International Journal of Research Publication and Reviews,
Journal Year:
2023,
Volume and Issue:
4(10), P. 2677 - 2682
Published: Oct. 16, 2023
Deproteinized
Leaf
Juice
(DPJ)
is
a
ground
breaking
innovation
poised
to
unlock
the
latent
potential
within
plant
leaves,
presenting
concentrated
reservoir
of
bioactive
compounds
with
diverse
applications.The
biochemical
analysis
DPJ
reveals
rich
mosaic
encompassing
polyphenols,
terpenoids,
alkaloids,
and
sennosides.These
imbue
pantheon
health
benefits,
ranging
from
antioxidant
fortification
antiinflammatory
support
immune
enhancement
digestive
health.These
findings
portend
future
where
serves
as
versatile
source
natural
remedies
functional
ingredients
catering
spectrum
conditions.Beyond
healthcare,
extends
its
promise
agriculture
an
environmentally
friendly
alternative
synthetic
pesticides
fertilizers.While
challenges
such
compositional
variability
need
for
in-depth
mechanistic
elucidation
remain.In
present
review
paper
we
have
compiled
information
which
explained
importance
(DPJ).
Allergy,
Journal Year:
2024,
Volume and Issue:
79(7), P. 1789 - 1811
Published: Feb. 23, 2024
Abstract
We
performed
a
systematic
review
to
investigate
the
current
evidence
on
association
between
allergic
diseases
and
short
chain
fatty
acids
(SCFAs),
which
are
microbially
produced
suggested
as
one
mechanism
how
gut
microbiome
affects
risk
of
diseases.
Medline,
Embase
Web
Science
were
searched
from
data
inception
until
September
2022.
identified
37
papers,
17
investigated
prenatal
or
early
childhood
SCFAs
development
in
childhood,
20
assessed
patients
with
pre‐existing
Study
design,
study
populations,
outcome
definition,
analysis
method
reporting
results
varied
papers.
Overall,
there
was
some
showing
that
three
main
(acetate,
propionate
butyrate)
first
few
years
life
had
protective
effect
against
diseases,
especially
for
atopic
dermatitis,
wheeze
asthma
IgE‐mediated
food
allergy
childhood.
The
each
SCFA
disease
appeared
be
different
by
age
assessment.
Further
research
can
determine
potentially
timing
specific
will
useful
used
treatment
prevention
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
14
Published: Jan. 9, 2025
The
microbiome-gut-testis
axis
has
emerged
as
a
significant
area
of
interest
in
understanding
testicular
cancer,
particularly
germ
cell
tumors
(TGCTs),
which
represent
the
most
common
malignancy
young
men.
interplay
between
gut
and
microbiomes
is
hypothesized
to
influence
tumorigenesis
reproductive
health,
underscoring
complex
role
microbial
ecosystems
disease
pathology.
encompasses
interactions
microbiome,
systemic
immune
modulation,
local
microenvironment
testis.
Dysbiosis
or
may
contribute
altered
responses,
inflammation,
hormonal
imbalances,
potentially
playing
pathogenesis
TGCTs.
Concurrently,
seminal
have
been
linked
variations
sperm
quality,
fertility
potential,
possibly
cancer
susceptibility,
need
for
further
evaluation.
This
review
explores
emerging
context
highlighting
its
implications
onset,
progression,
treatment
efficacy,
toxicity.
Identifying
potential
biomarkers,
followed
by
microbiota
modulation
restore
balanced
community,
might
offer
novel
supportive
strategy
improving
efficacy
refractory
TGCT
patients
while
reducing
chemotherapy-induced
We
suggest
better
association
dysregulated
environments
TGCTs
emphasizes
pathways
microbiome
cancer.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 4, 2025
Short-chain
fatty
acids
(SCFAs)
have
attracted
considerable
interest
as
potential
biomarkers,
therapeutic
targets,
and
nutritional
factors
in
athletic
training.
SCFAs
are
typically
produced
by
the
intestinal
microbiome
exhibit
various
structural
forms,
including
linear-
branched-chain
types.
In
particular,
been
associated
with
muscle
metabolism
during
exercise
loading.
Consequently,
accurate
efficient
analytical
methods
essential
for
identifying
these
biomarkers.
Liquid
chromatography-tandem
mass
spectrometry
is
a
suitable
technique
SCFA
analysis;
however,
stable
isotope
calibrations
required
all
analytes.
Because
of
technological
limitations,
available
species
restricted
to
certain
types
SCFAs.
To
address
this
issue,
study
performed
simple
conversion
reaction
involving
incorporation
18O
into
carboxyl
group.
Specifically,
oxygen
atoms
groups
were
substituted
sourced
from
commercially
H218O.
An
mixture
standard
solution
was
successfully
labeled
under
optimized
conditions,
SIL
purity
amount
sufficient
dilution
(95.2-96.9%,
250
assays
using
10
μL
H218O).
Moreover,
no
reversion
16O
observed
storage
or
analysis.
Analytical
validation
human
serum
isotopic
mixture,
achieving
good
accuracy
(90-110%)
precision
(<10%
relative
deviation)
across
three
concentration
levels.
Finally,
changes
patterns
examined
athletes
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: Nov. 24, 2023
Exploring
the
role
of
gut
microbiome
in
oncology
is
gaining
more
attention,
mainly
due
to
its
ability
shape
immune
system
cancer
patients.
A
well-balanced
microbial
composition
forms
a
symbiotic
relationship
with
host
organism.
Mounting
evidence
supports
potential
modifiable
lifestyle
factors,
such
as
diet
and
physical
activity,
restoring
intestinal
dysbiosis
related
development
treatment.
In
this
Minireview,
we
describe
host-microbiome
interplay
following
different
dietary
patterns,
including
high-fat
diet,
fiber-rich
rich
rice
beans,
Mediterranean
ketogenic
activity
preclinical
findings
clinical
settings.
According
results,
nutrition
critical
factor
influencing
communities.
Therefore,
knowledge
about
patient’s
nutritional
status
pre-treatment
treatment
becomes
crucial
for
further
management.
combination
individualized
habits
professional
training
plans
might
help
maintain
homeostasis,
potentially
improving
response
anti-cancer
therapy
quality
life
survivors.
However,
deep
understanding
underlying
mechanisms
large
trials
are
needed
uncover
clinically
relevant
correlations
personalized
approaches
leading
better
outcomes
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6348 - 6348
Published: June 8, 2024
Cancers
are
causing
millions
of
deaths
and
leaving
a
huge
clinical
economic
burden.
High
costs
cancer
drugs
limiting
their
access
to
the
growing
number
cases.
The
development
more
affordable
alternative
therapy
could
reach
patients.
As
gut
microbiota
plays
significant
role
in
treatment
cancer,
microbiome-targeted
has
gained
attention
recent
years.
Dietary
natural
compounds
can
modulate
composition
while
providing
broader
accessible
medicine.
Tea
have
been
shown
anti-cancer
properties
as
well
related
metabolites.
However,
there
is
no
comprehensive
review
that
focuses
on
modulatory
effects
tea
impact
reshaping
metabolic
profiles,
particularly
models.
In
this
review,
different
settings
discussed.
Furthermore,
relationship
between
these
modulated
bacteria
metabolites,
along
with
mechanisms
how
changes
led
intervention
summarized.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 19, 2024
Atypical
antipsychotics
are
crucial
for
the
management
of
schizophrenia
and
bipolar
disorder,
yet
they
exhibit
significant
pharmacokinetic
variability
which
leads
to
inconsistent
therapeutic
responses.
This
study
investigates
hypothesis
that
gut
microbiome
composition
critically
influences
oral
bioavailability
lurasidone,
a
poorly
soluble
weak
base
antipsychotic
with
pH-dependent
solubility.
To
investigate
this,
male
Sprague-Dawley
rats
underwent
systematic
manipulation
through
pretreatment
antibiotics
or
prebiotics
(inulin)
14
days
prior
single
dose
lurasidone.
Pharmacokinetic
analysis
collected
plasma
samples
revealed
4.3-fold
increase
in
lurasidone
following
prebiotic
pretreatment,
compared
control
(no
pretreatment)
group.
Conversely,
was
highly
variable
depleted
(i.e.,
antibiotic
treatment
group),
80%
animals
demonstrating
lower
than
Characterisation
short-chain
fatty
acid
(SCFA)
concentrations
demonstrated
positive
correlations
between
bioavailability,
microbial
diversity,
SCFA
levels,
mediated
by
modulation
luminal
pH.
Elevated
levels
created
favourable
environment
solubilisation
lowering
intestinal
These
findings
highlight
potential
optimising
pharmacokinetics
personalised
interventions.
Furthermore,
correlation
SCFAs
suggests
their
as
biomarkers
predicting
inter-patient
variability,
particularly
bases.
Thus,
new
avenues
opened
developing
novel
co-therapies
screening
tools
enhance
performance,
potentially
improving
outcomes
patients
disorder.
