Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 24, 2025
Polyphenols,
naturally
occurring
phytonutrients
found
in
plant-based
foods,
have
attracted
significant
attention
for
their
potential
therapeutic
effects
neurological
diseases
and
neuroinflammation.
These
compounds
possess
diverse
neuroprotective
capabilities,
including
antioxidant,
anti-inflammatory,
anti-amyloid
properties,
which
contribute
to
mitigating
the
progression
of
neurodegenerative
conditions
such
as
Alzheimer's
Disease
(AD),
Parkinson's
(PD),
Dementia,
Multiple
Sclerosis
(MS),
Stroke,
Huntington's
(HD).
Polyphenols
been
extensively
studied
ability
regulate
inflammatory
responses
by
modulating
activity
pro-inflammatory
genes
influencing
signal
transduction
pathways,
thereby
reducing
neuroinflammation
neuronal
death.
Additionally,
polyphenols
shown
promise
various
cellular
signaling
pathways
associated
with
viability,
synaptic
plasticity,
cognitive
function.
Epidemiological
clinical
studies
highlight
polyphenol-rich
diets
decrease
risk
alleviate
symptoms
disorders
Furthermore,
demonstrated
through
regulation
key
Akt,
Nrf2,
STAT,
MAPK,
play
critical
roles
neuroprotection
body's
immune
response.
This
review
emphasizes
growing
body
evidence
supporting
combating
neurodegeneration
neuroinflammation,
well
enhancing
brain
health.
Despite
substantial
promising
hypotheses,
further
research
investigations
are
necessary
fully
understand
role
establish
them
advanced
targets
age-related
neuroinflammatory
conditions.
Language: Английский
Interaction of starch nanoparticles with digestive enzymes and its effect on the release of polyphenols in simulated gastrointestinal fluids
Food Chemistry,
Journal Year:
2025,
Volume and Issue:
472, P. 142883 - 142883
Published: Jan. 11, 2025
Language: Английский
Exploring the Mechanism of β-Cyclodextrin-Encased Phenolic Acids Functionalized with TPP for Antioxidant Activity and Targeting
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(4), P. 465 - 465
Published: April 13, 2025
Oxidative
stress
on
the
mitochondria
in
a
human
cell
is
attributed
to
several
life-risking
conditions,
and
as
such,
importance
of
molecular
structures
packed
with
antioxidant
properties
structural
characteristics
enter
help
prevent
such
has
been
substantially
relevant
recent
years.
In
this
study,
we
investigated
triphenylphosphonium
(TPP)-conjugated
phenolic
acids
encapsulated
β-cyclodextrin
(β-CD).
We
synthesized
TPP
conjugates
caffeic,
coumaric,
cinnamic
formed
inclusion
complexes
β-CD.
Our
results
showed
successful
encapsulation
β-CD
high
efficiency.
The
maintained
activity,
slight
reductions
observed
complexes.
Furthermore,
viability
studies
low
cytotoxicity
dds.
Computational
analyses
revealed
that
conjugation
preserved
chemical
reactivity
acids.
Molecular
dynamics
simulations
demonstrated
stable
free
energy
calculations
indicated
significantly
enhanced
ability
caffeic
acid
translocate
across
mitochondrial
membranes.
These
highlight
potential
TPP-conjugated
effective
antioxidants
improved
targeting
capabilities.
Language: Английский