Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5842 - 5842

Published: May 27, 2024

This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.

Language: Английский

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The Networked Interaction between Probiotics and Intestine in Health and Disease: A Promising Success Story

Microorganisms, Journal Year: 2024, Volume and Issue: 12(1), P. 194 - 194

Published: Jan. 18, 2024

Probiotics are known to promote human health either precautionary in healthy individuals or therapeutically patients suffering from certain ailments. Although this knowledge was empirical past tomes, modern science has already verified it and expanded new limits. These microorganisms can be found nature various foods such as dairy products supplements formulated for clinical preventive use. The current review examines the different mechanisms of action probiotic strains how they interact with organism host. Emphasis is put on therapeutic use these beneficial conditions gastrointestinal tract. Diseases tract particularly any malfunction inflammation intestines seriously compromise whole organism. interaction between host’s microbiota alleviate signs symptoms while some cases, due course, intervene underlying pathology. Various safety issues probiotics also discussed.

Language: Английский

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The role of gut microbiota in MP/NP-induced toxicity

Environmental Pollution, Journal Year: 2024, Volume and Issue: 359, P. 124742 - 124742

Published: Aug. 15, 2024

Language: Английский

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Understanding How Pre- and Probiotics Affect the Gut Microbiome and Metabolic Health

AJP Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 327(1), P. E89 - E102

Published: May 29, 2024

The gut microbiome, a complex assembly of microorganisms, significantly impacts human health by influencing nutrient absorption, the immune system, and disease response. These microorganisms form dynamic ecosystem that is critical to maintaining overall well-being. Prebiotics probiotics are pivotal in regulating microbiota composition. nourish beneficial bacteria promote their growth, whereas help maintain balance within microbiome. This intricate extends several aspects health, including integrity barrier, responses, producing metabolites crucial for metabolic health. Dysbiosis, or an imbalance microbiota, has been linked disorders such as type 2 diabetes, obesity, cardiovascular disease. Impaired barrier function, endotoxemia, low-grade inflammation associated with toll-like receptors proinflammatory pathways. Short-chain fatty acids derived from microbial fermentation modulate anti-inflammatory system positively influence probiotics, especially Lactobacillus Bifidobacterium strains, may improve outcomes, glycemic control diabetes. It important consider strain-specific effects study variability when interpreting these findings, highlighting need further research optimize therapeutic potential. aim this report therefore review role prebiotics on microbiome role, integrating broad understanding physiological mechanisms clinical perspective.

Language: Английский

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A Fresh Look at Problem Areas in Research Methodology in Nutrition

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 972 - 972

Published: March 10, 2025

This paper makes a critical evaluation of several the research methods used to investigate relationship between diet, health, and disease. The two widely are randomized controlled trials (RCTs) prospective cohort studies. RCTs viewed as being more reliable than studies for that reason placed higher in hierarchy. However, have inherent flaws and, consequently, they may generate findings less those from text presents discussion errors occur result confounding. refers correlation exposure outcome with other variables can mask true association or produce false associations. Another source error is reverse causation, which most commonly associated cross-sectional These do not allow researchers determine temporal sequence lifestyle inputs together health-related outcomes. As result, it be unclear cause effect. also illustrated by inverse alcohol intake coronary heart Mechanistic investigation intricate details body functioning health disease this strategy biomedical science. evidence presented here case our information practical value field nutrition has come epidemiological research, including RCTs, whereas mechanistic been minor value.

Language: Английский

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Deciphering probiotic potential: a comprehensive guide to probiogenomic analyses

Future Microbiology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: April 14, 2025

In recent years, the study of probiotics has advanced significantly, driven by growing interest in their potential health benefits and applications food pharmaceutical industries. Probiotics are claimed to enhance gut health, modulate immune responses, improve digestion, synthesize beneficial compounds for host, even impact mental through gut-brain axis. However, traditional vitro methods identifying have limitations, such as low reproducibility phenotypic screening, limited capacity discover new strains, restricted evaluation safety, inefficiencies fully understanding biological properties responsible health-promoting effects. Advancements genomic analysis technology provided a cost-effective approach further explore probiotic strains molecular mechanisms driving effects hosts. Here, we describe comprehensive workflow probiogenomic aimed at establishing gold-standard pipeline screening based on genome sequencing. This encompasses steps from acquiring genomes safety-related features, plasticity, markers whole-genome addition, this outlines respective methodological approaches provides most database documented date, comprising 243 genes potentially associated with function.

Language: Английский

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Microbiota based personalized nutrition improves hyperglycaemia and hypertension parameters and reduces inflammation: a prospective, open label, controlled, randomized, comparative, proof of concept study

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17583 - e17583

Published: June 26, 2024

Background Recent studies suggest that gut microbiota composition, abundance and diversity can influence many chronic diseases such as type 2 diabetes. Modulating through targeted nutrition provide beneficial effects leading to the concept of personalized for health improvement. In this prospective clinical trial, we evaluated impact a microbiome-based diet on hyperglycaemic hyperlipidaemic individuals. Specifically, BugSpeaks ® -a microbiome profile test profiles using next generation sequencing provides nutritional recommendation based individual was evaluated. Methods A total 30 participants with diabetes hyperlipidaemia were recruited study. The 15 (test arm) whole genome shotgun metagenomics recommendations their provided. remaining (control provided diabetic guidance 3 months. Clinical anthropometric parameters HbA1c, systolic/diastolic pressure, c-reactive protein levels composition measured compared during Results arm (microbiome-based nutrition) showed statistically significant decrease in HbA1c level from 8.30 (95% confidence interval (CI), [7.74–8.85]) 6.67 CI [6.2–7.05]), p < 0.001 after 90 days. also 5% decline systolic pressure whereas control 7% increase. Incidentally, sub-cohort patients >130 mm Hg by 14%. Interestingly, CRP found drop 19.5%. Alpha measures increase Shannon measure ( 0.05), dietary intervention. intervention led minimum two-fold (Log2 fold change species like Phascolarctobacterium succinatutens, Bifidobacterium angulatum, Levilactobacillus brevis which might have role current context similar Alistipes finegoldii, Sutterella faecalis been earlier shown some negative host. Overall, study indicated net positive regime correlated parameters.

Language: Английский

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Unravelling the role of the skin microbiome in immunodermatological diseases: implications for therapeutic interventions

International Journal of Research in Dermatology, Journal Year: 2025, Volume and Issue: 11(2), P. 190 - 198

Published: Feb. 24, 2025

The skin microbiome, comprising diverse microbial communities, is pivotal in maintaining cutaneous homeostasis and modulating immune responses immunodermatological diseases. This review provides an overview of recent research investigating the interplay between microbiome autoimmune, allergic, inflammatory conditions, such as psoriasis, eczema, acne vulgaris. Current evidence suggests that alterations composition, termed dysbiosis, may contribute to disease pathogenesis exacerbate inflammation disorders. Furthermore, microbial-derived metabolites immune-modulating factors produced by commensal bacteria can influence local barrier function. Future directions include evaluating how interacts with host system, identifying biomarkers for diagnosis prognosis, exploring microbiome-targeted therapeutic interventions, probiotics, transplantation, metabolite supplementation. By leveraging insights from research, personalized approaches managing diseases offer novel avenues restoring improving patient outcomes.

Language: Английский

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Probiotics Supplementation during Pregnancy: Can They Exert Potential Beneficial Effects against Adverse Pregnancy Outcomes beyond Gestational Diabetes Mellitus?

Biology, Journal Year: 2024, Volume and Issue: 13(3), P. 158 - 158

Published: Feb. 28, 2024

Background: Probiotics, as supplements or food ingredients, are considered to exert promising healthy effects when administered in adequate quantity. Probiotics’ related with the prevention of many diseases, well decreasing symptom severity. Currently, most available data concerning their potential health associated metabolic disorders, including gestational diabetes mellitus. There is also clinical evidence supporting that they may beneficial against diverse adverse pregnancy outcomes. The purpose current narrative study extensively review and analyze existing studies probable positive impacts probiotics supplementation during a protective agent outcomes beyond Methods: comprehensive thorough literature search was conducted precise scientific databases, such PubMed, Scopus, Web Sciences, utilizing efficient, representative, appropriate keywords. Results: last few years, recent research has been several lipid metabolism dysregulation, hypertensive preterm birth, excessive weight gain, caesarean risk section, vaginal microbiota impairment, mental disturbances, others. Conclusion: up present day, there only preliminary not conclusive results for probiotics’ pregnancy, it remains questionable whether could be used supplementary treatment

Language: Английский

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Microbiota based personalized nutrition improves hyperglycaemia and hypertension parameters and reduces inflammation: A prospective, open label, controlled, randomized, comparative, proof of concept study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 28, 2023

Abstract Recent studies suggest that gut microbiota composition, abundance and diversity can influence many chronic diseases such as type 2 diabetes. Modulating through targeted nutrition provide beneficial effects leading to the concept of personalized for health improvement. In this prospective clinical trial, we evaluated impact a microbiome-based diet on hyperglycaemic hyperlipidaemic individuals. Specifically, BugSpeaks ® - microbiome profile test profiles using next generation sequencing provides nutritional recommendation based individual was evaluated. The arm [microbiome-based nutrition] showed statistically significant decrease in HbA1c level [from 8.30 ± 1.12 6.67 0.89, p<0.001] after 90 days. arm, also 5% decline systolic pressure whereas control 7% increase. Incidentally, sub-cohort patients with >130mm Hg by 14%. Interestingly, CRP found drop 19.5%. Alpha measures increase Shannon measure [p<0.05], dietary intervention. intervention led minimum 2-fold [Log2 fold change] species like Phascolarctobacterium succinatutens, Bifidobacterium angulatum, Levilactobacillus brevis , similar non-beneficial Alistipes finegoldii, Sutterella faecalis . Overall, study indicated net positive regime correlated parameters.

Language: Английский

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