Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 153, P. 104760 - 104760
Published: Oct. 30, 2024
Language: Английский
Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3821 - 3821
Published: Aug. 31, 2023
Lycopene is a compound of colored origin that shows strong antioxidant activity. The positive effect lycopene the result its pleiotropic effect. ability to neutralize free radicals via one foundations pro-health effect, including inhibit development many civilization diseases. Therefore, this study focuses on importance in inhibiting diseases such as cardiovascular diseases, within nervous system, diabetes, liver and ulcerative colitis. According research mentioned, supplementation has significant promise for treatment illnesses marked by chronic inflammation oxidative stress. However, majority supporting data lycopene′s health benefits comes from experimental research, whereas evidence clinical studies both scarcer less certain any benefits. Research humans still required establish effectiveness.
Language: Английский
Citations
29
Pharmacological Research, Journal Year: 2023, Volume and Issue: 196, P. 106925 - 106925
Published: Sept. 13, 2023
With changing lifestyles, non-alcoholic fatty liver disease (NAFLD) has become the most prevalent worldwide. A substantial increase in incidence, mortality, and associated burden of NAFLD-related advanced is expected. Currently, initial diagnosis NAFLD still based on ultrasound there no approved treatment method. Lipid-lowering drugs, vitamin supplementation, lifestyle improvement treatments are commonly used clinical practice. However, lipid-lowering drugs can produce poor patient compliance specific adverse effects. Therefore, exploration bio-diagnostic markers active lead compounds for development innovative urgently needed. More more studies have reported anti-NAFLD effects mechanisms natural products (NPs), which an important source new drug to treat due their high activity low side At present, berberine silymarin been by US FDA enter phase IV studies, demonstrating potential NPs against NAFLD. Studies found that regulation lipid metabolism, insulin resistance, oxidative stress, inflammation-related pathways may play roles process. continuous updating technical means scientific theories, in-depth research targets provide possibilities find drugs. As we know, FXR agonists, PPARα dual CCR2/5 inhibitors gradually coming stage Whether exert regulating these or some unknown remains be further studied. study reviewed targets. Some works discovery docking were also discussed. It hoped this review reference values non-invasive diagnostic clinic.
Language: Английский
Citations
27
Nutrition Journal, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 23, 2025
Ulcerative colitis (UC) has experienced a steady increase in global incidence and prevalence recently. Current research into UC pathogenesis focuses on the complex interplay of genetic environmental factors with immune system gut microbiome, leading to disruption intestinal barrier. Normally, epithelium, interact maintain homeostasis. However, when this equilibrium is disturbed, harmful cycle dysbiosis, dysregulation, inflammation emerges, resulting barrier dysfunction progression. Among various risk factors, diet significantly influences epithelial integrity architectural stability through both direct indirect mechanisms, shaping entire continuum from pre-clinical prevention active phase treatment remission maintenance. This review provides insights impact dietary content eating behaviors UC, focusing specific food, food groups, nutrients, intermittent fasting, while providing detailed explanation why microbiota may mediate sustained effects across all stages UC. Additionally, it addresses limitations current studies, explores underexamined areas proposes potential directions for future expansion. Not applicable.
Language: Английский
Citations
1
Poultry Science, Journal Year: 2025, Volume and Issue: 104(3), P. 104875 - 104875
Published: Feb. 2, 2025
Language: Английский
Citations
1
Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13
Published: Oct. 4, 2023
The microbiota gut brain (MGB) axis has been shown to play a significant role in the regulation of inflammatory and infective diseases. Exploring structure communication mode MGB is crucial for understanding its diseases, studying signaling pathways regulatory methods diseases also profound significance future clinical research. This article reviews composition, mechanism including Parkinson’s disease (PD), Alzheimer’s (AD), multiple sclerosis (MS), autism spectrum disorder (ASD), depression, psoriasis, irritable bowel syndrome (IBS), (IBD). In addition, our investigation delved into functions inflammasome, IFN-I, NF-κB, PARK7/DJ-1 innate immune pathway context Ultimately, we discussed efficacy various interventions, fecal transplantation (FMT), antibiotics, probiotics, prebiotics, synbiotics, postbiotics, management Understanding might make positive effects treatment
Language: Английский
Citations
20
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5238 - 5238
Published: May 11, 2024
Currently, metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) are considered to be the main causes of fibrosis. In turn, fibrosis may lead development hepatocellular carcinoma or advanced cirrhosis, i.e., potentially life-threatening conditions. It is likely that therapy aimed at reducing risk developing hepatic steatosis inflammation could helpful in minimizing threat/probability organ recent years, increasing attention has been paid influence nutraceuticals prevention treatment diseases. Therefore, aim this review was describe precise role selected ingredients such as vitamin C, beta-carotene, omega-3 fatty acids, curcumin. use these patients with MASLD/MASH, along behavioral pharmacological therapy, have a beneficial effect on combating inflammation, oxidative stress, thereby preventing damage.
Language: Английский
Citations
7
Plants, Journal Year: 2024, Volume and Issue: 13(12), P. 1584 - 1584
Published: June 7, 2024
Carotenoids constitute compounds of significant biological interest due to their multiple activities, such as antimicrobial, anticancer, antiadipogenic, antidiabetic, and antioxidant properties. Metabolic syndrome (MetS) comprehends a series metabolic abnormalities (e.g., hypertension, obesity, atherogenic dyslipidemia) that can affect children, adolescents, the elderly. The treatment MetS involves numerous medications, which, despite efficacy, pose challenges prolonged use, high costs, various side effects. derivatives have been proposed alternative treatments because they reduce serum triglyceride concentrations, promote insulin response, inhibit adipogenesis, downregulate angiotensin-converting enzyme activity. However, carotenoids are notably sensitive pH, light exposure, temperature. This review addresses activity lycopene, lutein, fucoxanthin, astaxanthin, crocin, β-carotene towards MetS. It includes discussion sources, extraction methods, characterization techniques for analyzing carotenoids. Encapsulation approaches critically reviewed alternatives prevent degradation improve performance A brief overview physiopathology epidemiology diseases, including MetS, is also provided.
Language: Английский
Citations
7
MedComm, Journal Year: 2024, Volume and Issue: 5(12)
Published: Nov. 20, 2024
Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.
Language: Английский
Citations
7
Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 21(1)
Published: July 18, 2024
Abstract Background Natural compounds can positively impact health, and various studies suggest that they regulate glucose‒lipid metabolism by influencing short-chain fatty acids (SCFAs). This is key to maintaining energy balance normal physiological functions in the body. review explores how SCFAs glucose lipid natural modulate these processes through SCFAs. provides a healthier approach treating disorders future. Methods article reviews relevant literature on glycolipid from PubMed Web of Science Core Collection (WoSCC). It also highlights range compounds, including polysaccharides, anthocyanins, quercetins, resveratrols, carotenoids, betaines, modulation SCFA pathway. Results enrich SCFA-producing bacteria, inhibit harmful operational taxonomic unit (OTU) abundance intestinal transport rate gut microbiota affect content intestine. However, most have been conducted animals, lack clinical trials, involve fewer target More research needed support conclusions develop interventions. Conclusions are crucial for human health produced mainly via dietary fiber fermentation. Eating foods rich fruits, vegetables, tea, coarse foods, hinder bacterial growth promote beneficial proliferation, thus increasing levels regulating metabolism. By investigating pathway, novel insights directions glucolipid be provided.
Language: Английский
Citations
6
Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(8), P. 5341 - 5356
Published: June 7, 2024
Abstract Polyphenols, natural micronutrients derived from plants, are valued for their anti‐inflammatory and antioxidant properties. The escalating global prevalence of non‐alcoholic fatty liver disease (NAFLD) underscores its status as a chronic progressive condition. Furthermore, the dysregulation gut microbiota (GM) is implicated in onset progression NAFLD through actions metabolites such bile acids (BAs), lipopolysaccharide (LPS), choline, short‐chain (SCFAs). Additionally, GM may influence integrity intestinal barrier. This review aims to evaluate potential effects polyphenols on barrier function, subsequent impact NAFLD. We searched wide range databases, Web Science, PubMed, EMBASE, Scopus gather information our non‐systematic English literature. functions composition can be regulated by chlorogenic acid, curcumin, green tea catechins, naringenin, quercetin, resveratrol, sulforaphane. Regulating improves alleviating inflammation, fat accumulation, enzymes. it serum lipid profile integrity. All these components affect GM, including SCFAs, LPS, BAs. Current evidence indicates that curcumin modulate improving positively impacting More studies necessary safety efficacy sulforaphane, catechin.
Language: Английский
Citations
5