Protective effects of sinomenine against dextran sulfate sodium-induced ulcerative colitis in rats via alteration of HO-1/Nrf2 and inflammatory pathway

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(3), P. 2007 - 2022

Published: April 4, 2024

Language: Английский

---

Cardiovascular protective effects of natural flavonoids on intestinal barrier injury

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Language: Английский

---

Apigenin unveiled: an encyclopedic review of its preclinical and clinical insights

Discover Plants., Journal Year: 2025, Volume and Issue: 2(1)

Published: Jan. 20, 2025

Language: Английский

---

Integrated microbiome and metabolomics analysis reveals the alleviating effect of Pediococcus acidilactici on colitis

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 26, 2025

Colitis is a complicated disease caused by multiple factors, seriously threatening the host health and development of animal husbandry. Probiotics have been demonstrate to participate in active regulation gastrointestinal disease, gut microbiota metabolism, but research on efficacy Pediococcus acidilactici isolated from dogs alleviating colitis remains scarce. Here, we aimed investigate ameliorative effects induced LPS its underlying molecular mechanisms. For this purpose, collected colon contents 15 mice for amplicon sequencing metabolic analysis. Results showed that could relieve damage cytokine disorder colitis. Microbiome analysis cause significant decrease microbial diversity abundance, administration restore index control level. Metabolomics 8 pathways 5 (spermine, L-Arginine, 15-Deoxy-Delta12,14-PGJ2, prostaglandin J2, 15(S)-HETE) metabolites may be involved alleviation acidilactici. In summary, these findings demonstrated positive effect metabolism one mechanisms alleviate Additionally, study also conveyed vital message serve as promising candidate ameliorate

Language: Английский

---

A systematic review on the role of gut microbiome in inflammatory bowel disease: Spotlight on virome and plant metabolites

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107608 - 107608

Published: April 1, 2025

Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, arise from various factors such as dietary, genetic, immunological, microbiological influences. The gut microbiota plays a crucial role in the development treatment of IBD, though exact mechanisms remain uncertain. Current research has yet to definitively establish beneficial effects microbiome on IBD. Bacteria viruses (both prokaryotic eukaryotic) are key components uniquely related Numerous studies suggest that dysbiosis microbiota, bacteria, viruses, bacteriophages, contributes IBD pathogenesis. Conversely, some indicates bacteria bacteriophages may positively impact outcomes. Additionally, plant metabolites play alleviating due their anti-inflammatory microbiome-modulating properties. This systematic review discusses patients evaluates potential connection between context pathophysiology.

Language: Английский

---

Akkermansia muciniphila Ameliorates Alcoholic Liver Disease in Experimental Mice by Regulating Serum Metabolism and Improving Gut Dysbiosis

Metabolites, Journal Year: 2023, Volume and Issue: 13(10), P. 1057 - 1057

Published: Oct. 7, 2023

Alcoholic liver disease (ALD) represents a significant global health concern, yet the available treatment options remain limited. Numerous studies have shown that gut microbiota is critical target for of ALD. Additionally, there increasing evidence host metabolism also plays crucial role in development Akkermansia muciniphila has been demonstrated to ameliorate experimental ALD through its modulatory effects on intestinal vascular barrier, enhancement mucus layer thickness, and promotion tight junction proteins. Nevertheless, dearth investigating impact A. microbiota. Here, C57BL/6 mice were utilized establish modified NIAAA model order investigate oral administration during Furthermore, we employed targeted metabolomics analyze serum metabolomic profiles 2bRAD-M sequencing comprehensively examine underlying mechanisms efficacy Our results illustrated alleviated alcohol-induced injury conjunction with encouraged levels ornithine diminished elevation oxalic acid induced by alcohol intake. In addition, inhibited proliferation harmful bacteria, such as Escherichia coli Helicobacter hepaticus, consumption while promoting growth butyrate-producing commensal including Paramuribaculum intestinale Bacteroides ovatus. conclusion, this study suggests restores regulating microbiota, corrective effect associated alterations metabolism. research supplies theoretical basis developing an innovative generation probiotic preventing managing

Language: Английский

---

Rosa Roxburghii Tratt Fruit Extract Prevents Dss-Induced Ulcerative Colitis in Mice by Modulating the Gut Microbiota and the IL-17 Signaling Pathway

Nutrients, Journal Year: 2023, Volume and Issue: 15(21), P. 4560 - 4560

Published: Oct. 27, 2023

Ulcerative colitis (UC) is a non-specific inflammatory bowel illness characterized by intestinal mucosal barrier degradation, inflammation, oxidative damage, and gut microbiota imbalances. Rosa roxburghii Tratt Fruit extract (RRTE) was extracted from fruit, exhibiting an excellent prevention effect against UC; RRTE could prevent the damage of DSS-induced human normal colonic epithelial (NCM 460) cells, especially in cell viability morphology, damage. Additionally, UC mice, limit increasing expression tight junction proteins mucin, reducing inflammation colon tissue. More importantly, can increase abundance beneficial bacteria to regulate such as Ruminococcus, Turicibacter, Parabacteroides, reduce harmful Staphylococcus Shigella. Furthermore, transcriptomics findings point out that on be attributed modulation responses IL-17 TNF signaling pathways. The qPCR results confirm did involve regulation several genes pathway. In conclusion, both vitro vivo.

Language: Английский

---

Cancer chemoprevention: signaling pathways and strategic approaches

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: April 17, 2025

Abstract Although cancer chemopreventive agents have been confirmed to effectively protect high-risk populations from invasion or recurrence, only over ten drugs approved by the U.S. Food and Drug Administration. Therefore, screening potent is crucial reduce constantly increasing incidence mortality rate of cancer. Considering lengthy prevention process, an ideal agent should be nontoxic, inexpensive, oral. Natural compounds become a natural treasure reservoir for chemoprevention because their superior ease availability, cost-effectiveness, safety. The benefits as in various studies. In light this, present review intended fully delineate entire scope chemoprevention, primarily focuses on aspects based compounds, specifically focusing mechanism action prevention, discussing detail how they exert effects affecting classical signaling pathways, immune checkpoints, gut microbiome. We also introduce novel strategies summarize role improving chemotherapy regimens. Furthermore, we describe discovering anticancer with low abundance high activity, revealing broad prospects drug discovery chemoprevention. Moreover, associate precision medicine, discuss challenges encountered Finally, emphasize transformative potential advancing field ability more effective less toxic preventive options oncology.

Language: Английский

---

Compound chenpi tea consumption reduces obesity‐related metabolic disorders by modulating gut microbiota and serum metabolites in mice

Journal of the Science of Food and Agriculture, Journal Year: 2023, Volume and Issue: 104(1), P. 431 - 442

Published: Aug. 28, 2023

Compound chenpi tea (CCT) is a popular herbal beverage made from citri reticulatae pericarpium, Ganoderma lucidum, and pu-erh tea. This study aimed to investigate the anti-obesity effect of CCT in mice fed high-fat diet (HFD) explore potential mediators by 16S ribosomal RNA sequencing serum metabolomic analysis.The results showed that supplementation can effectively reduce diet-induced obesity, hepatic steatosis, dyslipidemia, insulin resistance. Further analyses revealed could reverse changes 28 metabolites induced HFD, mainly affecting, amino acid metabolism, gut microbiota glycerophospholipid metabolism. also alleviate intestinal dysbiosis decreasing abundance Romboutsia, Gemella, [Eubacterium]_fissicatena_group, Faecalibaculum, increasing Oscillibacter, Blautia, Acetatifactor.Collectively, these findings demonstrated modulated obesity-related metabolic disorders mice. © 2023 Society Chemical Industry.

Language: Английский

---

Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by regulating TLR4/MyD88/NF-κB signaling pathway and intestinal flora

Food & Function, Journal Year: 2023, Volume and Issue: 15(1), P. 295 - 309

Published: Dec. 6, 2023

Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice.

---