Multi‐Targeting Phytochemicals for Alzheimer's Disease

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Alzheimer's disease (AD) is a type of neurodegenerative illness in which β-amyloid (Aβ) and tau protein accumulate neurons the form tangles. The pathophysiological pathway AD consists Aβ-amyloid peptides, proteins, oxidative stress increased neuro-inflammatory response. Food Drug Administration United States has authorized various drugs for effective treatment AD, include galantamine, rivastigmine, donepezil, memantine, sodium oligomannate, lecanemab, aducanumab. major disadvantage these that they only provide "symptomatic" relief. They are most early stages or mild to moderate cases disease, but not suitable long-term use. Besides conventional therapies, phytochemicals have potential stop progression AD. According research, use against gained attention due their potent anti-inflammatory, antioxidant, anti-hyperphosphorylation protein, metal chelation, anti-amyloid properties. This study seeks an up-to-date compilation current promising breakthroughs therapy using phytochemicals. It could be concluded light serve as However, more mechanistic investigations needed determine clinical implications treatment.

Language: Английский

---

State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 483 - 483

Published: April 10, 2024

Background: Despite some evidence supporting the synergy concept, commonly known assumption that combinations of several herbs in one formulation can have better efficacy due to additive or synergistic effects has yet be unambiguously and explicitly studied. Study aim: The study aimed reveal molecular interactions situ host cells response botanical hybrid preparations (BHP) intervention justify benefits implementing BHP clinical practice. Results: This prospective literature review provides results recent network pharmacology studies Rhodiola rosea L. (Arctic root) with other plants, including Withania somnifera (L.) Dunal (ashwagandha), (Camellia sinensis Kuntze (green tea), Eleutherococcus senticosus (Rupr. Maxim.) Maxim. (eleuthero), Schisandra chinensis (Turcz.) Baill. (schisandra), Leuzea carthamoides (Willd.) DC., caffeine, Cordyceps militaris L., Ginkgo biloba L.(ginkgo), Actaea racemosa (black cohosh), Crocus sativus (saffron), L-carnosine. Conclusions: most important finding from was interaction ingredients, revealing unexpected new pharmacological activities unique specific BHP. Some show superior compared mono-drugs. At same time, a priori-designed fail, presumably antagonistic crosstalk between targets within networks involved cellular overall organisms intervention. Network help predict at discovering indications unpredicted adverse events.

Language: Английский

---

Food matrices as delivery units of nutrients in processed foods

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(2)

Published: Feb. 1, 2025

Processed food products (PFPs) are amply consumed and important sources of nutrients worldwide. Evaluating PFPs by their composition fails to recognize that embedded in matrices processing modifies nutritional functionality, for example, the bioaccessibility bioavailability. with equivalent chemical may experience "food matrix effect": a difference outcome health potential. This review presents attained after significance. It also delves into complex kinetics digestion conducive nutrient release from interactions before absorption small intestine, role microbial fermentation colon. Matrices can be designed or redesigned manufactured tasty, nutritious, sustainable, as special foods vulnerable groups, innovative novel sources, feed healthy microbiota. The potential improvement is driven understanding materials science changes during processing, control formulation manufacturing variables, application technologies, multifactor toolbox supports rational design matrices.

Language: Английский

---

Crosstalk Between Antioxidants and Adipogenesis: Mechanistic Pathways and Their Roles in Metabolic Health

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 203 - 203

Published: Feb. 10, 2025

The interplay between oxidative stress and adipogenesis is a critical factor in the development of obesity its associated metabolic disorders. Excessive reactive oxygen species (ROS) disrupt key transcription factors such as peroxisome proliferator-activated receptor gamma (PPARγ) CCAAT/enhancer-binding protein alpha (C/EBPα), impairing lipid metabolism, promoting adipocyte dysfunction, exacerbating inflammation insulin resistance. Antioxidants, classified endogenous (e.g., glutathione, superoxide dismutase, catalase) exogenous polyphenols, flavonoids, vitamins C E), are pivotal mitigating these effects by restoring redox balance preserving functionality. Endogenous antioxidants neutralize ROS safeguard cellular structures; however, under heightened stress, defenses often insufficient, necessitating dietary supplementation. Exogenous derived from plant-based sources, polyphenols vitamins, act through direct scavenging, upregulation antioxidant enzymes, modulation signaling pathways like nuclear kappa B (NF-κB) PPARγ, reducing peroxidation, inflammation, dysfunction. Furthermore, they influence epigenetic regulation transcriptional networks to restore differentiation limit accumulation. Antioxidant-rich diets, including Mediterranean diet, strongly with improved health, reduced rates, enhanced sensitivity. Advances personalized therapies, guided biomarkers supported novel delivery systems, present promising avenues for optimizing therapeutic interventions. This review, "Crosstalk Between Antioxidants Adipogenesis: Mechanistic Pathways Their Role Metabolic Health", highlights mechanistic which regulate enhance health.

Language: Английский

---

Mediterranean-Type Diet Adherence and Body Mass Index through 20 Years of Follow-Up: Results from the ATTICA Cohort Study (2002–2022)

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1128 - 1128

Published: April 11, 2024

Evidence of the association between dietary habits and long-term body weight status is scarce. This study aimed to evaluate changes in Mediterranean-type diet (MTD) adherence relation during 20 years follow-up. Data from n = 1582 participants ATTICA cohort (2002–2022) were used. MTD was assessed via MedDietScore, mass index (BMI) by 3 different measurements. We found that this inversely related BMI at mean 20-year In multi-adjusted linear regression models, a 1/55 increase baseline, 10-year, MedDietScore associated with decrease 0.05–0.13 kg/m2 0.08–0.09 BMI. Being consistently close for >90% decreased risk maintaining overweight/obesity period. Strong, protective, long-lasting effects observed, even those who deviated follow-up (41% sample). Our results highlight need focus on overall quality minimize an excessive life-course.

Language: Английский

---

The Impacts of Dietary Intervention on Brain Metabolism and Neurological Disorders: A Narrative Review

Dietetics, Journal Year: 2024, Volume and Issue: 3(3), P. 289 - 307

Published: Aug. 9, 2024

Neurological disorders are increasing globally due to their complex nature, influenced by genetics and environmental factors. Effective treatments remain limited, early diagnosis is challenging. Recent evidence indicates that metabolic activities play a crucial role in the onset of neural defects. Molecular changes offer new diagnostic markers dietary targets for disease management. Diets such as MIND, DASH, omega-3 fatty acids, polyphenols show promise protecting brain metabolism through anti-inflammatory properties. Personalized interventions could mitigate neurodegenerative diseases. This review highlights effects various interventions, including calorie restriction, fasting, ketogenic diets, on neurological disorders. Additionally, it emphasizes nutritional impacts immunomodulation underlying mechanisms, influence gut microbiota function. Dietary serve adjunctive therapies

Language: Английский

---

Phytochemical-mediated efferocytosis and autophagy in inflammation control

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Dec. 18, 2024

Abstract Efferocytosis, the clearance of apoptotic cells, is a critical process that maintains tissue homeostasis and immune regulation. Defective efferocytosis linked to development chronic inflammatory conditions, including atherosclerosis, neurological disorders, autoimmune diseases. Moreover, interplay between autophagy crucial for inflammation control, as enhances ability phagocytic cells. Efficient efferocytosis, in turn, regulates autophagic pathways, fostering balanced cellular environment. Dysregulation this balance can contribute pathogenesis various disorders. Phytochemicals, bioactive compounds found plants, have emerged promising therapeutic agents owing their diverse pharmacological properties, antioxidant, anti-inflammatory, immunomodulatory effects. This review aims highlight pivotal role phytochemicals enhancing explore potential prevention treatment related study examines how influence key aspects cell activation, macrophage polarization, induction. The atherosclerosis diseases highlighted, emphasizing enhance reduce inflammation. also discusses innovative approaches, such nanoformulations combination therapies improve targeting bioavailability phytochemicals. Ultimately, inspires further research clinical applications phytochemical-mediated enhancement managing conditions.

Language: Английский

---

Developing sustainable food-based dietary guidelines for Lebanon: integrating health, economic resilience, and sustainability

Frontiers in Sustainable Food Systems, Journal Year: 2025, Volume and Issue: 9

Published: March 19, 2025

Background Developing Sustainable Food-Based Dietary Guidelines (SFBDGs) aligned with sustainable healthy diets (SHDs) is critical for addressing food and nutrition insecurity, mitigating diet-related diseases, improving public health, promoting environmental sustainability. Lebanon, a low-middle-income Eastern Mediterranean country, faces significant challenges including high prevalence of wide-spread noncommunicable limited natural resources ongoing economic, social crises. Objective To develop culture-specific SFBDGs Lebanon recommendations SHDs, integrating nutrition, factors. Methods The were formulated using diet optimization mathematical tool, Optimeal ® , which generates patterns resembling current while satisfying nutritional, cost, footprint (EFP) constraints. Data from the latest national consumption survey Lebanese adults served as reference pattern. Nutritional health constraints based on EAT-Lancet World Health Organization (WHO) Reference Intakes (DRIs). Cost maximized to match cost groups within pattern, EFP impact these groups. optimized was later translated into SFBDGs. Results Compared consumption, recommended increases in whole grains (+287%), dairy products (+61%), legumes (+50%), fish (+26%) reductions refined (−66%), red meat (−65%), poultry (−32%), added sugars fresh fruit juices (−12%). Diet led reduction calorie intake (−6%) EFPs, greenhouse gas emissions (−24%), energy use (−7%), water (−6%), maintaining cost. Conclusion developed resulting addressed sustainability providing scientific foundation policies SHDs that are affordable culture-specific, can mitigate insecurity malnutrition alleviate some country’s challenges.

Language: Английский

---

Combined Effects of Rhodiola Rosea and Caffeine Supplementation on Straight Punch Explosive Power in Untrained and Trained Boxing Volunteers: A Synergistic Approach

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 262 - 262

Published: April 10, 2025

This study aimed to investigate the effects of combined supplementation with Rhodiola rosea (RHO) and caffeine (CAF) on explosive power sustained output capacity lead rear straight punches in both untrained trained volunteers, a focus potential synergistic effects. randomized, double-blind, placebo-controlled design was employed, enrolling 96 participants (48 untrained, 48 trained). Participants were stratified randomly assigned control (CTR), CAF, RHO, or CAF+RHO group. All subjects completed an 8-week standardized boxing training program (twice per week). Punch performance assessed using professional equipment biomechanical testing system, evaluating punches, ground reaction force (GRF), 30 s continuous punching test. group showed significant improvements volunteers. Com-pared RHO group, this demonstrated higher punch velocity, shorter bi-lateral peak time during more test (p < 0.05). Compared CAF exhibited greater force, bilateral increased forefoot improved The also outperformed CTR across all parameters Combined supple mentation significantly enhances performance. may result from energy metabolism efficiency neuromuscular coordination, providing promising nutritional strategy for high-intensity intermittent exercise.

Language: Английский

---

The Relationship Between Diet Quality, Nutrition Self-Efficacy and Sources of Nutrition Information in Australian Pregnant Women: A Cross-Sectional Analysis

American Journal of Health Promotion, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Purpose To assess diet quality and nutrition self-efficacy in pregnant women, the relationship between self-efficacy, differences when information obtained from health non-health professionals. Design Observational cross-sectional study. Setting Online survey. Sample Australian women. Measures Eating Survey measured quality, Ralf Schwarzer Britta Renner scale self-efficacy. Analysis Spearman’s correlation association Linear regression examined influence of on quality. T-tests scores groups who did/did not obtain Results Participants (n = 171) (mean (SD) age 32.5 (3.9) years, 81.9% born Australia) reported a mean score 33.9 (8.7) out 73 14.7 (3.7) 20. A moderate positive linear was observed ( r s 0.27, P < .001). Nutrition by 88%, most commonly via internet. Diet were significantly different professionals t (24) −0.823, .32), however, higher U 856, z 2.18, .03). Conclusion Pregnant women report poor Improving may be effective for improving Evidence-based should accessible internet promoted authorities.

Language: Английский

---