Recent
interest
in
preventing
the
development
of
osteoporosis
has
focused
on
regulation
redox
homeostasis.
However,
action
lycopene
(LYC),
a
strong
natural
antioxidant
com-pound,
osteoporotic
bone
loss
remains
largely
unknown.
Here,
we
show
that
administra-tion
LYC
to
OVX
rats
reduces
body
weight
gain,
improves
lipid
metabolism
and
preserves
quality.
In
addition,
treatment
inhibits
ROS
overgeneration
serum
marrow
rats,
BMSCs
upon
H2O2
stimulation,
leading
inhibiting
adipogenesis
pro-moting
osteogenesis
during
remodeling.
Mechanically,
may
improve
quality
via
an
increase
expressions
FoxO1
Runx2,
decrease
PPARγ
C/EBPα
BMSCs.
Collectively,
these
findings
suggest
attenuates
through
promoting
regula-tion
FoxO1/PPARγ
pathway
driven
by
oxidative
stress,
presenting
novel
strategy
for
os-teoporosis
management.
Food Science & Nutrition,
Journal Year:
2024,
Volume and Issue:
12(11), P. 8715 - 8741
Published: Oct. 16, 2024
Certain
carotene
components,
such
as
lycopene
and
beta-carotene,
are
found
in
tomatoes,
carrots,
sweet
potatoes,
etc.
good
for
human
health.
It
gives
plants
their
distinctive
red
color.
A
class
of
lipid-soluble
natural
pigments
known
carotenoids
is
the
precursor
vitamin
vital
antioxidant
defense
against
peroxides
cells
tissues.
This
review
provides
an
overview
current
state
knowledge
research
on
sources,
structures,
physiochemical
properties,
absorption
metabolism,
functional
advantages,
prevention
many
diseases
associated
with
beta-carotene.
These
antioxidants
have
been
linked
to
a
lower
risk
cardiovascular
disease
cancer,
they
also
help
draw
pollinators
flowers.
Carrots
potatoes
rich
sources
which
strengthens
immune
system
improves
eye
The
vivid
color
reproductive
organs,
including
flowers
fruits,
caused
by
carotenoid,
secondary
metabolite
that
produced
plastids.
other
health
advantages
attributed
lycopene.
When
ingested
through
food
or
supplements,
beta-carotene
manage
prevent
number
diseases,
metabolic,
inflammatory,
cardiovascular,
hepatic,
ophthalmic,
skeletal,
infertility
disorders.
main
point
toxicity
uncommon,
these
generally
accepted
be
safe
at
different
doses.
Including
nutrients
your
diet
can
improve
general
provide
illness
prevention.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 524 - 524
Published: April 10, 2024
The
skin
is
the
largest
organ
of
body,
and
it
acts
as
a
protective
barrier
against
external
factors.
Chronic
wounds
affect
millions
people
worldwide
are
associated
with
significant
morbidity
reduced
quality
life.
One
main
factors
involved
in
delayed
wound
healing
oxidative
injury,
which
triggered
by
overproduction
reactive
oxygen
species.
Oxidative
stress
has
been
implicated
pathogenesis
chronic
wounds,
where
known
to
impair
causing
damage
cellular
components,
delaying
inflammatory
phase
healing,
inhibiting
formation
new
blood
vessels.
Thereby,
treatment
requires
multidisciplinary
approach
that
addresses
underlying
causes
wound,
provides
optimal
care,
promotes
healing.
Among
promising
approaches
taking
care
antioxidants
gaining
interest
since
they
offer
multiple
benefits
related
health.
Therefore,
this
review,
we
will
highlight
latest
advances
use
natural
polymers
generate
tissue
regeneration
microenvironments
for
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7603 - 7603
Published: July 11, 2024
This
article
presents
a
groundbreaking
perspective
on
carotenoids,
focusing
their
innovative
applications
and
transformative
potential
in
human
health
medicine.
Research
jointly
delves
deeper
into
the
bioactivity
bioavailability
of
revealing
therapeutic
uses
technological
advances
that
have
to
revolutionize
medical
treatments.
We
explore
pioneering
which
carotenoids
are
used
treat
chronic
diseases
such
as
cancer,
cardiovascular
disease,
age-related
macular
degeneration,
offering
novel
protective
mechanisms
benefits.
Our
study
also
shows
cutting-edge
innovations
carotenoid
extraction
bioavailability,
including
development
supramolecular
carriers
advanced
nanotechnology,
dramatically
improve
absorption
efficacy
these
compounds.
These
not
only
ensure
consistent
quality
but
tailor
therapies
each
patient's
needs,
paving
way
for
personalized
By
integrating
latest
scientific
discoveries
techniques,
this
research
provides
prospective
clinical
establishing
new
benchmark
future
studies
field.
findings
underscore
importance
optimizing
extraction,
administration,
bioactivity,
methods
develop
more
effective,
targeted,
treatments,
thus
visionary
insight
modern
practices.
Medicina,
Journal Year:
2024,
Volume and Issue:
60(4), P. 563 - 563
Published: March 29, 2024
The
gastrointestinal
tract
is
inhabited
by
the
gut
microbiota.
main
phyla
are
Firmicutes
and
Bacteroidetes.
In
non-alcoholic
fatty
liver
disease,
now
renamed
metabolic
dysfunction-associated
disease
(MAFLD),
an
alteration
in
Bacteroidetes
abundance
promotes
its
pathogenesis
evolution
into
steatohepatitis,
cirrhosis,
hepatocellular
carcinoma.
For
this
reason,
early
treatment
necessary
to
counteract
progression.
aim
of
present
narrative
review
evaluate
different
therapeutic
approaches
MAFLD.
most
important
for
MAFLD
lifestyle
changes.
regard,
Mediterranean
diet
could
be
considered
gold
standard
prevention
contrast,
a
Western
should
discouraged.
Probiotics
fecal
microbiota
transplantation
seem
valid,
safe,
effective
alternatives
treatment.
However,
more
studies
with
longer
follow-up
larger
cohort
patients
needed
underline
contrasting
Journal of Fungi,
Journal Year:
2024,
Volume and Issue:
10(9), P. 616 - 616
Published: Aug. 29, 2024
,
as
a
macrofungus
with
both
medicinal
and
dietary
applications,
is
renowned
for
its
rich
content
of
bioactive
substances.
The
recent
advancements
in
research
have
significantly
enhanced
our
understanding
polysaccharides,
cellulose-degrading
enzymes,
wide
range
secondary
metabolites.
This
paper
provides
comprehensive
review
the
artificial
cultivation
techniques
chemical
profiling
over
100
metabolites
identified
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2025,
Volume and Issue:
39(2)
Published: Jan. 27, 2025
ABSTRACT
Lycopene
(LYC)
is
an
extremely
powerful
antioxidant
with
the
potential
to
treat
a
range
of
diseases
and
inhibit
ferroptosis.
This
research
aims
elucidate
how
LYC
impacts
polycystic
ovarian
syndrome
(PCOS)
action
mechanisms.
A
PCOS
rat
model
was
constructed
by
injecting
DHEA.
Different
doses
were
injected
intraperitoneally
in
rats,
estrous
cycle
recorded.
The
histopathological
damage
ovary
rats
observed
HE
staining,
testosterone
(T),
estradiol
(E2),
luteinizing
hormone
(LH)
follicle
stimulating
(FSH)
levels
examined
ELISA
kits.
Transmission
electron
microscopy,
prussian
blue
biochemical
kits
determine
Immunohistochemistry
Western
blot
assess
ferroptosis‐related
AMPK/Nrf2
pathway‐related
proteins
explore
whether
affects
ferroptosis
through
this
pathway.
had
significantly
higher
body
weights,
weights
indices,
disorganized
cycles,
which
dose‐dependently
ameliorated
LYC.
In
addition,
restored
normal
secretion
T,
E2,
LH,
FSH.
attenuates
iron
deposition
tissues,
reduces
ROS
levels,
inhibits
Notably,
activated
pathway,
AMPK
inhibitor
intervention
attenuated
therapeutic
effect
suggesting
that
acts
disruption,
ameliorates
pathological
impairments,
modulating
