NRF2, a Superstar of Ferroptosis

Antioxidants, Journal Year: 2023, Volume and Issue: 12(9), P. 1739 - 1739

Published: Sept. 8, 2023

Ferroptosis is an iron-dependent and lipid peroxidation-driven cell death cascade, occurring when there imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2-related 2 (NFE2L2, also known as NRF2) key for cellular antioxidant responses, which promotes downstream genes transcription by binding to their response elements (AREs). Numerous studies suggest that NRF2 assumes extremely important role regulation ferroptosis, its various functions iron, lipid, amino acid metabolism, so on. Many pathological states are relevant ferroptosis. Abnormal suppression ferroptosis found many cases cancer, promoting progression metastasis. While during tissue damages, recurrently promoted, resulting a large number deaths even dysfunctions corresponding organs. Therefore, targeting NRF2-related signaling pathways, induce or inhibit has become great potential therapy combating cancers, well preventing neurodegenerative ischemic diseases. In this review, brief overview research process over past decade will be presented. particular, mechanisms focus on discussed. Finally, review briefly list some clinical applications pathway treatment

Language: Английский

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The mechanism of ferroptosis and its related diseases

Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)

Published: Oct. 16, 2023

Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.

Language: Английский

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The Multifaceted Roles of NRF2 in Cancer: Friend or Foe?

Antioxidants, Journal Year: 2024, Volume and Issue: 13(1), P. 70 - 70

Published: Jan. 2, 2024

Physiological concentrations of reactive oxygen species (ROS) play vital roles in various normal cellular processes, whereas excessive ROS generation is central to disease pathogenesis. The nuclear factor erythroid 2-related 2 (NRF2) a critical transcription that regulates the antioxidant systems response oxidative stress by governing expression genes encoding enzymes shield cells from diverse alterations. NRF2 and its negative regulator Kelch-like ECH-associated protein 1 (KEAP1) have been focus numerous investigations elucidating whether suppresses tumor promotion or conversely exerts pro-oncogenic effects. has found participate pathological including dysregulated cell proliferation, metabolic remodeling, resistance apoptosis. Herein, this review article will examine intriguing role phase separation activating transcriptional activity explore dual impacts on immunology, cancer stem cells, metastasis, long non-coding RNAs (LncRNAs). Taken together, aims discuss multifaceted both prevention while also addressing advantages, disadvantages, limitations associated with modulating therapeutically treatment.

Language: Английский

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Targeting Nrf2 for ferroptosis-based therapy: Implications for overcoming ferroptosis evasion and therapy resistance in cancer

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2023, Volume and Issue: 1869(7), P. 166788 - 166788

Published: June 10, 2023

Language: Английский

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Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(22), P. 12340 - 12355

Published: May 22, 2024

Lipid peroxidation (LP) leads to changes in the fluidity and permeability of cell membranes, affecting normal cellular function potentially triggering apoptosis or necrosis. This process is closely correlated with onset many diseases. Evidence suggests that phenolic hydroxyl groups food-borne plant polyphenols (FPPs) make them effective antioxidants capable preventing diseases triggered by membrane LP. Proper dietary intake FPPs can attenuate oxidative stress, especially damage phospholipids, activating Nrf2/GPx4 pathway. Nuclear factor E2-related 2 (Nrf2) an stress antagonist. The signaling pathway regulated Nrf2 a defense transduction organism against external stimuli such as reactive oxygen species exogenous chemicals. Glutathione peroxidase 4 (GPx4), under regulation Nrf2, only enzyme reduces lipid peroxides specificity, thus playing pivotal role regulating ferroptosis counteracting stress. study explored mechanism, antioxidant activity FPPs, mechanism It also highlighted bioprotective properties LP its associated mechanisms, including (i) activation pathway, GPx4 serving central target protein, (ii) activities, leading reduction production ROS other peroxides, (iii) effects on downstream phospholipid structure. In conclusion, play crucial natural However, further in-depth analysis coregulation multiple pathways required, combined these mechanisms need evaluation experimental models. Human trials could provide valuable insights into new directions for research application.

Language: Английский

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Wogonin inhibits the migration and invasion of fibroblast-like synoviocytes by targeting PI3K/AKT/NF-κB pathway in rheumatoid arthritis

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 755, P. 109965 - 109965

Published: March 27, 2024

Language: Английский

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Traditional Chinese medicine for the treatment of cancers of hepatobiliary system: from clinical evidence to drug discovery

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 1, 2024

Language: Английский

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The regulation and function of Nrf2 signaling in ferroptosis-activated cancer therapy

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: 45(11), P. 2229 - 2240

Published: July 17, 2024

Language: Английский

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Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

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Immune-related gene SOX10 affects ferroptosis in pancreatic cancer and facilitates tumor progression by targeting CMTM7-mediated Wnt/β-catenin signaling pathway

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 4, 2025

SOX10 is crucially implicated in various cancer, yet the regulatory role pancreatic cancer (PC) remains enigmatic. Underlying molecular mechanisms of PC were explored our study.

Language: Английский

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