Current Cancer Drug Targets,
Journal Year:
2023,
Volume and Issue:
24(2), P. 127 - 141
Published: May 15, 2023
Abstract:
EBV
promotes
many
cancers
such
as
lymphoma,
nasopharyngeal
carcinoma,
and
gastric;
Latent
Membrane
Protein
1
(LMP1)
is
considered
to
be
a
major
oncogenic
protein
encoded
by
Epstein–
Barr
virus
(EBV).
LMP1
functions
carcinogen
in
lymphoma
may
also
promote
gastric
cancer.
The
expression
level
of
host
cells
key
determinant
tumorigenesis
maintenance
specificity.
By
promoting
cell
immortalization
transformation,
proliferation,
affecting
immunity,
regulating
apoptosis,
plays
crucial
tumorigenic
role
epithelial
cancers.
However,
very
little
currently
known
about
Epstein-Barr
virus-associated
cancer
(EBVaGC);
the
main
reason
that
EBVaGC
comparatively
lower
than
other
EBV-encoded
proteins,
2A
(LMP2A),
nuclear
antigen
(EBNA1)
BamHI-A
rightward
frame
(BARF1),
date,
there
are
few
studies
related
EBVaGC.
Recent
have
demonstrated
phosphatidylinositol
3-kinase-
Akt
(PI3K-Akt),
Nuclear
factor-kappa
B
(NF-κB),
signaling
pathways
regulate
downstream
targets
Forkhead
box
class
O
(FOXO),
C-X-C-motif
chemokine
receptor
(CXCR),
COX-2
(Cyclooxygenase-2);
moreover,
gene
methylation
induced
has
become
one
characteristics
distinguish
this
(GC)
from
types
formation
tumor
microenvironment
(TME)
several
ways.
This
review
synthesizes
previous
relevant
literature,
aiming
highlight
latest
findings
on
mechanism
action
EBVaGC,
summarize
function
lay
theoretical
foundation
for
subsequent
new
research
contribute
development
novel
LMP1-targeted
drugs.
Biological and Pharmaceutical Bulletin,
Journal Year:
2025,
Volume and Issue:
48(5), P. 495 - 506
Published: May 1, 2025
Epstein-Barr
virus
(EBV)
is
one
of
the
most
pervasive
viruses
worldwide,
and
EBV
infection
inextricably
linked
to
a
multitude
lymphoid
epithelial
neoplasms.
responsible
for
advancement
malignant
disease
by
modifying
tumor
microenvironment
(TME),
which
sophisticated
evolving
system
that
facilitates
growth,
invasion,
metastasis.
has
profound
impact
on
cellular
noncellular
components
constitute
TME.
Our
review
presents
summary
composition
EBV-remodeled
TME,
with
particular
focus
EBV-induced
functional
phenotypes
in
non-tumor
cells.
Furthermore,
we
discuss
potential
reversing
EBV-driven
TME
remodeling
as
therapeutic
strategy
treating
malignancies
associated
infection.
Journal of Medical Virology,
Journal Year:
2022,
Volume and Issue:
95(1)
Published: Dec. 1, 2022
Epstein-Barr
virus
(EBV)
infection
is
associated
with
a
variety
of
the
autoimmune
diseases.
There
apparently
no
unified
model
for
role
EBV
in
In
this
article,
development
diseases
proposed
as
simple
two-step
process:
specific
initiators
may
cause
irreversible
changes
to
genetic
materials
that
increase
risks,
and
promoters
promote
disease
formation
once
cells
are
susceptible
autoimmunity.
has
several
types
latencies
including
type
III
latency
higher
proliferation
potential.
could
serve
some
At
same
time,
play
promotional
majority
by
repeated
replenishment
inflammatory
cytokine
productions
persistent
stage.
The
have
enhanced
capacity
antigen-presenting
would
facilitate
both
B
T
cell-mediated
achieved
naive
B-lymphocytes
produce
cytokines.
Presentation
viral
or
self-antigens
lymphocytes
autoreactive
cell
proliferation,
which
can
be
amplified
cells-mediated
cytokines
productions.
Different
require
different
kinds
pathogenic
immune
and/or
Frequency
determine
effect
promoter
functions.
A
initiator
plus
EBV-mediated
common
function
lead
link
EBV-infection
Current Cancer Drug Targets,
Journal Year:
2023,
Volume and Issue:
24(2), P. 127 - 141
Published: May 15, 2023
Abstract:
EBV
promotes
many
cancers
such
as
lymphoma,
nasopharyngeal
carcinoma,
and
gastric;
Latent
Membrane
Protein
1
(LMP1)
is
considered
to
be
a
major
oncogenic
protein
encoded
by
Epstein–
Barr
virus
(EBV).
LMP1
functions
carcinogen
in
lymphoma
may
also
promote
gastric
cancer.
The
expression
level
of
host
cells
key
determinant
tumorigenesis
maintenance
specificity.
By
promoting
cell
immortalization
transformation,
proliferation,
affecting
immunity,
regulating
apoptosis,
plays
crucial
tumorigenic
role
epithelial
cancers.
However,
very
little
currently
known
about
Epstein-Barr
virus-associated
cancer
(EBVaGC);
the
main
reason
that
EBVaGC
comparatively
lower
than
other
EBV-encoded
proteins,
2A
(LMP2A),
nuclear
antigen
(EBNA1)
BamHI-A
rightward
frame
(BARF1),
date,
there
are
few
studies
related
EBVaGC.
Recent
have
demonstrated
phosphatidylinositol
3-kinase-
Akt
(PI3K-Akt),
Nuclear
factor-kappa
B
(NF-κB),
signaling
pathways
regulate
downstream
targets
Forkhead
box
class
O
(FOXO),
C-X-C-motif
chemokine
receptor
(CXCR),
COX-2
(Cyclooxygenase-2);
moreover,
gene
methylation
induced
has
become
one
characteristics
distinguish
this
(GC)
from
types
formation
tumor
microenvironment
(TME)
several
ways.
This
review
synthesizes
previous
relevant
literature,
aiming
highlight
latest
findings
on
mechanism
action
EBVaGC,
summarize
function
lay
theoretical
foundation
for
subsequent
new
research
contribute
development
novel
LMP1-targeted
drugs.
