Cuproptosis: mechanisms and links with cancers

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: March 7, 2023

Abstract Cuproptosis was a copper-dependent and unique kind of cell death that separate from existing other forms death. The last decade has witnessed considerable increase in investigations programmed death, whether copper induced an independent form long been argued until mechanism cuproptosis revealed. After that, increasing number researchers attempted to identify the relationship between process cancer. Thus, this review, we systematically detailed systemic cellular metabolic processes copper-related tumor signaling pathways. Moreover, not only focus on discovery its mechanism, but also outline association cancers. Finally, further highlight possible therapeutic direction employing ion ionophores with cuproptosis-inducing functions combination small molecule drugs for targeted therapy treat specific

Language: Английский

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Regulatory roles of copper metabolism and cuproptosis in human cancers

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: March 23, 2023

Copper is an essential micronutrient for human body and plays a vital role in various biological processes including cellular respiration free radical detoxification. Generally, copper metabolism the stable state, there are specific mechanisms to regulate maintain homeostasis. Dysregulation of may have great connection with types diseases, such as Wilson disease causing overload Menkes deficiency. Cancer presents high mortality rates world due unlimited proliferation potential, apoptosis escape immune properties induce organ failure. thought cancer, elevated levels cancer tissue serum. also affects tumor progression by affecting angiogenesis, metastasis other processes. Notably, cuproptosis novel form cell death that provide targeting strategies developing therapy. chelators ionophores two coordinating compounds treatment cancer. This review will explore relationship between cancers, clarify targeted

Language: Английский

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Copper metabolism and cuproptosis in human malignancies: Unraveling the complex interplay for therapeutic insights

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e27496 - e27496

Published: March 1, 2024

Copper, a vital trace element, orchestrates diverse cellular processes ranging from energy production to antioxidant defense and angiogenesis. Copper metabolism cuproptosis are closely linked in the context of human diseases, with particular focus on cancer. Cuproptosis refers specific type copper-mediated cell death or copper toxicity triggered by disruptions within cells. This phenomenon encompasses spectrum mechanisms, such as oxidative stress, mitochondrial dysfunction, endoplasmic reticulum perturbations metal ion equilibrium. Mechanistically, is driven binding lipoylated enzymes tricarboxylic acid (TCA) cycle. interaction participates protein aggregation proteotoxic ultimately culminating death. Targeting its associated pathways cancer cells holds therapeutic potential selectively targeting eliminating cancerous Strategies modulate levels, enhance excretion, interfere cuproptotic being explored identify novel targets for therapy improve patient outcomes. Understanding relationship between malignancies remains an active area research. review provides comprehensive overview association metabolism, homeostasis, cancers, explicitly emphasizing mechanism implications pathogenesis. Additionally, we emphasize aspects treatment.

Language: Английский

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AI-Enhanced Comprehensive Liver Tumor Prediction using Convolutional Autoencoder and Genomic Signatures

International Journal of Advanced Computer Science and Applications, Journal Year: 2024, Volume and Issue: 15(2)

Published: Jan. 1, 2024

Liver tumor prediction plays a pivotal role in optimizing treatment strategies and improving patient outcomes. In our proposed work, we present an innovative AI-driven framework for liver prediction, uniting cutting-edge techniques to enhance precision depth of analysis. The integrates Histological Convolutional Autoencoder (HistoCovAE) meticulous segmentation medical imaging, Genomic Feature Extraction (MIRSLiC) nuanced understanding molecular markers. Additionally, Multidimensional module amalgamates videomics, radiomics, acoustics, clinical data, creating comprehensive dataset. These dimensions synergize unified model, offering detailed predictions encompassing characteristics, subtypes, prognosis. Model evaluation continuous improvement, guided by real-world outcomes, underscore reliability. This integrative approach transcends conventional boundaries, providing clinicians’ actionable insights personalized heralding new era prediction. Our model undergoes rigorous against diverse datasets, the performance metrics its reliability accuracy. With exceeding 87%, recall rates above 92%, Dice coefficient surpassing 0.89 segmentation, showcases exceptional accuracy robustness. prognostic modeling, survival consistently surpasses 84%, highlighting model's ability provide valuable into future trajectory cancer.

Language: Английский

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lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 26, 2024

Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.

Language: Английский

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Cuproptosis in cancers: Function and implications from bench to bedside

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116874 - 116874

Published: June 7, 2024

Copper, an indispensable micronutrient, is implicated in numerous vital biological processes and essential for all physiological activities. Recently, the discovery of a novel type copper-dependent cell death, known as cuproptosis, has shed light on its role cancer development. Extensive research currently underway to unravel mechanisms underlying cuproptosis correlation with various types. In this review, we summarize findings regarding roles types, including colorectal cancer, lung gastric breast liver cutaneous melanoma. Furthermore, effects copper-related agents such copper chelators ionophores proliferation, apoptosis, angiogenesis, tumor immunity, chemotherapy resistance have been explored preclinical clinical trials. These insights provide promising avenues development prospective anticancer drugs aimed at inducing cuproptosis.

Language: Английский

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Cuproptosis-Related lncRNA Gene Signature Establishes a Prognostic Model of Gastric Adenocarcinoma and Evaluate the Effect of Antineoplastic Drugs

Genes, Journal Year: 2022, Volume and Issue: 13(12), P. 2214 - 2214

Published: Nov. 25, 2022

Background: One of the most frequent malignancies digestive system is stomach adenocarcinoma (STAD). Recent research has demonstrated how cuproptosis (copper-dependent cell death) differs from other death mechanisms that were previously understood. Cuproptosis regulation in tumor cells could be a brand-new treatment strategy. Our goal was to create cuproptosis-related lncRNA signature. Additionally, order evaluate possible immunotherapeutic advantages and drug sensitivity, we attempted study association between these lncRNAs immune microenvironment STAD tumors. Methods: The TCGA database accessed download RNA sequencing data, genetic mutations, clinical profiles for STAD. To locate related build risk-prognosis models, three techniques used: co-expression network analysis, Cox-regression techniques, LASSO techniques. an integrated methodology used validate models’ predictive capabilities. Then, using GO KEGG discovered variations biological functions each group. link risk score various medications estimated mutational load (TMB) dysfunction rejection (TIDE) scores. Result: We gathered 22 genes linked based on prior literature. Six prognostic marker (AC016394.2, AC023511.1, AC147067.2, AL590705.3, HAGLR, LINC01094). After that, patients split into high-risk low-risk groups. A statistically significant difference overall survival two groups visible curves. independent factor affecting prognosis by both univariate multivariate Cox regression analysis. Different scores substantially immunological states patients, as further evidenced infiltration ssGSEA had differing burdens mutations. In addition, immunotherapy more effective group than group, connected with medication sensitivity. Conclusions: six cuproptosis-associated predictors, which may useful biomarkers stratification, evaluation immunotherapy, assessment sensitivity

Language: Английский

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Insights into prognosis and immune infiltration of cuproptosis-related genes in breast cancer

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 28, 2022

Introduction Breast cancer (BC) has been ranking first in incidence and the leading cause of death among female cancers worldwide based on latest report. Regulated cell (RCD) plays a significant role tumor initiation provides an important target treatment. Cuproptosis, novel form RCD, is ignited by mitochondrial stress, particularly lipoylated enzymes aggregation. However, cuproptosis-related genes (CRGs) generation progression remains unclear. Methods In this study, mRNA expression data CRGs BC normal breast tissue were extracted from TCGA database, protein patterns these analyzed using UALCAN. The prognostic values explored KaplanMeier plotter Cox regression analysis. Genetic mutations profiles evaluated cBioPortal database. Meanwhile, we utilized CIBERSORT TIMER 2.0 database to perform correlation analysis between immune infiltration. Results Our results indicated that significantly different tissues. Then found upregulated PDHA1 was associated with worse endpoint BC. Moreover, also performed infiltration CRGs, demonstrated closely related levels CD4+ memory T cell, macrophage M0 M1 mast Conclusions immunogenetic Therefore, can be independent biomarker potential for immunotherapy

Language: Английский

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Cuproptosis-Related Ferroptosis genes for Predicting Prognosis in kidney renal clear cell carcinoma

European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)

Published: May 15, 2023

Abstract Kidney renal clear cell carcinoma (KIRC) is a main subtype of kidney cancers. Cuproptosis and ferroptosis are correlated with immune infiltration prognosis in tumors. However, the role Cuproptosis-related Ferroptosis genes (CRFGs) KIRC has rarely been fully understood. Therefore, we constructed prognostic signature based on different expression CRFGs KIRC. All raw data this study were extracted from public TCGA datasets. collected previous research. Finally, total 36 significantly identified TCGA–KIRC cohort. Six-gene ( TRIB3 , SLC2A3 PML CD44 CDKN2A MIOX ) was by LASSO Cox regression CRFGs. The worse overall survival AUC 0.750. Functional enrichment indicated that mainly enriched metabolism, drug resistance, tumor immunity pathways. Besides, IC50 checkpoint differentially expressed between groups. proposed 6-CRFGs promising biomarker to predict clinical outcomes therapeutic responses for patient.

Language: Английский

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PANoptosis-related genes function as efficient prognostic biomarkers in colon adenocarcinoma

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: March 4, 2024

Background PANoptosis is a newly discovered cell death type, and tightly associated with immune system activities. To date, the mechanism, regulation application of in tumor largely unknown. Our aim to explore prognostic value PANoptosis-related genes colon adenocarcinoma (COAD). Methods Analyzing data from The Cancer Genome Atlas-COAD (TCGA-COAD) involving 458 COAD cases, we concentrated on five pathways Molecular Signatures Database (MSigDB) comprehensive set immune-related genes. approach involved identifying distinct genetic subtype clusters developing model based these parameters. Results research successfully identified two COAD, marked by profiles gene expression. A model, incorporating findings, demonstrated significant predictive power for survival outcomes, underscoring interplay between responses COAD. Conclusion This study enhances our understanding COAD’s framework, emphasizing synergy system. development insights offers promising tool personalized treatment strategies. Future should focus validating refining this clinical settings optimize therapeutic interventions

Language: Английский

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