Unraveling the clinical significance and prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammation response index, and delta neutrophil index: An extensive literature review

Turkish Journal of Emergency Medicine, Journal Year: 2024, Volume and Issue: 24(1), P. 8 - 19

Published: Jan. 1, 2024

In the field of critical care medicine, substantial research efforts have focused on identifying high-risk patient groups. This has led to development diverse diagnostic tools, ranging from basic biomarkers complex indexes and predictive algorithms that integrate multiple methods. Given ever-evolving landscape driven by rapid advancements, changing treatment strategies, emerging diseases, validation tools remains an ongoing dynamic process. Specific changes in complete blood count components, such as neutrophils, lymphocytes, monocytes, platelets, are key immune system responses influenced various factors crucial systemic inflammation, injury, stress. It been reported indices neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), immune-inflammation index (SII), inflammation response (SIRI), delta neutrophil calculated using ratios these elements, important predictors outcomes conditions where inflammatory process is at forefront. this narrative review, we concluded NLR, PLR, SII, SIRI show promise predicting for different health related inflammation. While tests accessible, reliable, cost-effective, their standalone performance a specific condition limited.

Language: Английский

---

Prognostic and clinicopathological value of systemic inflammation response index (SIRI) in patients with breast cancer: a meta-analysis

Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)

Published: April 3, 2024

Background Many studies have explored the value of systemic inflammation response index (SIRI) in predicting prognosis patients with breast cancer (BC); however, their findings remain controversial. Consequently, we performed present meta-analysis to accurately identify role SIRI BC prognosis.

Language: Английский

---

The associations of two novel inflammation indexes, systemic immune-inflammation index (SII) and system inflammation response index (SIRI), with periodontitis: evidence from NHANES 2009–2014

Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 28(2)

Published: Feb. 1, 2024

Language: Английский

---

Prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma: a systematic review and meta-analysis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 26, 2024

Background It is unclear whether the systemic inflammation response index (SIRI) can predict prognosis of patients with hepatocellular carcinoma (HCC). Consequently, present study focused on systematically identifying relationship between SIRI and HCC through a meta-analysis. Methods Systematic comprehensive studies were retrieved from PubMed, Web Science, Embase, Cochrane Library their inception to August 10, 2023. The role in predicting overall survival (OS) progression-free (PFS) was determined using pooled hazard ratios (HRs) 95% confidence intervals (CIs). Odds (ORs) CIs analyze correlations clinicopathological features HCC. Results Ten articles involving 2,439 included. An elevated significantly associated dismal OS (HR=1.75, CI=1.52–2.01, p<0.001) inferior PFS (HR=1.66, CI=1.34–2.05, Additionally, according combined results, increased related multiple tumor numbers (OR=1.42, CI=1.09–1.85, p=0.009) maximum diameter >5 cm (OR=3.06, CI=1.76–5.30, p<0.001). However, did not show any significant sex, alpha-fetoprotein content, Child-Pugh class, or hepatitis B virus infection. Conclusion According our predicted Moreover, aggressiveness. review registration https://inplasy.com/inplasy-2023-9-0003/ , identifier INPLASY202390003.

Language: Английский

---

Prognostic and clinicopathological role of pretreatment systemic immune-inflammation index in patients with oral squamous cell carcinoma: a meta-analysis

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 13

Published: Jan. 16, 2024

Background There are many studies regarding the use of systemic immune-inflammation index (SII) to help predict oral squamous cell carcinoma (OSCC) prognosis, but findings have been inconsistent. The present meta-analysis was conducted determine whether SII could contribute predicting OSCC prognosis. Methods PubMed, Embase, Cochrane Library and Web Science databases were thoroughly searched from their inceptions through August 20, 2023. role in prognosis determined combined hazard ratios (HRs) with relevant 95% confidence intervals (CIs). Correlations clinicopathological characteristics patients analyzed based on odds (ORs) CIs. Results This utilized 11 articles total, involving 3,464 patients. According results, an elevated markedly associated dismal overall survival (OS) (HR=1.85, 95%CI=1.48-2.29, p<0.001) poor disease-free (DFS) (HR=1.77, 95%CI=1.20-2.61, p=0.004) OSCC. Moreover, a higher correlated stage T3-T4 (OR=2.47, 95%CI=1.40-4.37, p=0.002), TNM III-IV (OR=2.29, 95%CI=1.53-3.44, p<0.001), low differentiation (OR=1.74, 95%CI=1.25-2.43, p=0.001). Conclusion meta-analysis, increased is significantly OS DFS, advanced tumor be potential important biomarker for clinical management Systematic review registration https://inplasy.com/inplasy-2023-9-0033/ ), identifier INPLASY202390033.

Language: Английский

---

Systemic inflammatory response index as a novel biomarker for age-related macular degeneration: a cross-sectional study from NHANES (2005–2008)

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 6, 2025

Background Chronic low-grade systemic inflammation plays a significant role in age-related macular degeneration (AMD) pathogenesis. The inflammatory response index (SIRI), novel marker, may predict various diseases. However, data on the relationship between SIRI and AMD are limited. This study examines assesses its potential as predictive biomarker. Methods A cross-sectional analysis of National Health Nutrition Examination Survey (NHANES) from 2005 to 2008 was conducted participants aged ≥40 years with status data. Multivariable logistic regression models adjusted for confounders were used assess association. Sensitivity subgroup analyses, along restricted cubic spline (RCS) curve analysis, performed. Results Among 5,365 participants, 425 (7.9%) had AMD. median higher patients (1.23 vs. 1.04, p < 0.001). Higher independently associated increased odds (adjusted OR: 1.18, 95% CI:1.07–1.29, = RCS analyses revealed dose–response ( 0.002). Subgroup showed positive association male individuals hypertension, obesity, non-smokers. levels risk 1.27, CI: 1.03–1.56, 0.023). Conclusion Elevated is U.S. population. serve biomarker identifying high-risk individuals, enabling early intervention. design limits causal inference, unmeasured affect results. could potentially non-invasive risk, pending further validation through longitudinal studies.

Language: Английский

---

Prognostic role of systemic inflammation response index (SIRI) in patients with pancreatic cancer: a meta-analysis

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 11, 2024

Background The significance of the systemic inflammation response index (SIRI) in predicting prognosis patients with pancreatic cancer (PC) has been extensively explored; however, findings remain controversial. As such, this meta-analysis was performed to more precisely determine utility SIRI PC prognosis. Methods A comprehensive literature search PubMed, Web Science, Embase, and Cochrane Library databases for relevant studies, published up June 25, 2024, performed. primary secondary endpoints were overall survival (OS) progression-free (PFS), respectively. prognostic estimated by calculating pooled hazard ratios (HRs) corresponding 95% confidence intervals (CIs). Results Seven studies comprising 1160 included present meta-analysis. Pooled revealed that elevated as a prominent marker OS (HR 2.40 [95% CI 1.88–3.05]; p<0.001) PFS 1.95 1.19–3.21]; p=0.008) diagnosed PC. According subgroup analysis, remained an outstanding OS, irrespective region, sample size, study center, design, TNM stage, type, cut-off value, treatment, or analysis type (all p<0.05). Moreover, based on demonstrated significant PFS, region threshold value (p<0.05). Conclusion increased significantly predicted Considering its cost-effectiveness availability, may be promising biomarker

Language: Английский

---

Association between systemic immune-inflammation index and risk of lower extremity deep venous thrombosis in hospitalized patients: a 10-year retrospective analysis

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 16, 2023

The systemic immune-inflammation index (SII), as a novel inflammatory biomarker, has recently attracted attention in cardiovascular disease research. However, the relationship between SII and risk of lower extremity deep venous thrombosis (LEDVT) remains unclear to date. Thus, this study aimed explore association large sample over 10-year period (2012-2022).All hospitalized patients undergoing compression ultrasonography (CUS) examination were consecutively screened by searching our hospital information system database. receiver operating characteristic (ROC) curve analysis was used identify optimal cut-off value for high low group. Multivariate logistic regression analyses performed investigate LEDVT risk. Propensity score matching (PSM), subgroup sensitivity also conducted. Moreover, restricted cubic spline (RCS) two-piecewise linear models assess dose-response natural log transformed [ln(SII)] LEDVT.A total 16,725 consecutive included, 1,962 events occurred. After adjusting confounding factors, group (≥ 574.2 × 109/L) showed 1.740-fold (95% CI: 1.546-1.959, P < 0.001), elevated ln(SII) associated with 36.1% increased 1.278-1.449, 0.001). PSM, confirmed robustness association. A non-linear observed (Pnon-linear threshold 5.6 109/L all events. Above threshold, each unit increase had 1.369-fold higher 1.271-1.475, existed both distal proximal LEDVT.Elevated is significantly an patients. Additionally, exhibit effect.

Language: Английский

---

U-shaped relationship found between fibrinogen-to-albumin ratio and systemic inflammation response index in osteoporotic fracture patients

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 17, 2024

The relationship between the Systemic Inflammatory Response Index (SIRI) and Fibrinogen-to-albumin ratio (FAR) has not been extensively investigated. objective of this study was to determine independent FAR SIRI in people with osteoporotic fractures (OPF). A cross-sectional conducted using retrospective data from 3431 hospitalized OPF patients. exposure variable baseline FAR, while outcome SIRI. Covariates, including age, gender, BMI, other clinical laboratory factors, were adjusted. Cross-correlation analysis linear regression models applied. generalized additive model (GAM) investigated non-linear relationships. Adjusted revealed an negative association patients (β = - 0.114, p 0.00064, 95% CI 0.180, 0.049). substantial U-shaped shown GAM (p < 0.001). indicated a for below 6.344% positive correlation over 6.344%. results our FAR. lowest conceivable bone-loose inflammatory disease might be 6.344%, suggesting that particular significance medical diagnosis therapy persons OPF. Consequently, term "inflammatory trough" is proposed. These offer fresh perspectives on controlling inflammation individuals preventing osteoporosis.

Language: Английский

---

Prognostic significance of C-reactive protein in patients with cervical cancer: a meta-analysis

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: Sept. 1, 2023

Background Numerous studies have investigated the significance of pretreatment C-reactive protein (CRP) levels for determining prognosis cervical cancer (CC). The results these studies, however, been inconsistent. present meta-analysis, therefore, focused on identifying exact relationship CRP with CC prognoses. Methods We searched following databases from their inception until April 18, 2023: PubMed; Web Science; Embase; and Cochrane Library. From search results, we estimated in CC, based combined hazard ratios (HRs) relevant 95% confidence intervals (CIs). Results meta-analysis included 12 encompassing 2,204 patients. Based data, an increased level was significantly related to unfavorable overall survival (OS) patients (HR = 1.63; CI 1.36–1.95; P &lt; 0.001). Moreover, associated shortened progression-free (PFS) 1.68; 1.39–2.03; According subgroup sensitivity analyses, a reliable factor Conclusion our were significant predictors poor OS PFS CC. level, could be independent inexpensive clinical settings. Systematic review registration INPLASY, identifier INPLASY202360074.

Language: Английский

---