Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: March 13, 2024
Animal
models
have
been
commonly
used
in
immunotherapy
research
to
study
the
cell
response
external
agents
and
assess
effectiveness
safety
of
new
therapies.
Over
past
few
decades,
immunocompromised
(also
called
immunodeficient)
mice
allowed
researchers
grow
human
tumor
cells
without
impact
host’s
immune
system.
However,
while
this
model
is
very
valuable
understand
biology
underlying
mechanism
immunotherapy,
results
may
not
always
directly
translate
humans.
The
microenvironment
has
significant
implications
for
engraftment,
growth,
invasion,
etc.,
system
plays
a
critical
role
shaping
microenvironment.
Human
immunocompetent
mice,
also
named
humanized
are
engineered
that
possess
functional
cells.
This
vivo
can
be
effectively
effect
implanted
tumor.
Moreover,
mimic
treatment.
section
an
overview
current
understanding
different
could
utilized
chordoma.
Genome Medicine,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Nov. 18, 2024
Inter-
and
intra-tumor
heterogeneity
is
considered
a
significant
factor
contributing
to
the
development
of
endocrine
resistance
in
breast
cancer.
Recent
advances
single-cell
RNA
sequencing
(scRNA-seq)
ATAC
(scATAC-seq)
allow
us
explore
inter-
at
resolution.
However,
such
integrated
analysis
has
not
yet
been
demonstrated
characterize
transcriptome
chromatin
accessibility
cancer
resistance.
In
this
study,
we
conducted
an
combining
scRNA-seq
scATAC-seq
on
more
than
80,000
tissue
cells
from
two
normal
tissues
(NTs),
three
primary
tumors
(PTs),
tamoxifen-treated
recurrent
(RTs).
A
variety
cell
types
among
tumor
were
identified,
PT-
RT-specific
states
(CSs)
defined,
heterogeneity-guided
core
signature
(HCS)
was
derived
through
analysis.
Functional
experiments
performed
validate
oncogenic
role
BMP7,
key
gene
within
signature.
We
observed
striking
level
cell-to-cell
six
delineated
progression,
underscoring
significance
these
clusters
classified
data.
defined
nine
CSs,
including
five
PT-specific,
RT-specific,
one
PT-RT-shared
identified
distinct
open
regions
as
well
HCS
137
genes.
addition,
predicted
specific
transcription
factors
(TFs)
associated
with
novel
biological/metabolism
pathways
that
mediate
communications
between
CSs
microenvironment
(TME).
finally
BMP7
plays
tamoxifen-resistant
modulating
MAPK
signaling
pathways.
Our
provides
comprehensive
understanding
tamoxifen
envision
epigenomic
transcriptomic
measure
will
become
powerful
approach
unravel
how
epigenetic
govern
uncover
potential
therapeutic
targets
circumvent
heterogeneity-related
failures.
IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 21, 2024
This
chapter
provides
a
detailed
overview
of
innovative
drug
delivery
strategies
in
breast
cancer
therapeutics,
emphasizing
emerging
and
futuristic
approaches.
Current
modalities,
including
conventional
chemotherapy,
targeted
therapies,
hormone
treatments,
are
critically
assessed
regarding
their
mechanisms
clinical
efficacy.
The
highlights
advancements
systems,
such
as
nanotechnology-based
formulations,
liposomal
carriers,
implantable
devices,
which
enhance
therapeutic
effectiveness
minimize
systemic
toxicity.
Futuristic
strategies,
particularly
precision
medicine,
explored
for
potential
to
tailor
treatments
based
on
genomic
molecular
profiling,
thereby
optimizing
responses
reducing
adverse
effects.
role
nanotechnology
achieving
therapeutics
cells
while
sparing
healthy
tissues
is
examined.
Additionally,
gene
editing
technologies,
CRISPR,
discussed
ability
selectively
modulate
cancer-related
genes,
promising
precise
lasting
also
covers
immunotherapeutic
innovations,
CAR
T-cell
therapy
vaccines,
leverage
the
immune
system’s
capacity
target
eliminate
cells.
In
summary,
this
elucidates
transformative
novel
cancer,
highlighting
integration
advanced
technologies
foster
effective,
personalized
treatment
paradigms.
Journal of Biotechnology,
Journal Year:
2023,
Volume and Issue:
380, P. 20 - 28
Published: Dec. 19, 2023
Cancer
stands
as
one
of
the
most
common
and
lethal
diseases,
imposing
a
substantial
burden
on
global
mortality
rates.
Breast
cancer
is
distinct
from
other
forms
in
which
it
primary
cause
death
for
women.
Early
detection
breast
can
significantly
lower
risk
mortality,
improving
prognosis
those
who
are
affected.
The
rate
has
been
steadily
rising,
according
to
epidemiological
data,
especially
since
COVID-19
pandemic.
This
emphasizes
necessity
sensitive
precise
technologies
that
be
utilized
early
diagnosis.
In
this
process,
biomarkers
play
pivotal
role
by
facilitating
diagnosis
cancer.
Currently,
wide
variety
have
identified,
accuracy
These
applied
liquid
biopsies
well
solid
tissues.
context
cancer,
particularly
valuable
determining
predisposed
disease,
predicting
at
time
diagnosis,
selecting
best
course
therapy.
review
comprehensively
explores
recently
developed
gene-based
biofluids
used
conventional
cutting-edge
techniques
employed
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: March 13, 2024
Animal
models
have
been
commonly
used
in
immunotherapy
research
to
study
the
cell
response
external
agents
and
assess
effectiveness
safety
of
new
therapies.
Over
past
few
decades,
immunocompromised
(also
called
immunodeficient)
mice
allowed
researchers
grow
human
tumor
cells
without
impact
host’s
immune
system.
However,
while
this
model
is
very
valuable
understand
biology
underlying
mechanism
immunotherapy,
results
may
not
always
directly
translate
humans.
The
microenvironment
has
significant
implications
for
engraftment,
growth,
invasion,
etc.,
system
plays
a
critical
role
shaping
microenvironment.
Human
immunocompetent
mice,
also
named
humanized
are
engineered
that
possess
functional
cells.
This
vivo
can
be
effectively
effect
implanted
tumor.
Moreover,
mimic
treatment.
section
an
overview
current
understanding
different
could
utilized
chordoma.
