Animal Reproduction Science, Journal Year: 2024, Volume and Issue: 273, P. 107664 - 107664
Published: Dec. 4, 2024
Language: Английский
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: April 28, 2025
SUMMARY The etiology of Alzheimer’s Disease (AD) remains largely unclear but is likely driven by gene-environment interactions. Here, we present a multi-organ untargeted metabolomics dataset (2,271 samples) generated from five tissue types in two genetic AD mouse models under colonized or germ-free conditions, complemented shotgun metagenomics sequencing data (666 samples). Systems-level analyses 3xTg and 5xFAD mice reveal clusters dysregulated molecular classes across tissues including carnitines, bile acids, B vitamins, neurotransmitters. This signature, coupled with microbiome profiles, suggests increased oxidative stress via mitochondrial dysfunction. Molecular feature tracking tissueMASST, mass spectrometry search tool developed to bridge animal model findings human data, identifies microbially-modulated phenylacetyl-carnitine as positively associated aging cognitive impairment studies. With hundreds yet-to-be-characterized metabolites, this public resource its tools will aid future research the pathophysiology AD.
Language: Английский
Citations
1
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 12, 2025
Gut microbiota has been increasingly linked to metabolic health and diseases over the past few decades. Bile acids (BAs), major components of bile, are bidirectionally intestinal microbiota, also known as gut microbiome-BA axis. microbiota-derived bile salt hydrolase (BSH, EC 3.5.1.24), which catalyzes “gateway” reaction in a wider pathway acid modification, not only shapes landscape, but modulates crosstalk between host health. Therefore, microbial BSHs exhibit potential directly or indirectly influence physiologies, have considered promising targets for modulation benefit animal human However, their physiological functions bacterial physiologies still controversial clear. In this review, we mainly discuss current evidence related roles that played health, possible underlying mechanisms. Meanwhile, present applications BSH-producing probiotics various fields. Finally, describe several important questions need be addressed by further investigations. A detailed exploration significance will contribute future diagnostic therapeutic improving
Language: Английский
Citations
1
Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 565, P. 120004 - 120004
Published: Oct. 16, 2024
Language: Английский
Citations
4
Journal of dementia and Alzheimer's disease, Journal Year: 2024, Volume and Issue: 1(2), P. 87 - 97
Published: Oct. 15, 2024
Endoplasmic reticulum (ER) stress is a detrimental cellular phenomenon in the cells and activated by accumulation of unfolded or misfolded proteins ER. The protein activates response (UPR), an adaptive mechanism designed to mitigate enhancing ER’s protein-folding capacity protecting from apoptotic stimuli neuroinflammation neurodegenerative diseases. However, chronic ER prolonged activation UPR can have adverse effects, including pro-apoptotic inflammatory signaling pathways, which contribute development progression disorders. Neurodegenerative diseases are complex devastating conditions with underlying pathogenesis that not fully understood. Genetic mutations leading phosphorylated tau amyloid-beta induce stress, resulting neuronal death. Several studies reported involvement increased Thus, inhibiting targeting their associated pathways represent significant area research interest. This review discusses critical molecules involved mechanisms diseases, latest developments available inhibitors. Despite extensive inhibitors over years, only limited number been approved as pharmaceutical drugs. There remains need for effective provide efficient treatments Alzheimer’s disease.
Language: Английский
Citations
4
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 17, 2024
Background Alzheimer’s disease (AD) is a neurodegenerative characterized by progressive decline in cognitive function, which significantly increases pain and social burden. However, few therapeutic interventions are effective preventing or mitigating the progression of AD. An increasing number recent studies support hypothesis that gut microbiome its metabolites may be associated with upstream regulators AD pathology. Methods In this review, we comprehensively explore potential mechanisms currently available targeting for improvement Our discussion structured around modern research advancements AD, bidirectional communication between brain, multi-target regulatory effects microbial on strategies aimed at modulating microbiota to manage Results The plays crucial role pathogenesis through continuous via microbiota-gut-brain axis. Among these, such as lipids, amino acids, bile acids neurotransmitters, especially sphingolipids phospholipids, serve central components gut-brain axis, regulating AD-related pathogenic including β-amyloid metabolism, Tau protein phosphorylation, neuroinflammation. Additionally, probiotic administration, fecal transplantation, antibiotic use have also provided evidence supporting association At same time, propose an innovative strategy treating AD: healthy lifestyle combined targeted probiotics other interventions, aiming restore intestinal ecology balance. Conclusion Despite previous efforts, molecular microbes act yet fully described. microorganisms become essential target connecting axis improving symptoms it requires joint exploration multiple centers disciplines.
Language: Английский
Citations
3
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102637 - 102637
Published: Dec. 1, 2024
Alzheimer's disease (AD) is a progressive, degenerative disorder of the central nervous system. Despite extensive research conducted on this disorder, its precise pathogenesis remains unclear. In recent years, microbiota-gut-brain axis has attracted considerable attention within field AD. The gut microbiota communicates bidirectionally with system through gut-brain axis, and alterations in structure function can influence progression Consequently, regulating to mitigate AD emerged as novel therapeutic approach. Currently, numerous studies concentrate intrinsic relationship between paper, we summarize multifaceted role present detailed strategies targeting microbiota, including treatment Traditional Chinese Medicine (TCM), which garnered increasing years. Finally, discuss potential for modulating alleviate AD, current challenges area research, provide an outlook future directions field.
Language: Английский
Citations
3
Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 1718 - 1724
Published: Jan. 1, 2025
Language: Английский
Citations
0
Neurobiology of Disease, Journal Year: 2025, Volume and Issue: 209, P. 106898 - 106898
Published: April 4, 2025
Language: Английский
Citations
0
Journal of Dispersion Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 32
Published: April 11, 2025
Language: Английский
Citations
0
The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown
Published: May 11, 2025
Abstract The interaction between liver and brain health is an emerging complex relationship implicated in Alzheimer's disease (AD). Divergence aerobic capacity influences independently; however, whether these factors converge to influence AD risk mechanistically unknown. Bile acid metabolism has been as a link modulated by capacity. Here, we examined rats selectively bred for high vs . low intrinsic [high low‐capacity runner (HCR or LCR)] on indices of hepatic following chronic low‐fat, high‐fat, high‐fat diet with bile sequestrant from 6 12 months age. Pre‐ post‐diet measures included learning, memory, volume metabolite levels. We additionally quantified Aβ proteins associated production clearance, well mitochondrial energetics species. found that not only did function, but also it modified levels across the brain. Additionally, altered profiles hippocampal addition lowered sexually dimorphic manner. Aerobic cognitive outcomes. Our results indicate diet‐induced alterations modulate respect AD‐like pathologies, whereas stimulation faecal loss could have positive effects lowering Aβ. image Key points function alter species energy loss. both homeostasis. modulates metabolism. learning middle‐aged rats.
Language: Английский
Citations
0