Cancers,
Journal Year:
2023,
Volume and Issue:
15(18), P. 4489 - 4489
Published: Sept. 9, 2023
Background:
Although
IGF2BP3
has
been
implicated
in
tumorigenesis
and
poor
outcomes
multiple
cancers,
its
role
soft-tissue
sarcoma
(STS)
remains
unknown.
Preliminary
data
have
suggested
an
association
with
expression
among
patients
well-differentiated/dedifferentiated
liposarcoma
(WD/DD
LPS),
a
disease
where
molecular
risk
stratification
is
lacking.
Methods:
We
examined
the
survival
associations
of
via
univariate
multivariate
Cox
regression
three
unique
datasets:
(1)
Cancer
Genome
Atlas
(TCGA),
(2)
in-house
gene
microarray,
(3)
tissue
microarray
(TMA).
A
fourth
dataset,
representing
independent
TMA,
was
used
for
validation.
Results:
Within
TCGA
prognostic
factor
uniquely
DD
LPS
(OS
1.6
vs.
5.0
years,
p
=
0.009).
WD/DD
associated
worse
7.7
21.5
0.02).
protein
also
portended
3.7
13.8
<
0.001),
which
confirmed
our
validation
cohort
2.7
14.9
0.001).
In
model,
OS,
(HR
2.55,
0.034).
Conclusion:
highly
expressed
subset
LPS.
Across
datasets,
biomarker
progression
survival.
Journal of Hepatocellular Carcinoma,
Journal Year:
2023,
Volume and Issue:
Volume 10, P. 2383 - 2395
Published: Dec. 1, 2023
Introduction:
RNA
modifications
mediated
by
the
m6A,
m1A,
and
m5C
regulatory
genes
are
crucial
for
progression
of
malignancy.This
study
aimed
to
explore
expression
regulator
m6A/m5C/m1A
methylation
at
single-cell
level
validate
their
in
cancerous
adjacent
para-cancerous
liver
tissues
adult
patients
with
HCC
who
underwent
tumor
resection.Methods:
The
bulk
sequencing
from
Cancer
Genome
Atlas
(TCGA)
database
(scRNA-seq)
data
obtained
Gene
Expression
Omnibus
(GEO)
were
used
identify
dysregulated
hepatocellular
carcinoma
(HCC).A
real-time
polymerase
chain
reaction
(real-time
PCR)
was
measure
collected
human
compared
tissues.Immune
cell
infiltration
these
significantly
expressed
methylation-related
evaluated
using
Timer2.0.Results:
A
discrepancy
gene
observed
between
scRNA-seq.The
clustered
heatmap
scRNA-seq-identified
TCGA
cohort
revealed
heterogeneous
regulators
within
cancer,
whereas
more
homogeneous.The
PCR
validated
significant
overexpression
DNMT1,
NSUN5,
TRMT6,
IGF2BP1,
IGFBP3,
which
identified
scRNA-seq,
IGFBP2,
sequencing.These
mainly
correlated
natural
killer
cells.Discussion:
This
suggests
that
cellular
diversity
inside
tumors
contributes
traditional
scRNA-seq.This
five
will
be
focus
further
studies
regarding
function
HCC.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: July 18, 2023
Abstract
Background
Although
some
studies
have
established
the
relationship
between
insulin-like
growth
factor
2
mRNA-binding
protein
(IGF2BP2)
rs4402960
polymorphism
and
pathogenesis
of
cancer.
But
results
are
contradictory.
We
conducted
a
meta-analysis
to
assess
IGF2BP2
gene
cancer
risk.
Furthermore,
expression
in
pan-cancer
tissues
normal
was
further
analyzed
from
perspective
bioinformatics
analysis.
Methods
Using
published
case–control
up
August
15,
2021,
literature
search
included
searches
PubMed,
Web
Science,
EMBASE
determine
samples
that
met
inclusion
criteria.
The
heterogeneity
test
used
five
genetic
models.
Odds
ratios
(OR),
95%
confidence
intervals
(CI),
p-values
were
evaluate
combined
effects
various
Sensitivity
analysis
publication
bias
also
performed.
Transcriptomic
information
on
corresponding
clinical
downloaded
TCGA
GTEx
databases.
Differences
kinds
analysed.
Results
This
contained
6
studies,
with
5,908
cases
7,890
controls.
There
only
an
association
risk
heterozygous
model
(heterozygous:
OR
=
1.080,
CI
1.003–1.163,
p
0.041).
sensitivity
examined
effect
research
by
deleting
one
study
turns.
No
found
over-expressed
breast
cancer,
non-small
cell
lung
colorectal
esophageal
(P
<
0.001).
Conclusions
showed
may
be
related
Breastcancer,
Non-small
Cell
Lung
Cancer,
Colorectal
Breast
tissues.
as
index
early
screening
prognosis
treatment.
