Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: July 16, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 17056 - 17056
Published: Dec. 2, 2023
Ongoing research is gradually broadening the idea of cancer treatment, with attention being focused on nanoparticles to improve stability, therapeutic efficacy, targeting, and other important metrics conventional drugs traditional drug delivery methods. Studies have demonstrated that carriers based biomaterials (e.g., protein lipids) inorganic materials metal nanoparticles) potential anticancer effects. Among these carriers, self-assembled proteins peptides, which are highly biocompatible easy standardize produce, strong candidates for preparation drugs. Breast (BC) cervical (CC) two most common deadly cancers in women. These not only threaten lives globally but also put a heavy burden healthcare system. Despite advances medical care, incidence cancers, particularly CC, almost entirely preventable, continues rise, mortality rate remains steady. Therefore, there still need in-depth develop more targeted, efficacious, safe therapies. This paper reviews types self-assembling peptides ferritin, albumin, virus-like particles) natural products soy paclitaxel) commonly used treatment BC CC describes can be delivered using as siRNAs, DNA, plasmids, mRNAs). The mechanisms (including self-assembly) by act discussed. mechanism action many similarities NF-KB Wnt). Thus, show CC.
Language: Английский
Citations
5
Neuroepidemiology, Journal Year: 2024, Volume and Issue: 58(3), P. 182 - 198
Published: Jan. 1, 2024
<b><i>Objective:</i></b> The objective of this study was to the primary risk factors for long-term trends mortality rates in ischemic stroke (IS) China. <b><i>Methods:</i></b> Using Global Burden Disease Study 2019 (GBD 2019) database, research conducted on 11 IS China from 1990 2019. This employed joinpoint regression software and age-period-cohort method evaluate divided by age, period, cohort over time. <b><i>Results:</i></b> From 2019, age-standardized rate (ASMR) caused a diet high red meat body mass index showed an upward trend. ASMR increased first then decreased due smoking, sodium, particulate matter pollution, fasting plasma glucose, systolic blood pressure. Low-density lipoprotein cholesterol (LDL-C), kidney dysfunction, low temperature, lead exposure remained relatively stable during period. In 35–45 age group, LDL-C up about 60%, smoking affected men more than women. Overall, LDL-C, pressure, pollution were most common patients with IS. death rose age. period relative risks that metabolic had greatest impact <b><i>Conclusion:</i></b> Metabolic have become Relevant authorities should pay attention their effects Effective public health policies interventions be implemented reduce burden
Language: Английский
Citations
1
International Journal of Epidemiology, Journal Year: 2024, Volume and Issue: 53(3)
Published: April 11, 2024
Abstract Background Epidemiological studies have shown inconsistent results regarding the link between smoking and breast cancer risk, despite biological plausibility of a positive association. Methods Participants were 166 611 women from nine prospective cohort in Japan which launched 1984–1994 followed for 8–22 years. Information on secondhand smoke was obtained through self-administered baseline questionnaires. Breast defined as code C50 according to International Classification Diseases Oncology, 3rd Edition or Diseases, 10th Revision. After adjusting several potential confounders, relative risks calculated individual current previous status active passive using Cox regression, by summary estimate hazard ratios random-effects meta-analyses. Results Of 60 441 participants who reported being premenopausal 106 170 postmenopausal at baseline, 897 1168 developed during follow-up, respectively. Compared with never smokers, smokers had higher risk developing before age 50 In addition, ever started 30 years younger, first childbirth, No association adulthood childhood exposure observed. Conclusion Smoking may increase cancer, earlier life might be especially harmful. The impact needs further investigation.
Language: Английский
Citations
1
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: March 20, 2024
Introduction Breast cancer remains the most significant affecting women worldwide, with an increasing incidence, especially in developing regions. The introduction of genomic tests like Oncotype DX has revolutionized personalized treatment, allowing for more tailored approaches to therapy. This study focuses on United Arab Emirates (UAE), where breast is leading cause cancer-related deaths among women, aiming assess predictive accuracy test categorizing patients based recurrence risk. Materials and methods A retrospective cohort was conducted 95 diagnosed at Tawam Hospital between 2013 2017 who underwent testing. Data patient demographics, tumor characteristics, treatment details, scores were collected. Survival analysis performed using Kaplan-Meier method, chi-square goodness fit assessing model's adequacy. Results cohort's age range 27-71 years, a mean 50, indicating concentration cases early post-menopausal period. classified 55 (57.9%) as low risk, 29 (30.5%) medium 11 (11.6%) high risk recurrence. majority, 73 (76.8%), did not receive chemotherapy, highlighting test's impact decisions. survival revealed no statistically difference rates across categories (p = 0.268231). Conclusion provides valuable approach by UAE. While influences decisions, particularly use this find correlation actual events. These findings underscore need further research optimize testing UAE's diverse population enhance strategies management.
Language: Английский
Citations
1
Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown
Published: July 16, 2024
Language: Английский
Citations
1