Chinese Medical Journal,
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 7, 2023
Abstract
Background:
High-grade
serous
ovarian
cancer
(HGSOC)
is
the
biggest
cause
of
gynecological
cancer-related
mortality
because
its
extremely
metastatic
nature.
This
study
aimed
to
explore
and
evaluate
characteristics
candidate
factors
associated
with
metastasis
progression
HGSOC.
Methods:
Transcriptomic
data
HGSOC
patients'
samples
collected
from
primary
tumors
matched
omental
were
obtained
three
independent
studies
in
National
Center
for
Biotechnology
Information
(NCBI)
Gene
Expression
Omnibus
(GEO)
database.
Differentially
expressed
genes
(DEGs)
selected
effects
on
prognosis
using
The
Cancer
Genome
Atlas
(TCGA)
Hub
genes'
immune
landscapes
estimated
by
Tumor
Immune
Estimation
Resource
(TIMER)
Finally,
25
tissues
10
normal
fallopian
tube
tissues,
immunohistochemistry
(IHC)
was
performed
quantify
expression
levels
hub
International
Federation
Gynecology
Obstetrics
(FIGO)
stages.
Results:
Fourteen
DEGs,
ADIPOQ
,
ALPK2
BARX1
CD37
CNR2
COL5A3
FABP4
FAP
GPR68
ITGBL1
MOXD1
PODNL1
SFRP2
TRAF3IP3
upregulated
every
database
while
CADPS
GATA4
STAR
TSPAN8
downregulated.
as
significantly
survival
recurrence.
All
correlated
tumor
microenvironment
infiltration,
especially
cancer-associated
fibroblasts
natural
killer
(NK)
cells.
Furthermore,
positively
stage,
their
increased
protein
compared
confirmed
IHC
(
P
=
0.0002
0.0001,
respectively).
Conclusions:
describes
screening
DEGs
integrated
bioinformatics
analyses.
We
identified
six
that
HGSOC,
particularly
which
might
provide
effective
targets
predict
novel
insights
into
individual
therapeutic
strategies
Biology,
Journal Year:
2024,
Volume and Issue:
13(4), P. 206 - 206
Published: March 23, 2024
Gliomas
have
displayed
significant
challenges
in
oncology
due
to
their
high
degree
of
invasiveness,
recurrence,
and
resistance
treatment
strategies.
In
this
work,
the
key
hub
genes
mainly
associated
with
different
grades
glioma,
which
were
represented
by
pilocytic
astrocytoma
(PA),
oligodendroglioma
(OG),
anaplastic
(AA),
glioblastoma
multiforme
(GBM),
identified
through
weighted
gene
co-expression
network
analysis
(WGCNA)
microarray
datasets
retrieved
from
Gene
Expression
Omnibus
(GEO)
database.
Through
this,
four
highly
correlated
modules
observed
be
present
across
PA
(GSE50161),
OG
(GSE4290),
AA
(GSE43378),
GBM
(GSE36245)
datasets.
The
functional
annotation
pathway
enrichment
done
Database
for
Annotation,
Visualization,
Integrated
Discovery
(DAVID)
showed
that
involved
signal
transduction,
transcription
regulation,
protein
binding,
collectively
deregulate
several
signaling
pathways,
PI3K/Akt
metabolic
pathways.
involvement
primarily
linked
other
including
cAMP,
MAPK/ERK,
Wnt/β-catenin,
calcium
indicates
potential
interconnectivity
influence
on
and,
subsequently,
glioma
severity.
Drug
Repurposing
Encyclopedia
(DRE)
was
used
screen
drugs
based
up-
downregulated
genes,
wherein
synthetic
progestin
hormones
norgestimate
ethisterone
top
drug
candidates.
This
shows
neuroprotective
effect
progesterone
against
its
EGFR
expression
Aside
these,
experimental
approved
candidates
also
identified,
include
an
adrenergic
receptor
antagonist,
a
PPAR-γ
agonist,
CDK
inhibitor,
sodium
channel
blocker,
bradykinin
dopamine
further
highlights
as
therapeutic
avenue
glioma.
World Journal of Gastroenterology,
Journal Year:
2022,
Volume and Issue:
28(28), P. 3535 - 3554
Published: July 27, 2022
Hepatocellular
carcinoma
(HCC)
is
the
most
common
type
of
liver
cancer
worldwide.
Viral
hepatitis
a
significant
risk
factor
for
HCC,
although
metabolic
syndrome
and
diabetes
are
more
frequently
associated
with
HCC.
With
increasing
prevalence,
there
expected
to
be
>
1
million
cases
annually
by
2025.
Therefore,
an
urgent
need
establish
potential
therapeutic
targets
cure
this
disease.
Peroxisome-proliferator-activated
receptor
gamma
(PPARγ)
ligand-activated
transcription
that
plays
crucial
role
in
patho-physiology
Many
synthetic
agonists
PPARγ
suppress
HCC
experimental
studies
clinical
trials.
These
have
shown
promising
results
inducing
cell
cycle
arrest
apoptosis
cells
preventing
invasion
metastasis
However,
some
also
pose
severe
side
effects
addition
their
efficacy.
Thus
natural
can
alternative
exploit
target
treatment.
In
review,
regulatory
pathogenesis
elucidated.
Furthermore,
scenario
both
against
discussed.
Most
available
literature
advocates
as
treatment
Cancer Discovery,
Journal Year:
2023,
Volume and Issue:
13(5), P. 1230 - 1249
Published: April 17, 2023
Abstract
Cancer-related
alterations
of
the
p53
tetramerization
domain
(TD)
abrogate
wild-type
(WT)
function.
They
result
in
a
protein
that
preferentially
forms
monomers
or
dimers,
which
are
also
normal
states
under
basal
cellular
conditions.
However,
their
physiologic
relevance
is
not
well
understood.
We
have
established
vivo
models
for
monomeric
and
dimeric
p53,
model
Li–Fraumeni
syndrome
patients
with
germline
TD
alterations.
inactive
protein.
Unexpectedly,
dimers
conferred
some
tumor
suppression
mediated
by
canonical
WT
activities.
upregulate
PPAR
pathway.
These
activities
associated
lower
prevalence
thymic
lymphomas
increased
CD8+
T-cell
differentiation.
Lymphomas
derived
from
mice
show
cooperating
pathway,
further
implicating
role
these
suppression.
Our
data
reveal
novel
functions
support
exploration
agonists
as
therapies.
Significance:
New
mouse
TP53R342P
(monomer)
TP53A347D
(dimer)
mutations
mimic
syndrome.
Although
lack
function,
noncanonical
tumor-suppressive
describe
facilitated
PPARs
propose
“basal”
See
related
commentary
Stieg
et
al.,
p.
1046.
article
Choe
1250.
This
highlighted
In
Issue
feature,
1027
Chinese Medical Journal,
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 7, 2023
Abstract
Background:
High-grade
serous
ovarian
cancer
(HGSOC)
is
the
biggest
cause
of
gynecological
cancer-related
mortality
because
its
extremely
metastatic
nature.
This
study
aimed
to
explore
and
evaluate
characteristics
candidate
factors
associated
with
metastasis
progression
HGSOC.
Methods:
Transcriptomic
data
HGSOC
patients'
samples
collected
from
primary
tumors
matched
omental
were
obtained
three
independent
studies
in
National
Center
for
Biotechnology
Information
(NCBI)
Gene
Expression
Omnibus
(GEO)
database.
Differentially
expressed
genes
(DEGs)
selected
effects
on
prognosis
using
The
Cancer
Genome
Atlas
(TCGA)
Hub
genes'
immune
landscapes
estimated
by
Tumor
Immune
Estimation
Resource
(TIMER)
Finally,
25
tissues
10
normal
fallopian
tube
tissues,
immunohistochemistry
(IHC)
was
performed
quantify
expression
levels
hub
International
Federation
Gynecology
Obstetrics
(FIGO)
stages.
Results:
Fourteen
DEGs,
ADIPOQ
,
ALPK2
BARX1
CD37
CNR2
COL5A3
FABP4
FAP
GPR68
ITGBL1
MOXD1
PODNL1
SFRP2
TRAF3IP3
upregulated
every
database
while
CADPS
GATA4
STAR
TSPAN8
downregulated.
as
significantly
survival
recurrence.
All
correlated
tumor
microenvironment
infiltration,
especially
cancer-associated
fibroblasts
natural
killer
(NK)
cells.
Furthermore,
positively
stage,
their
increased
protein
compared
confirmed
IHC
(
P
=
0.0002
0.0001,
respectively).
Conclusions:
describes
screening
DEGs
integrated
bioinformatics
analyses.
We
identified
six
that
HGSOC,
particularly
which
might
provide
effective
targets
predict
novel
insights
into
individual
therapeutic
strategies
