Microbiome Shifts and Their Impact on Gut Physiology in Irritable Bowel Syndrome DOI Open Access
Ιωάννα Αγγελετοπούλου, Christos Triantos

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12395 - 12395

Published: Nov. 19, 2024

Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal disorders characterized by recurrent abdominal pain and altered habits. The exact pathophysiological mechanisms for IBS development are not completely understood. Several factors, including genetic predisposition, environmental psychological influences, low-grade inflammation, alterations in motility, dietary habits, have been implicated pathophysiology disorder. Additionally, emerging evidence highlights role gut microbiota IBS. This review aims to thoroughly investigate how impact physiological functions such as brain-gut axis, immune system activation, mucosal permeability, intestinal motility. Our research focuses on dynamic "microbiome shifts", emphasizing enrichment or depletion specific bacterial taxa their profound disease progression pathology. data indicated that populations IBS, reductions beneficial species

Language: Английский

Disturbances of the Gut Microbiota and Microbiota-Derived Metabolites in Inflammatory Bowel Disease DOI Open Access
Yongjia Hu, Zhouzhou Chen, Chengchen Xu

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(23), P. 5140 - 5140

Published: Dec. 2, 2022

Inflammatory bowel disease (IBD), comprising Crohn's (CD) and ulcerative colitis (UC), is characterized as a chronic recurrent inflammatory whose pathogenesis still elusive. The gut microbiota exerts important diverse effects on host physiology through maintaining immune balance generating health-benefiting metabolites. Many studies have demonstrated that IBD associated with disturbances in the composition function of microbiota. Both abundance diversity are dramatically decreased patients. Furthermore, some particular classes microbiota-derived metabolites, principally short-chain fatty acids, tryptophan, its bile acids also been implicated IBD. In this review, we aim to define disturbance key metabolites pathogenesis. addition, focus scientific evidence probiotics, not only molecular mechanisms underlying beneficial probiotics but challenges it faces safe appropriate application.

Language: Английский

Citations

70
Intestinal barrier permeability: the influence of gut microbiota, nutrition, and exercise DOI Creative Commons
Tetiana R. Dmytriv, Kenneth B. Storey, Volodymyr I. Lushchak

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: July 8, 2024

The intestinal wall is a selectively permeable barrier between the content of lumen and internal environment body. Disturbances permeability can potentially lead to unwanted activation enteric immune system due excessive contact with gut microbiota its components, development endotoxemia, when level bacterial lipopolysaccharides increases in blood, causing chronic low-intensity inflammation. In this review, following aspects are covered: structure barrier; influence on via regulation functioning tight junction proteins, synthesis/degradation mucus antioxidant effects; molecular mechanisms pro-inflammatory response caused by invasion through TLR4-induced TIRAP/MyD88 TRAM/TRIF signaling cascades; nutrition permeability, exercise an emphasis exercise-induced heat stress hypoxia. Overall, review provides some insight into how prevent associated inflammatory processes involved many if not most pathologies. Some diets physical supposed be non-pharmacological approaches maintain integrity function provide efficient operation. However, at early age, increased has hormetic effect contributes system.

Language: Английский

Citations

26
Microbiota of the gastrointestinal tract: Friend or foe? DOI Creative Commons
M. A. Senchukova

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(1), P. 19 - 42

Published: Jan. 3, 2023

The gut microbiota is currently considered an external organ of the human body that provides important mechanisms metabolic regulation and protection. encodes over 3 million genes, which approximately 150 times more than total number genes present in genome. Changes qualitative quantitative composition microbiome lead to disruption synthesis key bacterial metabolites, changes intestinal barrier function, inflammation can cause development a wide variety diseases, such as diabetes, obesity, gastrointestinal disorders, cardiovascular issues, neurological disorders oncological concerns. In this review, I consider issues related role its influence on physiological pathological processes occurring body, potential new therapeutic strategies aimed at restoring microbiome. Herewith, it understand should be single biological system, where change one element will inevitably affect other components. Thus, study impact health only taking into account numerous factors, has not yet been fully elucidated.

Language: Английский

Citations

31
Intestinal permeability and its significance in psychiatric disorders – A narrative review and future perspectives DOI
Jakub Wasiak, Oliwia Gawlik-Kotelnicka

Behavioural Brain Research, Journal Year: 2023, Volume and Issue: 448, P. 114459 - 114459

Published: April 28, 2023

Language: Английский

Citations

26
Gut dysbiosis-derived β-glucuronidase promotes the development of endometriosis DOI Creative Commons
Yajing Wei, Hao Tan,

Ruyu Yang

et al.

Fertility and Sterility, Journal Year: 2023, Volume and Issue: 120(3), P. 682 - 694

Published: May 12, 2023

To explore the role of gut dysbiosis-derived β-glucuronidase (GUSB) in development endometriosis (EMs).16S rRNA sequencing stool samples from women with (n = 35) or without 30) and a mouse model was conducted to assess microbiome changes identify molecular factors influencing endometriosis. Experiments vivo an C57BL6 vitro verified level GUSB its EMs.Department Obstetrics Gynecology, The First Affiliated Hospital Sun Yat-sen University; Guangdong Provincial Clinical Research Center for Obstetrical Gynecological Diseases.Women reproductive age histological diagnosis were enrolled group infertile healthy age-matched who had undergone gynecological radiological examination control 30). Fecal blood taken day before surgery. Paraffin-embedded sections 50 bowel endometriotic lesions, uterosacral normal endometria collected.None.Changes patients EMs mice effect on proliferation invasion endometrial stromal cells lesions assessed.No difference α β diversity found between controls. Immunohistochemistry analysis showed higher expression ligament than endometrium (p<0.01). β-Glucuronidase promoted migration during cell counting kit-8, Transwell, wound-healing assays. Macrophage levels, especially M2, controls, M0 M2 transition. Medium conditioned by β-glucuronidase-treated macrophages migration. increased number volume present model.This directly indirectly causing macrophage dysfunction. characterization pathogenic has potential therapeutic implications.

Language: Английский

Citations

25
Daily Cashew and Brazil Nut Consumption Modifies Intestinal Health in Overweight Women on Energy-Restricted Intervention: A Randomized Controlled Trial (Brazilian Nuts Study) DOI Creative Commons
Brenda Kelly Souza Silveira, Daniela Mayumi Usuda Prado Rocha, Hércia Stampini Duarte Martino

et al.

Journal of Nutrition, Journal Year: 2024, Volume and Issue: 154(3), P. 962 - 977

Published: Jan. 21, 2024

Language: Английский

Citations

11
Intestinal toxicity of Pb: Structural and functional damages, effects on distal organs and preventive strategies DOI

Zhihua Liu,

Shu Ai,

Yanzhou Xia

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 931, P. 172781 - 172781

Published: April 27, 2024

Language: Английский

Citations

10
Effect of Dendrobium officinale polysaccharides on central nervous system disease: Based on gut microbiota DOI
Lei Xu, Xiaoxiong Zeng, Yanan Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 240, P. 124440 - 124440

Published: April 14, 2023

Language: Английский

Citations

18
Unraveling the microbial puzzle: exploring the intricate role of gut microbiota in endometriosis pathogenesis DOI Creative Commons
Fan Tang, Mengqi Deng,

Chunyu Xu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 16, 2024

Endometriosis (EMs) is a prevalent gynecological disorder characterized by the growth of uterine tissue outside cavity, causing debilitating symptoms and infertility. Despite its prevalence, exact mechanisms behind EMs development remain incompletely understood. This article presents comprehensive overview relationship between gut microbiota imbalance pathogenesis. Recent research indicates that plays pivotal role in various aspects EMs, including immune regulation, generation inflammatory factors, angiopoietin release, hormonal endotoxin production. Dysbiosis can disrupt responses, leading to inflammation impaired clearance endometrial fragments, resulting endometriotic lesions. The dysregulated contribute release lipopolysaccharide (LPS), triggering chronic promoting ectopic adhesion, invasion, angiogenesis. Furthermore, involvement estrogen metabolism affects levels, which are directly related development. review also highlights potential as diagnostic tool therapeutic target for EMs. Interventions such fecal transplantation (FMT) use preparations have demonstrated promising effects reducing symptoms. progress made, further needed unravel intricate interactions paving way more effective prevention treatment strategies this challenging condition.

Language: Английский

Citations

6
Prostate and gut: Any relationship? A narrative review on the available evidence and putative mechanisms DOI
Lorenzo Romano, Luigi Napolitano, Felice Crocetto

et al.

The Prostate, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 14, 2024

Abstract Background Gut microbiome is a community of microorganisms that lives in the human intestine and exerts various functions on host, including metabolic, immunoregulatory, control over cell proliferation. alterations have been associated with pathological conditions, such as diabetes mellitus, obesity, cardiovascular diseases. Gut‐prostate axis explained by association between gut quantitative functional along increased intestinal epithelial permeability prostatediseases. However, pathophysiological mechanisms clinical importance this are not completely clarified yet. Methods We conducted narrative review most relevant articles Medline (US National Library Medicine, Bethesda, MD, USA), Scopus (Elsevier, Amsterdam, The Netherlands) Web Science Core Collection (Thomson Reuters, Toronto, ON, Canada) databases. No chronological restrictions were applied, related papers published until December 2023 included. Results microbiota (GM) its metabolites capable modifying host androgen level, well prostate cancer (PCa) therapy response. Moreover, patients inflammatory bowel disease higher rates prostatitis‐like symptoms potential risk developing PCa. Conclusions There evidence interventions GM high to serve diagnostic therapeutic tools for diseases,

Language: Английский

Citations

5