Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106761 - 106761
Published: March 1, 2025
Language: Английский
Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 568, P. 120125 - 120125
Published: Jan. 8, 2025
Language: Английский
Citations
1
Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120168 - 120168
Published: Jan. 1, 2025
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3915 - 3915
Published: April 21, 2025
Neurological diseases, including neurodegenerative disorders and stroke, represent significant medical challenges due to their complexity the limitations of current treatment approaches. This review explores potential stem cell (SC)-derived exosomes (Exos) as a transformative therapeutic strategy for these diseases. Exos, especially those derived from SCs, exhibit natural targeting ability, biocompatibility, capacity cross blood-brain barrier (BBB), making them ideal vehicles drug delivery. provides an in-depth discussion properties advantages SC-Exos. It highlights synergistic benefits in approaches treat neurological article discusses mechanisms action SC-Exos, highlighting ability target specific cells, modulate disease pathways, provide controlled release agents. Applications have been investigated, demonstrating improve outcomes conditions such Alzheimer's Disease (AD), Parkinson's (PD), stroke. Moreover, Exos-coated nanoparticles (NPs) combine Exos with multifunctionality NPs. integration takes advantage exosome membrane biocompatibility capabilities while preserving NPs' beneficial features, loading release. As result, NPs may enhance precision, efficacy, safety interventions. In conclusion, SC-Exos promising innovative approach treating
Language: Английский
Citations
1
Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: July 26, 2024
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that affects the central nervous system (CNS). Neuroinflammation crucial factor in pathological advancement of PD. PD characterized by presence activated microglia and increased levels proinflammatory factors, which play role its pathology. During immune response PD, regulation significantly influenced microRNA (miRNA). The excessive activation microglia, persistent neuroinflammation, abnormal polarization macrophages brain can be attributed to dysregulation certain miRNAs. Additionally, there are miRNAs possess ability inhibit neuroinflammation. miRNAs, small non-coding epigenetic regulators, have modulate microglial activity both normal conditions. They also significant impact on promoting communication between neurons microglia.
Language: Английский
Citations
6
MedComm, Journal Year: 2024, Volume and Issue: 5(8)
Published: July 15, 2024
Exosomes are nanoscale vesicles of cellular origin. One the main characteristics exosomes is their ability to carry a wide range biomolecules from parental cells, which important mediators intercellular communication and play an role in physiological pathological processes. have advantages biocompatibility, low immunogenicity, biodistribution. As researchers' understanding has increased, various strategies been proposed for use diagnosing treating diseases. Here, we provide overview biogenesis composition exosomes, describe relationship between disease progression, focus on as biomarkers early screening, monitoring, guiding therapy refractory diseases such tumors neurodegenerative We also summarize current applications especially engineered efficient drug delivery, targeted therapies, gene immune vaccines. Finally, challenges potential research directions clinical application discussed. In conclusion, emerging molecule that can be used diagnosis treatment diseases, combined with multidisciplinary innovative solutions, will applications.
Language: Английский
Citations
4
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: Oct. 5, 2024
Language: Английский
Citations
3
Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 7, 2025
HIV-associated neurocognitive disorder (HAND) is a complex neurological complication resulting from human immunodeficiency virus (HIV) infection, affecting about 50% of individuals with HIV and significantly diminishing their quality life. HAND includes variety cognitive, motor, behavioral disorders, severely impacting patients' life social functioning. Although combination antiretroviral therapy (cART) has greatly improved the prognosis for patients, incidence remains high, underscoring urgent need to better understand its pathological mechanisms develop early diagnostic methods. This review highlights latest advancements in neuroimaging exosome biomarkers research. Neuroimaging, particularly magnetic resonance imaging (MRI), offers non-invasive repeatable method monitor subtle changes brain structure function, potentially detecting signs HAND. Meanwhile, exosomes are nano-sized vesicles secreted by cells that serve as key mediators intercellular communication, playing crucial role neuropathology acting critical bridge between peripheral blood central nervous system lesions. Thus, combining plasma indicators derived scans may enhance diagnosis summarizes evidence supporting reliable detection management Furthermore, we emphasize correlation explore potential combined use. discusses technical challenges methodological limitations integrating these two types proposes future research directions. multidisciplinary integrative approach not only promises improve health patients but also offer valuable insights into other neurodegenerative diseases.
Language: Английский
Citations
0
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106761 - 106761
Published: March 1, 2025
Language: Английский
Citations
0