Nanominerals Packaged in pH‐Responsive Alginate Microcapsules Exhibit Selective Delivery in Small Intestine and Enhanced Absorption and Bioavailability

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(46)

Published: Aug. 20, 2024

Abstract Mineral supplementation is crucial for human nutrition to facilitate appropriate growth, disease prevention, and improved reproductive health. The conventional forms of mineral involve an ionic form elements mixed with biomolecules; however, suffer from unfavorable reactions under acidic environment stomach, ROS generation, poor absorption in the small intestine. To address this, nanominerals (NMs) six essential are synthesized packed pH‐responsive microcapsule. Each NMs coated biomolecules that known rapidly absorb through intestinal epithelium. Microcapsules found intact at pH (pH: 2.0–6.5); selectively release ≥7.0. vitro study demonstrates mixture microcapsules biocompatible exhibits excellent scavenging ability physiological pH. Oral administration NMs‐loaded rats shows enhanced levels minerals, vitamin B12, hemoglobin, total antioxidant activity blood. liver, kidneys, spleen show expression Cu/Zn‐SOD Mn‐SOD enzymes due high bioavailability ZnO, Cu 2 O, MnO Thus, hold promise effectively stealth encapsulated nutrient materials stomach precisely deliver them

Language: Английский

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Causal Effect of Fatty Fish Consumption on Influenza: Evidence From Two-Sample Mendelian Randomization

Journal of Multidisciplinary Healthcare, Journal Year: 2025, Volume and Issue: Volume 18, P. 1123 - 1133

Published: Feb. 1, 2025

Influenza continues to pose a significant public health threat, with substantial morbidity and mortality worldwide. While vaccines antiviral treatments exist, the role of dietary factors, particularly fatty fish consumption, in modulating influenza susceptibility remains underexplored. Fatty fish, rich omega-3 polyunsaturated acids (PUFAs), is believed influence immune responses, but its specific impact on risk not fully understood. This study aims investigate causal relationship between consumption using two-sample Mendelian randomization (MR) approach. Genetic instruments for were derived from publicly available genome-wide association studies (GWAS). Summary-level data sourced largest GWAS available. A MR analysis was conducted inverse-variance weighted (IVW) MR-Egger methods assess effect risk. The revealed potential protective higher susceptibility. Genetically predicted intake associated reduced influenza, suggesting that PUFAs may help lower virus. Sensitivity analyses confirmed absence horizontal pleiotropy, supporting robustness results. provides evidence increased decreased influenza. These findings have implications recommendations strategies aimed at reducing burden. However, this has some limitations, such as gene-environment interactions predominantly European-based population, which limit generalizability. Future research should aim replicate these diverse populations further explore biological mechanisms linking

Language: Английский

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Pathological and Inflammatory Consequences of Aging

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 404 - 404

Published: March 12, 2025

Aging is a complex, progressive, and irreversible biological process that entails numerous structural functional changes in the organism. These affect all bodily systems, reducing their ability to respond adapt environment. Chronic inflammation one of key factors driving development age-related diseases, ultimately causing substantial decline abilities older individuals. This persistent inflammatory state (commonly known as “inflammaging”) characterized by elevated levels pro-inflammatory cytokines, an increase oxidative stress, perturbation immune homeostasis. Several factors, including cellular senescence, contribute this milieu, thereby amplifying conditions such cardiovascular disease, neurodegeneration, metabolic disorders. Exploring mechanisms chronic aging essential for developing targeted interventions aimed at promoting healthy aging. review explains strong connection between inflammation, highlighting potential therapeutic approaches like pharmacological treatments, dietary strategies, lifestyle changes.

Language: Английский

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Supramolecular Self-Assembled Hydrogel for Antiviral Therapy through Glycyrrhizic Acid-Enhanced Zinc Absorption and Intracellular Accumulation

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(44), P. 60027 - 60044

Published: Oct. 28, 2024

Respiratory syncytial virus (RSV) is a common pathogen that causes respiratory infections in infants and children worldwide, significantly impacting hospitalization rates this age group. Zinc ions are considered to have broad-spectrum antiviral potential against RNA viruses, including RSV. However, poor organism absorption low intracellular accumulation of zinc require repeated high-dose supplementation, which may lead unnecessary toxic side effects. In research, Zn2+-mediated glycyrrhizinic acid (GA)-based hydrogel (ZnGA Gel) was introduced potentially developed be clinically available drug candidate for RSV therapy. ZnGA Gel fabricated based on the cooperation two inhibiting molecules (Zn2+ GA), where Zn2+ promoted self-assembly GA reduced its gel concentration distribution lung tissue vivo. The facile construction supramolecular by self-assembled coordination complex made it an injectable, temperature-sensitive, pH-responsive controlled-release delivery Zn2+. Most importantly, observed enhance identified as ionophore first time. can colonize cell membrane disturb potential, resulting enhanced permeability. presence GA, more than 4.7-fold increasing concentrations materialized cytoplasm, compared alone administration. This directly boosted activities through improved inhibition replication-associated proteins inhibited replication. Oral administration RSV-infected mice model achieved ideal therapeutic effect effectively lowering viral load lungs, alleviating injury symptoms, reducing inflammatory infiltration at pathological sites. mechanism involved replication-related proteins, aligning with our vitro results. Additionally, had demonstrated biocompatibility, reasonable supplementation acceptable effective clinical practice. Hence, us holds promise anti-RSV medicine future.

Language: Английский

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Malnutrition and the Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Multi-Institutional Population-Based Propensity Score-Matched Analysis

Life, Journal Year: 2024, Volume and Issue: 14(6), P. 746 - 746

Published: June 12, 2024

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a global health crisis, exacerbating issues like malnutrition due increased metabolic demands and reduced intake during illness. Malnutrition, significant risk factor, is linked worse outcomes in patients with COVID-19, such as mortality extended hospital stays. This retrospective cohort study investigated the relationship between clinical within 90–180 days using data obtained from TriNetX database. Patients aged >18 years diagnosed COVID-19 1 January 2022, 31 March 2024 were enrolled study. The propensity score-matching (PSM) method was used match (malnutrition group) those without (control group). primary composite outcome cumulative hazard ratio (HR) for post-COVID-19 condition, all-cause hospitalization, 90 180 after diagnosis. secondary individual components of outcomes. Two cohorts, each consisting 15,004 balanced baseline characteristics, identified PSM. During 90–180-day follow-up period, group exhibited higher incidence mortality, or condition (HR = 2.315, 95% confidence interval: 2.170–2.471, p < 0.0001). Compared malnutrition, may be associated adverse

Language: Английский

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Dissolved trace elements in the upper reaches of Lancang River, southeast Qinghai-Tibet Plateau: Current status and distribution, risk and source

Environmental Research, Journal Year: 2024, Volume and Issue: 260, P. 119749 - 119749

Published: Aug. 8, 2024

Language: Английский

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Strategies and bibliometric analysis of legumes biofortification to address malnutrition

Planta, Journal Year: 2024, Volume and Issue: 260(4)

Published: Sept. 4, 2024

Language: Английский

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Alterations of Nutrient Elements in Hepatocellular Carcinoma Patients Treated with Atezolizumab-Bevacizumab

Nutrition and Cancer, Journal Year: 2024, Volume and Issue: 77(2), P. 244 - 251

Published: Oct. 14, 2024

Currently, the combination of atezolizumab and bevacizumab (Atez/Bev) is recommended as first-line therapy for patients with advanced hepatocellular carcinoma (HCC). However, there a lack research on levels nutrient elements in HCC receiving Atez/Bev treatment. In this study, data from 35 37 healthy individuals similar age sex were included. The alanine aminotransferase, aspartate alkaline phosphatase significantly increased HCC. These returned to reference range after three rounds Additionally, blood urea nitrogen creatinine (Cr) patients, calcium (Ca), iron (Fe), copper (Cu) higher, while sodium (Na), magnesium (Mg), zinc (Zn) lower compared individuals. changes reversed conclusion, our findings indicate that treatment influences Ca, Fe, Cu, Na, Mg, Zn alterations these caused by require mechanistic future.

Language: Английский

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