Association between Life’s Crucial 9 and overactive bladder: the mediating role of weight-adjusted-waist index

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 6, 2025

Research suggests a potential connection between cardiovascular health, obesity, and overactive bladder (OAB). However, the mechanisms by which obesity influences relationship health OAB remain unclear. Life's Crucial 9 (LC9) is recently proposed method for assessing while weight-adjusted waist index (WWI) novel more accurate measure of obesity. This study investigates LC9 assesses whether WWI moderates this relationship. Data came from National Health Nutrition Examination Survey (NHANES). We used subgroup analyses, restricted cubic spline curves (RCS), multivariate logistic regression to explore OAB. Additionally, mediation analysis was conducted investigate association levels A total 25,319 participants were included in study, among 5,038 reported incidents After adjusting all variables using multivariable regression, an increase 10 units associated with 28% reduction incidence (OR = 0.72, 95% CI: 0.69, 0.76), one unit 40% 1.40, 1.29, 1.51). Consistent results also observed when categorized into quartiles, P trend <0.001. The splines indicated linear negative correlation LC9. Mediation revealed that 13.89% mediated (p 0.002). found significant OAB, acting as partial mediator provides new insights future research role mediator.

Language: Английский

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Association of non-highdensity lipoprotein cholesterol to highdensity lipoprotein cholesterol ratio (NHHR) and subsequent hypertension and heart diseases: findings from the CHARLS cohort

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: Jan. 21, 2025

Abstract Purpose NHHR, the ratio of non-high-density lipoprotein cholesterol to high-density cholesterol, is a novel lipid marker associated with risk heart diseases and various health conditions. However, there limited evidence regarding relationship between NHHR onset hypertension diseases. The aim this study was investigate association new-onset among Chinese middle-aged older general population. Methods This prospective cohort utilized data from nationally representative sample residents aged 45 older, sourced China Health Retirement Longitudinal Study (CHARLS). primary outcomes were To diseases, multivariate logistic regression models restricted cubic spline (RCS) method employed. Additionally, mediating effects on assessed using bootstrap method. Results A total 5349 participants included in final analysis three groups identified, including low-stable, medium-stable, high-stable NHHR. By 2020, 1,631 (30.5%) had been newly diagnosed hypertension, while 1233 (23.1%) developed Compared those low-stable individuals other two showed significantly increased developing findings remained consistent across sensitivity analyses. According RCS analysis, partial U-shaped existed (P for nonlinear < 0.001). Furthermore, found partially mediate Conclusion closely an In addition, mediated development by promoting progression. prevention treatment managing both levels blood pressure crucial.

Language: Английский

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The association between Planetary Health Diet Index (PHDI) and chronic obstructive pulmonary disease (COPD): the mediating role of dietary inflammatory index (DII)

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 31, 2025

Given global changes in the environment and dietary habits, it is critical to understand potential impact of factors inflammation on respiratory diseases, including COPD. Studying these relationships can help develop more effective prevention strategies. PHDI a scoring system designed balance human health environmental sustainability by promoting increased consumption plant-based foods reduced intake red meat, sugar, highly processed foods. In contrast, DII quantifies inflammatory diet. This study examines association between COPD assesses whether mediates this relationship. We used subgroup analysis, smooth curve fitting, multivariable logistic regression investigate connection occurrence Furthermore, mediation analysis was carried out any possible correlation link 30,304 participants were included investigation, 1,498 them reported events. For every 10-point increase each unit associated with 9% reduction (OR = 0.91, 95% CI: 0.86, 0.97) an 8% 1.08, 1.02, 1.13) prevalence COPD, respectively, when all variables adjusted for using regression. Additionally, results remain robust are converted tertile. An investigation fitting showed linear risk PHDI. The that 17.95% relationship mediated (p 0.034). Higher levels lower appears mediate relationship, suggesting anti-inflammatory diet may provide benefits.

Language: Английский

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Associations between ultra-processed foods intake and preserved ratio impaired spirometry in U.S. adults

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 31, 2025

Preserved Ratio Impaired Spirometry (PRISm) is increasingly recognized as a precursor to Chronic Obstructive Pulmonary Disease (COPD). The impact of Ultra-Processed Foods (UPFs) intake on PRISm and lung function remains underexplored, we aimed explore their associations. This study included 8,336 U.S. adults. Weighted logistic linear regression models were employed for main analysis. Dose-response relationship was examined through restricted cubic spline (RCS) analysis, subgroup analyses explored interactions with selected covariates. Participants in the group older exhibited various adverse health characteristics. percentage total daily energy from UPFs (%Kcal) associated non-significant increase risk (OR 1.67, 95% CI: 0.96-2.92, p = 0.07). However, highest quartile significantly linked increased 1.36, 0.99-1.86, P trend 0.043). Furthermore, higher negatively affected function, participants showing significant reduction forced expiratory volume 1 s (FEV1) -45.5 mL (95% -87.6 -3.4, 0.045) decrease vital capacity (FVC) -139.4 -223.5 -55.4, < 0.001) compared those lowest quartile. RCS analysis demonstrated relationships both function. Subgroup revealed susceptibility primarily among individuals occupational exposure. Additionally, sensitivity indicated that (%Grams) an 1.86, 1.07-3.25, 0.03). Higher affects particularly

Language: Английский

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Atherogenic Index of Plasma mediates the association between Life’s Crucial 9 with overactive bladder: a secondary data analysis from NHANES

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Background Some studies suggest a potential link between cardiovascular health, lipid, and overactive bladder (OAB). Life’s Crucial 9 (LC9) is recently developed method for assessing while the Atherogenic Index of Plasma (AIP) represents novel marker atherosclerotic lipid profiles. However, relationship role in unclear. This study investigates evaluates whether influences this association. Methods conducted cross-sectional analysis 25,628 U.S. participants NHANES database from 2005-2018. Firstly, we used multivariate logistic regression to investigate bladder. Subsequently, subgroup restricted cubic splines (RCS) were further verify their relationship. Additionally, mediation was explore levels association Results A total included study, among whom 5,150 reported events. After using adjust age, sex, race, marital status, education level, poverty-to-income ratio (PIR), smoking, alcohol consumption, hypertension, diabetes, hypercholesterolemia, 10-unit increase associated with 28% reduction incidence (OR = 0.72, 95% CI: 0.69-0.76), 1-unit 7% 1.07, 1.01-1.14). Similar results obtained when categorized into tertiles, significant trend (P &lt; 0.05). Restricted spline revealed linear negative correlation incidence. Mediation indicated that 6.49% mediated by 0.014). Conclusion found bladder, partially mediating These findings highlight health underscoring reducing incidence, possibly through its effects on lowering levels.

Language: Английский

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Systemic inflammation partially mediates the association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and chronic cough

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 6, 2025

Non-high-density lipoprotein cholesterol to high-density ratio (NHHR), a new biomarker, reflects blood lipid status. Nevertheless, the association between NHHR and chronic cough remains uncertain. This investigation included 9725 individuals from NHANES. research employed multiple statistical models illustrate cough. These logistic regression models, Shapley Additive Explanations (SHAP) model, trend tests, mediation analysis, restricted cubic splines (RCS), subgroup analyses. The adjusting all covariables, showed positive with (OR: 1.08; 95% CI: 1.02-1.14). Trend tests RCS further proved that had linear association. analysis systemic immune inflammation index (SII) inflammatory response (SIRI) partially mediated SHAP model suggested top five important markers for predicting were SII, smoking, NHHR, BMI, SIRI. discovered was positively associated Regular monitoring may serve as potential tool identifying at higher risk of

Language: Английский

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Association between body roundness index and sleep disorder: the mediating role of depression

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 7, 2025

Several studies have indicated a potential association between obesity, depression, and sleep disorders. However, the role of depression in mediating relationship obesity disorders remains unclear. The Body Roundness Index (BRI), more precise anthropometric measure than traditional body mass index (BMI), is particularly effective assessing visceral fat levels. This study examines BRI disorders, with focus on whether influences this association. included data from 32,504 participants National Health Nutrition Examination Survey (NHANES) 2005–2018 cycle. was examined through subgroup analysis, restricted cubic spline (RCS) modeling, threshold effect multivariable logistic regression. Furthermore, predictive capabilities various indices—including BRI, weight-adjusted waist (WWI), BMI, weight—on disorder incidence were assessed using Receiver Operating Characteristic (ROC) curve analysis. Finally, Mediation analysis also performed to explore relationship. participants, whom 4,568 reported After adjusting for all covariates regression, each one-unit increase associated 13% higher prevalence (OR = 1.13, 95% CI: 1.09, 1.16) an 8% 1.08, 1.05, 1.11). Similar results obtained when divided into tertiles, significant trend (P < 0.05). RCS analyses revealed nonlinear prevalence, breakpoint 3.508. ROC that had superior capability compared indices, area under (AUC) 0.637 (95% CI, 0.628–0.645, P 0.001). further 14% mediated by Elevated levels linked acting as partial mediator These findings emphasize connection highlighting importance managing mitigate risk Not applicable.

Language: Английский

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Mediating role of the ratio of family income to poverty in the association between depressive symptoms and stroke: Evidence from a large population-based study

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Association of the dietary index for gut microbiota with sleep disorder among US adults: the mediation effect of dietary inflammation index

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 17, 2025

Previous studies have confirmed the relationship between gut microbiota and sleep disorders, characterized by persistent inability to achieve adequate sleep, with dietary composition playing a key role in maintaining homeostasis. Our study aims explore newly proposed Dietary Index for Gut Microbiota (DI-GM) as well whether Inflammatory (DII) mediates this relationship. This is based on data from 30,406 participants National Health Nutrition Examination Survey (NHANES) 2005 2018, cross-sectional survey that represents U.S. adult population. We used multivariable logistic regression models examine DI-GM disorders. Subgroup interaction analyses were conducted assess stability of results. Mediation analysis was employed effect The score significantly negatively correlated After adjusting covariates, each unit increase associated 5% reduction prevalence disorders (p < 0.001). Additionally, there trend toward decrease increasing (trend p 0.05). Dose-response curve revealed linear higher scores being lower DII positively 0.001) decreased increased (β = -0.37, showed mediated mediation proportion 27.36% results indicate A incidence while Specifically, an may attenuate protective

Language: Английский

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The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and pulmonary function: evidence from NHANES 2007–2012

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 19, 2025

Background This research aims to explore the potential association between lung function and ratio of non-high-density lipoprotein cholesterol (NHL) high-density (NHHR). Previous has shown that lipid metabolism imbalance is closely linked cardiovascular disease, however, there a lack information regarding its impact on function. Methods used from National Health Nutrition Examination Survey (NHANES) spanning years 2007 2012, including large-scale sample 9,498 adults aged 20 older. A cross-sectional study employing multivariable regression models was aimed at examining relevance NHHR indicators (FEV1, FVC, FEV1/FVC). Adjustments were made for wide range confounding factors, encompassing race, gender, age, BMI, smoking status, physical activity, diabetes, alcohol consumption, education level. Data analysis included categorizing into quartiles using trend tests evaluate dose–response relationships Sensitivity analyses conducted by excluding participants with asthma COPD ensure reliability results. Results The results manifested significant correlation decreased FEV1 FVC values elevated NHHR, most notably within highest quartile (Q4), where pronounced. Additionally, test indicated linear negative both FVC. However, FEV1/FVC showed nonlinear U-shaped pattern. Suggesting differential impacts various indicators. findings’ robustness sensitivity analysis, which revealed even after omitting people COPD, remained significant. Conclusion emphasizes significance tracking levels in evaluating respiratory health offers early evidence favor as probable biomarker Further longitudinal occasion prove causal relationship underlying biological mechanisms.

Language: Английский

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