Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 3, 2025
Aberrant
lipid
metabolism
is
a
well-recognized
hallmark
of
cancer.
Notably,
breast
cancer
(BC)
arises
from
lipid-rich
microenvironment
and
depends
significantly
on
metabolic
reprogramming
to
fulfill
its
developmental
requirements.
In
this
review,
we
revisit
the
pivotal
role
in
BC,
underscoring
impact
progression
tumor
microenvironment.
Firstly,
delineate
overall
landscape
highlighting
roles
patient
prognosis.
Given
that
lipids
can
also
act
as
signaling
molecules,
next
describe
exchanges
between
BC
cells
other
cellular
components
Additionally,
summarize
therapeutic
potential
targeting
aspects
processes,
lipid-related
transcription
factors
immunotherapy
BC.
Finally,
discuss
possibilities
problems
associated
with
clinical
applications
lipid‑targeted
therapy
propose
new
research
directions
advances
spatiotemporal
multi-omics.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 4, 2025
Background
The
complexity
of
the
galaninergic
system
is
still
not
fully
understood,
especially
under
specific
pre-existing
comorbidities
related
to
metabolic
dysfunction.
A
plant-derived
triterpenoid
celastrol
was
demonstrated
exert
a
complex
effect
on
and
have
hepatoprotective
anti-obesity
properties.
However,
exact
molecular
mechanisms
responsible
for
these
effects
remain
unclear.
Specifically,
there
are
no
data
impact
heart
liver
system.
Therefore,
this
study
aimed
investigate
expression
in
mice
suffering
from
diet-induced
obesity
dysfunction-associated
steatotic
disease
steatohepatitis
(MASLD/MASH).
Methods
male
C57BL/6J
were
fed
Western-type
high-fat
diet
16
20
weeks
induce
MASLD/MASH.
Celastrol
administered
along
with
last
4
evaluate
its
progression
conditions.
Moreover,
inhibitor
sterol
regulatory
element-binding
protein
1/2
(SREBP1/2),
fatostatin,
also
tested
compare
influence
celastrol.
Results
demonstrates
that
treatment
safe
led
reduction
food
energy
intake,
body
fat
weights,
MASLD-to-MASH
improved
glucose
tolerance,
serum
biochemistry
markers,
hepatic
lipid
peroxidation
mice.
Quantitative
gene
originally
showed
significant
regulation
galanin
all
three
receptors
(GalR1/2/3)
ventricles
only
GalR2
obese
influenced
receptors:
it
downregulated
Galr1
upregulated
Galr2
Galr3
ventricles,
potentially
affecting
metabolism,
oxidative
stress,
inflammation.
Fatostatin
suppressed
detected
members
depicting
role
SREBP
process.
Conclusion
These
findings
suggest
may
beneficially
modulate
progression,
indicating
potential
as
therapeutic
agent
disorders
associated
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 3, 2025
Aberrant
lipid
metabolism
is
a
well-recognized
hallmark
of
cancer.
Notably,
breast
cancer
(BC)
arises
from
lipid-rich
microenvironment
and
depends
significantly
on
metabolic
reprogramming
to
fulfill
its
developmental
requirements.
In
this
review,
we
revisit
the
pivotal
role
in
BC,
underscoring
impact
progression
tumor
microenvironment.
Firstly,
delineate
overall
landscape
highlighting
roles
patient
prognosis.
Given
that
lipids
can
also
act
as
signaling
molecules,
next
describe
exchanges
between
BC
cells
other
cellular
components
Additionally,
summarize
therapeutic
potential
targeting
aspects
processes,
lipid-related
transcription
factors
immunotherapy
BC.
Finally,
discuss
possibilities
problems
associated
with
clinical
applications
lipid‑targeted
therapy
propose
new
research
directions
advances
spatiotemporal
multi-omics.
