Unraveling the gut-skin axis in atopic dermatitis: exploiting insights for therapeutic strategies DOI Creative Commons
Marcela Rios-Carlos, Daniel Cervantes‐García, Laura Elena Córdova-Dávalos

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 27, 2024

Gut microbiota exert functions of high importance in the intestine. Furthermore, there is increasing evidence for its role immune regulation and maintenance homeostasis many physiological processes taking place distant tissues. In particular, this review, we explore impact metabolites produced by gut on development atopic dermatitis (AD). Probiotics prebiotics balance promote generation bacterial metabolites, such as short-chain fatty acids tryptophan derivates, which exacerbated AD response through regulatory T cells IL-10 TGF-β cytokines. Metabolites also have a direct action keratinocytes once they reach bloodstream. Besides, probiotics decrease levels associated with onset, phenols. Understanding all these crosstalk between skin reveals number possibilities, mainly manipulation microbiome, may represent therapeutic strategies that can contribute to standard treatments patients improve their quality life.

Language: Английский

Tryptophan Metabolism and Gut Microbiota: A Novel Regulatory Axis Integrating the Microbiome, Immunity, and Cancer DOI Creative Commons

Yingjian Hou,

Jing Li,

Shuhuan Ying

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(11), P. 1166 - 1166

Published: Nov. 20, 2023

Tryptophan metabolism and gut microbiota form an integrated regulatory axis that impacts immunity, metabolism, cancer. This review consolidated current knowledge on the bidirectional interactions between microbial tryptophan processing host. We focused how microbiome controls breakdown via indole, kynurenine, serotonin pathways. Dysbiosis of induces disruptions in catabolism which contribute to disorders like inflammatory conditions, neuropsychiatric diseases, metabolic syndromes, These affect immune homeostasis, neurotransmission, gut-brain communication. Elucidating mechanisms modulation could enable novel therapeutic approaches psychobiotics microbiome-targeted dietary interventions. Overall, further research microbiota-tryptophan has potential revolutionize personalized diagnostics treatments for improving human health.

Language: Английский

Citations

48
Indole‐3‐Lactic Acid Inhibits Doxorubicin‐Induced Ferroptosis Through Activating Aryl Hydrocarbon Receptor/Nrf2 Signalling Pathway DOI Creative Commons
Jiangfang Lian, Hangyuan Guo,

Zuoquan Zhong

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(2)

Published: Jan. 1, 2025

ABSTRACT The clinical application of doxorubicin (DOX) is limited due to its cardiotoxicity, which primarily attributed interaction with iron in mitochondria, leading lipid peroxidation and myocardial ferroptosis. This study aimed investigate the role gut microbiota‐derived metabolite, indole‐3‐lactic acid (ILA), mitigating DOX‐induced cardiotoxicity (DIC). Cardiac function, pathological changes, ferroptosis were assessed vivo. cardioprotective effects mechanisms ILA explored using multi‐omics approaches, including single‐nucleus RNA sequencing (snRNA‐seq) bulk RNA‐seq, further validated Nrf2 knockout mice. findings revealed that DOX treatment disrupted microbiota, significantly reducing levels tryptophan metabolite ILA. In DIC models, supplementation markedly improved cardiac reduced collagen deposition, mitigated atrophy. snRNA‐seq analyses indicated played a crucial Experimental data demonstrated decreased both mice DOX‐treated H9C2 cells, evidenced by restoration GPX4 SLC7A11 reduction ACSL4. Mechanistically, functions as ligand for aryl hydrocarbon receptor (AhR), upregulation expression. protective against abolished silencing AhR. Moreover, beneficial on eliminated Nrf2‐deficient conclusion, exerts therapeutic inhibiting through activation AhR/Nrf2 signalling pathway. Identifying microbial could offer viable strategies DIC.

Language: Английский

Citations

1
The tryptophan metabolic pathway of the microbiome and host cells in health and disease DOI Creative Commons
Kentaro Miyamoto, Tomohisa Sujino, Takanori Kanai∥

et al.

International Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: June 13, 2024

Abstract The intricate and dynamic tryptophan (Trp) metabolic pathway in both the microbiome host cells highlights its profound implications for health disease. This involves complex interactions between cellular bacteria processes, producing bioactive compounds such as 5-hydroxytryptamine (5-HT) kynurenine derivatives. Immune responses to Trp metabolites through specific receptors have been explored, highlighting role of aryl hydrocarbon receptor inflammation modulation. Dysregulation this is implicated various diseases, Alzheimer’s Parkinson’s mood disorders, neuronal autoimmune diseases multiple sclerosis (MS), cancer. In article, we describe impact 5-HT, Trp, indole, on Furthermore, review microbiome-derived that affect immune contribute maintaining homeostasis, especially an experimental encephalitis model MS.

Language: Английский

Citations

8
Exploring tryptophan metabolism: The transition from disturbed balance to diagnostic and therapeutic potential in metabolic diseases DOI
Zhizhong Luo, Yuqing Liu, Xin Wang

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116554 - 116554

Published: Sept. 1, 2024

Language: Английский

Citations

6
Sex-specific post-inflammatory dysbiosis mediates chronic visceral pain in colitis DOI Creative Commons

Maria J. Arzamendi,

Yasaman Bahojb Habibyan,

Manon Defaye

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Oct. 3, 2024

Despite achieving endoscopic remission, over 20% of inflammatory bowel disease (IBD) patients experience chronic abdominal pain. Visceral pain and the microbiome exhibit sex-dependent interactions, while visceral in IBD shows a sex bias. Our aim was to evaluate whether post-inflammatory microbial perturbations contribute hypersensitivity manner.

Language: Английский

Citations

4
Bacterial small molecule metabolites implicated in gastrointestinal cancer development DOI
Tayah Turocy, Jason M. Crawford

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Language: Английский

Citations

4
Metabolomics analysis of anaphylactoid reactions induced by Xueshuantong injection in normal and immunocompromised mice DOI Creative Commons

Xiaoqian Guo,

Chi Zhang, Yingyu Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Xueshuantong injection (Lyophilized) (XSTI) is widely used to treat cardiovascular and cerebrovascular diseases. However, anaphylactoid reactions (ARs) are frequently reported as one of its side effects, the mechanisms ARs their relationship with different immune status still not well understood. This article aims examine sensitizing effect XSTI, explore impact normal immunocompromised states on ARs, analyze AR-related metabolic pathways by metabolomics. An mouse model was established through intraperitoneal cyclophosphamide (CTX). Normal mice were then treated saline (NS), histamine (HIS), respectively. Behavioral responses, auricle blue staining, Evans (EB) exudation indices evaluate sensitization XSTI both mice. Subsequently, models statuses established, validated measuring four serum indicators using enzyme-linked immunosorbent assay (ELISA). Finally, LC-MS metabolomics analysis performed pathways. The intensity induced in found increase administered dose, exhibiting higher AR intensities compared Metabolomic revealed significant changes XSTI-treated predicted from these metabolites include biotin metabolism, histidine glycerolipid bile secretion, arachidonic acid sphingolipid niacin nicotinamide tryptophan steroid biosynthesis, arginine proline metabolism. Research indicated that dose-dependent, weakened functions exhibit lower sensitivity. Through research, differential analyzed, inducing predicted. study offers guidance safe medication perspective organism susceptibility lays a foundation for research potential ARs.

Language: Английский

Citations

0
Dianthus Superbus L. Alleviates Liver Injury Via Regulating Gut Microbiota-Mediated Tryptophan Metabolism DOI

Xiao-Lei Jiang,

Yan Zhuang, Tianwei Meng

et al.

Published: Jan. 1, 2025

IntroductionHepatic injury (HI), characterized by the impairment of liver tissue, can be precipitated a multitude factors including trauma, pharmacological agents, and pathologies, leading to spectrum functional anomalies associated clinical sequelae. Despite longstanding application Dianthus Superbus L. (DS) in management hepatic disorders, precise pathways through which it modulates gut microbiota their byproducts alleviate damage remain largely elusive.ObjectivesIts purpose is identify underlying mechanisms DS's therapeutic effects on CCL4-induced HI rats.MethodsDS components were analyzed using Ultra Performance Liquid Chromatography-Mass Spectrometer (UPLC-MS/MS).A 40% model SD rats was used evaluate efficacy DS biochemical marker assessment. Liver tissue examined immunohistochemically determine expression collagen-I -SMA, as well ZO-1 Occludin colon tissues. Non-targeted metabolomics analysis performed serum samples, while 16S rDNA targeted tryptophan conducted fecal samples. Further experiments investigating role included antibiotic treatment transplantation (FMT).ResultsThis study identified 30 chemical constituents DS, correlated with disease. Our findings indicate that induced CCL4 show an inhibition DS.A significant reduction mRNA levels α-SMA (p<0.05) Collagen I(p<0.05) detected immunohistochemistry, indicating decrease severity HI,and increase ZO-1(p<0.05) Occludin(p<0.05) colonic suggesting improvement intestinal barrier function. Similar trends observed α-SMA(p<0.05) I recipient underwent FMT DS. metabolomic indicated may exert hepatoprotective influencing biosynthesis steroid hormones, purine metabolism, metabolism. Analysis gene sequences demonstrated abundance beneficial bacterial groups such HT002, Lactobacillaceae, Lactobacillus, Romboutsia. Transplantation from DS-treated led enrichment Lactobacillus probiotics relative pseudo-sterile controls. Targeted feces restored multiple metabolites normal, improve modulating immune responses, reducing oxidative stress, enhancing function.ConclusionIn microbiota-dependent manner, ameliorates metabolism . It appears have potential use modulator prevention HI.

Language: Английский

Citations

0
Horizontal and longitudinal targeted metabolomics in healthy pregnancy and gestational diabetes mellitus DOI

Fang-Fang Chen,

Sha Lu, Wen Hua

et al.

Acta Diabetologica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Language: Английский

Citations

0
Early Post-natal Methionine Supplementation in Ewe Lambs: Long-Term Effects on Feed Efficiency, Milk Yield and Fatty Acid Profile, Metabolism, Gut Microbiome, and Epigenetic Regulation DOI
Mahsa Dehnavi, Alba Martín, Javier Mateo

et al.

Animal Feed Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 116245 - 116245

Published: Jan. 1, 2025

Language: Английский

Citations

0