Age period cohort analysis of cancer incidence from 1990 to 2019 in Türkiye

Cancer Epidemiology, Journal Year: 2025, Volume and Issue: 96, P. 102803 - 102803

Published: March 22, 2025

Language: Английский

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Survival Outcomes of Breast-Conserving Surgery Versus Mastectomy in Locally Advanced Breast Cancer Following Neoadjuvant Chemotherapy: A Meta-Analysis

Technology in Cancer Research & Treatment, Journal Year: 2024, Volume and Issue: 23

Published: Jan. 1, 2024

Background Mastectomy (MT) and breast conservation surgery (BCS) are two common surgical options for the treatment of locally advanced cancer (LABC). Neoadjuvant chemotherapy (NACT) is frequently administered before to shrink tumors improve outcomes. However, there a lack consensus on optimal approach after NACT its impact survival Objective This meta-analysis aims compare outcomes between MT BCS in patients treated with NACT. Method A PRISMA selection was used identify studies across electronic database such as PubMed, Cochrane Library from inception until 11 th July, 2023. total 10 comparative involving 5018 were included. Among them, 2898 underwent while 2120 receiving The assessed 5-year overall (OS) disease-free (DFS). data included pooled, odds ratios (OR) 95% confidence intervals (CI) calculated evaluate differences terms Prospero: CRD42024496831. Result revealed that who had higher OS compared those (OR 2.68, CI [2.19-3.28; p < 0.00001]). Additionally, DFS significantly better 3.11, [1.80-5.38; 0.0001]). Conclusion may be associated BCS.

Language: Английский

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Women in Interventional Cardiology: A Survey of Radiation Exposure and Breast Cancer Occurrence

Journal of Interventional Cardiology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background and Aims: Breast cancer (BC) is the leading cause of in women. Female interventional cardiologists are potentially at a higher risk developing BC due to occupational radiation exposure. This survey aimed understanding safety awareness current clinical practice, occurrence BC, among female cardiologists. Methods: A was conducted worldwide 64 cardiac laboratories from September 2022 December 2022. Results: 195 physicians (mean age 41.0 ± 7.4 years) completed survey: 33 (16.9%) reported being exposed X‐ray for less than five years, 78 (40%) between ten years 84 (43.1%) more years; 13 (6.7%) performing 50 procedures/year, 52 (26.7%) 100 130 (66.6%) procedures/year. 126 wearing three or dosimeters; 72 not using tableside shielding protect themselves direct scattered radiation. occurred four (2.1%) physicians, all whom worked electrophysiology laboratory relatively long time (one with 5–10 exposure mean presentation 46.5 3.7 years). All tumours were left‐sided BC. Conclusions: provides snapshot possible professional threat addition its real‐life epidemiology, negative impact on women’s lives laboratories. efforts should be made eliminate workers.

Language: Английский

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Global, Regional, and National Burden of Breast Cancer, 1990–2021, and Projections to 2050: A Systematic Analysis of the Global Burden of Disease Study 2021

Thoracic Cancer, Journal Year: 2025, Volume and Issue: 16(9)

Published: May 1, 2025

ABSTRACT Background This study analyzes the global burden of breast cancer (BC) over past 30 years, identifies key risk factors, and projects future incidence mortality through 2050. Methods Data were sourced from 2021 Global Burden Disease (GBD) database. The estimated annual percentage change (EAPC) was used to assess trends, country development measured using Socio‐Demographic Index (SDI). Projections conducted Bayesian age‐period‐cohort autoregressive integrated moving average models. Results In 2021, approximately 2.12 million new cases 674 199 deaths recorded globally. From 1990 prevalence increased, while disability‐adjusted life years (DALYs) declined overall. Regional national variations observed, alongside age gender differences in disease burden. A diet high red meat a body mass index leading factors for deaths. BC positively correlated with SDI across 21 GBD regions. Decomposition analysis highlighted demographic as main drivers increased three decades. indicate that will continue rise Conclusions While has decreased continues rise. Low‐SDI regions face increasing challenges, incidence, mortality, DALYs persistently climb. These findings underscore need targeted public health strategies equitable resource distribution mitigate rising cancer.

Language: Английский

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Long-term trends in the burden of colorectal cancer in Europe over three decades: a joinpoint regression and age-period-cohort analysis

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Dec. 5, 2023

Background The burden of colorectal cancer (CRC) in Europe is at a high level, but the epidemiological features have not yet been systematically studied. This study aimed to provide timely and reliable assessment trends CRC scientific basis for its prevention treatment. Methods We analyzed data on 44 European countries between 1990 2019 from Global Burden Disease (GBD) 2019. In addition, joinpoint regression model was applied reflect temporal trends. age-period-cohort constructed explore age, period, birth cohort effects that influence risk morbidity mortality. Results Europe, new cases, disability-adjusted life years (DALYs) deaths rose by 70.01%, 22.88% 38.04% 2019, respectively. age-standardized incidence rate (ASIR) has increased, while DALY mortality (ASMR) declined. found men experienced significantly higher than women. Age-period-cohort analysis showed increased with age time; it lower later-born earlier-born cohort. Conclusion ASIR generally trended upwards stabilizing recent still level. varied considerably different countries. There pronounced gender difference burden, middle-aged older should be priority population

Language: Английский

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Comparative age-period-cohort analysis

BMC Medical Research Methodology, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 18, 2023

Cancer surveillance researchers analyze incidence or mortality rates jointly indexed by age group and calendar period using age-period-cohort models. Many studies consider age- period-specific in two more strata defined sex, race/ethnicity, etc. A comprehensive characterization of trends patterns within each stratum can be obtained (APC) estimable functions (EF). However, currently available approaches for joint analysis synthesis EF are limited.We develop a new method called Comparative Age-Period-Cohort Analysis to quantify similarities differences across strata. identifies whether the stratum-specific hazard proportional age, period, cohort.Proportionality imposes natural constraints on that exploited gain efficiency simplify interpretation data. also identify diversity relationships between subsets ("pattern heterogeneity"). We present three examples cancer from United States Surveillance, Epidemiology, End Results Program: non-malignant meningioma sex; multiple myeloma among men stratified race/ethnicity; situ melanoma anatomic site white women.For with through around 10 strata, which covers many outstanding questions research, our provides comprehensive, coherent, reproducible approach functions.

Language: Английский

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A comparative study of sericin and gluten for magnetic nanoparticle-mediated drug delivery to breast cancer cell lines

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 5, 2024

With breast cancer emerging as a pressing global health challenge, characterized by escalating incidence rates and geographical disparities, there is critical need for innovative therapeutic strategies. This comprehensive research navigates the landscape of nanomedicine, specifically focusing on potential magnetic nanoparticles (MNPs), with magnetite (Fe3O4) taking center stage. MNPs, encapsulated in biocompatible polymers like silica known (MSN), are augmented phosphotungstate (PTA) enhanced chemodynamic therapy (CDT). PTA recognized its dual role natural chelator electron shuttle, expediting transfer from ferric (Fe3+) to ferrous (Fe2+) ions within nanoparticles. Additionally, protein-based charge-reversal nanocarriers silk sericin gluten introduced encapsulate (MSN-PTA) nanoparticles, offering dynamic facet drug delivery systems revolutionization therapy. study successfully formulates characterizes protein-coated nanocapsules, MSN-PTA-SER, MSN-PTA-GLU, optimal physicochemical attributes applications. The careful optimization concentrations results finely tuned showcasing uniform size, negative zeta potential, remarkable stability. Various analyses, Dynamic Light Scattering (DLS) scanning microscopy (SEM) transmission (TEM), Fourier Transform Infrared Spectroscopy (FTIR), X-Ray diffraction analysis (XRD), Thermogravimetric (TGA), provide insights into structural integrity surface modifications. Vibrating Sample Magnetometer (VSM) underscores superparamagnetic behavior, positioning these nanocapsules promising candidates targeted delivery. In vitro evaluations demonstrate dose-dependent inhibition cell viability MCF-7 Zr-75–1 cells, emphasizing MSN-PTA-SER MSN-PTA-GLU. interplay charge pH-dependent cellular uptake highlights robust stability versatility tumor microenvironment, paving way advancements personalized nanomedicine. comparative explores suitability gluten, unraveling avenue development advanced, targeted, efficient treatments.

Language: Английский

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Structure-Based Drug Design of 2-Amino-[1,1′-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(17), P. 15816 - 15836

Published: Aug. 20, 2024

CCNE1 amplification occurs in breast cancer and currently lacks effective therapies. PKMYT1 as a synthetic lethal target for holds promise the treatment of CCNE1-amplified cancer. Herein, we discover series 2-amino-[1,1′-biphenyl]-3-carboxamide derivatives potent selective inhibitors using structure-based drug design. The representative compound 8ma exhibited excellent potency against PKMYT1, while sparing WEE1. It also suppressed proliferation HCC1569 cell line showed synergistic cytotoxicity combination with gemcitabine. X-ray cocrystallography confirmed that introduction key binding interactions between residues Asp251 Tyr121 greatly enhanced selectivity compounds.

Language: Английский

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N-acetyl-d-glucosamine decorated solid lipid nanoparticles for targeted tamoxifen delivery to breast cancer cells

Journal of Nanoparticle Research, Journal Year: 2024, Volume and Issue: 26(11)

Published: Oct. 25, 2024

Language: Английский

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Exploration of epithelial-mesenchymal transition-related lncRNA signature and drug sensitivity in breast cancer

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: July 19, 2023

Background Breast cancer (BRCA) has become the most diagnosed worldwide for female and seriously endanger health. The epithelial-mesenchymal transition (EMT) process is associated with metastasis drug resistance in BRCA patients. However, prognostic value of EMT-related lncRNA still needs to be revealed. aim this study construct an (ERL) signature accuracy predictive ability prognosis Methods RNA-seq expression data Clinical characteristics obtained from TCGA (The Cancer Genome Atlas) were used study. First, we identified by Pearson correlation analysis. An lncRNAs risk was constructed using univariate Cox regression Lasso-penalized analyses. model’s performance validated Kaplan-Meier (KM) survival analysis, ROC curve C-index. Finally, a nomogram clinical practice evaluating patients calibration decision analysis (DCA). We also evaluated sensitivity tumor immune cell infiltration breast cancer. Results 10-lncRNA score based on EMT process. could assign high- low-risk group according median score. showed excellent demonstrated sufficient independence other characteristics. that related subtype. Drug proved ERLs effectively predict common chemotherapy drugs provide guidance high-risk Conclusion Our ERL have reliable tools guidance.

Language: Английский

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