Electrolytes as predictors of fibro fatigue scores in Long-COVID patients DOI Creative Commons
Wasim Talib Mahdi Al Masoodi,

Sami Waheed Radhi,

Hussein Kadhem Al‐Hakeim

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(8), P. e0309348 - e0309348

Published: Aug. 28, 2024

The complex effects of Long-COVID, a syndrome marked by enduring symptoms after COVID-19 infection, with an emphasis on patients' differing degrees fibro fatigue (FF). Electrolyte disturbances may affect the severity FF and be used as predictive tool for severe in Long-COVID patients.

Language: Английский

Printable molecule-selective core–shell nanoparticles for wearable and implantable sensing DOI
Minqiang Wang, Cui Ye, Yiran Yang

et al.

Nature Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Language: Английский

Citations

5
Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID DOI Creative Commons
A. Satyanarayan Naidu, Chin‐Kun Wang, Pingfan Rao

et al.

npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)

Published: March 30, 2024

Language: Английский

Citations

9
Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19 DOI Creative Commons

Rae Maeda,

Natsumi Seki,

Yoshifumi Uwamino

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Dec. 20, 2023

Abstract Effective early-stage markers for predicting which patients are at risk of developing SARS-CoV-2 infection have not been fully investigated. Here, we performed comprehensive serum metabolome analysis a total 83 from two cohorts to determine that the acceleration amino acid catabolism within 5 days disease onset correlated with future severity. Increased levels de-aminated catabolites involved in de novo nucleotide synthesis pathway were identified as early prognostic initial viral load. We further employed mice models SARS-CoV2-MA10 and influenza demonstrate such de-amination acids nucleotides associated abnormal proliferation airway vascular tissue cells lungs during stages infection. Consequently, it can be concluded lung parenchymal remodeling respiratory infections induces systemic metabolic key valid predictors excessive inflammatory response later stages.

Language: Английский

Citations

20
Immune activation and immune-associated neurotoxicity in Long-COVID: A systematic review and meta-analysis of 103 studies comprising 58 cytokines/chemokines/growth factors DOI
Abbas F. Almulla,

Yanin Thipakorn,

Bo Zhou

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 122, P. 75 - 94

Published: Aug. 9, 2024

Language: Английский

Citations

7
Anxiety due to Long COVID is partially driven by activation of the tryptophan catabolite (TRYCAT) pathway DOI
Hussein Kadhem Al‐Hakeim,

Anwar Khairi Abed,

Abbas F. Almulla

et al.

Asian Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 88, P. 103723 - 103723

Published: Aug. 7, 2023

Language: Английский

Citations

12
Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms DOI Creative Commons
Abbas F. Almulla, Michaël Maes, Bo Zhou

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 5, 2023

Abstract Background Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Objectives To examine whether its accompanying CFS are associated with immunoglobulin (Ig)A/IgM/IgG directed at neuronal proteins including myelin basic protein (MBP), oligodendrocyte glycoprotein (MOG), synapsin, α+β-tubulin, neurofilament (NFP), cerebellar protein-2 (CP2), blood-brain-barrier-brain-damage (BBD) claudin-5 S100B. Methods IgA / IgM/IgG above proteins, human herpes virus-6 (HHV-6) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were measured in 90 COVID patients healthy controls, while C-reactive (CRP), advanced oxidation products (AOPP) association ratings additionally assessed a subgroup thereof. Results is significant increases IgG tubulin (IgG-tubulin), MBP, MOG synapsin; IgM-MBP, MOG, CP2, synapsin BBD; IgA-CP2 synapsin. IgM-SARS-CoV-2 IgM-HHV-6 antibody titers significantly correlated IgA/IgG/IgM-tubulin -CP2, IgG/IgM-BBD, IgM-MOG, IgA/IgM-NFP, IgG/IgM-synapsin. Binary logistic regression analysis shows that IgM-MBP IgG-MBP best predictors COVID. Multiple IgG-MOG, CRP AOPP explain together 41.7% variance severity CFS. Neural network IgM-synapsin, IgA-MBP, IgA-synapsin, IgA-CP2, most important due predictive accuracy r=0.801. Conclusion Brain-targeted autoimmunity contributes pathogenesis physio-affective phenome.

Language: Английский

Citations

12
Monomeric C-reactive protein as a biomarker for major depressive disorder DOI Creative Commons
Mary G. Hornick, Lawrence A. Potempa

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 5, 2024

Neuroinflammation has been postulated to be a key factor in the pathogenesis of major depressive disorder (MDD). With this is mind, there wave research looking into pro-inflammatory mediators as potential biomarkers for MDD. One such mediator acute phase protein, C-reactive protein (CRP). While several studies have investigated CRP biomarker MDD, results inconsistent. explanation lack consistent findings may that high-sensitivity tests utilized these only measure pentameric isoform (pCRP). Recent research, however, indicated monomeric (mCRP) responsible function CRP, while pCRP weakly anti-inflammatory. The objective minireview re-examine evidence involvement MDD with view mCRP biomarker.

Language: Английский

Citations

4
Significance of nitrosative stress and glycoxidation products in the diagnosis of COVID-19 DOI Creative Commons
Blanka Wolszczak-Biedrzycka, Justyna Dorf, Joanna Matowicka-Karna

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 22, 2024

Abstract Nitrosative stress promotes protein glycoxidation, and both processes can occur during an infection with the SARS-CoV-2 virus. Therefore, aim of this study was to assess selected nitrosative parameters glycoxidation products in COVID-19 patients convalescents relative healthy subjects, including reference severity symptoms. The diagnostic utility biomarkers also evaluated patients. involved 218 COVID-19, 69 convalescents, 48 subjects. (NO, S-nitrosothiols, nitrotyrosine) (tryptophan, kynurenine, N-formylkynurenine, dityrosine, AGEs) were measured blood plasma or serum use colorimetric/fluorometric methods. levels NO ( p = 0.0480), S-nitrosothiols 0.0004), nitrotyrosine 0.0175), kynurenine < 0.0001), N-formylkynurenine dityrosine AGEs 0.0001) significantly higher, whereas tryptophan fluorescence lower than control group. Significant differences analyzed observed different stages COVID-19. In turn, concentrations controls. ROC analysis revealed that be useful for diagnosing infections virus because they differentiate (KN: sensitivity—91.20%, specificity—92.00%; NFK: sensitivity—92.37%, AGEs: sensitivity—99,02%, specificity—100%) sensitivity—82.22%, specificity—84.00%; sensitivity—82,86%, specificity—86,00%; DT: sensitivity—100%, specificity—100%; AGE: from subjects high sensitivity specificity. are intensified after redox fluctuate disease. Circulating stress/protein have potential convalescents.

Language: Английский

Citations

4
Long COVID as a Disease of Accelerated Biological Aging: An Opportunity to Translate Geroscience Interventions DOI
Areez Shafqat, Mary Clare Masters, Utkarsh Tripathi

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102400 - 102400

Published: June 28, 2024

Language: Английский

Citations

4
From human herpes virus‐6 reactivation to autoimmune reactivity against tight junctions and neuronal antigens, to inflammation, depression, and chronic fatigue syndrome due to Long COVID DOI Creative Commons
Michael Maes, Abbas F. Almulla,

Xiaoou Tang

et al.

Journal of Medical Virology, Journal Year: 2024, Volume and Issue: 96(8)

Published: Aug. 1, 2024

Inflammation and autoimmune responses contribute to the pathophysiology of Long COVID, its affective chronic fatigue syndrome symptoms, labeled "the physio-affective phenome." To investigate whether COVID phenome are linked autoimmunity tight junction proteins, zonulin occludin (ZOOC), immune reactivity lipopolysaccharides (LPS), latter associated with signs human herpes virus-6 (HHV-6) reactivation, directed against oligodendrocyte neuronal including myelin basic protein. IgA/IgM/IgG severe acute respiratory coronavirus 2 (SARS-CoV-2), HHV-6, ZOOC, C-reactive protein (CRP), advanced oxidation products (AOPPs), were measured in 90 patients healthy controls. The was conceptualized as a factor extracted from physical symptom domains. Neural network identified IgA LPS (IgA-LPS), IgG-ZOOC, IgG-LPS, IgA-ZOOC important variables diagnosis an area under ROC curve 0.755. Partial Least Squares analysis showed that 40.9% variance explained by CRP, IgA-myelin (MBP), IgG-MBP. A large part variances both MBP (36.3%-39.7%) (IgA IgG) ZOOC. strongly indicants HHV-6 which turn increased IgM-SARS-CoV-2. Autoimmunity components junctions bacterial translocation may be involved COVID's phenome.

Language: Английский

Citations

4