Probiotics and Postbiotics as an Alternative to Antibiotics: An Emphasis on Pigs

Pathogens, Journal Year: 2023, Volume and Issue: 12(7), P. 874 - 874

Published: June 26, 2023

Probiotics are being used as feed/food supplements an alternative to antibiotics. It has been demonstrated that probiotics provide several health benefits, including preventing diarrhea, irritable bowel syndrome, and immunomodulation. Alongside probiotic bacteria-fermented foods, the different structural components, such lipoteichoic acids, teichoic peptidoglycans, surface-layer proteins, offer advantages. can produce antimicrobial enzymes, peptides, vitamins, exopolysaccharides. Besides live probiotics, there growing interest in consuming inactivated farm animals, pigs. Several reports have shown killed boost immunity, modulate intestinal microbiota, improve feed efficiency growth performance, decrease incidence of positioning them interesting strategy a potential supplement for Therefore, effective selection approach use might essential features using important functional This review aimed systematically investigate effects lactic acid bacteria their forms on

Language: Английский

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Beyond probiotics, uses of their next‐generation for poultry and humans: A review

Journal of Animal Physiology and Animal Nutrition, Journal Year: 2024, Volume and Issue: 108(5), P. 1336 - 1347

Published: April 30, 2024

The production of healthy food is one the basic requirements and challenges. Research efforts have been introduced in human's industry to reduce microbial resistance use safe alternatives with a high durability. However, conducted work about these issues field livestock animal started since 2015. Inappropriate extensive antibiotics has resulted increase antimicrobial resistance, presence drug residues tissues, destruction gut microbiome. Therefore, discovering developing antibiotic substitutes were urgent demands. Probiotic compounds containing living micro-organisms are important alternative that beneficially extensively used humans, animals, poultry. some probiotics show obstacles during applications. Accordingly, this review article proposes comprehensive description next-generation including postbiotics, proteobiotics, psychobiotics, immunobiotics paraprobiotics their effects on poultry therapy. These proved great efficiency terms restoring health, improving performance general health conditions, modulating immune response reducing pathogenic micro-organisms. more future research should be carried out regarding issue.

Language: Английский

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Postbiotics are a candidate for new functional foods

Food Chemistry X, Journal Year: 2024, Volume and Issue: 23, P. 101650 - 101650

Published: July 14, 2024

Accumulating studies have highlighted the great potential of postbiotics in alleviating diseases and protecting host health. Compared with traditional functional foods (such as probiotics prebiotics), advantages a single composition, high physiological activity, long shelf life, easy absorption, targeting, etc. The development has led to wide range applications food drug development. However, lack clinical trial data, mechanism analyses, safety evaluations, effective regulatory frameworks limited application postbiotic products. This review describes definition, classification, sources, preparation methods postbiotics, progress preclinical research improving diseases, their food. Strengthen understanding recognition related products lay theoretical foundation.

Language: Английский

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Prebiotics, Probiotics and Postbiotics: The Changing Paradigm of Functional Foods

Journal of Dietary Supplements, Journal Year: 2024, Volume and Issue: 21(5), P. 709 - 735

Published: June 16, 2024

The rampant use of antibiotics has led to the emergence multidrug resistance and is often coupled with gut dysbiosis. To circumvent harmful impact antibiotics, probiotics have emerged as an effective intervention. However, while new are being added list, more recently, nature role their counterparts, viz. prebiotics, postbiotics parabiotics also drawn considerable attention. As such, intricate relationships among these gut-biotics vis-à-vis in imparting health benefits be delineated a holistic manner. Prebiotic dietary fibers selectively fermented by promote colonization gut. proliferation leads production fermentation by-products (postbiotics) which affect growth enteropathogens lowering pH producing inhibitory bacteriocins. After completing life-cycle, dead remnants (parabiotics e.g. exopolysaccharides cell wall glycoproteins) inhibit adhesion biofilm formation pathogens on epithelium. These beneficial effects not just endemic but systemic response witnessed at different gut-organ axes. Thus, decipher probiotics, it imperative unravel interdependence between components. This review elaborates recent advancements various aspects mechanism potential attributes like anti-oxidant, anti-inflammatory, anti-neoplastic, anti-lipidemic anti-hyperglycemic benefits.

Language: Английский

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Probiotic, Postbiotic, and Paraprobiotic Effects of Lactobacillus rhamnosus as a Modulator of Obesity-Associated Factors

Foods, Journal Year: 2024, Volume and Issue: 13(22), P. 3529 - 3529

Published: Nov. 5, 2024

Obesity is a pandemic currently affecting the world's population that decreases quality of life and promotes development chronic non-communicable diseases.

Language: Английский

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Prognosis of Patients with Esophageal Carcinoma After Routine Thoracic Duct Resection

Annals of Surgery, Journal Year: 2021, Volume and Issue: 277(5), P. e1018 - e1025

Published: Dec. 16, 2021

To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy.Although TD can cause nutritional disadvantage and immune suppression, it has been performed for surrounding lymph nodes.We analyzed 12,237 from Comprehensive Registry Esophageal Cancer in Japan who underwent esophagectomy between 2007 2012. preservation groups were compared terms prognosis, perioperative outcomes, initial recurrent patterns using strict propensity score matching. Particularly, year history primary other organs added as covariates.After matching, 1638 c-Stage I-IV participated each group. The 5 overall survival cause-specific rates 57.5% 65.6% TD-resected group 55.2% 63.4% TD-preserved group, respectively, without significant differences. had significantly more retrieved mediastinal nodes (30 vs 21, P < 0.0001) fewer node recurrence (376 450, = 0.0029) However, total number distant metastatic was greater than (499 421, 0.0024).TD did not improve esoph-ageal cancer. Despite having nodes, caused metastases to preservation. Hence, prophylactic should be recommended

Language: Английский

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Lacticaseibacillus rhamnosus CP-1 mitigates LPS-induced acute lung injury in mice via TLR/NF-κB pathway and gut microbiota modulation

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106429 - 106429

Published: March 1, 2025

Language: Английский

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Analysis of risk factors and development of predictive model for malnutrition in patients with traumatic brain injury

Nutritional Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: April 25, 2024

Malnutrition is a highly prevalent complication in patients with traumatic brain injury (TBI), and it closely related to the prognosis of patients. Accurate identification at high risk malnutrition essential. Therefore, we analyzed factors TBI developed model predict malnutrition. A retrospective collection 345 TBI, they were divided into comparison groups according occurrence Univariate correlation multifactor logistic regression analyses performed determine patients' factors. We used univariate (forward stepwise method) identify significant predictors associated predictive for prediction. The model's discrimination, calibration, clinical utility evaluated using receiver operating characteristic (ROC) curve, calibration plots, decision curve analysis (DCA). total 216 (62.6%) Multifactorial showed that pulmonary infection, urinary tract dysphagia, application NGT, GCS score ≤ 8, low ADL independent (

Language: Английский

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Respiratory Commensal Bacteria Increase Protection against Hypermucoviscous Carbapenem-Resistant Klebsiella pneumoniae ST25 Infection

Pathogens, Journal Year: 2022, Volume and Issue: 11(9), P. 1063 - 1063

Published: Sept. 19, 2022

In a previous work, we demonstrated that nasally administered Corynebacterium pseudodiphtheriticum 090104 beneficially modulated the respiratory innate immune response and improved protection against Respiratory Syncytial Virus Streptococcus pneumoniae in mice. this aimed to evaluate whether immunomodulatory strain was able enhance resistance infection induced by hypermucoviscous carbapenemase-producing (KPC-2) Klebsiella strains belonging sequence type (ST) 25. The nasal treatment of mice with C. before challenge multiresistant K. ST25 significantly reduced lung bacterial cell counts tissue damage. protective effect related its ability regulate triggered challenge. pseudifteriticum differentially recruitment leukocytes into production TNF-α, IFN-γ IL-10 levels tract serum. Our results make an advance positioning as next-generation probiotic for encourage further research bacterium promising alternative develop non-antibiotic therapeutical approaches prevention infections produced microorganisms multiple antimicrobials such KPC-2-producing ST25.

Language: Английский

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Impact of long‐term nasal airflow deprivation on sinonasal structures and chronic rhinosinusitis in total laryngectomy patients

Laryngoscope Investigative Otolaryngology, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 17, 2024

Total laryngectomy (TL) patients are good models in which to evaluate the effects of nasal airflow cessation on sinonasal tract. Here, we evaluated changes structures and association with sinus opacification computed tomography (CT) images 3 years post-TL.

Language: Английский

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