Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We? DOI Creative Commons

Lylian Ellen Militão dos Santos Xavier,

T. Reis,

Amylly Sanuelly da Paz Martins

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1369 - 1369

Published: Nov. 8, 2024

Inflammatory bowel diseases (IBD) pose a growing public health challenge with unclear etiology and limited efficacy of traditional pharmacological treatments. Alternative therapies, particularly antioxidants, have gained scientific interest. This systematic review analyzed studies from MEDLINE, Cochrane, Web Science, EMBASE, Scopus using keywords like “Inflammatory Bowel Diseases” “Antioxidants.” Initially, 925 publications were identified, after applying inclusion/exclusion criteria—covering July 2015 to June 2024 murine models or clinical trials in humans evaluating natural synthetic substances affecting oxidative stress markers—368 articles included. comprised 344 animal 24 human studies. The most investigated antioxidants polyphenols active compounds medicinal plants (n = 242; 70.3%). found strong link between inflammation IBD, especially on nuclear factor kappa B erythroid 2-related 2 pathways. However, it remains whether occurs first IBD. Lipid peroxidation was the studied damage, followed by DNA damage. Protein damage rarely investigated. relationship gut microbiota examined 103 Human markers scarce, reflecting major research gap IBD treatment. PROSPERO registration: CDR42022335357 CRD42022304540.

Language: Английский

Mechanism of Action and Therapeutic Implications of Nrf2/HO-1 in Inflammatory Bowel Disease DOI Creative Commons

Lingling Yuan,

Yingyi Wang, Na Li

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 1012 - 1012

Published: Aug. 20, 2024

Oxidative stress (OS) is a key factor in the generation of various pathophysiological conditions. Nuclear erythroid 2 (NF-E2)-related (Nrf2) major transcriptional regulator antioxidant reactions. Heme oxygenase-1 (HO-1), gene regulated by Nrf2, one most critical cytoprotective molecules. In recent years, Nrf2/HO-1 has received widespread attention as regulatory pathway for intracellular defense against oxidative stress. It considered potential target treatment inflammatory bowel disease (IBD). This review highlights mechanism action and therapeutic significance IBD complications (intestinal fibrosis colorectal cancer (CRC)), well phytochemicals targeting IBD. The results suggest that effects on mainly involve following aspects: (1) Controlling to reduce intestinal inflammation injury; (2) Regulation flora repair mucosal barrier; (3) Prevention ferroptosis epithelial cells. However, due complex role Nrf2/HO-1, more nuanced understanding exact mechanisms involved way forward future.

Language: Английский

Citations

8
Li-Hong Tang alleviates dextran sodium sulfate-induced colitis by regulating NRF2/HO-1 signaling pathway and gut microbiota DOI Creative Commons

Hong Gu,

Yuwen Tian, Jingjing Xia

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 30, 2024

Ulcerative colitis (UC) is marked by recurring inflammation. Existing treatments are ineffective and may have toxic side effects. Thus, new therapeutic agents urgently needed. We studied the botanical formula "Li-Hong Tang (LHT)", which contains two main ingredients,

Language: Английский

Citations

4
Recent developments and new directions in the use of natural products for the treatment of inflammatory bowel disease DOI

Yaqian Feng,

Mengting Pan,

Ruiqiong Li

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155812 - 155812

Published: June 13, 2024

Language: Английский

Citations

4
Lactobacillus salivarius alleviated Dextran sulfate sodium (DSS)-induced colitis in mice by mitigating oxidative stress and inflammatory responses through modulation of the intestinal flora DOI

Jinping Ma,

Dao‐Yi Wu,

Xu Chang

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107696 - 107696

Published: May 1, 2025

Language: Английский

Citations

0
Anti-Inflammatory Mechanism Prediction of Sinomenine Based on Network Pharmacology and Its Biological Activity Verification DOI Creative Commons
Da Song, Afsar Khan, Ming-Hong Dong

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(5), P. 543 - 543

Published: May 13, 2025

Inflammation is a widespread physiological response that occurs when the body stimulated by pathogens or endogenous signals [...]

Language: Английский

Citations

0
Immune dysregulation in ulcerative colitis: pathogenic mechanisms and therapeutic strategies of traditional Chinese medicine DOI Creative Commons
Xudong Tang,

Yilin Huang,

Ying Zhu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: June 5, 2025

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized primarily by immune dysregulation. Its pathogenesis involves multiple factors, including dysregulation of T-cell subsets, hypersecretion pro-inflammatory cytokines, imbalance in the gut microbiota, and disruption intestinal barrier. Among abnormal activation Th1 Th17 cells, conjunction with Treg dysfunction, significantly amplifies local signals. Pro-inflammatory such as TNF-α, IL-6, IL-17, exacerbate apoptosis disrupt tight junctions (TJs) epithelial cells (IECs), thereby creating favorable conditions for invasion pathogenic bacteria their metabolites. Intestinal microecological not only leads to significant alterations structure bacterial flora but also fluctuations its metabolites that directly regulate homeostasis, factor closely associated severity inflammation prognosis ulcerative colitis. Recent studies have demonstrated treatment UC, traditional Chinese medicine (TCM) achieves multi-target, multi-pathway integrated intervention regulating cell differentiation, balancing levels, repairing barrier, remodeling flora. This article reviews mechanisms underlying UC advances research on TCM’s role regulation, anti-inflammatory repair, modulation, encompassing action individual active ingredients classic TCM compound formulas. Although some preliminarily confirmed potential modulate immunity repair breakthroughs mechanism analysis, herb standardization, large-scale validation remain forthcoming. It anticipated unique advantages will be translated into more precise therapeutic strategy through modern molecular systems biology approaches.

Language: Английский

Citations

0
Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We? DOI Creative Commons

Lylian Ellen Militão dos Santos Xavier,

T. Reis,

Amylly Sanuelly da Paz Martins

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1369 - 1369

Published: Nov. 8, 2024

Inflammatory bowel diseases (IBD) pose a growing public health challenge with unclear etiology and limited efficacy of traditional pharmacological treatments. Alternative therapies, particularly antioxidants, have gained scientific interest. This systematic review analyzed studies from MEDLINE, Cochrane, Web Science, EMBASE, Scopus using keywords like “Inflammatory Bowel Diseases” “Antioxidants.” Initially, 925 publications were identified, after applying inclusion/exclusion criteria—covering July 2015 to June 2024 murine models or clinical trials in humans evaluating natural synthetic substances affecting oxidative stress markers—368 articles included. comprised 344 animal 24 human studies. The most investigated antioxidants polyphenols active compounds medicinal plants (n = 242; 70.3%). found strong link between inflammation IBD, especially on nuclear factor kappa B erythroid 2-related 2 pathways. However, it remains whether occurs first IBD. Lipid peroxidation was the studied damage, followed by DNA damage. Protein damage rarely investigated. relationship gut microbiota examined 103 Human markers scarce, reflecting major research gap IBD treatment. PROSPERO registration: CDR42022335357 CRD42022304540.

Language: Английский

Citations

1