Antibody Cross-Reactivity in Auto-Immune Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13609 - 13609

Published: Sept. 2, 2023

Autoimmunity is defined by the presence of antibodies and/or T cells directed against self-components. Although unknown etiology, autoimmunity commonly associated with environmental factors such as infections, which have been reported to increase risk developing autoimmune diseases. Occasionally, similarities between infectious non-self and self-tissue antigens may contribute immunological cross-reactivity in These reactions be interpreted molecular mimicry, describes foreign pathogens self-antigens that cause tissue damage development autoimmunity. By focusing on nature antibodies, general, antibody–antigen interactions, this review aims characterize potential cross-reactive immune but not actually disease onset.

Language: Английский

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Effect of Epstein-Barr Virus infection on gene regulation in immune cells of patients with Immune-Mediated Diseases

Journal of Autoimmunity, Journal Year: 2025, Volume and Issue: 150, P. 103355 - 103355

Published: Jan. 1, 2025

Language: Английский

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Virological Markers in Epstein–Barr Virus-Associated Diseases

Viruses, Journal Year: 2023, Volume and Issue: 15(3), P. 656 - 656

Published: Feb. 28, 2023

Epstein–Barr virus (EBV) is an oncogenic infecting more than 95% of the world’s population. After primary infection—responsible for infectious mononucleosis in young adults—the persists lifelong infected host, especially memory B cells. Viral persistence usually without clinical consequences, although it can lead to EBV-associated cancers such as lymphoma or carcinoma. Recent reports also suggest a link between EBV infection and multiple sclerosis. In absence vaccines, research efforts have focused on virological markers applicable practice management patients with diseases. Nasopharyngeal carcinoma malignancy which serological molecular are widely used practice. Measuring blood DNA load additionally, useful preventing lymphoproliferative disorders transplant patients, this marker being explored various other lymphomas. New technologies based next-generation sequencing offer opportunity explore biomarkers methylome, strain diversity, viral miRNA. Here, we review utility different Indeed, evaluating existing new malignancies immune-mediated inflammatory diseases triggered by continues be challenge.

Language: Английский

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Associations between of chronic hepatitis B infection and inflammatory bowel diseases in East Asian populations

Future Virology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Jan. 16, 2025

Aim This study aims to investigate the effect of chronic hepatitis B (CHB) infection on inflammatory bowel disease (IBD) in East Asian populations.

Language: Английский

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Expert consensus statement on the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: 2024 update

Annals of the Rheumatic Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

In light of the introduction new Janus kinase inhibitors (JAKi), indications for JAKi and recent safety considerations that have arisen since preceding consensus statement on therapy, a multidisciplinary taskforce was assembled, encompassing patients, health care professionals, clinicians with expertise in therapy across specialties. This taskforce, informed by two comprehensive systematic literature reviews, undertook objective to update previous expert using developed 2019. The deliberated overarching principles, indications, dosage comedication strategies, warnings contraindications, screening protocols, monitoring recommendations, adverse effect profiles. methodology based European Alliance Associations Rheumatology standard operating procedures, voting these important elements. Furthermore, an updated research agenda proposed. task force did not address when should be prescribed but rather once this decision has been made. aimed equip necessary knowledge guidance efficient safe administration expanding significant class drugs.

Language: Английский

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The Role of NK Cells in EBV Infection and Related Diseases: Current Understanding and Hints for Novel Therapies

Cancers, Journal Year: 2023, Volume and Issue: 15(6), P. 1914 - 1914

Published: March 22, 2023

The Epstein–Barr virus (EBV) is a ubiquitous herpesvirus most often transmitted during infancy and infecting the vast majority of human beings. Usually, EBV infection nearly asymptomatic results in life-long persistency latent state under control host immune system. Yet can cause an acute infectious mononucleosis (IM), particularly adolescents, associated with several malignancies severe diseases that pose serious threat to individuals specific inborn error immunity (IEI). While there general consensus on requirement for functional CD8 T cells infection, role natural killer (NK) innate arm more enigmatic. Here we provide overview interaction between NK immunocompetent as well context primary secondary immunodeficiencies. Moreover, report vitro data mechanisms regulate capacity recognize kill EBV-infected cell targets discuss potential recently optimized cell-based immunotherapies treatment EBV-associated diseases.

Language: Английский

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Anti‐EBV antibodies: Roles in diagnosis, pathogenesis, and antiviral therapy

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(5)

Published: May 1, 2023

Epstein-Barr virus (EBV) infection is prevalent in global population and associated with multiple malignancies autoimmune diseases. During the infection, EBV-harbored or infected cell-expressing antigen could elicit a variety of antibodies significant role viral host response pathogenesis. These have been extensively evaluated found to be valuable predicting disease diagnosis prognosis, exploring mechanisms, developing antiviral agents. In this review, we discuss versatile roles EBV as important biomarkers for EBV-related diseases, potential driving factors autoimmunity, promising therapeutic agents

Language: Английский

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Systemic lupus erythematosus is associated with lower risk of hepatitis B virus infection: A multivariable Mendelian randomization study in East Asian population

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(11)

Published: Nov. 1, 2023

Abstract The relationship between systemic lupus erythematosus (SLE) and hepatitis B virus (HBV) infection is still unclear. We conducted a two‐sample Mendelian randomization (MR) analysis using summary statistics from genome‐wide association studies for SLE HBV in individuals of East Asian ancestry. inverse‐variance weighted (IVW) method, median (WM) MR‐Egger method were used to estimate the causal effect on infection. Additionally, we performed multivariable MR adjusting effects body mass index rheumatoid arthritis. This study included total 225 106 ancestry, comprising 5616 cases 219 490 controls. IVW (OR: 0.79, p = 3.34E−08) WM 9.09E−06) revealed genetically predicted low risk suggested associated with 0.83, 2.89E−06). Our supports

Language: Английский

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Shared Pathogenicity Features and Sequences between EBV, SARS-CoV-2, and HLA Class I Molecule-binding Motifs with a Potential Role in Autoimmunity

Clinical Reviews in Allergy & Immunology, Journal Year: 2023, Volume and Issue: 65(2), P. 206 - 230

Published: July 28, 2023

Language: Английский

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Leptospirosis-associated meningitis in a patient with sjögren’s syndrome: a case report

BMC Infectious Diseases, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 9, 2023

Leptospirosis is a zoonotic disease that afflicts both humans and animals. It progresses from flu-like symptoms to more severe hepatic renal failure, may also lead aseptic meningitis. Individuals with autoimmune diseases (ADs) are potentially susceptible Leptospirosis. Thus far, limited data has documented the association between disorders.The patient had definitive pathological diagnosis of Sjögren's syndrome (SS). Due recurrent headaches, sought consultation neurologist. Lumbar puncture revealed elevated white blood cells protein levels in cerebrospinal fluid, along decreased glucose. Tuberculous meningitis was suspected. Radiographic imaging exhibited meningeal enhancement, ventricular enlargement, hydrocephalus. The commenced treatment anti-tuberculosis therapy corticosteroids. Subsequently, high-throughput sequencing (HTS) fluid identified presence Leptospira interrogans. ultimately diagnosed Leptospiral meningitis, underwent antimicrobial immunosuppressive therapy, resulting stabilization condition gradual symptom recovery.The case highlights challenges diagnosing managing leptospirosis-related ADs emphasizes importance utilizing HTS for accurate pathogen detection. potential correlation leptospirosis SS warrants further investigation, as does need multidisciplinary involvement strategies such complex cases.

Language: Английский

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