Unraveling the gut-skin axis in atopic dermatitis: exploiting insights for therapeutic strategies DOI Creative Commons
Marcela Rios-Carlos, Daniel Cervantes‐García, Laura Elena Córdova-Dávalos

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 27, 2024

Gut microbiota exert functions of high importance in the intestine. Furthermore, there is increasing evidence for its role immune regulation and maintenance homeostasis many physiological processes taking place distant tissues. In particular, this review, we explore impact metabolites produced by gut on development atopic dermatitis (AD). Probiotics prebiotics balance promote generation bacterial metabolites, such as short-chain fatty acids tryptophan derivates, which exacerbated AD response through regulatory T cells IL-10 TGF-β cytokines. Metabolites also have a direct action keratinocytes once they reach bloodstream. Besides, probiotics decrease levels associated with onset, phenols. Understanding all these crosstalk between skin reveals number possibilities, mainly manipulation microbiome, may represent therapeutic strategies that can contribute to standard treatments patients improve their quality life.

Language: Английский

Tryptophan Metabolism and Gut Microbiota: A Novel Regulatory Axis Integrating the Microbiome, Immunity, and Cancer DOI Creative Commons

Yingjian Hou,

Jing Li,

Shuhuan Ying

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(11), P. 1166 - 1166

Published: Nov. 20, 2023

Tryptophan metabolism and gut microbiota form an integrated regulatory axis that impacts immunity, metabolism, cancer. This review consolidated current knowledge on the bidirectional interactions between microbial tryptophan processing host. We focused how microbiome controls breakdown via indole, kynurenine, serotonin pathways. Dysbiosis of induces disruptions in catabolism which contribute to disorders like inflammatory conditions, neuropsychiatric diseases, metabolic syndromes, These affect immune homeostasis, neurotransmission, gut-brain communication. Elucidating mechanisms modulation could enable novel therapeutic approaches psychobiotics microbiome-targeted dietary interventions. Overall, further research microbiota-tryptophan has potential revolutionize personalized diagnostics treatments for improving human health.

Language: Английский

Citations

50
The tryptophan metabolic pathway of the microbiome and host cells in health and disease DOI Creative Commons
Kentaro Miyamoto, Tomohisa Sujino, Takanori Kanai∥

et al.

International Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: June 13, 2024

Abstract The intricate and dynamic tryptophan (Trp) metabolic pathway in both the microbiome host cells highlights its profound implications for health disease. This involves complex interactions between cellular bacteria processes, producing bioactive compounds such as 5-hydroxytryptamine (5-HT) kynurenine derivatives. Immune responses to Trp metabolites through specific receptors have been explored, highlighting role of aryl hydrocarbon receptor inflammation modulation. Dysregulation this is implicated various diseases, Alzheimer’s Parkinson’s mood disorders, neuronal autoimmune diseases multiple sclerosis (MS), cancer. In article, we describe impact 5-HT, Trp, indole, on Furthermore, review microbiome-derived that affect immune contribute maintaining homeostasis, especially an experimental encephalitis model MS.

Language: Английский

Citations

9
Indole‐3‐Lactic Acid Inhibits Doxorubicin‐Induced Ferroptosis Through Activating Aryl Hydrocarbon Receptor/Nrf2 Signalling Pathway DOI Creative Commons
Jiangfang Lian, Hangyuan Guo,

Zuoquan Zhong

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(2)

Published: Jan. 1, 2025

ABSTRACT The clinical application of doxorubicin (DOX) is limited due to its cardiotoxicity, which primarily attributed interaction with iron in mitochondria, leading lipid peroxidation and myocardial ferroptosis. This study aimed investigate the role gut microbiota‐derived metabolite, indole‐3‐lactic acid (ILA), mitigating DOX‐induced cardiotoxicity (DIC). Cardiac function, pathological changes, ferroptosis were assessed vivo. cardioprotective effects mechanisms ILA explored using multi‐omics approaches, including single‐nucleus RNA sequencing (snRNA‐seq) bulk RNA‐seq, further validated Nrf2 knockout mice. findings revealed that DOX treatment disrupted microbiota, significantly reducing levels tryptophan metabolite ILA. In DIC models, supplementation markedly improved cardiac reduced collagen deposition, mitigated atrophy. snRNA‐seq analyses indicated played a crucial Experimental data demonstrated decreased both mice DOX‐treated H9C2 cells, evidenced by restoration GPX4 SLC7A11 reduction ACSL4. Mechanistically, functions as ligand for aryl hydrocarbon receptor (AhR), upregulation expression. protective against abolished silencing AhR. Moreover, beneficial on eliminated Nrf2‐deficient conclusion, exerts therapeutic inhibiting through activation AhR/Nrf2 signalling pathway. Identifying microbial could offer viable strategies DIC.

Language: Английский

Citations

1
Early Post-natal Methionine Supplementation in Ewe Lambs: Long-Term Effects on Feed Efficiency, Milk Yield and Fatty Acid Profile, Metabolism, Gut Microbiome, and Epigenetic Regulation DOI
Mahsa Dehnavi, Alba Martín, Javier Mateo

et al.

Animal Feed Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 116245 - 116245

Published: Jan. 1, 2025

Language: Английский

Citations

1
Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1559 - 1559

Published: April 29, 2025

Neurodegenerative disorders such as Alzheimer's disease (AD), the most common form of dementia, represent a growing global health crisis, yet current treatment strategies remain primarily palliative. Recent studies have shown that neurodegeneration through complex interactions within gut-brain axis largely depends on gut microbiota and its metabolites. This review explores intricate molecular mechanisms linking dysbiosis to cognitive decline, emphasizing impact microbial metabolites, including short-chain fatty acids (SCFAs), bile acids, tryptophan neuroinflammation, blood-brain barrier (BBB) integrity, amyloid-β tau pathology. The paper highlights major microbiome signatures associated with disease, detailing their metabolic pathways inflammatory crosstalk. Dietary interventions promise in modulating composition, potentially mitigating neurodegenerative processes. critically examines influence dietary patterns, Mediterranean Western diets, microbiota-mediated neuroprotection. Bioactive compounds like prebiotics, omega-3 polyphenols exhibit neuroprotective effects by reducing neuroinflammation. Furthermore, it discusses emerging microbiome-based therapeutic strategies, probiotics, postbiotics, fecal transplantation (FMT), potential for slowing progression. Despite these advances, several knowledge gaps remain, interindividual variability responses need large-scale, longitudinal studies. study proposes an integrative, precision medicine approach, incorporating science into paradigms. Ultimately, cognizance at mechanistic level could unlock novel avenues, offering non-invasive, diet-based strategy managing improving health.

Language: Английский

Citations

1
Exploring tryptophan metabolism: The transition from disturbed balance to diagnostic and therapeutic potential in metabolic diseases DOI
Zhizhong Luo, Yuqing Liu, Xin Wang

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116554 - 116554

Published: Sept. 1, 2024

Language: Английский

Citations

7
Bacterial small molecule metabolites implicated in gastrointestinal cancer development DOI
Tayah Turocy, Jason M. Crawford

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Language: Английский

Citations

5
Sex-specific post-inflammatory dysbiosis mediates chronic visceral pain in colitis DOI Creative Commons

Maria J. Arzamendi,

Yasaman Bahojb Habibyan,

Manon Defaye

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Oct. 3, 2024

Despite achieving endoscopic remission, over 20% of inflammatory bowel disease (IBD) patients experience chronic abdominal pain. Visceral pain and the microbiome exhibit sex-dependent interactions, while visceral in IBD shows a sex bias. Our aim was to evaluate whether post-inflammatory microbial perturbations contribute hypersensitivity manner.

Language: Английский

Citations

4
Exploring the Relationship between Gut Microbiome Composition and Blood Indole-3-acetic Acid in Hemodialysis Patients DOI Creative Commons
Ping‐Hsun Wu,

Yu-Fang Tseng,

Wangta Liu

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 148 - 148

Published: Jan. 10, 2024

Indole-3-acetic acid (IAA), a protein-bound uremic toxin resulting from gut microbiota-driven tryptophan metabolism, increases in hemodialysis (HD) patients. IAA may induce endothelial dysfunction, inflammation, and oxidative stress, elevating cardiovascular cognitive risk HD However, research on the microbiome-IAA association is limited. This study aimed to explore microbiome's relationship with plasma levels 72 chronic patients aged over 18 (August 2016-January 2017). were measured using tandem mass spectrometry, microbiome analysis utilized 16s rRNA next-generation sequencing. Linear discriminative effect size random forest distinguished microbial species linked levels. Patients higher had reduced diversity. Six significantly associated identified;

Language: Английский

Citations

4
Metabolomics analysis of anaphylactoid reactions induced by Xueshuantong injection in normal and immunocompromised mice DOI Creative Commons

Xiaoqian Guo,

Chi Zhang, Yingyu Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Xueshuantong injection (Lyophilized) (XSTI) is widely used to treat cardiovascular and cerebrovascular diseases. However, anaphylactoid reactions (ARs) are frequently reported as one of its side effects, the mechanisms ARs their relationship with different immune status still not well understood. This article aims examine sensitizing effect XSTI, explore impact normal immunocompromised states on ARs, analyze AR-related metabolic pathways by metabolomics. An mouse model was established through intraperitoneal cyclophosphamide (CTX). Normal mice were then treated saline (NS), histamine (HIS), respectively. Behavioral responses, auricle blue staining, Evans (EB) exudation indices evaluate sensitization XSTI both mice. Subsequently, models statuses established, validated measuring four serum indicators using enzyme-linked immunosorbent assay (ELISA). Finally, LC-MS metabolomics analysis performed pathways. The intensity induced in found increase administered dose, exhibiting higher AR intensities compared Metabolomic revealed significant changes XSTI-treated predicted from these metabolites include biotin metabolism, histidine glycerolipid bile secretion, arachidonic acid sphingolipid niacin nicotinamide tryptophan steroid biosynthesis, arginine proline metabolism. Research indicated that dose-dependent, weakened functions exhibit lower sensitivity. Through research, differential analyzed, inducing predicted. study offers guidance safe medication perspective organism susceptibility lays a foundation for research potential ARs.

Language: Английский

Citations

0