Epigenetic and Posttranscriptional Regulation in Retinoblastoma DOI Open Access
Tovar-Hernández Karla,

Ruíz-Cruz Matilde,

Marco Antonio Meraz‐Ríos

et al.

Advances in Bioscience and Biotechnology, Journal Year: 2023, Volume and Issue: 14(04), P. 190 - 209

Published: Jan. 1, 2023

The Retinoblastoma 1 (RB1) gene, located on chromosome 13q14 and encodes the tumor-suppressor retinoblastoma protein, is cause of Retinoblastoma. mutational inactivation both gene alleles brings this cancer. (RB) high-risk histopathological characteristics indicate metastasis or local recurrence with rapid progresses following RB1 inactivation. There growing interest in regulatory activities unconnected to coding region genome, exome, addition epigenetic control mechanisms. altered epigenome significant, though by no means only, problem etiology After all, cancer development a multistep process which numerous dissimilar genetic, epigenetic, posttranscriptional modifications result shared phenotype. This study emphasizes most recent developments change epigenetics related tumor biology. Here, we highlight novel biomarkers has expressed improve patient survival.

Language: Английский

CircBCL2L13 attenuates cardiomyocyte oxidative stress and apoptosis in cardiac ischemia‒reperfusion injury via miR‐1246/PEG3 signaling DOI
Hua Wu, Hairui Li, Qian Zhang

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(4)

Published: April 1, 2024

Abstract Ischemia‒reperfusion (I/R) is a common complication in the clinical treatment of acute myocardial infarction (MI), which cardiomyocytes play pivotal role recovery cardiac function after reperfusion injury. The expression numerous circular ribonucleic acids (circRNAs) disrupted I/R‐induced damage, but potential circRNAs I/R damage has not been fully elucidated. purpose present study was to clarify biological action and molecular mechanism circRNA 002166 (also termed circCL2L13) postmyocardial I/R. Oxygen–glucose deprivation/reoxygenation (OGD/R) an vivo model performed simulate damage. real‐time polymerase chain reaction analysis also conducted evaluate relationships SOD1, SOD2, NRF2, HO1 GPX4 indicators with oxidative stress TUNEL immunofluorescence used degree cardiomyocyte apoptosis different groups. circBCL2L13 level markedly upregulated tissues from mouse model. Overexpression attenuated stress‐related genes OGD/R‐induced cardiomyocytes. A mechanistic revealed that functions as ceRNA for miR‐1246 modulates paternally expressed gene 3 (PEG3). Eventually, proven regulate PEG3 by targeting miR‐1246, thereby protecting against apoptosis. In conclusion, our confirmed circBCL2L13/miR‐1246/PEG3 axis suppressed progression OGD/R injury cardiomyocytes, might lead new therapeutic strategies

Language: Английский

Citations

6
Exosomal circular RNA: a signature for lung cancer progression DOI Creative Commons
Bashdar Mahmud Hussen, Snur Rasool Abdullah,

Goran Sedeeq Hama Faraj

et al.

Cancer Cell International, Journal Year: 2022, Volume and Issue: 22(1)

Published: Dec. 1, 2022

Membrane vesicles having a diameter of 30-150 nm are known as exosomes. Several cancer types secrete exosomes, which may contain proteins, circular RNAs (circRNAs), microRNAs, or DNA. CircRNAs endogenous that do not code for proteins and can create continuous covalently closed loops. In pathogenesis, especially metastasis, exosomal circRNAs (exo-circRNAs) have crucial role mainly due to the frequently aberrant expression levels within tumors. However, neither activities nor regulatory mechanisms exo-circRNAs in advancing lung (LC) obvious. A better understanding regulation network connections will lead treatment LCs. The main objective current review is highlight functions LC assess relationships between exo-circRNA dysregulation progression. addition, underline possible therapeutic targets based on modulating.

Language: Английский

Citations

19
Competing endogenous RNA (ceRNA) networks in Parkinson's disease: A systematic review DOI Creative Commons

Mohammad Reza Asadi,

Samin Abed,

Ghazal Kouchakali

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Jan. 24, 2023

Parkinson's disease (PD) is a distinctive clinical syndrome with several causes and manifestations. Aside from an infectious cause, PD rapidly developing neurological disorder global rise in frequency. Notably, improved knowledge of molecular pathways the novel diagnostic methods may result better therapy for patients. In this regard, amount research on ceRNA axes rising, highlighting importance these PD. CeRNAs are transcripts that cross-regulate one another via competition shared microRNAs (miRNAs). These be either coding RNAs (mRNAs) or non-coding (ncRNAs). This used systematic review to assess validated loops The Prisma guideline was conduct review, which entailed systematically examining articles seven databases. Out 309 entries, forty met all criteria inclusion were summarized appropriate table. CeRNA have been described through vital components axes, including lncRNAs such as NEAT1, SNHG family, HOTAIR, MALAT1, XIST, circRNAs, lincRNAs. Understanding multiple aspects regulatory structure aid elucidating unknown causal providing innovative therapeutic targets medical fields.

Language: Английский

Citations

12
Advanced strategies of targeting circular RNAs as therapeutic approaches in colorectal cancer drug resistance DOI Creative Commons
Bashdar Mahmud Hussen, Snur Rasool Abdullah,

Abdulqahar Azizkhan Mohammed

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155402 - 155402

Published: June 14, 2024

Colorectal cancer (CRC) stands second in terms of mortality and third among the highest prevalent kinds globally. CRC prevalence is rising moderately poorly developed regions greater economically advanced regions. Despite breakthroughs targeted therapy, resistance to chemotherapeutics remains a significant challenge long-term management CRC. Circular RNAs (circRNAs) have been involved growing therapy resistance, particularly CRC, according an increasing number studies recent years. CircRNAs are one novel subclasses non-coding RNAs, previously thought as viroid. According studies, circRNAs recommended biological markers for therapeutic targets diagnostic prognostic purposes. That notable given that expression has linked hallmarks since they responsible drug patients; thereby, chemotherapy failure. Moreover, knowledge concerning relatively unclear despite using all these techniques. Here, this study, we will go over most published work highlight critical roles development main strategies overcome improve clinical outcomes.

Language: Английский

Citations

3
CircUTRN24/miR-483-3p/IGF-1 Regulates Autophagy Mediated Liver Fibrosis in Biliary Atresia DOI
Dong Liu,

Zhouguang Wu,

Jiahui Gao

et al.

Molecular Biotechnology, Journal Year: 2023, Volume and Issue: 66(6), P. 1424 - 1433

Published: June 27, 2023

Language: Английский

Citations

2
The Role of Long Noncoding RNAs in Progression of Leukemia: Based on Chromosomal Location DOI

Fatemeh Sabaghi,

Saina Yousefi Sadat,

Zohreh Mirsaeedi

et al.

MicroRNA, Journal Year: 2024, Volume and Issue: 13(1), P. 14 - 32

Published: Jan. 25, 2024

Abstract: Long non-coding RNA [LncRNA] dysregulation has been seen in many human cancers, including several kinds of leukemia, which is still a fatal disease with poor prognosis. LncRNAs have demonstrated to function as tumor suppressors or oncogenes leukemia. This study covers current research findings on the role lncRNAs prognosis and diagnosis leuke-mia. Based recent results, are emerging biomarkers for prognosis, di-agnosis, even treatment outcome prediction leukemia shown play critical roles controlling cell activities, such proliferation, death, metastasis, drug resistance. As result, lncRNA profiles may superior predictive diagnostic potential Accordingly, this review concentrates significance pro-gression based their chromosomal position.

Language: Английский

Citations

0
Epigenetic and Posttranscriptional Regulation in Retinoblastoma DOI Open Access
Tovar-Hernández Karla,

Ruíz-Cruz Matilde,

Marco Antonio Meraz‐Ríos

et al.

Advances in Bioscience and Biotechnology, Journal Year: 2023, Volume and Issue: 14(04), P. 190 - 209

Published: Jan. 1, 2023

The Retinoblastoma 1 (RB1) gene, located on chromosome 13q14 and encodes the tumor-suppressor retinoblastoma protein, is cause of Retinoblastoma. mutational inactivation both gene alleles brings this cancer. (RB) high-risk histopathological characteristics indicate metastasis or local recurrence with rapid progresses following RB1 inactivation. There growing interest in regulatory activities unconnected to coding region genome, exome, addition epigenetic control mechanisms. altered epigenome significant, though by no means only, problem etiology After all, cancer development a multistep process which numerous dissimilar genetic, epigenetic, posttranscriptional modifications result shared phenotype. This study emphasizes most recent developments change epigenetics related tumor biology. Here, we highlight novel biomarkers has expressed improve patient survival.

Language: Английский

Citations

1