Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Nov. 13, 2024
Background
Pruritus
ani
(PA),
a
neurofunctional
dermatosis,
is
one
of
the
most
common
complications
hemorrhoids,
which
seriously
affects
quality
life
patients.
Medical
hemorrhoid
gel
(MHG),
product
mainly
composed
herbal
medicine,
widely
used
for
treatment
PA
clinically.
This
study
aim
to
assess
alleviating
effect
and
mechanism
MHG
on
based
rectal
epidermis-spinal
cord-brain
axis
using
animal
models.
Methods
A
chloroquine-induced
mouse
itching
model
croton
oil
preparation-induced
rat
were
established
evaluate
anti-PA
MHG.
Scratching
behaviors
mice
recorded,
histopathology
skin
ano-rectal
tissues
was
observed
through
H&E
staining.
Network
pharmacology
western
blotting
employed
explore
potential
Results
The
indicated
that
significantly
alleviated
improved
pathological
injuries
in
tissues.
suggested
might
regulate
JAK/STAT
signaling
pathway.
Experimental
findings
showed
downregulated
TRPV1
TRPA1
tissue,
c-Fos
GRPR
spinal
cord
5-HT1a
protein
brain
while
upregulating
TRPM8
tissue.
Furthermore,
inhibited
activation
JAK2/STAT3
pathway
axis.
Conclusion
improves
by
inhibiting
transmission
signals
via
pathway,
providing
experimental
evidence
its
clinical
application.
Plants,
Journal Year:
2024,
Volume and Issue:
13(24), P. 3515 - 3515
Published: Dec. 16, 2024
Chronic
pruritus,
or
persistent
itching,
is
a
debilitating
condition
that
severely
impacts
quality
of
life,
especially
in
palliative
care
settings.
Traditional
treatments
often
fail
to
provide
adequate
relief
are
associated
with
significant
side
effects,
prompting
interest
alternative
therapies.
This
review
investigates
the
antipruritic
potential
eight
medicinal
plants:
chamomile
(Matricaria
chamomilla),
aloe
vera
(Aloe
barbadensis),
calendula
(Calendula
officinalis),
curcumin
(Curcuma
longa),
lavender
(Lavandula
angustifolia),
licorice
(Glycyrrhiza
glabra),
peppermint
(Mentha
piperita),
and
evening
primrose
(Oenothera
biennis).
These
plants
analyzed
for
their
traditional
applications,
active
bioactive
compounds,
mechanisms
action,
clinical
evidence,
usage,
dosage,
safety
profiles.
Comprehensive
searches
were
conducted
databases
including
PubMed,
Web
Science,
Scopus,
b-on,
focusing
on
vitro,
animal,
studies
using
keywords
like
“plant”,
“extract”,
“pruritus”.
Studies
included
regardless
publication
date
limited
English-language
articles.
Findings
indicate
compounds
such
as
polysaccharides
vera,
curcuminoids
turmeric,
menthol
exhibit
anti-inflammatory,
antioxidant,
immune-modulating
properties.
Chamomile
alleviate
itching
through
anti-inflammatory
skin-soothing
while
offer
antimicrobial
benefits
alongside
relief.
Evening
primrose,
rich
gamma-linolenic
acid,
effective
atopic
dermatitis-related
itching.
Despite
promising
preclinical
results,
challenges
remain
standardizing
dosages
formulations.
The
highlights
necessity
further
trials
ensure
efficacy
safety,
advocating
integrating
these
botanical
therapies
into
complementary
practices.
Such
approaches
emphasize
holistic
treatment,
addressing
chronic
pruritus’s
physical
emotional
burden,
thereby
enhancing
patient
well-being.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(12), P. 1707 - 1707
Published: Dec. 8, 2023
Itch
(pruritus)
is
a
sensation
in
the
skin
that
provokes
desire
to
scratch.
The
of
itch
mediated
through
subclass
primary
afferent
sensory
neurons,
termed
pruriceptors,
which
express
molecular
receptors
are
activated
by
itch-evoking
ligands.
Also
expressed
pruriceptors
several
types
Transient
Receptor
Potential
(TRP)
channels.
TRP
channels
diverse
class
cation
responsive
various
somatosensory
stimuli
like
touch,
pain,
itch,
and
temperature.
In
can
be
intracellular
signaling
cascades
initiated
pruritogen
underly
neuronal
activation.
this
review,
we
discuss
role
TRPA1,
TRPV1,
TRPV2,
TRPV3,
TRPV4,
TRPM8,
TRPC3/4
acute
chronic
pruritus.
Since
these
often
mediate
association
with
receptors,
also
Mas-related
G-protein-coupled
(Mrgprs)
protease-activated
(PARs).
Additionally,
cover
exciting
therapeutic
targets
amongst
family,
as
well
Mrgprs
PARs
for
treatment
Acta Dermato Venereologica,
Journal Year:
2024,
Volume and Issue:
104, P. adv40127 - adv40127
Published: June 17, 2024
Heat
application
is
known
to
activate
transient
receptor
potential
(TRP)
channels,
which
play
a
crucial
role
in
sensory
perception,
including
itch.
In
this
study,
the
effect
of
5-s,
49°C
heat
on
itch
intensity
atopic
dermatitis
(AD)
patients
was
evaluated.
The
study
comprised
2
parts:
controlled
trial
investigating
impact
brief
treatment
mechanically
induced
itch,
and
real-life
AD
experiencing
attacks.
A
significant
immediate
reduction
sensations
following
shown,
with
effects
enduring
over
time.
This
response,
however,
showed
notable
individual
variability,
underscoring
personalized
approaches
treatment.
Repeated
applications
no
habituation
effect,
suggesting
its
viability
as
non-pharmacological,
patient-tailored
option
for
managing
AD.
Further
research
larger
cohorts
warranted
refine
protocols
deepen
understanding
mechanisms
involved.
Journal of Palliative Medicine,
Journal Year:
2024,
Volume and Issue:
27(12), P. 1666 - 1671
Published: July 9, 2024
Even
though
pruritus
affects
a
significant
number
of
people
with
chronic
disease,
it
is
rarely
adequately
treated.
Drug
therapies
often
rely
on
antihistamines,
which
have
not
shown
to
be
beneficial
in
systemic
pruritus.
Hydroxyzine
frequently
used
treat
associated
kidney
failure.
Since
Canada's
sole
manufacturer
hydroxyzine
no
longer
making
this
product,
an
ideal
time
review
the
mechanisms
itch
advanced
organ
failure
and
specific
that
give
relief.
Although
there
literature
describing
patients
cancer,
article
limited
pathogenesis
treatment
secondary
chronic,
noncancer
diseases.
We
summarize
recent
systematic
reviews,
although
studies
included
these
reviews
are
small,
mostly
cohort
studies.
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 30, 2024
Introduction
Pruritus,
a
medical
symptom
also
known
as
itch,
is
characterized
by
an
unpleasant
feeling
coupled
with
the
urge
to
scratch.
Patients
chronic
kidney
disease
(CKD)
often
have
symptoms
of
pruritus
due
uremia,
which
has
adversely
affected
their
quality
life.
The
treatment
protocol
for
CKD
still
being
debated
its
unclear
etiopathogenesis.
Pregabalin,
anticonvulsant
medication,
and
sertraline,
antidepressant
been
used
treat
uremic
(UP)
patients
on
maintenance
hemodialysis.
Objectives
There
are
no
adequate
investigations
comparing
efficacy
pregabalin
particularly
in
under-resourced
countries
such
Pakistan.
Method
research
was
randomized
trial
period
four
weeks
at
nephrology
department
Mayo
Hospital,
Lahore.
A
total
62
were
randomly
assigned
take
either
(aged
48.06±13.44)
or
sertraline
47.45±10.97)
tablet
once
day,
31
each
group.
group
specified
25
mg
first
week,
50
second
75
third
fourth
week.
Similarly,
prescribed
week
remaining
three
weeks.
However,
if
patient
shows
improvement
lowest
dosage,
therapy
same
minimum
dose
proposed
be
continued.
Lastly,
itching
score
assessed
5D
scale.
Visit
1
(no
drug)
evaluated
against
post-therapy
scores
two-week
intervals
2
(week
2)
3
4).
Statistical
analysis
done
using
Product
Service
Solutions
(SPSS,
version
26;
IBM
SPSS
Statistics
Windows,
Armonk,
NY)
significance
level
set
p<0.05
95%
confidence
level.
Conclusion
This
concluded
that
both
significantly
improved
intensity
group;
however,
there
significant
difference
between
two
drugs
reducing
UP
based
scores.
In
domain
scale,
found
post-follow-up
therapy.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 18, 2024
AbstractObjective
This
study
aimed
to
investigate
the
clinical
characteristics
and
risk
factors
for
pruritus
in
patients
with
neuromyelitis
optica
spectrum
disorders
(NMOSD)
evaluate
its
impact
on
patient
quality
of
life.
Methods
Patients
NMOSD
at
Department
Neurology
our
hospital
from
December
2021
August
2023
were
followed
up
by
outpatient
visits
or
telephone
interviews.
The
5-D
itch
scale
was
used
intensity,
course
pruritus-related
interference
daily
life
during
entire
disease
course.
We
explored
correlated
comparing
features
without
pruritus.
Results
A
total
112
enrolled.
32(28.6%)
had
All
these
myelitis.
22
(68.8%)
less
than
6
hours/day,
26
(81.2%)
moderate
severe
16
(50%)
complete
relief,
30
(93.8%)
never
occasionally
affected
Compared
pruritus,
more
common
males
(P=0.030),
younger
age
(P=0.018),
a
shorter
(P=0.000),
cervical
cord
lesions
longitudinally
extensive
transverse
myelitis
(P=0.013
0.022,
respectively).
Multivariate
logistic
regression
analysis
revealed
that
(OR=0.031,
95%
CI=0.002-0.421,
P=0.009),
short
duration
(OR=0.810,
CI=0.721-0.909,
P=0.000),
(OR=7.346,
CI=1.172-46.052,
P=0.033),
(OR=8.023,
CI=1.501-42.852,
P=0.015)
independent
NMOSD.
Conclusions
Pruritus
is
feature
NMOSD,
it
can
be
initial
symptom
some
patients.
A
course,
age,
involvement
are
Pruritus
has
minor
effect
majority
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Nov. 13, 2024
Background
Pruritus
ani
(PA),
a
neurofunctional
dermatosis,
is
one
of
the
most
common
complications
hemorrhoids,
which
seriously
affects
quality
life
patients.
Medical
hemorrhoid
gel
(MHG),
product
mainly
composed
herbal
medicine,
widely
used
for
treatment
PA
clinically.
This
study
aim
to
assess
alleviating
effect
and
mechanism
MHG
on
based
rectal
epidermis-spinal
cord-brain
axis
using
animal
models.
Methods
A
chloroquine-induced
mouse
itching
model
croton
oil
preparation-induced
rat
were
established
evaluate
anti-PA
MHG.
Scratching
behaviors
mice
recorded,
histopathology
skin
ano-rectal
tissues
was
observed
through
H&E
staining.
Network
pharmacology
western
blotting
employed
explore
potential
Results
The
indicated
that
significantly
alleviated
improved
pathological
injuries
in
tissues.
suggested
might
regulate
JAK/STAT
signaling
pathway.
Experimental
findings
showed
downregulated
TRPV1
TRPA1
tissue,
c-Fos
GRPR
spinal
cord
5-HT1a
protein
brain
while
upregulating
TRPM8
tissue.
Furthermore,
inhibited
activation
JAK2/STAT3
pathway
axis.
Conclusion
improves
by
inhibiting
transmission
signals
via
pathway,
providing
experimental
evidence
its
clinical
application.
