Nanobiotechnology Reports, Journal Year: 2024, Volume and Issue: 19(5), P. 645 - 666
Published: Oct. 1, 2024
Language: Английский
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 134, P. 111073 - 111073
Published: June 22, 2024
One of the most challenging and controversial issues in microbiome research is related to gut microbial metabolism neuropsychological disorders. Psychobiotics affect human behavior central nervous system processes via gut-brain axis, involving neuronal, immune, metabolic pathways. They have therapeutic potential treatment several neurodegenerative neurodevelopmental disorders such as depression, anxiety, autism, attention deficit hyperactivity disorder, Alzheimer's disease, Parkinson's schizophrenia, Huntington's anorexia nervosa, multiple sclerosis. However, mechanisms underlying interaction between psychobiotics abovementioned diseases need further exploration. This review focuses on relationship microbiota its impact neurological disorders, examining a preventive approach, summarising recent axis beneficial effects psychobiotics, highlighting for investigation this area.
Language: Английский
Citations
10
Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Language: Английский
Citations
1
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112928 - 112928
Published: Aug. 18, 2024
Language: Английский
Citations
4
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Language: Английский
Citations
0
Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2381 - 2381
Published: July 23, 2024
Alzheimer’s disease (AD) is a neurodegenerative process responsible for almost 70% of all cases dementia. The clinical signs consist in progressive and irreversible loss memory, cognitive, behavioral functions. main histopathological hallmark the accumulation amyloid-ß (Aß) peptide fibrils brain. To date, origin Aß has not been determined. Recent studies have shown that gut microbiota produces Aß, dysbiotic states identified AD patients animal models AD. Starting from hypothesis maintaining or restoring microbiota’s eubiosis essential to control Aß’s production deposition brain, we used mixture probiotics prebiotics (symbiotic) treat APPPS1 male female mice, an model AD, 2 8 months age evaluated their cognitive performances, mucus secretion, Aβ serum concentration, composition. results showed treatment was able prevent memory deficits, reduced increased blood levels, imbalance found mice. present study demonstrates gut–brain axis plays critical role genesis impairment, modulation can ameliorate AD’s symptomatology.
Language: Английский
Citations
2
IBRO Neuroscience Reports, Journal Year: 2024, Volume and Issue: 17, P. 441 - 455
Published: Nov. 8, 2024
Language: Английский
Citations
2
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102637 - 102637
Published: Dec. 1, 2024
Alzheimer's disease (AD) is a progressive, degenerative disorder of the central nervous system. Despite extensive research conducted on this disorder, its precise pathogenesis remains unclear. In recent years, microbiota-gut-brain axis has attracted considerable attention within field AD. The gut microbiota communicates bidirectionally with system through gut-brain axis, and alterations in structure function can influence progression Consequently, regulating to mitigate AD emerged as novel therapeutic approach. Currently, numerous studies concentrate intrinsic relationship between paper, we summarize multifaceted role present detailed strategies targeting microbiota, including treatment Traditional Chinese Medicine (TCM), which garnered increasing years. Finally, discuss potential for modulating alleviate AD, current challenges area research, provide an outlook future directions field.
Language: Английский
Citations
2
Biomolecules & Therapeutics, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 16, 2024
Neurodegenerative diseases (NDDs), characterized by the progressive deterioration of structure and function nervous system, represent a significant global health challenge.Emerging research suggests that gut microbiota plays critical role in regulating neurodegeneration via modulation gut-brain axis.Probiotics, defined as live microorganisms confer benefits to host, have garnered attention owing their therapeutic potential NDDs.This review examines current trends related microbiome-gut-brain axis across various NDDs, highlighting key findings implications.Additionally, effects specific probiotic strains, including Lactobacillus plantarum, Bifidobacterium breve, rhamnosus, on neurodegenerative processes were assessed, focusing benefits.Overall, this emphasizes probiotics promising agents for underscoring importance further investigation into emerging field.
Language: Английский
Citations
2
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Journal Year: 2024, Volume and Issue: 16(4)
Published: Oct. 1, 2024
A systematic review and meta-analysis examined the impact of gut microbiota in Alzheimer's disease (AD) pathogenesis. Dysbiosis may influence neurodegeneration by affecting permeability neurotrophic factors, leading to cognitive decline. The study analyzed microbiome differences between patients with AD healthy individuals, as well various interventions both preclinical clinical studies. Of 60 studies reviewed, 12 were excluded from due unsuitable data or lack control groups. Meta-analyses revealed significant impairment animal models, specific tests identifying these deficits. Notably,
Language: Английский
Citations
0
Nanobiotechnology Reports, Journal Year: 2024, Volume and Issue: 19(5), P. 645 - 666
Published: Oct. 1, 2024
Language: Английский
Citations
0