Ferroptosis, from the virus point of view: opportunities and challenges DOI
Xia Zhao, Yan Zhang, Bing Luo

et al.

Critical Reviews in Microbiology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: April 8, 2024

Ferroptosis is a new type of cell death, which mainly dependent on the formation and accumulation reactive oxygen species lipid peroxides mediated by iron. It distinct from other forms regulation death in morphology, immunology, biochemistry, molecular biology. Various mechanisms have been observed many viral infections, virus-induced has long considered as double-edged sword that can inhibit or aggravate infections. However, understanding role ferroptosis various infections limited. Special attention will be paid to mediating infection antiviral treatment associated with ferroptosis. In this paper, we outlined mechanism Additionally, paper also review research perspective virus, discussed status virus classified summarized interaction between

Language: Английский

Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo DOI
John T. Randolph, Matthew J. O’Connor, Fei Han

et al.

Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 66(6), P. 3852 - 3865

Published: March 6, 2023

Compounds that inhibit glutathione peroxidase 4 (GPX4) hold promise as cancer therapeutics in their ability to induce a form of nonapoptotic cell death called ferroptosis. Our research identified 24, structural analog the potent GPX4 inhibitor RSL3, has much better plasma stability (t1/2 > 5 h mouse plasma). The bioavailability 24 provided efficacious drug concentrations with IP dosing, thus enabling vivo studies assess tolerability and efficacy. An efficacy study using GPX4-sensitive tumor model found doses up 50 mg/kg were tolerated for 20 days but had no effect on growth, although partial target engagement was observed homogenate.

Language: Английский

Citations

26
Cuproptosis, ferroptosis and PANoptosis in tumor immune microenvironment remodeling and immunotherapy: culprits or new hope DOI Creative Commons
Xiaojie Zhang, Bufu Tang, Jinhua Luo

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 15, 2024

Normal life requires cell division to produce new cells, but death is necessary maintain balance. Dysregulation of can lead the survival and proliferation abnormal promoting tumor development. Unlike apoptosis, necrosis, autophagy, newly recognized forms regulated (RCD) cuproptosis, ferroptosis, PANoptosis provide novel therapeutic strategies for treatment. Increasing research indicates that immune cells mediated by these discovered regulate microenvironment (TME) influence effectiveness immunotherapy. This review primarily elucidates molecular mechanisms their complex effects on TME. also summarizes exploration nanoparticle applications in therapy based vivo vitro evidence derived from induction or inhibition RCD pathways.

Language: Английский

Citations

15
Understanding the unique mechanism of ferroptosis: a promising therapeutic target DOI Creative Commons
Yuanyuan Kong, Jing Li,

Run-Xiang Lin

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 11

Published: March 18, 2024

Ferroptosis is an iron-dependent form of regulated cell death and characterized by high concentrations intracellular lipid peroxide a redox imbalance in the cells. shows distinct morphological biological features compared with other prominent mechanisms programmed death. The characteristics ferroptosis include dysfunction repair enzyme glutathione peroxidase 4, presence ferrous iron overload, peroxidation polyunsaturated fatty acids. Several metabolic pathways (including iron, lipid, amino acid metabolism) ferritinophagy, as well transcription factors, can modulate ferroptosis. However, to date, molecular mechanism has not been elucidated. This review outlines discovery, characterization, regulatory mechanisms, crosstalk Further, we have noted controversial elements ferroptosis-related mechanisms. Our inferences may provide partial reference for developing strategies regulate

Language: Английский

Citations

13
Targeting ferroptosis: a promising approach for treating lung carcinoma DOI Creative Commons
Ziyang Wu, Tao Zhang, Wei Zhong

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 29, 2025

Abstract Lung carcinoma incidence and fatality rates remain among the highest on a global scale. The efficacy of targeted therapies immunotherapies is commonly compromised by emergence drug resistance other factors, resulting in lack durable therapeutic benefits. Ferroptosis, distinct pattern cell death marked buildup iron-dependent lipid peroxides, has been shown to be novel potentially more effective treatment for lung carcinoma. However, mechanism regulatory network ferroptosis are exceptionally complex, many unanswered questions remain. In addition, research diagnosis cancer growing exponentially. Therefore, it necessary provide thorough summary latest advancements field ferroptosis. Here, we comprehensively analyze mechanisms underlying preconditions ferroptosis, defense system, associated molecular networks. potential strategies also highlighted. Targeting improves tumor enhances effectiveness drugs immunotherapies. These findings may shed fresh light management carcinoma, as well development related

Language: Английский

Citations

1
Bidirectional Interplay Among Non-Coding RNAs, the Microbiome, and the Host During Development and Diseases DOI Open Access

Shanshan Nai,

Ji‐Ying Song, Wenting Su

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(2), P. 208 - 208

Published: Feb. 8, 2025

It is widely known that the dysregulation of non-coding RNAs (ncRNAs) and dysbiosis gut microbiome play significant roles in host development progression various diseases. Emerging evidence has highlighted bidirectional interplay between ncRNAs microbiome. This article aims to review current understanding molecular mechanisms underlying crosstalk ncRNAs, especially microRNA (miRNA), context diseases, such as colorectal cancer, inflammatory bowel neurological disorders, obesity, cardiovascular disease. Ultimately, this seeks provide a foundation for exploring potential interactions biomarkers therapeutic targets clinical diagnosis treatment, ncRNA mimics, antisense oligonucleotides, small-molecule compounds, well probiotics, prebiotics, diets.

Language: Английский

Citations

1
Aberrant DNA methylation as a key modulator of cell death pathways: insights into cancer progression and other diseases DOI

Ambreen Zahoor,

Rafia Khazer,

Insha Mehraj

et al.

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 1, 2025

Language: Английский

Citations

1
Alloimperatorin activates apoptosis, ferroptosis, and oxeiptosis to inhibit the growth and invasion of breast cancer cells in vitro DOI
Jing Zhang,

Runfang Gao,

Jie Li

et al.

Biochemistry and Cell Biology, Journal Year: 2022, Volume and Issue: 100(3), P. 213 - 222

Published: March 9, 2022

Breast cancer is the most common malignant tumour in women. Our research on alloimperatorin from Angelica dahurica showed that inhibited breast cell viability a concentration- and time-dependent manner; it also apoptosis ferroptosis inhibitors significantly weakened antisurvival effect of alloimperatorin. Alloimperatorin clearly induced increased activities caspase-3, caspase-8, caspase-9, poly (ADP-ribose) polymerase; caused significant mitochondrial shrinkage, promoted accumulation Fe2+, reactive oxygen species, malondialdehyde, reduced mRNA protein expression levels SLC7A11 GPX4, indicating induces ferroptosis. In addition, Kelch-like ECH-associated 1 (Keap1) expression; although did not affect PGAM5 (mitochondrial serine/threonine phosphatase) apoptosis-inducing factor mitochondria associated (AIFM1), phosphorylation level AIFM1. After downregulating Keap1, PGAM5, or AIFM1, inhibitory was weakened, regulates Keap1/PGAM5/AIFM1 pathway to promote oxeiptosis. invasion cells, while Keap1 siRNA GPX4 overexpression vectors enhanced effectively reversed anti-invasive Therefore, apoptosis, ferroptosis, oxeiptosis, thereby inhibiting growth invasion.

Language: Английский

Citations

32
CircSCN8A suppresses malignant progression and induces ferroptosis in non-small cell lung cancer by regulating miR-1290/ACSL4 axis DOI Creative Commons
Baoxing Liu,

Haibo Ma,

Xingyu Liu

et al.

Cell Cycle, Journal Year: 2022, Volume and Issue: 22(7), P. 758 - 776

Published: Dec. 8, 2022

Circular RNAs (CircRNAs) are reported to exert vital regulatory roles in the occurrence and development of various human malignancies, including non-small cell lung cancer (NSCLC). Bioinformatics methods identified down-regulation circSCN8A (circBase ID: hsa_circ_0026337) NSCLC tissues. However, its biological functions molecular mechanisms remain unknown. In this study, we found that expression was down-regulated tissues cells. Low positively associated with aggressive clinicopathological characteristics poor prognosis patients. CircSCN8A suppressed proliferation, migration, invasion, epithelial-mesenchymal transition (EMT) vitro blocked tumor growth vivo. Moreover, promoted ferroptosis NSCLC. Mechanistically, acted as a competing endogenous RNA (ceRNA) by sponging miR-1290 enhance long-chain acyl-CoA synthetase-4 (ACSL4). Furthermore, knockdown ACSL4 or overexpression reversed effect on facilitating inhibiting proliferation metastasis. summary, represses metastasis regulating miR-1290/ACSL4 axis induce ferroptosis. Thus, may represent promising therapeutic target against

Language: Английский

Citations

29
A pH/ATP-responsive nanomedicine via disrupting multipath homeostasis of ferroptosis for enhanced cancer therapy DOI
Xiangyu Meng,

Zhuoxuan Lu,

Liming Zhang

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 457, P. 141313 - 141313

Published: Jan. 4, 2023

Language: Английский

Citations

17
Liproxstatin-1 Alleviated Ischemia/Reperfusion-Induced Acute Kidney Injury via Inhibiting Ferroptosis DOI Creative Commons
Zhiyuan Shi,

Yifan Du,

Jianzhong Zheng

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 182 - 182

Published: Jan. 31, 2024

Ferroptosis, as a novel regulable cell death, is characterized by iron overload, glutathione depletion, and an accumulation of lipid peroxides. Recently, it has been discovered that ferroptosis involved in ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) plays crucial role renal tubular death. In this study, we tried to investigate the effect mechanism liproxstatin-1 (Lip-1) I/R-induced AKI seek key regulator AKI. Mice were administrated with clamping bilateral pedicles for 30 min. We found early growth response 1 (EGR1) might be ferroptosis, Lip-1 could suppress via EGR1. Meanwhile, reduce macrophage recruitment release inflammatory cytokines. These findings indicated alleviated regulating EGR1, pave theoretical basis new therapeutic strategy

Language: Английский

Citations

7