Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(3), P. 709 - 709
Published: Feb. 25, 2023
Gastric
cancer
(GC)
therapies
include
gastrectomy
and
chemoradiotherapy.
The
tumor
immune
microenvironment
(TME)
has
implications
for
potential
immunotherapy.
We
analyzed
the
expression
of
PD-L1,
CD8,
CTLA-4
IFN-γ
in
regional
lymph
node
(LN)
patients
with
GC
compared
it
clinical
pathological
data.
Paraffin
blocks
were
collected
from
97
undergoing
gastrectomy/lymphadenectomy
GC.
Double
immunohistochemistry
was
performed
CD8
PD-L1
double
immunofluorescence
IFN-γ.
Statistical
significance
set
at
p
<
0.05.
cells
associated
intestinal
type
(p
=
0.046),
density
macrophages
+
T
0.001,
both).
median
number
CD8+
higher
PD-L1-positive
than
-negative
tumors.
A
cut-off
28.5
one
high-magnification
field
predicted
tumors
(AUROC
0.797,
sensitivity
74.2%,
specificity
77.3%).
found
37
GCs
positively
CTLA4+
lymphocytes
LN
0.027)
CTLA4+/IFN-γ+
(all
0.001).
overall
survival
(OS)
17
months.
In
group
deceased
patients,
metastases
correlated
lower
OS
(RHO
-0.314,
0.008).
TME
suppressive
CTLA4+/IFNγ+
LN.
Discover Oncology,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: May 1, 2024
Interleukin-4
inducible
gene
1
(IL4I1)
regulates
tumor
progression
in
numerous
types.
However,
its
correlation
with
immune
infiltration
and
prognosis
of
patients
a
pan-cancer
setting
remains
unclear.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(2), P. 553 - 553
Published: Jan. 16, 2023
Abnormal
FBLN5
expression
levels
are
related
to
various
cancer
types.
This
study
is
the
first
explore
its
clinical
and
biological
significances
in
gastric
(GC).
We
used
The
Cancer
Genome
Atlas-GC
(TCGA-GC)
Gene
Expression
Omnibus
(GEO)
databases
identify
differential
of
FBLN5,
association
with
pathological
characteristics
was
analyzed.
A
Kaplan-Meier
plotter
calculate
impact
on
GC
patient
prognosis,
functions
were
In
addition,
we
constructed
a
tissue
microarray,
performed
an
immunohistochemical
staining
verify
our
findings.
Western
blotting
conducted
simultaneously
confirm
that
overexpressed
GC.
found
high
level
mRNA
associated
poor
prognosis.
High
significantly
correlated
INFc
N3
lymph
node
metastasis.
Univariate
multivariate
analyses
showed
metastasis
rate
independent
risk
factors
which
can
be
combined
construct
nomogram
serve
patients.
Therefore,
believe
prognosis
valuable
prognostic
indicator
evaluate
Journal of Innovative Optical Health Sciences,
Journal Year:
2023,
Volume and Issue:
16(03)
Published: March 24, 2023
The
tumor
microenvironment
(TME)
promotes
pro-tumor
and
anti-inflammatory
metabolisms
suppresses
the
host
immune
system.
It
prevents
cells
from
fighting
against
cancer
effectively,
resulting
in
limited
efficacy
of
many
current
treatment
modalities.
Different
therapies
aim
to
overcome
immunosuppressive
TME
by
combining
various
approaches
synergize
their
effects
for
enhanced
anti-tumor
activity
augmented
stimulation
Immunotherapy
has
become
a
major
therapeutic
strategy
because
it
unleashes
power
system
activating,
enhancing,
directing
responses
prevent,
control,
eliminate
cancer.
Phototherapy
uses
light
irradiation
induce
cell
death
through
photothermal,
photochemical,
photo-immunological
interactions.
induces
immunogenic
death,
which
is
precursor
enhancer
immunity.
However,
phototherapy
alone
on
long-term
systemic
responses.
can
be
combined
with
immunotherapy
improve
tumoricidal
effect
killing
target
cells,
enhancing
infiltration
tumors,
rewiring
pathways
pro-inflammatory.
Phototherapy-enhanced
triggers
effective
cooperation
between
innate
adaptive
immunities,
specifically
targeting
whether
they
are
localized
or
distant.
Herein,
successes
limitations
other
modalities
will
discussed.
Specifically,
we
review
synergistic
different
elimination
remodeling
TME.
Overall,
phototherapy,
combination
modalities,
establish
pro-inflammatory
phenotypes
activated
tumor-infiltrating
T
B
activate
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(3), P. 709 - 709
Published: Feb. 25, 2023
Gastric
cancer
(GC)
therapies
include
gastrectomy
and
chemoradiotherapy.
The
tumor
immune
microenvironment
(TME)
has
implications
for
potential
immunotherapy.
We
analyzed
the
expression
of
PD-L1,
CD8,
CTLA-4
IFN-γ
in
regional
lymph
node
(LN)
patients
with
GC
compared
it
clinical
pathological
data.
Paraffin
blocks
were
collected
from
97
undergoing
gastrectomy/lymphadenectomy
GC.
Double
immunohistochemistry
was
performed
CD8
PD-L1
double
immunofluorescence
IFN-γ.
Statistical
significance
set
at
p
<
0.05.
cells
associated
intestinal
type
(p
=
0.046),
density
macrophages
+
T
0.001,
both).
median
number
CD8+
higher
PD-L1-positive
than
-negative
tumors.
A
cut-off
28.5
one
high-magnification
field
predicted
tumors
(AUROC
0.797,
sensitivity
74.2%,
specificity
77.3%).
found
37
GCs
positively
CTLA4+
lymphocytes
LN
0.027)
CTLA4+/IFN-γ+
(all
0.001).
overall
survival
(OS)
17
months.
In
group
deceased
patients,
metastases
correlated
lower
OS
(RHO
-0.314,
0.008).
TME
suppressive
CTLA4+/IFNγ+
LN.
