JNCI Journal of the National Cancer Institute, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 10, 2024
Language: Английский
Obesity Research & Clinical Practice, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
1
Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 965 - 965
Published: March 10, 2025
With the prevalence of obesity and overweight increasing at an alarming rate, more researchers are focused on identifying effective weight loss strategies. The ketogenic diet (KD), used as a treatment in epilepsy management for over 100 years, is additionally gaining popularity method. Although its efficacy well documented, areas where it may be beneficial to other dietary approaches need carefully examined. objective this paper identify potential benefits KD alternative strategies based comprehensive literature review. It has been shown that bioenergetically efficient than strategies, inter alia owing effect curtailing hunger, improving satiety decreasing appetite (influence hunger hormones sensation hunger), inducing faster initial (associated with lower glycogen levels reduced water retention), controlling glycaemia insulinemia (directly attributable low-carbohydrate nature indirectly described). These effects accompanied by improved insulin sensitivity, inflammation (through ketone bodies avoidance pro-inflammatory sugars), pharmacological control (the diet’s mechanisms similar those medication but without side effects), positive impacts psychological factors food addiction. Based authors’ review latest research, reasonable conclude that, due these many additional health benefits, advantageous diet-based This important hypothesis deserves further exploration, which could achieved including outcome measures future clinical trials, especially when comparing different diets equal caloric value.
Language: Английский
Citations
1
Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 16, 2025
Abstract Aim To explore the effects of sex and baseline body mass index (BMI) on efficacy safety survodutide in people with a BMI ≥27 kg/m 2 . Materials Methods Totally 387 (aged 18–75 years, , without diabetes) were randomized 1:1:1:1:1 to once‐weekly subcutaneous (0.6, 2.4, 3.6 or 4.8 mg) placebo for 46 weeks (20‐week dose escalation; 26‐week maintenance). Participants categorized according BMI. Data analysed descriptively full analysis set (FAS), assigned at randomization (planned treatment) using on‐treatment data all censored COVID‐19‐related treatment discontinuations. ( ClinicalTrials.gov number: NCT04667377). Results After treatment, females had greater reductions bodyweight waist circumference than males. lower proportional those higher BMI; trend was reversed circumference. Rates adverse events (AEs) comparable between subgroups Nausea most frequently reported gastrointestinal AE subgroups. Conclusions In associated clinically meaningful when compared placebo, prespecified based BMI, tolerated doses tested.
Language: Английский
Citations
0
Annals of Pharmacotherapy, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Objective: To summarize the current knowledge on therapeutic potential of GLP-1 receptor agonists in managing metabolic associated steatotic liver disease (MASLD). Data Sources: A literature review was conducted using search terms , MASLD NAFLD nonalcoholic fatty treatment and therapy PubMed (from January 1, 2019, through February 2025), National Institutes Health (NIH) Scopus World Organization (WHO) data. Study Selection Extraction: All relevant clinical trials, articles, package inserts, guidelines evaluating clinically evidence regarding were considered for inclusion. Synthesis: RAs have shown promising results treatment. Semaglutide has demonstrated efficacy reducing fat content, inflammation, fibrosis, with trials indicating improvements hepatic biomarkers cardiometabolic risk factors. Similarly, tirzepatide been substantial weight loss significant reductions fibrosis markers. Both agents exert their effects mechanisms involving improved insulin sensitivity, reduced lipid accumulation, attenuation inflammation. Relevance to Patient Care Clinical Practice: Given high prevalence patients obesity type 2 diabetes, semaglutide could play a critical role practice by addressing multiple facets disease. fat, improving biomarkers, mitigating risks, which are leading causes morbidity mortality patients. Incorporating these therapies into significantly enhance patient outcomes targeting both liver-related systemic complications Conclusions: GLP1 show great promoting loss, glycemic control,
Language: Английский
Citations
0
Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(3), P. 238 - 243
Published: March 18, 2025
Background: This study compares the effectiveness of metformin (MET) monotherapy versus a combination MET and liraglutide (LIRA) in managing metabolic syndrome overweight women with polycystic ovary (PCOS), focusing on weight reduction body mass index (BMI). Methods: A prospective cohort was conducted at Lady Dufferin Hospital, Karachi from April 2024 to Oct 2024, involving 70 aged 18–40 years, diagnosed PCOS based Rotterdam criteria, having BMI ≥ 27.5 kg/m². Participants were randomly assigned into two groups: Group received (1500 mg/day), B mg/day) plus LIRA (1.2 for 12 weeks. Baseline post-treatment outcomes, including weight, BMI, waist circumference, lipid profiles, analyzed. Results: Both treatment regimens significantly improved parameters. demonstrated superior results an average loss 10.30 ± 1.30 kg 3.72 0.67, compared A’s 5.99 2.87 2.24 1.07 (p < 0.001). Improvements triglyceride levels, HDL cholesterol, circumference more pronounced B. However, no significant changes hypertension parameters observed either group. Conclusion: The is effective than patients. dual therapy offers enhanced benefits, potentially improving both reproductive overall health. Further long-term, multicenter studies are warranted explore its broader impacts sustainability.
Language: Английский
Citations
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Diabetes Metabolic Syndrome and Obesity, Journal Year: 2025, Volume and Issue: Volume 18, P. 805 - 818
Published: March 1, 2025
Proteomics was used to study the effect of semaglutide on expression renal protein in obese mice, and looking for proteins that could improve prognosis Kidney Renal Clear Cell Carcinoma (KIRC). Thirty-six mice were randomly divided into normal-fat diet group (NFD), high-fat (HFD), plus intervention (HS). Collected serum, urine, kidney tissue samples, detected urinary protein/creatinine, blood glucose, lipid, inflammation, oxidative stress other related indicators. Different staining methods analyze pathological changes mice's kidneys. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis total kidneys mice. Finally, bioinformatics technology significantly different expressed (DEPs). The mechanism protecting phosphorylation, PPAR signaling pathway, thiamine, butyric acid tryptophan metabolism pathways. Moreover, increase Man1a1 Ntn4 while high-expression KIRC population had a better overall survival rate. Semaglutide regulate development by up-adjusting Ntn4.
Language: Английский
Citations
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Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)
Published: April 16, 2025
Abstract Fibromyalgia (FM) is a pain disorder characterized by pervasive musculoskeletal associated with exhaustion, depression, and irregular sleep patterns. Semaglutide, an innovative glucagon-like peptide-1 (GLP-1) agonist, has shown analgesic effects modulating hypersensitivity in animal models of inflammatory pain. The objective this study to ascertain semaglutide's therapeutic potential against FM-like symptoms caused reserpine. Reserpine (1 mg/kg/day; SC) was administered into rats for 3 consecutive days, then they were treated daily semaglutide intraperitoneally low (5 nmol/kg), intermediate (10 or high doses (20 respectively, 14 days. Semaglutide alleviated reserpine induced histopathological immunohistopathological changes spinal cord evidenced remarkable rise immuno-expression cluster differentiation 163 (CD163) contrary significant diminution CD86 level as compared group. also had effect improved motor incoordination, depression brought on Furthermore, it anti-inflammatory impact via stimulating cyclic adenosine monophosphate (cAMP)/ protein kinase A (PKA)/ cAMP response element (CRE)-binding (CREB) signaling pathway shifting M1/M2 macrophage polarization towards the M2. Semaglutide's actions manifested through inhibition inducible nitric oxide synthase reduction dorsal root ganglia concentrations tumor necrosis factor-α together elevation levels arginase-1 interleukin-4. Graphical
Language: Английский
Citations
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THE MIND - Bulletin on Mind-Body Medicine Research, Journal Year: 2024, Volume and Issue: 3
Published: Dec. 12, 2024
Conclusion:A Charité MBM course has shown beneficial effects to reduce perceived negative stress, increase self-awareness, mindfulness and empathy as well promote integrative concepts of doctor-patient relationship.Further research including RCT trials are needed validate the benefits courses for medical students in a larger study population
Language: Английский
Citations
1
Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(12), P. 14514 - 14541
Published: Dec. 23, 2024
Initially intended to control blood glucose levels in patients with type 2 diabetes, semaglutide, a potent glucagon-like peptide 1 analogue, has been established as an effective weight loss treatment by controlling appetite. Integrating the latest clinical trials, semaglutide or without diabetes presents significant therapeutic efficacy ameliorating cardiometabolic risk factors and physical functioning, independent of body reduction. Semaglutide may modulate adipose tissue browning, which enhances human metabolism exhibits possible benefits skeletal muscle degeneration, accelerated obesity ageing. This be attributed anti-inflammatory, mitochondrial biogenesis, antioxidant autophagy-regulating effects. However, most supporting evidence on mechanistic actions is preclinical, demonstrated rodents not actually confirmed humans, therefore warranting caution interpretation. article aims explore potential innovative molecular mechanisms action restoring balance several interlinking aspects metabolism, pointing distinct functions inflammation oxidative stress insulin-sensitive musculoskeletal tissues. Moreover, applications protection from infections anti-aging properties are discussed. enhancement core involved progress although mostly provide framework for future research diseases overall.
Language: Английский
Citations
1
Cancers, Journal Year: 2024, Volume and Issue: 17(1), P. 78 - 78
Published: Dec. 30, 2024
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstrated significant efficacy in obesity treatment beyond their original development for type-2 diabetes management. This comprehensive study investigated the relationship between GLP-1RA use and cancer incidence individuals with across a 5-year follow-up period. Methods: We conducted large-scale cohort using TriNetX US Collaborative Network database (2013–2023) examining adult patients obesity. The utilized propensity score matching to pair GLP-1RA-treated controls (1:1) nearest neighbor method. Cancer served as primary outcome measure over follow-up, subgroup analyses considering individual agents, patient sex, BMI categories. Results: Analysis revealed cancer-risk reductions associated multiple types compared matched controls. Notable risk were observed gastrointestinal (HR 0.67, 95% CI 0.59–0.75), skin 0.62, 0.55–0.70), breast 0.72, 0.64–0.82), female genital 0.61, 0.53–0.71), prostate 0.68, 0.58–0.80), lymphoid/hematopoietic cancers 0.69, 0.60–0.80). Semaglutide superior protective effects, particularly 0.45, 0.37–0.53). Conversely, liraglutide showed increased risks thyroid 1.70, 1.03–2.82) respiratory 1.62, 1.13–2.32). Conclusions: research provides compelling evidence GLP-1RA’s potential role reduction, semaglutide showing promising results. differential effects among agents emphasize importance of personalized medicine approaches. These findings suggest implications clinical practice future both management prevention.
Language: Английский
Citations
1