Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Numerous research works have emphasized the critical role that circadian rhythm plays in tumor microenvironment (TME). The goal of clarifying chrono-pharmacological strategies for improving cancer treatment clinical settings is a continuous endeavor. Consequently, to enhance use time-based pharmaceutical therapies oncology, combining existing knowledge on rhythms' roles within TME essential. This perspective elucidates functions rhythms across various stages development, progression, and metastasis. Specifically, aging, angiogenesis, inflammation are implicated modulating TME. Furthermore, exerts profound influence current treatments thereby generates chronotheray manage tumors. From perspective, offers promising opportunities prevention treatment; nevertheless, further study needed address unanswered scientific problems.

Language: Английский

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Analysis of nutritional risk, skeletal muscle depletion, and lipid metabolism phenotype in acute radiation enteritis

World Journal of Gastrointestinal Surgery, Journal Year: 2023, Volume and Issue: 15(12), P. 2831 - 2843

Published: Dec. 26, 2023

Radiation enteritis, which often occurs during radiation-induced acute intestinal symptoms (RIAIS), is the most common and important complication radiotherapy for cervical cancer. RIAIS caused by abdominal pelvic will affect nutrient intake, digestion, absorption, metabolism, leading to malnutrition or poorer nutritional status. In patients with malignant tumors, can adversely curative effect response of reducing radiosensitivity, affecting precision placement increasing incidence radiotherapy-related adverse reactions.

Language: Английский

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Nomogram Predicting Grade ≥2 Acute Radiation Enteritis in Patients With Cervical Cancer Receiving Concurrent Chemoradiotherapy

American Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: March 15, 2024

Purpose: To analyze the risk factors for grade ≥2 ARE in patients with cervical cancer receiving concurrent chemoradiotherapy. Methods: A total of 273 chemoradiotherapy at our hospital were retrospectively enrolled. The divided into training and validation groups. Clinical parameters analyzed using univariate analysis multivariate logistic regression analysis. nomogram model was established based on independent selected regression. areas under receiver operating characteristic (ROC) curve, calibration decision curve (DCA) used to evaluate nomogram. low-score high-score groups scores calculated compared. Results: Malnutrition, monocyte-lymphocyte ratio ≥0.82 after radiotherapy, platelet-lymphocyte <307.50 bowelbag volume least 5 40 Gy incorporated ( P <0.05). ROC DCA suggested that had good discrimination, concordance, net benefit clinical. medium score 146.50 points as cutoff point, incidence group higher than Conclusion: has predictive ability clinical utility, is convenient clinicians identify high-risk develop early prevention treatment strategies.

Language: Английский

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Establishment of a prognostic nomogram based on the clinical and inflammatory parameters as well as acute radiation enteritis for patients with cervical cancer receiving radiotherapy

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 29, 2024

Acute radiation enteritis is one of the most common complications radiotherapy for patients with cervical cancer. This study aims to investigate effect acute on prognosis cancer receiving and establish a nomogram predicting patients' overall survival (OS).

Language: Английский

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Association of the time of day of chemoradiotherapy and durvalumab with tumor control in lung cancer

Radiotherapy and Oncology, Journal Year: 2024, Volume and Issue: unknown, P. 110658 - 110658

Published: Dec. 1, 2024

Language: Английский

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