A Nonlinear Association of Serum Uric Acid with All-cause and Cardiovascular Mortality among Patients with Cardiovascular Disease: A Cohort Study from NHANES DOI Creative Commons

Yan-Lin Lv,

Yongming Liu,

Kai-Xuan DONG

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 18, 2024

Abstract Background The relationship between serum uric acid (SUA) and mortality in patients with cardiovascular disease (CVD) remains controversial. We aimed to explore the SUA all-cause (ACM) (CVM) adult CVD. Methods This cohort study included 3977 CVD from National Health Nutrition Examination Survey (2005–2018). Death outcomes were determined by linking Index (NDI) records through December 31, 2019. explored association of using weighted Cox proportional hazards regression models, subgroup analysis, Kaplan-Meier survival curves, restricted cubic spline (RCS) threshold effect analysis among Results During a median follow-up 68 months (interquartile range, 34–110 months), 1,369 (34.4%) 3,977 died, which 536 (13.5%) died deaths 833 (20.9%) non-cardiovascular deaths. In multivariable-adjusted model (Model 3), risk ACM (HR 1.38, 95% CI 1.16–1.64, p < 0.001) CVM 1.40, 1.06–1.10, for participants Q4 group significantly higher. CVD, RCS revealed nonlinear (p 0.001 all nonlinearities) SUA, ACM, CVM. Subgroup showed combined chronic kidney (CKD), thresholds 5.49 5.64, respectively. Time-dependent ROC curves indicated areas under curve 0.61, 0.60, 0.58, 0.55 1-, 3-, 5-, 10-year 0.69, 0.59, 0.56 CVM, Conclusions demonstrate that is an independent prognostic factor supporting U-shaped mortality, CKD, nonlinear.

Language: Английский

The neutrophil–lymphocyte ratio as a risk factor for all-cause and cardiovascular mortality among individuals with diabetes: evidence from the NHANES 2003–2016 DOI Creative Commons

Gaiying Dong,

Man Gan,

Shilin Xu

et al.

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Sept. 29, 2023

Evidence regarding the neutrophil-lymphocyte ratio (NLR) and mortality risk in diabetes patients is scarce. This study investigated relationship of NLR with all-cause cardiovascular patients.Diabetes (n = 3251) from seven National Health Nutrition Examination Survey (NHANES) cycles (2003-2016) were included this study. The cause death status participants obtained Death Index records. Restricted cubic spline (RCS) was used to visualize association risk. maximally selected rank statistics method (MSRSM) determine optimal cutoff value corresponding most significant survival outcomes. Weighted multivariable Cox regression models subgroup analyses adopted assess mortality. Time-dependent receiver operating characteristic curve (ROC) analysis conducted evaluate accuracy predicting outcomes.During a median follow-up 91 months (interquartile range, 55-131 months), 896 (27.5%) 3251 died, including 261 (8.0%) deaths 635 (19.5%) noncardiovascular deaths. RCS showed positive linear between (both p > 0.05 for nonlinearity) patients. Participants divided into higher (> 3.48) lower (≤ groups according MSRSM. In multivariable-adjusted model, compared NLR, those had significantly both (HR 2.03, 95% confidence interval (CI) 1.64-2.51, < 0.0001) 2.76, CI 1.84-4.14, 0.0001). consistent based on age, sex, smoking status, drinking hypertension, no interaction aforementioned characteristics (p 0.05). time-dependent ROC that areas under 1-, 3-, 5-, 10-year rates 0.72, 0.66, 0.64, 0.64 0.69, 0.71, 0.69 0.65, respectively, mortality.An elevated independently associated increased

Language: Английский

Citations

65
Association of cardiovascular health using Life's Essential 8 with depression: Findings from NHANES 2007–2018 DOI
Guixing Zeng, Yujie Lin, Jiarong Lin

et al.

General Hospital Psychiatry, Journal Year: 2024, Volume and Issue: 87, P. 60 - 67

Published: Jan. 30, 2024

Language: Английский

Citations

11
Geriatric nutritional risk index as a predictor of mortality in women with chronic inflammatory airway disease: evidence from NHANES 1999–2018 DOI Creative Commons
Chen Zhao,

Youli Wen,

Wenqiang Li

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 10, 2025

Background The incidence of Chronic Inflammatory Airway Diseases (CIAD) has been steadily increasing, making it a significant contributor to the global disease burden. Additionally, risk airway diseases in elderly women continues rise each year, with nutritional factors playing crucial role progression CIAD. Geriatric Nutritional Risk Index (GNRI) is novel tool for assessing individual status. This study aims assess relationship between GNRI and all-cause cardiovascular mortality CIAD, providing guidance interventions reduce risk. Methods Data from female patients relevant indicators were sourced National Health Nutrition Examination Survey (NHANES) database. status was assessed using GNRI, divided into four groups based on their quartiles. Weighted Cox proportional hazards regression models used examine as well restricted cubic spline (RCS) analysis applied explore association different outcomes, subgroup conducted further validate robustness findings. Results A total 1,417 CIAD included this study. During median follow-up 91 months, 515 deaths all causes 157 occurred. Multivariable-adjusted indicated that compared lowest quartile, other quartiles showed general decreasing trend both ( p &lt; 0.05). In fully adjusted model, highest quartile had risks (HR = 0.40, 95% CI: 0.22–0.72, 0.05) 0.29, 0.11–0.78, 0.05).The RCS demonstrated nonlinear P nonlinearity &lt;0.001). Conclusion lower levels are associated an increased may serve potential predictive mortality, valuable insights clinical decision-making.

Language: Английский

Citations

1
The neutrophil-lymphocyte ratio predicts all-cause and cardiovascular mortality among United States adults with COPD: results from NHANES 1999–2018 DOI Creative Commons
Chen Zhao,

Wenqiang Li,

Y. Tang

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 25, 2024

Background Neutrophil-to-lymphocyte ratio (NLR) is considered a biomarker of systemic inflammation and immune activation. However, its relationship with the risk mortality in patients chronic obstructive pulmonary disease (COPD) remains unclear. This study aimed to investigate association between NLR all-cause cardiovascular COPD. Methods Data were collected from National Health Nutrition Examination Survey (NHANES) January 1999 December 2018. The calculation method involves dividing neutrophil count by lymphocyte total blood cell count. optimal threshold associated survival outcomes was determined using maximally selected rank statistics (MSRSM). COPD investigated weighted multivariable Cox regression model. Additionally, restricted cubic spline (RCS) employed discuss potential different groups mortality. Results In this study, 716 adults included method, among whom 208 had higher (≥2.56) 508 lower (&lt;2.56). During median follow-up 111.5 months, 162 died all causes, 49 diseases. After adjusting for demographic, socioeconomic status, lifestyle factors, (HR = 2.07, 95%CI: 1.46–2.94) 3.03, 1.63–5.65) increased 2–3 times compared those NLR. Kaplan–Meier analysis revealed significantly rates ( p &lt; 0.05). Restricted showed linear correlation Conclusion has high value independently predicting long-term risks community-dwelling patients. Therefore, can serve as cost-effective widely available indicator assessing prognosis

Language: Английский

Citations

7
Systemic inflammation response index association with gout in hyperuricemic adults: NHANES 2007–2018 DOI Creative Commons

Xiaochan Tian,

Guixing Zeng, Junping Wei

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

Hyperuricemia is the underlying condition of gout. Previous studies have indicated that specific strategies may be effective in preventing progression hyperuricemia to However, there a lack widely applicable methods for identifying high-risk populations Gout linked inflammation, especially hyperuricemic population. Systemic inflammation response index (SIRI) novel method evaluating an individual's systemic inflammatory activity. association between SIRI and gout population has not been studied. The study utilized data from National Health Nutrition Examination Survey (NHANES) 2007-2018.SIRI was log2-transformed before analysis. Multivariable logistic regression, subgroup analysis, smooth curve fitting were employed comprehensively evaluate correlation prevalence Additionally, we compared with other markers. A total 6,732 patients included, which 3,764 men. After adjusting all covariates, found significantly positively correlated female group ([OR = 1.385, 95% CI (1.187, 1.615), p < 0.001]), its diagnostic performance superior In male group, log2-SIRI significant 0.994, (0.892, 1.108), 0.916]). But positive correlations 20-45 age 1.362, (1.021, 1.818), 0.036]). Subgroup analyses revealed results largely consistent when individuals divided into different subgroups (FDR adjusted interaction >0.05 all). Our suggests Inflammation Response Index potential as predictive marker risk women. given higher men, this limited. analyses, however, relationship prevalence, well statistical significance, varied across groups. Future research could further explore by investigating cohorts.

Language: Английский

Citations

0
Association between compound dietary antioxidant index and all-cause and cancer mortality in patients with chronic obstructive pulmonary disease: results from NHANES 1999–2018 DOI Creative Commons

Wenqiang Li,

Jingshan Bai,

Ge Yanlei

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 21, 2025

Objective Chronic obstructive pulmonary disease (COPD) is one of the most important causes death in world, and its core chronic inflammation. Antioxidants play a positive role onset prognosis respiratory diseases. In maintaining human health, composite dietary antioxidant index (CDAI) plays an function. Therefore, purpose current study was to investigate relationship between CDAI all-cause cancer mortality individuals with COPD. Methods A prospective cohort conducted by investigating NHANES data 1999–2018. The included people who satisfied inclusion exclusion criteria. this study, association investigated using weighted Cox regression. them illustrated drawing constrained cubic spline curves (RCS). Finally, subgroup analysis used further verify. Results 1,534 participants. associated COPD patients mortality, after adjusting for multiple factors, we observed 5% reduction risk (HR = 0.95, 95% CI: 0.92–0.97) 9% lower each one-unit increase 0.91, 0.85–0.98). After high reduced group having 35% than those low ( HR 0.65, CI : 0.50–0.85), had 61% 0.39,95% 0.23–0.68). Subgroup sensitivity showed consistent mortality. Conclusion Our highlights inverse Further studies are needed confirm

Language: Английский

Citations

0
Association of the Dietary Index for Gut Microbiota With Severity, Renal Function, and Sarcopenia in Patients With Chronic Kidney Disease: A Population-Based Cross-Sectional Study DOI
Xiaofeng Xu,

Huiyi Su,

Junhong Chen

et al.

Journal of the American Nutrition Association, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: May 18, 2025

The aim of this research was to clarify the relationship between Dietary Index for Gut Microbiota (DI-GM) and severity chronic kidney disease (CKD), renal function, prevalence sarcopenia in patients with CKD, as well role Systemic Immune-Inflammation (SII) therein. Using data from National Health Nutrition Examination Survey (NHANES) 2007-2018, study included 2169 participants CKD. DI-GM calculated on a scale 0 13, higher scores indicating healthier gut microbiome. CKD categorized by estimated glomerular filtration rate (eGFR), defined using appendicular lean mass adjusted body index. Statistical analyses weighted regression models, restricted cubic spline, subgroup analysis, mediation analysis. Higher were associated lower (odds ratio [OR], 0.85; 95% confidence interval [CI], 0.78-0.94; p = .001), improved function (eGFR, β 1.078, .020; serum creatinine, -1.548, .026; blood urea nitrogen, -0.091, .026), reduced (OR, 0.70; CI, 0.57-0.87; .002). SII score partially mediated association accounting 12.11% effect (p < .001). No significant associations found all-cause or cardiovascular mortality among population Findings suggest that dietary interventions targeting microbiota may have benefits managing severity, improving reducing risk.

Language: Английский

Citations

0
Relationship of the Neutrophil–Lymphocyte Ratio with All-Cause and Cardiovascular Mortality in Patients with Diabetic Kidney Disease: A Prospective Cohort Study of NHANES Study DOI Creative Commons
Guixing Zeng, Yu‐Jie Lin,

Peirui Xie

et al.

Journal of Multidisciplinary Healthcare, Journal Year: 2024, Volume and Issue: Volume 17, P. 2461 - 2473

Published: May 1, 2024

To investigate the association between NLR and risk of all-cause cardiovascular mortality in US adults with diabetic kidney disease (DKD).

Language: Английский

Citations

3
Association of serum uric acid with all-cause and cardiovascular mortality in cardiovascular disease patients DOI Creative Commons

Yan-Lin Lv,

Yongming Liu,

Kai-Xuan Dong

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 4, 2024

The relationship between serum uric acid (SUA) and mortality in patients with cardiovascular disease (CVD) remains controversial. We aimed to explore the SUA all-cause (ACM) (CVM) adult CVD. This cohort study included 3977 CVD from National Health Nutrition Examination Survey (2005–2018). Death outcomes were determined by linking Index (NDI) records through December 31, 2019. explored association of using weighted Cox proportional hazards regression models, subgroup analysis, Kaplan-Meier survival curves, restricted cubic spline (RCS) threshold effect analysis among During a median follow-up 68 months (interquartile range, 34–110 months), 1,360 (34.2%) 3,977 died, which 536 (13.5%) died deaths 824 (20.7%) non-cardiovascular deaths. In multivariable-adjusted model (Model 3), risk ACM (HR 1.38, 95% CI 1.16–1.64) CVM 1.39, 1.04–1.86) for participants Q4 group significantly higher. CVD, RCS revealed nonlinear (p < 0.001 all nonlinearities) SUA, ACM, overall population men. Subgroup showed combined chronic kidney (CKD), thresholds 5.49 5.64, respectively. Time-dependent ROC curves indicated areas under curve 0.61, 0.60, 0.58, 0.55 1-, 3-, 5-, 10-year 0.69, 0.59, 0.56 CVM, demonstrate that is an independent prognostic factor supporting U-shaped mortality, CKD, nonlinear.

Language: Английский

Citations

2
Association of weight-adjusted waist index with hyperuricemia and gout among middle-aged and older adults in America: a cross-sectional analysis of NHANES 2007–2014 DOI
Xiaohe Ren, Yingying Cai, Mengyuan Zhang

et al.

Clinical Rheumatology, Journal Year: 2024, Volume and Issue: 43(8), P. 2615 - 2626

Published: June 11, 2024

Language: Английский

Citations

0