecture behavioral capacities. In present study, we describe a method combine structural MRI, Nissl, immunofluorescent histology from individual monkeys reconstruct, 3 dimensions, entire macaque nucleus. Using these combined methods, standardized volume was determined, high-resolution confocal images tyrosine hydroxylase-positive were mapped into volume. representation allows definitions proposed for three distinct subnuclei, medial region lateral (based location respect gray, inside or outside, respectively), compact (defined by densely packed within compartment). enabled estimated cell density calculated independently each subnucleus first time. combination methods should allow precise characterization potential do same other nuclei molecular features.

Language: Английский

Citations

1
Mild cognitive impairment and its determinants in urban and rural areas among older adults: A Cross-Sectional Study DOI
Z. Rostami, Mahmoud Rahmati, Leili Rostamnia

et al.

Payām-i naw., Journal Year: 2024, Volume and Issue: 21(2), P. 40 - 42

Published: June 1, 2024

Language: Английский

Citations

1
Locus Coeruleus Contrast and Diffusivity: Effects of Age and Relations to Memory DOI Creative Commons
Ilana J. Bennett, Jason Langley, Andrew Sun

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 29, 2024

Abstract Neurocognitive aging researchers are increasingly focused on the locus coeruleus, a neuromodulatory brainstem structure that degrades with age. With this rapid growth, field will benefit from consensus regarding which magnetic resonance imaging (MRI) metrics of coeruleus most sensitive to age and cognition. To address need, current study acquired magnetization transfer- diffusion-weighted MRI images in younger older adults who also completed free recall memory task. Results revealed significantly larger differences between for maximum than average transfer-weighted contrast (MTC), axial mean or radial single-tensor diffusivity (DTI), restricted multi-compartment diffusion (NODDI) coeruleus; MTC being best predictor group. Age effects NODDI interacted sex such group were seen males females. DTI rostral, caudal, subdivision. Within adults, however, there no significant any measure structure. Finally, independent sex, higher was related better (lower) variability, but not recall. Whereas has been widely used literature, our comparison metrics, inclusion make important novel contributions understanding

Language: Английский

Citations

0
A Combined MRI, Histological and Immunohistochemical Rendering of the Rhesus Macaque Locus Coeruleus (Lc) Enables the Differentiation of Three Distinct Lc Subcompartments DOI
Carol A. Barnes, Irina Sinakevitch,

Kelsey McDermott

et al.

Published: Jan. 1, 2024

Highlights• A novel method has been introduced that combines structural MRI, Nissl, and immunofluorescent histology from individual monkeys.• This innovative approach allows the reconstruction of entire macaque LC nucleus in three dimensions.• detailed representation led to proposed definitions for distinct subnuclei: medial, lateral, compact.• As a result, volume cell density each subnucleus could be estimated calculated independently first time.

Language: Английский

Citations

0
Pharmacological target sites for restoration of age‐associated deficits in NMDA receptor‐mediated norepinephrine release in brain DOI Creative Commons

Yousef Aljohani,

William D. Payne,

Robert P. Yasuda

et al.

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: 169(1)

Published: Dec. 10, 2024

Aging affects virtually all organs of the body, but perhaps it has most profound effects on brain and its neurotransmitter systems, which influence a wide range crucial functions, such as attention, focus, mood, neuroendocrine autonomic sleep cycles. All these essential well fundamental cognitive processes memory, recall, processing speed, utilize neuronal circuits that depend signaling between neurons. Glutamate (Glu), main excitatory in CNS, is involved including release norepinephrine (NE). Previous studies from our lab demonstrated age-associated decline Glu-stimulated NE rat cerebral cortex hippocampus mediated by NMDA glutamate receptors, deficits dendritic spines, functions are fully rescued CNS stimulant amphetamine. Here we further investigated to identify additional novel target sites for restoration release. We found blockade alpha-2 adrenergic receptors restores levels young controls. In addition, density responsiveness potential underlying mechanism could account observed basal state receptor (no added glycine) aged rats was similar. However, contrast, presence 10 μM glutamate, opens channel increases number available [3H]-MK-801 binding within channel, significantly less rats.

Language: Английский

Citations

0