Expert Opinion on Drug Delivery, Journal Year: 2023, Volume and Issue: 20(11), P. 1623 - 1642
Published: Nov. 2, 2023
Tumors pose a significant global economic and health burden, with conventional cancer treatments lacking tumor specificity, leading to limited efficiency undesirable side effects. Targeted therapy is imminent. Tumor cells produce lactate hydrogen ions (H
Language: Английский
Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12
Published: Aug. 29, 2022
Tumor acidity is one of the cancer hallmarks and associated with metabolic reprogramming use glycolysis, which results in a high intracellular lactic acid concentration. Cancer cells avoid stress major by activation expression proton lactate transporters exchangers have an inverted pH gradient (extracellular pHs are alkaline, respectively). The shift tumor acid-base balance promotes proliferation, apoptosis avoidance, invasiveness, metastatic potential, aggressiveness, immune evasion, treatment resistance. For example, weak-base chemotherapeutic agents may substantially reduced cellular uptake capacity due to "ion trapping". Lactic negatively affects functions activated effector T cells, stimulates regulatory them express programmed cell death receptor 1. On other hand, inversion could be weakness that will allow development new promising therapies, such as tumor-targeted pH-sensitive antibodies pH-responsible nanoparticle conjugates anticancer drugs. regulation levels pharmacological inhibition proteins (monocarboxylate transporters, H
Language: Английский
Citations
92
Advanced Engineering Materials, Journal Year: 2023, Volume and Issue: 25(21)
Published: Aug. 29, 2023
Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, robots, wearable devices, sensors, self‐expanding structures, and biomedical thanks to their ability change shapes functional properties in response external stimuli including light, humidity, heat, pH, electric field, solvent, magnetic field or combinations two more these stimuli. In recent years, additive manufacturing (AM) aka 3D printing technology SRPs, also known as 4D printing, has gained phenomenal attention different engineering fields, its unique develop complex, personalized, innovative undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, other complex morphological transformations. Herein, an effort made provide insightful information about the AM techniques, type applications including, but not limited tissue engineering, bionics, construction, smart textiles. This article incorporates current challenges prospects, hoping basis utilization this fields. It is expected that amalgamation with SRPs would unparalleled advantages arenas.
Language: Английский
Citations
84
Critical Reviews in Oncology/Hematology, Journal Year: 2023, Volume and Issue: 185, P. 103961 - 103961
Published: March 13, 2023
Language: Английский
Citations
54
Polymers, Journal Year: 2024, Volume and Issue: 16(6), P. 843 - 843
Published: March 19, 2024
Chemotherapy together with surgery and/or radiotherapy are the most common therapeutic methods for treating cancer. However, off-target effects of chemotherapy known to produce side and dose-limiting toxicities. Novel delivery platforms based on natural synthetic polymers enhanced pharmacokinetic potential treatment cancer have grown tremendously over past 10 years. Polymers can facilitate selective targeting, enhance prolong circulation, improve delivery, provide controlled release cargos through various mechanisms, including physical adsorption, chemical conjugation, internal loading. Notably, that biodegradable, biocompatible, physicochemically stable considered be ideal carriers. This biomimetic bio-inspired system offers a bright future effective drug overcome obstacles encountered. review focuses barriers impact success as well recent developments improving
Language: Английский
Citations
24
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 946, P. 173865 - 173865
Published: June 14, 2024
Language: Английский
Citations
19
International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100265 - 100265
Published: June 26, 2024
Cancer remains a major global health challenge, and despite available treatments, its prognosis poor. Recently, researchers have turned their attention to intelligent nanofibers for cancer drug delivery. These exhibit remarkable capabilities in targeted controlled release. Their inherent characteristics, such as high surface area-to-volume ratio, make them attractive candidates delivery applications. Smart can release drugs response specific stimuli, including pH, temperature, magnetic fields, light. This unique feature not only reduces side effects but also enhances the overall efficiency of systems. Electrospinning, widely used method, allows precision fabrication smart nanofibers. Its advantages include efficiency, user-friendliness, ability control various manufacturing parameters. In this review, we explore latest developments producing electrospun treatment. Additionally, discuss materials these critical parameters involved electrospinning process.
Language: Английский
Citations
18
AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(1)
Published: Jan. 13, 2025
Language: Английский
Citations
3
Journal of Materials Science, Journal Year: 2023, Volume and Issue: 58(3), P. 1214 - 1228
Published: Jan. 1, 2023
Language: Английский
Citations
38
Bioactive Materials, Journal Year: 2023, Volume and Issue: 31, P. 440 - 462
Published: Sept. 6, 2023
Cancer immunotherapy has gained momentum for treating malignant tumors over the past decade. Checkpoint blockade and chimeric antigen receptor cell therapy (CAR-T) have shown considerable potency against liquid solid cancers. However, tumor microenvironment (TME) is highly immunosuppressive hampers effect of currently available cancer immunotherapies on overall treatment outcomes. Advancements in design engineering nanomaterials opened new avenues to modulate TME. Progress current nanocomposite technology can overcome immunosuppression trigger robust immunotherapeutic responses by integrating synergistic functions different molecules. We will review recent advancements nanomedical applications discuss specifically designed nanocomposites modulating TME immunotherapy. In addition, we provide information landscape clinical-stage
Language: Английский
Citations
33
Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(6), P. 1948 - 1961
Published: Jan. 1, 2023
"Smart" biomaterials that are responsive to pathological abnormalities an appealing class of therapeutic platforms for the development personalized medications. The such requires novel techniques could precisely deliver agents diseased tissues, resulting in enhanced effects without harming normal tissues. Among various platforms, injectable pH-responsive promising respond change environmental pH. Aqueous solutions exhibit a phase transition from sol-to-gel response pH changes. hydrogel depot can provide spatially and temporally controlled release bioactive including chemotherapeutic drugs, peptides, proteins. Therapeutic imbibed into hydrogels by simple mixing use toxic solvents used long-term storage or situ injection using syringe catheter form stable gel acts as minimally invasive manner. Tunable physicochemical properties hydrogels, biodegradability, ability interact with drugs mechanical properties, control agent. This review highlights advances design biodegradable forming physiological conditions. Special attention has been paid amphoteric their utilization biomedical applications. We also highlight key challenges future directions clinical translation.
Language: Английский
Citations
23