Ferroptosis, from the virus point of view: opportunities and challenges DOI
Xia Zhao, Yan Zhang, Bing Luo

et al.

Critical Reviews in Microbiology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: April 8, 2024

Ferroptosis is a new type of cell death, which mainly dependent on the formation and accumulation reactive oxygen species lipid peroxides mediated by iron. It distinct from other forms regulation death in morphology, immunology, biochemistry, molecular biology. Various mechanisms have been observed many viral infections, virus-induced has long considered as double-edged sword that can inhibit or aggravate infections. However, understanding role ferroptosis various infections limited. Special attention will be paid to mediating infection antiviral treatment associated with ferroptosis. In this paper, we outlined mechanism Additionally, paper also review research perspective virus, discussed status virus classified summarized interaction between

Language: Английский

Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases DOI Open Access
Ying Liu, Wei Ding, Jianxun Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114993 - 114993

Published: June 9, 2023

Cardiovascular disease (CVD) is a major contributor to increasing morbidity and mortality worldwide seriously threatens human health life. Cardiomyocyte death considered the pathological basis of various CVDs, including myocardial infarction, heart failure, aortic dissection. Multiple mechanisms, such as ferroptosis, necrosis, apoptosis, contribute cardiomyocyte death. Among them, ferroptosis an iron-dependent form programmed cell that plays vital role in physiological processes, from development aging immunity CVD. The dysregulation has been shown be closely associated with CVD progression, yet its underlying mechanisms are still not fully understood. In recent years, growing amount evidence suggests non-coding RNAs (ncRNAs), particularly microRNAs, long RNAs, circular involved regulation thus affecting progression. Some ncRNAs also exhibit potential value biomarker and/or therapeutic target for patients this review, we systematically summarize findings on their We focus clinical applications diagnostic prognostic biomarkers well targets treatment. DATA AVAILABILITY: No new data were created or analyzed study. Data sharing applicable article.

Language: Английский

Citations

53
Ferroptosis in colorectal cancer: a future target? DOI
Hong Yan, Ronan Talty, Oladimeji Aladelokun

et al.

British Journal of Cancer, Journal Year: 2023, Volume and Issue: 128(8), P. 1439 - 1451

Published: Jan. 26, 2023

Language: Английский

Citations

51
Metabolic Signature of Warburg Effect in Cancer: An Effective and Obligatory Interplay between Nutrient Transporters and Catabolic/Anabolic Pathways to Promote Tumor Growth DOI Open Access

Marilyn Mathew,

Nhi Nguyen, Yangzom D. Bhutia

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 504 - 504

Published: Jan. 24, 2024

Aerobic glycolysis in cancer cells, originally observed by Warburg 100 years ago, which involves the production of lactate as end product glucose breakdown even presence adequate oxygen, is foundation for current interest cancer-cell-specific reprograming metabolic pathways. The renewed cell metabolism has now gone well beyond original effect related to other pathways that include amino acid metabolism, one-carbon pentose phosphate pathway, nucleotide synthesis, antioxidant machinery, etc. Since and acids constitute primary nutrients fuel altered transporters mediate transfer these their metabolites not only across plasma membrane but also mitochondrial lysosomal membranes have become an integral component expansion effect. In this review, we focus on interplay between facilitates reprogramming, a hallmark cells. beneficial outcome recent understanding unique signature surrounding identification novel drug targets development new generation therapeutics treat cancer.

Language: Английский

Citations

25
The Role of Iron in Cancer Progression DOI Creative Commons

Qianqian Guo,

Liwen Li,

Shanshan Hou

et al.

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: Nov. 10, 2021

Iron is an essential trace element for the human body, and its deficiency or excess can induce a variety of biological processes. Plenty evidences have shown that iron metabolism closely related to occurrence development tumors. In addition, plays important role in cell death, which very potential strategies tumor treatment. Here, we reviewed latest research about disorders various types tumors, functions properties ferroptosis ferritinophagy, new opportunities iron-based on treatment methods providing more information regarding prevention

Language: Английский

Citations

96
Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression DOI

Shiyao Sui,

Shouping Xu, Da Pang

et al.

Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 232, P. 107992 - 107992

Published: Oct. 1, 2021

Language: Английский

Citations

85
The calcium–iron connection in ferroptosis-mediated neuronal death DOI
Silvia Gleitze, Andrea Paula-Lima, Marco T. Núñez

et al.

Free Radical Biology and Medicine, Journal Year: 2021, Volume and Issue: 175, P. 28 - 41

Published: Aug. 27, 2021

Language: Английский

Citations

66
Ferroptosis and Its Multifaceted Role in Cancer: Mechanisms and Therapeutic Approach DOI Creative Commons

Heshu Chen,

Chenyu Wang, Zemin Liu

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1504 - 1504

Published: July 31, 2022

Ferroptosis, a new type of non-apoptotic cell death modality, is different from other modes and has been primarily found in tumor cells. Previous studies have reported that ferroptosis can be triggered by specific modulators (e.g., drugs, nutrients, iron chelators), leading to increased intracellular lipid reactive oxygen species (ROS) accumulation overload. Recent reports shown at the cellular organism levels prevent an inflammatory storm cancer development. Emerging evidence suggests potential mechanisms system Xc-, glutathione peroxidase 4 (GPX4), peroxidation, (GSH), chelators) are involved ferroptosis, which may mediate biological processes such as oxidative stress overload treat cancer. To date, there least three pathways cells: Xc-/GSH/GPX4, FSP1/CoQ10/NAD(P)H, ATG5/ATG7/NCOA4. Here, we summarize recent advances occurrence development context cancer, associations between various modulators, therapeutic strategies targeting for treatment

Language: Английский

Citations

59
The mechanisms of ferroptosis and its role in alzheimer’s disease DOI Creative Commons

MA Hong-yue,

Yan Dong,

Yanhui Chu

et al.

Frontiers in Molecular Biosciences, Journal Year: 2022, Volume and Issue: 9

Published: Aug. 26, 2022

Alzheimer's disease (AD) accounts for two-thirds of all dementia cases, affecting 50 million people worldwide. Only four the more than 100 AD drugs developed thus far have successfully improved symptoms. Furthermore, these improvements are only temporary, as no treatment can stop or reverse progression. A growing number recent studies demonstrated that iron-dependent programmed cell death, known ferroptosis, contributes to AD-mediated nerve death. The ferroptosis pathways within cells include iron homeostasis regulation, cystine/glutamate (Glu) transporter (system xc-), glutathione (GSH)/glutathione peroxidase 4 (GPX4), and lipid peroxidation. In regulation pathway homeostasis, abnormal uptake, excretion storage in lead increased intracellular free Fenton reactions. decreased Glu expression leads accumulation outside cells, resulting inhibition system xc- pathway. GSH depletion causes abnormalities GPX4, leading excessive peroxides. Alterations specific amino acid metabolism eventually ferroptosis. This review explores connection between signaling metabolism, potentially informing future diagnosis methodologies.

Language: Английский

Citations

59
Sanguinarine Represses the Growth and Metastasis of Non-small Cell Lung Cancer by Facilitating Ferroptosis DOI
Rongzhong Xu, Jianchun Wu, Yingbin Luo

et al.

Current Pharmaceutical Design, Journal Year: 2022, Volume and Issue: 28(9), P. 760 - 768

Published: Feb. 18, 2022

Ethnopharmacological relevance: Sanguinarine (SAG), a natural benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis Linn. (Bloodroot), possesses potential anticancer activity. Lung carcinoma is chief cause malignancy-related mortality in China. Non-small cell lung (NSCLC) main subtype and accounts for about eighty-five percent this disease. Current treatment controlling curing NSCLC remains deficient.The role underlying mechanism SAG repressing growth metastasis were explored.The regulating proliferation invasion cells was evaluated vitro xenograft model. After with SAG, Fe2+ concentration, reactive oxygen species (ROS) levels, malondialdehyde (MDA), glutathione (GSH) content assessed to evaluate effect on facilitating ferroptosis.SAG exhibited dose- time-dependent cytotoxicity A549 H3122 cells. effectively repressed We, first time, verified that triggered ferroptosis cells, as evidenced by increased ROS level, MDA content, decreased GSH content. Mechanistically, protein stability peroxide 4 (GPX4) through E3 ligase STUB1-mediated ubiquitination degradation endogenous GPX4. GPX4 overexpression restored treated inhibiting inhibits STUB1/GPX4-dependent ferroptosis.

Language: Английский

Citations

39
Wogonin induces ferroptosis in pancreatic cancer cells by inhibiting the Nrf2/GPX4 axis DOI Creative Commons
Xing Liu,

Xinhui Peng,

Shuai Cen

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 22, 2023

Pancreatic cancer is a common gastrointestinal tract malignancy. Currently, the therapeutic strategies for pancreatic cancers include surgery, radiotherapy, and chemotherapy; however, surgical procedure invasive, overall curative outcomes are poor. Furthermore, usually asymptomatic during early stages have high degree of malignancy, along with rate recurrence metastasis, thereby increasing risk mortality. Studies shown that ferroptosis regulates cell proliferation tumour growth reduces drug resistance. Hence, could play role in preventing treating cancers. Wogonin flavonoid anticancer activity against various cancers, including cancer. It extracted from root Scutellaria baicalensis Georgi . In this study, we show wogonin inhibits survival human lines induces death. We performed RNA-sequencing analysed differentially expressed gene potential molecular mechanism to determine if reduced via ferroptosis. Our results showed upregulates levels Fe 2+ , lipid peroxidation superoxide decreases protein expression suppressor genes, downregulates level glutathione cells. addition, inhibitors rescue ferroptosis-related events induced by wogonin, confirming A significant increase was observed after treatment both inducer. These significantly induce Nrf2/GPX4 axis. Therefore, be potentially used patients

Language: Английский

Citations

33