Vagus innervation in the gastrointestinal tumor: Current understanding and challenges DOI
Yanting Li, Wenzhen Yuan, Weilin Jin

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(3), P. 188884 - 188884

Published: March 28, 2023

Language: Английский

Portrayal of the Complex Molecular Landscape of Multidrug Resistance in Gastric Cancer: Unveiling the Potential Targets DOI

S. Biswas,

Riya Kanodia,

Suman Seervi

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114580 - 114580

Published: April 1, 2025

Language: Английский

Citations

0
Prognostic stratification of gastric cancer patients by intratumoral microbiota-mediated tumor immune microenvironment DOI

Wei Gao,

Li Fei-Fei, Tina Wu

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: 200, P. 107296 - 107296

Published: Jan. 12, 2025

Language: Английский

Citations

0
The Hidden Messengers: Tumor Microenvironment-Derived Exosomal ceRNAs in Gastric Cancer Progression DOI

Mohamed J. Saadh,

Hanan Hassan Ahmed,

Radhwan Abdul Kareem

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155905 - 155905

Published: March 9, 2025

Language: Английский

Citations

0
Role of Soluble Cytokine Receptors in Gastric Cancer Development and Chemoresistance DOI Open Access
Francesco Severini, Geppino Falco, Tiziana Notarangelo

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2534 - 2534

Published: March 12, 2025

Gastric cancer is among the top five most important malignancies in world due to high burden of disease and its lethality. Indeed, it fourth common cause death worldwide, characterized by a poor prognosis low responsiveness chemotherapy. Multidrug resistance limits clinical management patient. Among these, role chronic activation inflammatory pathways underlying gastric tumorigenesis should be highlighted. Furthermore, immunosuppressive TME influences response therapy. This review discusses soluble cytokine receptors development chemoresistance cancer, considered as molecular marker target strategies overcome resistance.

Language: Английский

Citations

0
Research progress on molecular mechanism of liver metastasis of gastric cancer and treatment with traditional Chinese medicine DOI Creative Commons
Caiyue Liu, Zheng Li,

F Cheng

et al.

Journal of Cancer, Journal Year: 2025, Volume and Issue: 16(6), P. 1944 - 1957

Published: March 3, 2025

Gastric cancer liver metastasis (GCLM) refers to the process of cells from stomach spreading liver, which is an important sign deterioration gastric (GC) and has a profound influence on treatment prognosis patients. Once GC metastasis, becomes more complex challenging, seriously affects survival rate patients with GC. Therefore, studying mechanism GCLM extremely necessary. At present, continuous research revealed that its occurrence development involves comprehensive effect multiple targets links. Traditional Chinese medicine (TCM) advantages wide sources, excellent efficacy, small toxicity side effects, have become focus current antitumor research. TCM, monomers, or TCM compounds can inhibit growth In recent years, made substantial achievements in experimental intervention GCLM. This article reviews progress mechanism.

Language: Английский

Citations

0
The role of the tumor microenvironment and inflammatory pathways in driving drug resistance in gastric cancer: A systematic review and meta-analysis DOI Creative Commons
F. Albano, Francesco Severini, Giovanni Calice

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167821 - 167821

Published: April 1, 2025

Tumor microenvironment (TME) plays a pivotal role in progression and low responsiveness to chemotherapy of gastric cancer (GC). The cascade events that culminate with sustained chronic activation inflammatory pathways underlies tumorigenesis. Infiltrating immune cells enrolling crosstalk regulate status, generating an immunosuppressive TME influences the response therapy. Here we discuss comprehend strategies improve drug response. Furthermore, provides systematic insight cytotypes related signatures reinforcing critical roles TAMs Tregs, promoting GC chemoresistance tumor progression.

Language: Английский

Citations

0
Immunotherapy with Immune Checkpoint Inhibitors for Advanced Colorectal Cancer: A Promising Individualized Treatment Strategy DOI Creative Commons
Ying Yang, Wenjian Meng, Ziqiang Wang

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2023, Volume and Issue: 28(4)

Published: April 6, 2023

Colorectal cancer (CRC) is one of the high incident and lethal malignant tumors, most patients are diagnosed at an advanced stage. The treatment CRC mainly includes surgery, chemotherapy, radiotherapy molecular targeted therapy. Despite these approaches have increased overall survival (OS) patients, prognosis remains poor. In recent years, remarkable breakthroughs been made in tumor immunotherapy, especially immune checkpoint inhibitors (ICIs) therapy, bringing long-term benefits to patients. With increasing wealth clinical data, ICIs achieved significant efficacy microsatellite instability/deficient mismatch repair (MSI-H/dMMR) CRC, but therapeutic effects on stable (MSS) currently unsatisfactory. As numbers large trials performed globally, treated with therapy also immunotherapy-related adverse events resistance. Therefore, a number still needed evaluate effect safety CRC. This article will focus current research status discuss predicament treatment.

Language: Английский

Citations

9
TRIM44 regulates tumor immunity in gastric cancer through LOXL2-dependent extracellular matrix remodeling DOI
Xin Zhang, Xiusheng Wu, Ying Sun

et al.

Cellular Oncology, Journal Year: 2022, Volume and Issue: 46(2), P. 423 - 435

Published: Dec. 13, 2022

Language: Английский

Citations

13
Evolving perspectives regarding the role of the PD-1/PD-L1 pathway in gastric cancer immunotherapy DOI Creative Commons
Xianzhe Yu, Xiaoqian Zhai,

Juan Wu

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2023, Volume and Issue: 1870(1), P. 166881 - 166881

Published: Sept. 9, 2023

Language: Английский

Citations

7
The origin of gastric cancer stem cells and their effects on gastric cancer: Novel therapeutic targets for gastric cancer DOI Creative Commons
Ying Yang, Wenjian Meng, Ziqiang Wang

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Sept. 15, 2022

Gastric cancer (GC) is one of the most prevalent malignancies and common causes cancer-related mortality worldwide. Furthermore, prognosis advanced GC remains poor even after surgery combined with chemoradiotherapy. As a small group cells unlimited differentiation self-renewal ability in GC, accumulating evidence shows that stem (GCSCs) are closely associated refractory characteristics such as drug resistance, recurrence, metastasis. With extensive development research on GCSCs, GCSCs seem to be promising therapeutic targets for GC. However, relationship between profound intricate, its mechanism action still under exploration. In this review, we elaborate source key concepts systematically summarize role their underlying mechanisms. Finally, review latest information available treatment by targeting GCSCs. Thus, article may provide theoretical basis future novel based

Language: Английский

Citations

11