Standardized Mortality Ratios (SMRs) and Radon Exposure Analysis for Lung Cancer and All-Cause Mortality in Locorotondo, Southern Italy DOI Creative Commons
Giovanni Maria Ferri, Luigi De Maria, G. Delvecchio

et al.

Medicina, Journal Year: 2024, Volume and Issue: 61(1), P. 47 - 47

Published: Dec. 31, 2024

Background and Objectives: Radon is a known risk factor for lung cancer, residential radon exposure the leading cause of cancer in never smokers; however, Italy, there still lack public awareness regarding caused by exposure. In this mortality study, which was carried out an Italian Apulian town (Locorotondo) Bari province, we aimed to analyze all-cause population highly exposed radon. Materials Methods: The study period 1998–2021. Local national data were collected from National Institute Statistics (ISTAT) website platform. using copies Health Authority death certificates. Results: We identified 117 cancers studied period. trends revealed decrease all-causes standardized ratios (SMRs), increases incidence rates colorectal recent years, noncancer diseases. also found high SMRs until 2016 among older females. With respect cardio-circulatory system, only 2014 did male significantly influence total SMR; after period, decreasing stable trend observed. Conclusions: natural balance decreasing, all causes. A future will be needed assess associations between observed cases domestic drive mitigation health strategies.

Language: Английский

Prognostic significance of a signature based on senescence-related genes in colorectal cancer DOI Creative Commons
Zoltán Ungvári, Anna Ungvari, Giampaolo Bianchini

et al.

GeroScience, Journal Year: 2024, Volume and Issue: 46(5), P. 4495 - 4504

Published: April 25, 2024

Colorectal cancer, recognized as a quintessential age-related disease, underscores the intricate interplay between aging mechanisms and disease pathogenesis. Cellular senescence, DNA damage-induced cellular stress response, is characterized by cell cycle arrest, expression of an inflammatory senescence-associated secretory phenotype, alterations in extracellular matrix metabolism. It widely fundamental evolutionarily conserved mechanism aging. Guided geroscience principles, which assert that pathogenesis diseases involves aging, this study delves into role senescence-related genes colon cancer progression. Leveraging gene set reflective pathways, we employed uni- multivariate Cox proportional hazards survival analysis combined with determination false discovery rate to analyze correlations survival. The integrated database 1130 specimens available relapse-free time relapse event data from ten independent cohorts provided robust platform for analyses. We identified associated differential levels linked shorter Our findings unveil prognostic signature utilizing (hazard ratio: 2.73, 95% CI 2.12-3.52, p = 6.4E - 16), offering valuable insights prediction cancer. Multivariate underscored independence epidemiological pathological variables. This highlights potential biomarkers. Overall, our results underscore pivotal

Language: Английский

Citations

15
Global, regional, and national trends in colorectal cancer burden from 1990 to 2021 and projections to 2040 DOI Creative Commons
Tao Zhang, Yuchen Guo,

Binxu Qiu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 16, 2025

Colorectal cancer (CRC) is a common malignancy with notable recent shifts in its burden distribution. Current data on CRC can guide screening, early detection, and treatment strategies for efficient resource allocation. This study utilized from the latest Global Burden of Diseases, Injuries, Risk Factors (GBD) Study. Initially, series descriptive statistics were performed incident cases, deaths, disability-adjusted life years (DALYs), age-standardized rates (ASRs) CRC. Percentage changes average annual percentage (AAPC) then calculated to understand trends disease burden. Decomposition frontier analyses conducted, finally, Bayesian age-period-cohort (BAPC) model was used predict ASRs up 2040. The GBD 2021 estimates indicate significant increase global DALYs 1990 2021. incidence rate (ASIR) increased (AAPC: 0.2), while mortality (ASMR) -0.72) -0.73) decreased. Males bore higher than females, though similar both sexes. Although developed regions had DALYs, they showed more declines ASRs. analysis revealed that population growth aging primary drivers Frontier as Socio-demographic Index increased, disparity among countries widened, having greater potential reduce these rates. By 2040, BAPC projects ASMR rates, ASIR expected decrease females but males across remains public health issue regional gender differences, necessitating region- population-specific prevention strategies.

Language: Английский

Citations

1
Gut microbiota in colorectal cancer: From pathogenesis to clinic DOI Creative Commons
William G. Fusco,

Ludovica Bricca,

Francesco Kaitsas

et al.

Best Practice & Research Clinical Gastroenterology, Journal Year: 2024, Volume and Issue: 72, P. 101941 - 101941

Published: Aug. 3, 2024

Colorectal cancer is the third most common type of cancer, with a significant burden on healthcare and social systems. Its incidence constantly rising, due to spread unhealthy lifestyle, i.e. Western diet. Increasing evidence suggests that westernization-driven microbiome alterations may play critical role in colorectal tumorigenesis. The current screening strategies for this neoplasm, mainly fecal immunochemical tests, are burdened by unsatisfactory accuracy. Novel, non-invasive biomarkers rising as new frontier screening, microbiome-based ones showing positive optimistic results. This Review describes our knowledge gut microbiota from its pathogenetic action clinical potential diagnostic biomarker.

Language: Английский

Citations

5
Burden and risk factors of colorectal cancer in Europe from 1990 to 2021 DOI
Tao Zhang, Shuai Wang, Dongming Li

et al.

European Journal of Cancer Prevention, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Background Colorectal cancer (CRC) poses a significant health burden in Europe, but comprehensive studies on this region are limited. Methods Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2021, we analyzed regional distribution temporal trends CRC early-onset Europe 1990 to 2021. Decomposition analysis was applied quantify contributions population growth, aging, epidemiological changes. The research also evaluated major risk factors associated with CRC. Results found be higher than global average. While age-standardized incidence rate (ASIR) increased, both mortality (ASMR) disability-adjusted life years (ASDR) decreased. Early-onset exhibits similar characteristics patterns change. Males had significantly females. Population aging primary driver increased Europe. factor revealed that low whole grain intake high red meat consumption were contributors elevated ASMR ASDR Additionally, BMI fasting plasma glucose showed an increasing trend. Conclusion overall remains level, ASIR decreasing ASDR. Targeted prevention control strategies should developed based for Older adults men prioritized interventions.

Language: Английский

Citations

0
Investigating temporal patterns of colorectal cancer incidence in Spain: A comprehensive analysis of age, period and cohort effects, 1990-2019 DOI Creative Commons
Lucía Cayuela, Gema Flox-Benítez,

Clara Peiró Villalba

et al.

Revista Española de Enfermedades Digestivas, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This study aimed to evaluate how age, period, and cohort (A-P-C) impact colorectal cancer (CRC) incidence in Spain from 1990 2019.

Language: Английский

Citations

1
Comparison analysis of the burden and attributable risk factors of early-onset and late-onset colorectal cancer in China from 1990 to 2019 DOI

Mingmin Gong,

Tian Xia,

Zefu Chen

et al.

European Journal of Cancer Prevention, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

Objectives The project intended to analyze the impact of burden and related risk factors late-onset colorectal cancer (LOCRC) early-onset (EOCRC) in China, thus offering essential references for optimizing prevention control strategies. Method Global Burden Disease Study was employed describe changes EOCRC LOCRC China during 1990–2019, containing numbers incidence, deaths, prevalence, disability-adjusted life years (DALYs), compare attributable deaths DALYs varying age sex segments. Results corresponding crude rates 1990–2019 demonstrated an upward trend across all categories, with males being dramatically predominant. Overall, over time, a low-calcium diet low-fiber on mortality DALY decreased, while other increased. In terms gender, affecting changed greatly, smoking, inadequate milk intake, low whole-grain main 2019, 1990, were diet, intake. Conclusion is concerning. Patients grouped by diagnostic exhibit different characteristics, indicating need high-quality research future achieve personalized medicine tailored population characteristics.

Language: Английский

Citations

0
Global Burden of Drug-Resistant Tuberculosis and HIV Co-Infection and Its Attributable Risk Factors, 1990 to 2021, with Projections to 2031 DOI Creative Commons

Liting Feng,

Yubao Wang, Li Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Abstract Background The continuous spread of HIV and drug-resistant tuberculosis (DR-TB) co-infection is a significant challenge threatens global (TB) control. objective this study was to analyze the burden across different age groups, genders, Socio-demographic Index (SDI) regions attributable risk factors. Methods Data from GBD 2021 joinpoint regression analysis were utilized examine trends 1990 genders SDI regions. A BAPC model employed forecast up 2031. Results Co-infection with Multidrug-resistant (MDR-TB) shows no gender difference, while extensively (XDR-TB) more prevalent in men (all P < 0.01). varies by SDI, low having MDR-TB high-middle XDR-TB. Unsafe sex primary factor for DR-TB, drug use being second major contributor intimate partner violence women. Projections DR-TB status indicate gradual decline 2019 Conclusion Despite declining trends, remains substantial, especially resource-limited areas. To combat co-infections XDR-TB, addition reducing unsafe sexual practices, it necessary implement measures curb abuse among protect women violence. Clinical trial number: not applicable.

Language: Английский

Citations

0
Standardized Mortality Ratios (SMRs) and Radon Exposure Analysis for Lung Cancer and All-Cause Mortality in Locorotondo, Southern Italy DOI Creative Commons
Giovanni Maria Ferri, Luigi De Maria, G. Delvecchio

et al.

Medicina, Journal Year: 2024, Volume and Issue: 61(1), P. 47 - 47

Published: Dec. 31, 2024

Background and Objectives: Radon is a known risk factor for lung cancer, residential radon exposure the leading cause of cancer in never smokers; however, Italy, there still lack public awareness regarding caused by exposure. In this mortality study, which was carried out an Italian Apulian town (Locorotondo) Bari province, we aimed to analyze all-cause population highly exposed radon. Materials Methods: The study period 1998–2021. Local national data were collected from National Institute Statistics (ISTAT) website platform. using copies Health Authority death certificates. Results: We identified 117 cancers studied period. trends revealed decrease all-causes standardized ratios (SMRs), increases incidence rates colorectal recent years, noncancer diseases. also found high SMRs until 2016 among older females. With respect cardio-circulatory system, only 2014 did male significantly influence total SMR; after period, decreasing stable trend observed. Conclusions: natural balance decreasing, all causes. A future will be needed assess associations between observed cases domestic drive mitigation health strategies.

Language: Английский

Citations

0