Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Nov. 27, 2024
Gut
microbiota
exert
functions
of
high
importance
in
the
intestine.
Furthermore,
there
is
increasing
evidence
for
its
role
immune
regulation
and
maintenance
homeostasis
many
physiological
processes
taking
place
distant
tissues.
In
particular,
this
review,
we
explore
impact
metabolites
produced
by
gut
on
development
atopic
dermatitis
(AD).
Probiotics
prebiotics
balance
promote
generation
bacterial
metabolites,
such
as
short-chain
fatty
acids
tryptophan
derivates,
which
exacerbated
AD
response
through
regulatory
T
cells
IL-10
TGF-β
cytokines.
Metabolites
also
have
a
direct
action
keratinocytes
once
they
reach
bloodstream.
Besides,
probiotics
decrease
levels
associated
with
onset,
phenols.
Understanding
all
these
crosstalk
between
skin
reveals
number
possibilities,
mainly
manipulation
microbiome,
may
represent
therapeutic
strategies
that
can
contribute
to
standard
treatments
patients
improve
their
quality
life.
Metabolites,
Journal Year:
2023,
Volume and Issue:
13(11), P. 1166 - 1166
Published: Nov. 20, 2023
Tryptophan
metabolism
and
gut
microbiota
form
an
integrated
regulatory
axis
that
impacts
immunity,
metabolism,
cancer.
This
review
consolidated
current
knowledge
on
the
bidirectional
interactions
between
microbial
tryptophan
processing
host.
We
focused
how
microbiome
controls
breakdown
via
indole,
kynurenine,
serotonin
pathways.
Dysbiosis
of
induces
disruptions
in
catabolism
which
contribute
to
disorders
like
inflammatory
conditions,
neuropsychiatric
diseases,
metabolic
syndromes,
These
affect
immune
homeostasis,
neurotransmission,
gut-brain
communication.
Elucidating
mechanisms
modulation
could
enable
novel
therapeutic
approaches
psychobiotics
microbiome-targeted
dietary
interventions.
Overall,
further
research
microbiota-tryptophan
has
potential
revolutionize
personalized
diagnostics
treatments
for
improving
human
health.
International Immunology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 13, 2024
Abstract
The
intricate
and
dynamic
tryptophan
(Trp)
metabolic
pathway
in
both
the
microbiome
host
cells
highlights
its
profound
implications
for
health
disease.
This
involves
complex
interactions
between
cellular
bacteria
processes,
producing
bioactive
compounds
such
as
5-hydroxytryptamine
(5-HT)
kynurenine
derivatives.
Immune
responses
to
Trp
metabolites
through
specific
receptors
have
been
explored,
highlighting
role
of
aryl
hydrocarbon
receptor
inflammation
modulation.
Dysregulation
this
is
implicated
various
diseases,
Alzheimer’s
Parkinson’s
mood
disorders,
neuronal
autoimmune
diseases
multiple
sclerosis
(MS),
cancer.
In
article,
we
describe
impact
5-HT,
Trp,
indole,
on
Furthermore,
review
microbiome-derived
that
affect
immune
contribute
maintaining
homeostasis,
especially
an
experimental
encephalitis
model
MS.
Journal of Cellular and Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
29(2)
Published: Jan. 1, 2025
ABSTRACT
The
clinical
application
of
doxorubicin
(DOX)
is
limited
due
to
its
cardiotoxicity,
which
primarily
attributed
interaction
with
iron
in
mitochondria,
leading
lipid
peroxidation
and
myocardial
ferroptosis.
This
study
aimed
investigate
the
role
gut
microbiota‐derived
metabolite,
indole‐3‐lactic
acid
(ILA),
mitigating
DOX‐induced
cardiotoxicity
(DIC).
Cardiac
function,
pathological
changes,
ferroptosis
were
assessed
vivo.
cardioprotective
effects
mechanisms
ILA
explored
using
multi‐omics
approaches,
including
single‐nucleus
RNA
sequencing
(snRNA‐seq)
bulk
RNA‐seq,
further
validated
Nrf2
knockout
mice.
findings
revealed
that
DOX
treatment
disrupted
microbiota,
significantly
reducing
levels
tryptophan
metabolite
ILA.
In
DIC
models,
supplementation
markedly
improved
cardiac
reduced
collagen
deposition,
mitigated
atrophy.
snRNA‐seq
analyses
indicated
played
a
crucial
Experimental
data
demonstrated
decreased
both
mice
DOX‐treated
H9C2
cells,
evidenced
by
restoration
GPX4
SLC7A11
reduction
ACSL4.
Mechanistically,
functions
as
ligand
for
aryl
hydrocarbon
receptor
(AhR),
upregulation
expression.
protective
against
abolished
silencing
AhR.
Moreover,
beneficial
on
eliminated
Nrf2‐deficient
conclusion,
exerts
therapeutic
inhibiting
through
activation
AhR/Nrf2
signalling
pathway.
Identifying
microbial
could
offer
viable
strategies
DIC.
Foods,
Journal Year:
2025,
Volume and Issue:
14(9), P. 1559 - 1559
Published: April 29, 2025
Neurodegenerative
disorders
such
as
Alzheimer's
disease
(AD),
the
most
common
form
of
dementia,
represent
a
growing
global
health
crisis,
yet
current
treatment
strategies
remain
primarily
palliative.
Recent
studies
have
shown
that
neurodegeneration
through
complex
interactions
within
gut-brain
axis
largely
depends
on
gut
microbiota
and
its
metabolites.
This
review
explores
intricate
molecular
mechanisms
linking
dysbiosis
to
cognitive
decline,
emphasizing
impact
microbial
metabolites,
including
short-chain
fatty
acids
(SCFAs),
bile
acids,
tryptophan
neuroinflammation,
blood-brain
barrier
(BBB)
integrity,
amyloid-β
tau
pathology.
The
paper
highlights
major
microbiome
signatures
associated
with
disease,
detailing
their
metabolic
pathways
inflammatory
crosstalk.
Dietary
interventions
promise
in
modulating
composition,
potentially
mitigating
neurodegenerative
processes.
critically
examines
influence
dietary
patterns,
Mediterranean
Western
diets,
microbiota-mediated
neuroprotection.
Bioactive
compounds
like
prebiotics,
omega-3
polyphenols
exhibit
neuroprotective
effects
by
reducing
neuroinflammation.
Furthermore,
it
discusses
emerging
microbiome-based
therapeutic
strategies,
probiotics,
postbiotics,
fecal
transplantation
(FMT),
potential
for
slowing
progression.
Despite
these
advances,
several
knowledge
gaps
remain,
interindividual
variability
responses
need
large-scale,
longitudinal
studies.
study
proposes
an
integrative,
precision
medicine
approach,
incorporating
science
into
paradigms.
Ultimately,
cognizance
at
mechanistic
level
could
unlock
novel
avenues,
offering
non-invasive,
diet-based
strategy
managing
improving
health.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Oct. 3, 2024
Despite
achieving
endoscopic
remission,
over
20%
of
inflammatory
bowel
disease
(IBD)
patients
experience
chronic
abdominal
pain.
Visceral
pain
and
the
microbiome
exhibit
sex-dependent
interactions,
while
visceral
in
IBD
shows
a
sex
bias.
Our
aim
was
to
evaluate
whether
post-inflammatory
microbial
perturbations
contribute
hypersensitivity
manner.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(1), P. 148 - 148
Published: Jan. 10, 2024
Indole-3-acetic
acid
(IAA),
a
protein-bound
uremic
toxin
resulting
from
gut
microbiota-driven
tryptophan
metabolism,
increases
in
hemodialysis
(HD)
patients.
IAA
may
induce
endothelial
dysfunction,
inflammation,
and
oxidative
stress,
elevating
cardiovascular
cognitive
risk
HD
However,
research
on
the
microbiome-IAA
association
is
limited.
This
study
aimed
to
explore
microbiome's
relationship
with
plasma
levels
72
chronic
patients
aged
over
18
(August
2016-January
2017).
were
measured
using
tandem
mass
spectrometry,
microbiome
analysis
utilized
16s
rRNA
next-generation
sequencing.
Linear
discriminative
effect
size
random
forest
distinguished
microbial
species
linked
levels.
Patients
higher
had
reduced
diversity.
Six
significantly
associated
identified;
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 6, 2025
Xueshuantong
injection
(Lyophilized)
(XSTI)
is
widely
used
to
treat
cardiovascular
and
cerebrovascular
diseases.
However,
anaphylactoid
reactions
(ARs)
are
frequently
reported
as
one
of
its
side
effects,
the
mechanisms
ARs
their
relationship
with
different
immune
status
still
not
well
understood.
This
article
aims
examine
sensitizing
effect
XSTI,
explore
impact
normal
immunocompromised
states
on
ARs,
analyze
AR-related
metabolic
pathways
by
metabolomics.
An
mouse
model
was
established
through
intraperitoneal
cyclophosphamide
(CTX).
Normal
mice
were
then
treated
saline
(NS),
histamine
(HIS),
respectively.
Behavioral
responses,
auricle
blue
staining,
Evans
(EB)
exudation
indices
evaluate
sensitization
XSTI
both
mice.
Subsequently,
models
statuses
established,
validated
measuring
four
serum
indicators
using
enzyme-linked
immunosorbent
assay
(ELISA).
Finally,
LC-MS
metabolomics
analysis
performed
pathways.
The
intensity
induced
in
found
increase
administered
dose,
exhibiting
higher
AR
intensities
compared
Metabolomic
revealed
significant
changes
XSTI-treated
predicted
from
these
metabolites
include
biotin
metabolism,
histidine
glycerolipid
bile
secretion,
arachidonic
acid
sphingolipid
niacin
nicotinamide
tryptophan
steroid
biosynthesis,
arginine
proline
metabolism.
Research
indicated
that
dose-dependent,
weakened
functions
exhibit
lower
sensitivity.
Through
research,
differential
analyzed,
inducing
predicted.
study
offers
guidance
safe
medication
perspective
organism
susceptibility
lays
a
foundation
for
research
potential
ARs.