Medicine of Extreme Situations,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: March 1, 2024
The
onset
and
progression
of
various
disorders,
including
chronic
urticaria,
are
associated
with
stress.
gut-brain-skin
axis
is
used
to
describe
correlations
among
the
nervous
system,
gastrointestinal
tract
states
systemic
skin
inflammation.
We
have
summarized
inflammatory
immune
mechanisms
underlying
urticaria
stress
in
context
axis.
study
was
aimed
show
relationships
between
substance
P,
neurotransmitter,
diamine
oxidase,
enzyme
disrupting
histamine
gut
patients
suffering
from
urticaria.
A
total
165
adults
aged
18–68
were
enrolled;
97
had
comparison
group
formed
68
nominally
healthy
individuals.
ELISA
(Cloud-Clone
Corp;
China)
simultaneously
estimate
serum
levels
histamine.
revealed
a
significant
positive
correlation
(ρ
=
0.5;
p
<
0.05)
P
oxidase
group,
which
confirmed
existence
paper
provides
theoretical
background
new
targets
for
treatment
possibility
prevention
these
disorders
by
modulation
microbiota
discussed,
place
diet
lifestyle
modification
contributing
improvement
general
health
determined.
Molecular Psychiatry,
Journal Year:
2023,
Volume and Issue:
28(9), P. 3625 - 3637
Published: Sept. 1, 2023
Abstract
The
human
body
harbors
a
diverse
ecosystem
of
microorganisms,
including
bacteria,
viruses,
and
fungi,
collectively
known
as
the
microbiota.
Current
research
is
increasingly
focusing
on
potential
association
between
microbiota
various
neuropsychiatric
disorders.
resides
in
parts
body,
such
oral
cavity,
nasal
passages,
lungs,
gut,
skin,
bladder,
vagina.
gut
gastrointestinal
tract
has
received
particular
attention
due
to
its
high
abundance
role
psychiatric
neurodegenerative
However,
presents
other
tissues,
though
less
abundant,
also
plays
crucial
immune
system
homeostasis,
thus
influencing
development
progression
For
example,
imbalance
associated
periodontitis
might
increase
risk
for
Additionally,
studies
using
postmortem
brain
samples
have
detected
widespread
presence
bacteria
brains
patients
with
Alzheimer’s
disease.
This
article
provides
an
overview
emerging
host
disorders
discusses
future
directions,
underlying
biological
mechanisms,
reliable
biomarkers
microbiota,
microbiota-targeted
interventions,
this
field.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Aug. 25, 2024
The
human
gastrointestinal
tract,
boasting
the
most
diverse
microbial
community,
harbors
approximately
100
trillion
microorganisms
comprising
viruses,
bacteria,
fungi,
and
archaea.
profound
genetic
metabolic
capabilities
of
gut
microbiome
underlie
its
involvement
in
nearly
every
facet
biology,
from
health
maintenance
development
to
aging
disease.
Recent
recognition
microbiota
–
brain
axis,
referring
bidirectional
communication
network
between
microbes
their
host,
has
led
a
surge
interdisciplinary
research.
This
review
begins
with
an
overview
current
understandings
regarding
influence
on
intestinal
blood-brain
barrier
integrity.
Subsequently,
we
discuss
mechanisms
examining
role
microbiota-related
neural
transmission,
metabolites,
hormones
immunity.
We
propose
concept
microbiota-mediated
multi-barrier
modulation
potential
treatment
neurological
disorders.
Furthermore,
lymphatic
function
is
discussed,
providing
insights
into
lesser-known
conduits
ecosystem
within
brain.
In
final
section,
conclude
by
describing
ongoing
frontiers
understanding
axis's
impact
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 14, 2024
Background:
Psoriasis,
a
chronic
skin
condition
characterized
by
systemic
inflammation
and
altered
gut
microbiota,
has
been
target
of
Traditional
Chinese
Medicine
(TCM)
for
centuries.
Shenling
Baizhu
Powder
(SLBZP),
TCM
formulation,
holds
promise
treating
inflammatory
diseases,
but
its
specific
role
in
psoriasis
impact
on
microbiota
is
not
fully
understood.
Objective:
This
study
aims
to
elucidate
the
mechanism
SLBZP
psoriasis,
integrating
component
analysis,
network
pharmacology,
experimental
validation
mice
models.
Methods:
We
commenced
with
detailed
analysis
using
liquid
chromatograph
mass
spectrometer
(LC-MS).
Network
pharmacology
was
used
predict
potential
action
targets
pathways
psoriasis.
An
vivo
experiment
conducted
models,
treated
SLBZP.
Therapeutic
effects
were
assessed
via
symptomatology,
histopathology,
immunohistochemical
analysis.
Gut
composition
analyzed
16S
rRNA
gene
sequencing.
Results:
A
total
42
main
components
quality
markers
identified,
primarily
from
licorice
ginseng,
including
flavonoids,
saponins
other
markers.
PPI
topology
showed
that
TNF,
IL-6,
IL-1β,
TP53
JUN
core
DEPs.
168
signaling
lipid
atherosclerosis,
AGE-RAGE
pathway,
IL-17
pathway
Th17
cell
differentiation
enriched
KEGG.
demonstrated
significant
therapeutic
mice,
alterations
pathology
biomarkers.
Additionally,
notable
changes
observed
post-treatment,
indicating
possible
gut-skin
axis
involvement.
Conclusion:
research
pinpointed
metabolism
as
key
treatment
It
explores
how
SLBZP’s
modulation
can
alleviate
suggesting
balancing
may
reduce
mediators
offer
benefits.
underscores
new
strategy
treatment.
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 8, 2024
Allergy
and
immunological
disorders
like
autoimmune
diseases
are
vastly
prevalent
worldwide.
These
conditions
account
for
a
substantial
amount
of
personal
social
burden.
Such
illnesses
have
lengthy,
uncertain,
spotted
courses
with
unpredictable
exacerbations.
A
definite
tendency
improving
the
overall
quality
life
individuals
suffering
from
such
is
crucial
to
tackling
these
diseases,
especially
through
diet
or
lifestyle
modification.
Further,
interventions
microbiome-based
therapeutics
as
prebiotics
probiotics
were
explored.
Changes
in
microbial
population
evident
during
flare-up
allergic
conditions.
The
realization
that
human
microbiome
central
player
hallmark
its
potential
usefulness
therapy
illnesses.
This
review
focuses
on
intricate
symphony
orchestra
immune
system.
New
therapeutic
strategies
involving
appear
be
future
personalized
medicine.
Through
this
review,
we
explore
narrative
reaffirm
their
use
preventive
agents
disorders.
Clinical & Experimental Allergy,
Journal Year:
2024,
Volume and Issue:
54(9), P. 669 - 681
Published: June 12, 2024
Early
intervention
and
active
management
of
infant
atopic
eczema
may
play
a
crucial
role
in
limiting
severity
preventing
the
onset
immediate-type
food
allergy.
Eczema
involves
education,
skincare
medications
targeting
skin
inflammation
barrier
repair.
Topical
corticosteroids
are
mainstay
anti-inflammatory
therapy,
with
nonsteroidal
options
available
for
some
infants.
Proactive
addressing
subclinical
inflammation,
is
useful
flares,
especially
infants
recurrent
flares
despite
reactive
therapy.
In
clinical
practice,
holistic
consideration
overall
family
health
essential.
Providing
advice
on
maternal
stress
management,
nutritional
guidance
recommendations
proper
sleep
lifestyle
well-being
children
their
families,
not
limited
to
treatment
alone.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(3), P. 411 - 411
Published: March 13, 2025
Rosacea
is
a
common
inflammatory
skin
disease,
characterized
by
erythema,
papules
and
pustules.
The
pathophysiology
of
rosacea
remains
unclear,
but
the
complex
interplay
between
environmental
genetic
factors
may
act
as
trigger
to
an
abnormal
innate
immune
response
associated
with
multifaceted
neurovascular
reaction.
Increasing
evidence
suggests
that
gut
microbiota
significantly
involved
in
pathogenesis
rosacea,
playing
important
role
cutaneous
response.
Dysbiosis,
small
intestinal
bacterial
overgrowth,
Helicobacter
pylori
infection
system
dysregulation
mutually
contribute
more
extensive
future
research
needed
better
clarify
their
precise
mechanisms
action.
Many
dietary
triggers
have
been
postulated
for
this
disease;
however,
there
lack
well-made
controlled
studies
able
undoubtedly
demonstrate
causal
relationship
diet.
We
analyzed
available
on
diet
microbiome
positive
clinical
effects
reported
current
literature
probiotics,
prebiotics,
postbiotics
nutrients.
Ultimately,
article
improves
our
understanding
gut–skin
axis
focusing
how
probiotic
supplementation
could
improve
management
patients
affected
debilitating
disease.
Clinics in Dermatology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
The
bidirectional
communication
between
the
skin
and
brain
has
emerged
as
a
promising
scientific
paradigm
in
dermatology
cosmetic
medicine.
Neurocosmetics,
frontier
at
intersection
of
neuroscience,
dermatology,
psychodermatology,
aim
to
target
this
skin-brain
axis
enhance
not
only
health
but
also
emotional
well-being.
This
commentary
explores
underlying
neurocutaneous
neuroimmune
mechanisms,
emerging
role
microbiome
emotion-linked
responses,
how
artificial
intelligence
(AI)
technologies
can
help
personalize
these
strategies.
convergence
neuroscience
may
pave
way
for
new
generation
evidence-based
skincare
with
psychophysiological
impact,
transformative
concept
both
clinical
practice.
AIMS neuroscience,
Journal Year:
2024,
Volume and Issue:
11(3), P. 289 - 311
Published: Jan. 1, 2024
<p>The
study
of
the
brain-gut
axis
and
its
impact
on
cognitive
function
in
development
neurodegenerative
diseases
is
a
very
timely
topic
interest
to
researchers.
This
review
summarizes
information
basic
mechanisms
gut-brain
communication.
We
then
discuss
roles
gut
microbiome
as
neuroprotective
factor
neurodegeneration.
The
microbiota
extremely
important
maintaining
body's
homeostasis,
shaping
human
immune
system
proper
functioning
brain.
intestinal
microflora
affects
processes
neuroplasticity,
synaptogenesis,
neuronal
regeneration.
aims
explain
changes
composition
bacterial
population
among
patients
with
Alzheimer's
disease,
Parkinson's
multiple
sclerosis.
Abnormalities
are
also
noted
stress,
depression,
or
autism
spectrum
development.
New
observations
psychobiotic
supplementation
alleviating
symptoms
presented.</p>
